scholarly journals Studies of the correlation between dual-source CT measured thyroid iodine concentrations, contents and thyroid function

2019 ◽  
Author(s):  
ZhengTeng Li ◽  
Dongmei Pan ◽  
Rui Zhai ◽  
Min Wang
Keyword(s):  
Thyroid Function ◽  
Thyroid Tissue ◽  
Iodine Content ◽  
Iodine Concentration ◽  
Dual Source Ct ◽  
Total Iodine ◽  
Total Triiodothyronine ◽  
Total Thyroxine ◽  
Dual Source ◽  
The Mean

Abstract Background The aim of this study is to investigate the correlation between dual-source CT measured iodine concentration, total iodine content and blood measured thyroid parameters.Methods Dual-source CT was used to scan the neck of thyroid patients. The mean iodine concentration and thyroid tissue volume were measured to calculate the total iodine content of thyroid. Relevant test of triiodothyronine (FT3), total triiodothyronine (TT3), total thyroxine (TT4), free thyroxine (FT4), and thyroid hormone (TSH) were conducted. The correlation of thyroid mean iodine concentration and total iodine content with blood measured thyroid function was analyzed.Result The total iodine content in thyroid was positively correlated with FT3, but negatively correlated with TSH. The mean iodine concentration of thyroid was positively correlated with both FT3 and TT3.Conclusion The thyroid iodine content measured by dual-source CT can be used to determine the human iodine nutritional status and evaluate thyroid functions, which will provide help for the diagnosis and treatment of thyroid diseases.

scholarly journals Iodine concentration and content measured by dual-source computed tomography are correlated to thyroid hormone levels in euthyroid  patients: a cross-sectional study in China

2019 ◽  
Author(s):  
ZhengTeng Li ◽  
Rui Zhai ◽  
HongMei Liu ◽  
Min Wang ◽  
Dongmei Pan
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Function ◽  
Thyroid Tissue ◽  
Iodine Content ◽  
Iodine Concentration ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Total Iodine ◽  
Cross Sectional ◽  
The Mean

Abstract Background: The aim of this study was to investigate the correlation of the dual energy CT measured iodine concentration and total iodine content with blood measured thyroid parameters. Methods: 43 patients with normal thyroid function at our hospital from August 2017 to October 2019 were included in this retrospective study. Dual energy CT was used to scan the neck of thyroid patients. The mean iodine concentration and thyroid tissue volume were measured to calculate the total iodine content of the thyroid. Relevant tests of triiodothyronine (FT3), total triiodothyronine (TT3), total thyroxine (TT4), free thyroxine (FT4), and thyroid hormone (TSH) were conducted. The correlation of the thyroid mean iodine concentration and total iodine content with blood-measured thyroid function was analysed. Result: The total iodine content in the thyroid was positively correlated with FT3 but negatively correlated with TSH. The mean iodine concentration of the thyroid was positively correlated with both FT3 and TT3. Conclusion : The thyroid iodine content measured by dual energy CT can be used to determine the human iodine nutritional status and evaluate thyroid function, which will facilitate the diagnosis and treatment of thyroid diseases.

scholarly journals Iodine concentration and content measured by dual-source computed tomography are correlated to thyroid hormone levels in euthyroid patients

2019 ◽  
Author(s):  
ZhengTeng Li ◽  
Rui Zhai ◽  
HongMei Liu ◽  
Dongmei Pan
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Function ◽  
Thyroid Tissue ◽  
Iodine Content ◽  
Iodine Concentration ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Total Iodine ◽  
Normal Thyroid Function ◽  
The Mean

