scholarly journals The interaction between serum uric acid and triglycerides level on blood The interaction between serum uric acid and triglycerides level on blood pressure in middle-aged and elderly individuals in China: result from a large national cohort study

2020 ◽  
Author(s):  
Lin Zhang ◽  
Jin-long Li ◽  
Lei-lei Guo ◽  
Hong Li ◽  
Dan Li ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Linear Regression ◽  
Serum Uric Acid ◽  
Linear Regression Analysis ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Confounding Factors ◽  
Middle Aged ◽  
Elderly Individuals

Abstract Background: The purpose of the research was to explore the extent of interaction between triglycerides (TG) and serum uric acid (SUA) level with blood pressure (BP) in middle-aged and elderly individuals in China. Methods: Data were selected from the China Health and Retirement Longitudinal Study (CHARLS), a cross-sectional study. 3345(46.99%) men with average ages of 60.24 ± 9.24 years and 3774 (53.01%) women with average ages of 59.91 ± 9.95 years were included in the study. Differences between gender, or between categories of blood pressure levels were evaluated by t-test or chi-square test. The adjusted associations between various characteristics and BP status were first compared using linear regression models, as appropriate. Then, A general linear model adjusted for confounding factors(socio-demographic characteristics, health behaviors , medical history) metabolic measures [C-reactive protein(CRP), hemoglobin A1c (HbA1c), fasting plasma glucose(FPG), low-density lipoprotein cholesterol(LDL-C), high-density lipoprotein cholesterol(HDL-C), estimated glomerular filtration rate(eGFR), body mass index(BMI)]) was used to examine the synergistic effect of SUA and TG level on BP in middle-aged and elderly individuals in China. Results: Age-adjusted partial Pearson’s correlation coefficient showed that SUA and TG level positively correlated with both systolic blood pressure (SBP) and diastolic blood pressure (DBP) in both men and women. Multiple linear regression analysis showed the TG level was significantly and positively associated with SBP and DBP in both men (SBP: β =0.068, P =0.001; DBP: β =0.064, P=0.002) and women (SBP: β =0.061, P =0.002; DBP: β =0.084, P=0.000), but SUA were significantly and positively associated with SBP in both men (SBP: β =0.047, P =0.013) and women (SBP: β =0.040, P =0.028), regardless of other confounding factors. After adjusting for related potential confounders, evidence of interaction between SUA and TG level on SBP (men: β =-1.090, P =0.726; women: β =-0.692, P=0.861) and DBP (men: β=-1.026, P =0.572; women: β =-0.794, P =0.842) was not observed. Conclusion: The interaction effect of SUA and TG level on BP was not observed in our study. Moreover, high SUA level was significantly associated with DBP, while high TG level was strongly related to both DBP and SBP.

The interaction between serum uric acid and triglycerides level on blood pressure for middle-aged and elderly individuals in China

2019 ◽  
Author(s):  
Lin Zhang ◽  
Jin-long Li ◽  
Lei-lei Guo ◽  
Hong Li ◽  
Dan Li ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Linear Regression ◽  
Systolic Blood Pressure ◽  
Serum Uric Acid ◽  
Linear Regression Analysis ◽  
General Linear ◽  
Confounding Factors ◽  
Middle Aged ◽  
Elderly Individuals

Abstract Background The purpose of the research is to explore the extent of interaction between triglycerides (TG) and serum uric acid (SUA) level with blood pressure (BP) in middle-aged and elderly individuals in China.Methods Data were selected from the CHARLS, a cross-sectional study. A total of 7119 individuals aged 45 to 96 in our study was included. Differences between gender, or between categories of blood pressure levels were evaluated by t-test or chi-square test. The adjusted associations between various characteristics and BP status were first compared using linear regression models, as appropriate. Then, general linear models adjusting for related potential confounders were used to examine the synergistic effect of SUA and TG level on blood pressure (BP) for middle-aged and elderly individuals in China.Results Age-adjusted partial Pearson’s correlation coefficient showed that SUA and TG level positively correlated with both SBP and DBP in men and women. Multiple linear regression analysis showedTG levels were significantly and positively associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in both males (SBP: β =0.068, P =0.001; DBP: β =0.064, P =0.002) and females (SBP: β =0.061, P =0.002; DBP: β =0.084, P =0.000), but serum uric acid (SUA) were significantly and positively associated with systolic blood pressure (SBP) in both males (SBP: β =0.047, P =0.013) and females (SBP: β =0.040, P =0.028), regardless of other confounding factors. A general linear model adjusted for confounding factors was used to assessed the statistical significance of the synergistic relationship between serum uric acid (SUA) and triglycerides (TG) level. Evidence of interaction between serum uric acid (SUA) and triglycerides (TG) level on SBP (men: β =-1.090, P =0.726; women: β =-0.692, P =0.861) and DBP (men: β=-1.026, P =0.572; women: β =-0.794, P =0.842) was not observed.Conclusion The interaction effect of serum uric acid (SUA) and triglycerides (TG) level on blood pressure (BP) was not observed in our study.