Abstract Background: The aim of this study was to investigate the correlation of the dual energy CT measured iodine concentration and total iodine content with blood measured thyroid parameters. Methods: 43 patients with normal thyroid function at our hospital from August 2017 to October 2019 were included in this retrospective study. Dual energy CT was used to scan the neck of thyroid patients. The mean iodine concentration and thyroid tissue volume were measured to calculate the total iodine content of the thyroid. Relevant tests of triiodothyronine (FT3), total triiodothyronine (TT3), total thyroxine (TT4), free thyroxine (FT4), and thyroid hormone (TSH) were conducted. The correlation of the thyroid mean iodine concentration and total iodine content with blood-measured thyroid function was analysed. Result: The total iodine content in the thyroid was positively correlated with FT3 but negatively correlated with TSH. The mean iodine concentration of the thyroid was positively correlated with both FT3 and TT3. Conclusion: The thyroid iodine content measured by dual energy CT can be used to determine the human iodine nutritional status and evaluate thyroid function, which will facilitate the diagnosis and treatment of thyroid diseases.

scholarly journals Iodine and iodothyronine content in human neonate thyroid gland

2002 ◽  
Vol 54 (3-4) ◽  
pp. 69-74 ◽  
Author(s):  
Svetlana Savin-Zegarac ◽  
Dubravka Cvejic ◽  
Olgica Nedic ◽  
R. Radosavljevic ◽  
Ivana Petrovic
Keyword(s):  
Thyroid Gland ◽  
Gestational Age ◽  
Thyroid Tissue ◽  
Iodine Content ◽  
Postnatal Life ◽  
Total Iodine ◽  
Mean Values ◽  
Human Neonate ◽  
The Mean ◽  
Human Neonates

A few years after the iodine content of salt in Serbia was increased from 7 to 15 mg/kg NaCI, iodine, thyroxine (T4) and triiodothyronine (T3) concentrations were measured in thyroid tissue obtained at autopsy from 21 human neonates who died within 30 days after birth. The thyroidal iodine as well as T4 and T3 content per gland in?creased progressively with gestational age of human neonates (r = 0.73, 0.70 and 0.67 respectively, p < 0.001). In seven newborns (gestational age 36 to 41 weeks) the mean values for total iodine, T4 and T3 per gland were 109.1 ?g, 52.2 ?g and 4.4 ?g respectively. The results of iodine and iodothyroninc content found in neonatal thyroid gland, particularly at the end of gestation and a few days of postnatal life, indicates that the iodine supply was satisfactory.

scholarly journals Evaluation of thyroid function status in patients with alopecia areata

2018 ◽  
Vol 4 (3) ◽  
pp. 277
Author(s):  
Ehimen P. Odum ◽  
Collins Amadi ◽  
Bolaji I. Otike-Odibi
Keyword(s):  
Thyroid Function ◽  
Alopecia Areata ◽  
Clinical Status ◽  
Thyroid Stimulating Hormone ◽  
Port Harcourt ◽  
High Prevalence ◽  
Total Triiodothyronine ◽  
Total Thyroxine ◽  
The Mean ◽  
The University

<p class="abstract"><strong>Background:</strong> Epidemiologic reports suggest a high prevalence of thyroid function abnormalities among patients with alopecia areata. Hence, this study was designed to investigate this hypothesis among indigenous Nigeria patients with alopecia areata.</p><p class="abstract"><strong>Methods:</strong> The study was a retrospective analysis of records of thyroid function investigations of patients with alopecia areata who had presented to the Department of Chemical Pathology and Metabolic Medicine of the University of Port Harcourt Teaching Hospital (UPTH), Nigeria over a 10-year period (1<sup>st</sup> January 2007 and 31<sup>st</sup> December 2016). Records of patients’ age, sex, thyroid stimulating hormone (TSH), total thyroxine (T4), and total triiodothyronine (T3) were acquired from laboratory records and analyzed using SPSS version 15. A p&lt;0.05 was applied as being significant.<strong></strong></p><p class="abstract"><strong>Results:</strong> One hundred and thirteen (113) records of patients with alopecia areata were reviewed, among them 55 (48.7%) males and 58 (51.3%) females with no sex difference (p=0.778). The mean age of study cohorts was 29.42±10.27 (range 16–63) with the majority (61.9%) between the age group 20 to 40 years. No difference in the mean age, TSH, and T3 levels were observed between the males and females. Thyroid function abnormalities were observed in 27.3% of study cohorts and the most prevalent abnormality was hypothyroidism (16.8% subclinical and 4.4% primary) with a female preponderance.</p><p><strong>Conclusions:</strong> The study suggests an association of alopecia areata with thyroid function abnormalities. Patients with alopecia areata should be screened for thyroid function abnormalities irrespective of clinical status.</p>

Abstract 2598: Radiation Exposure, Procedure Time And Contrast Load In Patients Referred For Coronary Angiography: Head-to-head Comparison Of Dual Source Ct With Conventional Coronary Angiography.

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Carlos A Van Mieghem ◽  
Annick C Weustink ◽  
Marcel Kofflard ◽  
A. Schreve-Steensma ◽  
Niels A Matheijssen ◽  
...  
Keyword(s):  
Coronary Angiography ◽  
Radiation Exposure ◽  
Contrast Material ◽  
Conventional Coronary Angiography ◽  
Dual Source Ct ◽  
Procedure Time ◽  
X Ray ◽  
Iodinated Contrast ◽  
Dual Source ◽  
The Mean

Introduction and aim: Dual Source CT (DSCT) scanners, with an increased temporal resolution (83 ms), are becoming widely available. To evaluate the current potential of this scanner in the clinical arena, we performed a head-to-head comparison with conventional coronary angiography (CCA) taking into account the following parameters: radiation exposure, procedure time and contrast load. Methods: During a one-year period (april 2006 to march 2007) we compared a consecutive patient group who underwent DSCT (318 patients, 222 male, mean age 68±11 years) and CCA (352 patients, 258 male, mean age 61±12) respectively. Patients with previous bypass surgery were excluded. In DSCT, the volume of iodinated contrast material was adapted to the scan time. A contrast bolus was injected in an antecubital vein at a flow rate of 5.0 ml/s followed by a saline chaser of 40 ml at 5.0 ml/s. Each tube provided 412 mAs/rot (maximum), and full X-ray tube current was given during 25–70% of the RR-interval. Exposure data were collected using the x-ray dosimetrical reports from DSCT and CCA. Results: The mean procedure time using DSCT and CCA was 16.1±4.7 min and 44.1±25.5 min (p<0.001), respectively. The mean contrast load in DSCT and CCA was 77.9±7.6 ml and 175.3±4.3ml (p<0.001), respectively. The overall radiation exposure for DSCT and CCA was calculated as 15.3±4.0 mSv and 5.7±4.3 mSv, respectively. Radiation exposure with DSCT was significantly lower (p<0.001) in patients with a heart rate of >70 bpm (12.9±3.1 mSv ) as compared with patients with heart rates <70 bpm (16.4±3.8 mSv). Conclusion: In today’s practice currently available DSCT scanners perform favorably as compared with CCA, considering procedure time and patient contrast load. Radiation exposure with DSCT remains higher but should not be considered a major disadvantage taking into account the relatively old age group that generally undergoes coronary angiography and the major benefit of not being exposed to the risks of an invasive procedure.

Thyroid function of subjects with goitre and cretinism in an endemic goitre area of rural China after use of iodized salt

1988 ◽  
Vol 118 (3) ◽  
pp. 444-448 ◽  
Author(s):  
Xuan-Ping Pang ◽  
An Ouyang ◽  
Tian-Sue Su ◽  
Jerome M. Hershman
Keyword(s):  
Thyroid Function ◽  
Rural China ◽  
Public Health Problem ◽  
Iodine Content ◽  
Iodine Concentration ◽  
Epidemiological Survey ◽  
Iodized Salt ◽  
Endemic Goitre ◽  
Serum Thyroglobulin ◽  
Serum Free