scholarly journals The Effects of Cardiometabolic Factors on the Association Between Serum Uric Acid and Chronic Kidney Disease in Chinese Middle-aged and Older Population: a Mediation Analysis

2021 ◽  
Author(s):  
Lu Xu ◽  
Hang Sun ◽  
Lili Liu ◽  
Siyan Zhan ◽  
Shengfeng Wang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
Uric Acid ◽  
Blood Glucose ◽  
Kidney Disease ◽  
Linear Regression ◽  
Serum Uric Acid ◽  
Dose Response ◽  
Mediation Analysis ◽  
Density Lipoprotein

Abstract Background: To explore whether dyslipidemia, hyperglycemia or hypertension has mediating effect on the association between serum uric acid (SUA) and the development of chronic kidney disease (CKD).Methods: We conducted a mediation analysis to explore the potential mediating effects of systolic blood pressure (SBP), diastolic blood pressure (DBP), blood glucose, triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) on the association between SUA and estimated glomerular filtration rate (eGFR). The data were obtained from China Health and Retirement Longitudinal Study (CHARLS), covering 5 762 individuals. Results: SUA had a negative dose-response total effect on eGFR (β -3.11, 95% CI -3.40 to -2.82, P-value<0.001). The linear regression between SUA and seven potential mediators indicated that blood glucose (β 0.80, 95% CI 0.18 to 1.42, P-value=0.012), TG (β 10.01, 95% CI 8.22 to 11.79, P-value<0.001), TC (β 2.64, 95% CI 1.83 to 3.45, P-value<0.001), HDL-C (β -0.27, 95% CI -0.52 to -0.02, P-value=0.034) and LDL-C (β 1.15, 95% CI 0.49 to 1.80, P-value=0.001) all had significant dose-response association with SUA, but SBP and DBP showed no significant association with SUA. In terms of the association between potential mediators and eGFR, only TG did not have significant linear association with eGFR (β 0.00, 95% CI 0.00 to 0.01, P-value=0.117). The linear regression showed that SUA was directly associated with eGFR (P-value<0.001).Conclusions: This study supported that the association between SUA and the risk of CKD was not mediated by hypertension, hyperglycemia or dyslipidemia.

scholarly journals The Effects of Cardiometabolic Factors on the Association Between Serum Uric Acid and Chronic Kidney Disease in Chinese Middle-Aged and Older Population: A Mediation Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Lu Xu ◽  
Hang Sun ◽  
Lili Liu ◽  
Siyan Zhan ◽  
Shengfeng Wang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
Uric Acid ◽  
Blood Glucose ◽  
Kidney Disease ◽  
Linear Regression ◽  
Serum Uric Acid ◽  
Dose Response ◽  
Mediation Analysis ◽  
Density Lipoprotein

IntroductionTo explore whether dyslipidemia, hyperglycemia or hypertension has mediating effect on the association between serum uric acid (SUA) and the development of chronic kidney disease (CKD).MethodsWe conducted a mediation analysis to explore the potential mediating effects of systolic blood pressure (SBP), diastolic blood pressure (DBP), blood glucose, triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) on the association between SUA and estimated glomerular filtration rate (eGFR). The data were obtained from China Health and Retirement Longitudinal Study (CHARLS), covering 5,762 individuals.ResultsSUA had a negative dose-response total effect on eGFR (β -3.11, 95% CI -3.40 to -2.82, P-value&lt;0.001). The linear regression between SUA and seven potential mediators indicated that blood glucose (β 0.80, 95% CI 0.18 to 1.42, P-value=0.012), TG (β 10.01, 95% CI 8.22 to 11.79, P-value&lt;0.001), TC (β 2.64, 95% CI 1.83 to 3.45, P-value&lt;0.001), HDL-C (β -0.27, 95% CI -0.52 to -0.02, P-value=0.034) and LDL-C (β 1.15, 95% CI 0.49 to 1.80, P-value=0.001) all had significant dose-response association with SUA, but SBP and DBP showed no significant association with SUA. In terms of the association between potential mediators and eGFR, only TG (β 0.003, 95% CI -0.001 to 0.01, P-value=0.117) and HDL-C (β 0.01, 95% CI -0.02 to 0.04, P-value=0.444) did not have significant linear association with eGFR. The linear regression showed that SUA was directly associated with eGFR (P-value&lt;0.001).ConclusionsThis study supported that the association between SUA and the risk of CKD was not mediated by hypertension, hyperglycemia or dyslipidemia.