Abstract. Endemic goitre and cretinism are still a public health problem in China. An epidemiological survey showed that about 5% of the inhabitants in Daxin village, Henan province, had goitre or cretinism after an iodized salt prevention programme had been carried out for two decades. The main food for the inhabitants of this area has an iodine content <30 nmol/kg and the water for cooking and drinking has an iodine concentration between 7–12 nmol/l. We studied thyroid function in subjects of this village. There were 42 with grade 0 goitre (males 29, females 13), 42 grade I (males 23, females 19), 27 grade II (males 9, females 18), 31 grade III (males 14, females 17) and 34 cretinism patients (males 30, females 4) diagnosed and classified according to WHO criteria. Serum T4, free T4, T3, free T3, T3 uptake, TSH and thyroglobulin were measured in these subjects. The patients with goitre or cretinism had significantly decreased serum free T4 and increased serum T3 and free T3 levels compared with those of controls. Thyroid size was positively correlated with age and serum thyroglobulin concentrations. Serum thyroglobulin was significantly increased even in the grade 0 goitre subjects. The percentages of subjects with serum free T4 < 12 nmol/l, T3 >2.5 nmol/l, free T3 >5.2 pmol/l, TSH >3.5 mU/l, T3/T4 ratio >0.03 and free T3/free T4 ratio >0.36 were significantly higher among goitre and cretinism patients than among controls. The data suggest that there is partial compensation for a marginal deficiency of iodine in the inhabitants of this village.

Lacking evidence for release of thyroid hormones from circulating thyroglobulin during subtotal thyroidectomy

1988 ◽  
Vol 117 (2) ◽  
pp. 219-224 ◽  
Author(s):  
J. Date ◽  
M. Blichert-Toft ◽  
U. Feldt-Rasmussen ◽  
V. Haas
Keyword(s):  
Thyroid Hormones ◽  
Mean Value ◽  
Thyroid Stimulating Hormone ◽  
Mean Values ◽  
Thyroid Resection ◽  
Free Thyroxine Index ◽  
Total Triiodothyronine ◽  
Total Thyroxine ◽  
The Mean ◽  
Peak Value

Abstract. The effect of subtotal thyroid resection for thyrotoxicosis on concentrations of serum thyroid hormones and thyroglobulin (Tg), was determined in 10 patients during operation and the subsequent 18 days. Mean serum Tg responded drastically, increasing from a pre-operative value of 0.30 nmol/l to a peak value of approximately 26 nmol/l during operation followed by a gradual decline to levels lower than before surgery on day 18. Mean serum total thyroxine was 114 nmol/l pre-operatively and free thyroxine index (FT4I) 105 units. Both fluctuated only slightly during operation. Postsurgically, the mean values decreased to below 50% of the pre-operative level. Mean serum total triiodothyronine (TT3) was 1.46 nmol/l pre-operatively. It decreased during operation, reaching a nadir of 0.55 nmol/l on day 2, whereafter the concentration increased slightly. Mean serum reverse T3 (rT3) was 0.45 nmol/l pre-operatively, increased 62% during surgery, and decreased postsurgically. The mean value of serum thyroid stimulating hormone (TSH) was 0.61 mU/l pre-operatively and remained below 1 mU/l during and after operation, but from day 10 concentration began to rise steadily. It is concluded that the vast release of Tg during thyroid resection did not contribute to the concentration of serum T4 to an extent of clinical relevance.

Total serum thyroxine and triiodothyronine; a comparison between Graves' disease and hyperthyroxinaemia due to thyroxine replacement

1984 ◽  
Vol 107 (2) ◽  
pp. 213-217 ◽  
Author(s):  
C.J. Pearce ◽  
R. L. Himsworth
Keyword(s):  
Molar Ratio ◽  
Total Serum ◽  
Graves Disease ◽  
Convenient Means ◽  
Significant Linear Correlation ◽  
Total Triiodothyronine ◽  
Total Thyroxine ◽  
Group A ◽  
The Mean ◽  
N 93