Serum uric acid is associated with metabolic risk factors for cardiovascular disease in the Uygur population

2009 ◽  
Vol 34 (6) ◽  
pp. 1032-1039 ◽  
Author(s):  
Nan F. Li ◽  
Hong M. Wang ◽  
Jin Yang ◽  
Ling Zhou ◽  
Xiao G. Yao ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Blood Pressure ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Resistance Index ◽  
Lipoprotein Cholesterol ◽  
Model Assessment

The prevalence of hyperuricemia is low in Uygurs, who have a high prevalence of cardiovascular risk factors such as hypertension, overweight–obesity, dyslipidemia, hyperglycemia, and insulin resistance (IR). This study sought to investigate the relationships between serum uric acid (UA) and these risk factors in this population. A cross-sectional study was conducted in Uygurs (859 males, 1268 females) aged 20 to 70 years. Demographic data, systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), and fasting and postprandial blood were obtained, and biological measurements were determined. The mean of BMI, SBP, DBP, total cholesterol, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), triglycerides, fasting blood glucose, fasting insulin, and homeostasis model assessment insulin resistance index (HOMA-IR), and the prevalence of hypertension, IR, hyperglycemia, overweight–obesity, hypercholesteremia, hyper-LDL-c, and hypertriglyceridemia increased with UA but the prevalence of hypo-HDL-c decreased (p < 0.05). Logistic regression analysis showed that the odds ratios for IR, overweight–obesity, hypercholesteremia, hyper-LDL-c, and hypertriglyceridemia against the lowest UA group increased but decreased for hypo-HDL-c (p < 0.05). The UA in the hypo-HDL-c group was lower than that of the controls; the prevalence of hypo-HDL-c in hyperuricemia subjects was lower than in those with normal UA (p < 0.05). But the opposite results were observed between overweight–obesity, hyperglycemia, IR, hypercholesteremia, hypertriglyceridemia, and hyper-LDL-c and correspondence controls, respectively (p < 0.05). In Uygur, elevated UA is associated with overweight–obesity, hypercholesteremia, hyper-LDL-c, hypertriglyceridemia, hyperglycemia, and IR. The HDL-c level significantly increases with UA, whereas the prevalence of hypo-HDL-c decreases. Further studies are needed to clarify why UA is positively correlated to HDL-c.

Aerobic Capacity, Obesity, and Atherosclerotic Risk Factors in Male Adolescents

PEDIATRICS ◽  
1985 ◽  
Vol 75 (5) ◽  
pp. 813-818
Author(s):  
Raymond R. Fripp ◽  
James L. Hodgson ◽  
Peter O. Kwiterovich ◽  
John C. Werner ◽  
H. Gregg Schuler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Regression Analysis ◽  
Body Mass ◽  
Linear Regression Analysis ◽  
Density Lipoprotein ◽  
Plasma Triglyceride ◽  
Lipoprotein Cholesterol ◽  
Atherosclerotic Risk Factors

Correlations between aerobic capacity, obesity, and atherosclerotic risk factors were evaluated in adolescents with low-to-moderate levels of physical fitness. Subjects with higher levels of fitness had a more favorable risk profile with decreased body mass index, lower systolic and diastolic blood pressure and plasma triglyceride levels, and higher plasma high-density lipoprotein-cholesterol levels. Simple linear regression analysis revealed an association between body mass index and blood pressure, plasma triglyceride and plasma highdensity lipoprotein-cholesterol. The level of aerobic fitness as determined by exercise duration was also associated with the same atherosclerotic risk factors. However, multiple linear regression analysis demonstrated that body mass index provided the largest explanation, by those variables examined, of the interindividual variance in blood pressure, plasma triglyceride, and high-density lipoprotein-cholesterol. Aerobic fitness contributed only minimally to the variation in these risk factors. These findings suggest that if aerobic conditioning is used to modify atherosclerotic risk factors, it should be accompanied by a reduction in weight in adolescents with low-to-moderate levels of physical fitness.