Abstract. Serum concentrations of total thyroxine (T4) and total triiodothyronine (T3) were measured in a group of patients (n = 113) presenting with untreated hyperthyroidism due to Graves' disease and in subjects receiving oral T4 replacement (n = 93) in whom the total T4 concentration was supraphysiological (> 150 nmol/l). The mean total T4 concentration in the hyperthyroid group was 226 nmol/l, sd 59, range 151–420, and the mean total T3 concentration was 6.8 nmol/l, sd 2.73, range 3.1–17.5. For the group receiving T4 the mean total T4 concentration was 175 nmol/l, sd 25, range 150–258, and the mean total T3 concentration was 2.66 nmol/l, sd 0.45, range 1.7–4.2. In the hyperthyroid group a highly significant linear correlation was found between total T4 and total T3, T3 = 0.0354 T4 – 1.21, r = 0.761, P ⪡0.001, while in the patients taking T4 this correlation was less close, T3 = 0.0073 T4 + 1.39, r = 0.398, P⪡0.001. The two groups are readily distinguished by expressing total T4 as a molar ratio of total T3. In the hyperthyroid group the mean T4:T3 ratio was 35.6, sd 7.8, range 19.9–56.1, compared to the patients on T4 where the mean T4:T3 ratio was 67.0, sd 11.7, range 44.3–114 (t = 22.5, P⪡0.0001). An arbitrarily chosen value of 50 for the T4:T3 ratio affords a simple and convenient means of distinguishing the two categories: in only 3 patients with Graves' disease (2.6%) was the ratio above this, and it was below in only 5 patients (5.4%) taking T4. Where there is doubt as to the aetiology of hyperthyroxinaemia this simple operation will differentiate between hyperthyroidism caused by Graves' disease and surreptitious ingestion of T4. In other clinical situations where symptoms of hyperthyroidism are associated with a T4:T3 ratio greater than 50 the combination may suggest subacute thyroiditis or iodide-induced thyroid dysfunction.

scholarly journals Biochemical and Microstructural Profile of the Thyroid Gland from Lambs Raised on Experimental Diets

2020 ◽  
Vol 50 (4) ◽  
pp. 670-680
Author(s):  
Tatyana Giro ◽  
Andrey Kulikovsky ◽  
Alexandra Knyazeva ◽  
Ivan Domnitsky ◽  
Anna Giro
Keyword(s):  
Thyroid Tissue ◽  
Reproductive Function ◽  
Iodine Content ◽  
Iodine Concentration ◽  
Essential Elements ◽  
Feed Additives ◽  
Control Group ◽  
Organic Iodine ◽  
Thyroid Glands ◽  
Negative Effect

Introduction. The present research featured biochemical and microstructural features of thyroid glands obtained from lambs raised on various feeds enriched with essential elements. The article focuses on iodine as the most important physiologically active microelement. Iodine participates in the synthesis of thyroid hormones, namely thyroxine and triiodothyronine, which are known to regulate metabolic processes. Iodine deficiency may impair reproductive function and cause such diseases as endemic goiter. Study objects and methods. The study involved thyroid glands from lambs of the Edilbaev breed aged seven months. The lambs were divided into four experimental groups, ten animals in each. The lambs received several feed additives. Ioddar-Zn and DAFS-25 had a balanced protein and carbohydrate content, while the mineral feed of Coretron brand contained such trace elements and minerals as iodine, selenium, and silicon. Results and discussion. The experiment made it possible to describe the microstructural profile of the thyroid glands extracted from seven-month-old lambs raised on feeds enriched with iodine and selenium. Ioddar-Zn and DAFS-25 did not harm the structure of the thyroid tissue, while causing its functional activation in some cases. The morphological parameters of the thyroid glands indicated some breed differences. The iodine concentration in the thyroid glands obtained from the experimental animals was five or six times higher than that in the control group. The content of mono- and diiodotyrosine depended on the accumulation profile of organic iodine. Conclusion. Diets enforced with DAFS-25, Ioddar-Zn, silicon, and a protein-carbohydrate complex produced no negative effect on the structure of the thyroid tissue. It fact, the diet increased the organic iodine content in the thyroid glands in the form of iodotyrosines. The gland structure revealed some cubic epithelium or follicular cells. The mass spectrometric studies confirmed the presence of covalently bound iodine in the form of mono- and diiodotyrosine. Thus, the abovementioned feed additives can be recommended for industrial use.

Sign in / Sign up

Export Citation Format

Share Document