scholarly journals Serum uric acid: Association with anthropometric, lipid and complete blood count parameters in Iranian healthy population

2020 ◽  
Author(s):  
Hamid Soori ◽  
Parinaz Rezapour ◽  
Hadis Najafimehr ◽  
Toktam Alirezaei
Keyword(s):  
Uric Acid ◽  
Lipid Profile ◽  
Multiple Regression ◽  
Serum Uric Acid ◽  
Body Fat ◽  
Serum Lipid ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Healthy Population ◽  
Lymphocyte Ratio

Abstract Objectives A relationship between elevated serum uric acid (SUA) and hypertension, metabolic syndrome and cardiovascular disease has been established. In this study, the relationship of SUA levels and anthropometric measures, serum lipid profile and neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) was examined.Methods Anthropometric parameters including body-mass index (BMI), waist circumference (WC), waist to height ratio(WHtR), waist to hip ratio(W/H), waist to pelvic ratio(W/P), neck circumference(NC), body fat mass(BFM) were obtained, and serum lipid profile containing, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol, triglycerides(TG), also, NLP, PLR, basal metabolic rate (BMR), visceral fat level (VFL) and percent body fat (PBF) were measured among 2921 healthy subjects of young and middle-aged Iranian people. Statistical analysis was performed using SPSS 21 software. To assess the normality of data, the Kolmogorov–Smirnov test was used. Logarithmic transformation was performed for some variables with non-normal distribution. The association between 2 quantitative variables was measured using bivariate correlation (Pearson or Spearman). Pearson correlations and multiple regression analysis were performed to assess the correlation between variables. Simple and multiple regression analyses were performed to predict some variables. P- value <0.05 was considered significant.Results There were 1113 males (mean age, 41.49 ± 8.62 years) and 1808 females (mean age, 42.36 ± 9.07 years) in this study. the male group had a mean SUA level of 4.81± 1.2 mg/dl and the female group had a mean of 4.76 ± 1.1 mg/dl. The results of data analysis showed all studied factors were correlated with SUA level except VFL, BFM, and PLR. The highest correlation was related to skinfold fat thickness, BMR and HDL.Conclusion According to the finding of this study, SUA level measurement might be advisable in healthy population to identify those at increased risk of health problems who might benefit from further evaluation.

scholarly journals U-Shaped Association Between Serum Uric Acid Level and Hypertensive Heart Failure: A Genetic Matching Case-Control Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Hongxuan Xu ◽  
Quan Wang ◽  
Yunqing Liu ◽  
Lingbing Meng ◽  
Huanyu Long ◽  
...  
Keyword(s):  
Heart Failure ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Serum Uric Acid Level ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Public Healthcare ◽  
Quadratic Term ◽  
Cross Sectional ◽  
Failure Group

Background: Heart failure (HF) is a global pandemic and lays an added burden on public healthcare. Previous studies indicated that high and low serum uric acid levels are associated with worse outcomes in many diseases. Reduced serum uric acid may not result in a better outcome.Methods: A comparative, matched cross-sectional study design was implemented. The matching variables were age, sex, BMI, BP, and histories of CKD, CVD, diabetes mellitus, stroke, hyperlipidemia. We reviewed the electronic medical records to identify patients diagnosed with hypertension or hypertensive heart failure (HHF) admitted to Beijing Hospital's cardiology department.Results: The median age of the two groups after matching are 71. There are 55.6% males in the hypertension group and 53.8% in the heart failure group. Univariate logistic regression analysis showed that UA's quadratic term is significant (OR = 1.00, 95% CI 1.00 to 1.00; P = 0.03), which indicated a u-shaped relationship between hypertension and HHF. FBS (OR = 0.22, 95% CI 0.05 to 0.95, p = 0.07) and HDL (OR = 1.23, 95% CI 1.00 to 1.54, P = 0.05) were not significant but close.Conclusion: Our results supported that both low and high uric acid levels were predictive of hypertensive heart failure. Besides, high-density lipoprotein cholesterol and fasting blood sugar were also associated with hypertensive heart failure. Low-density lipoprotein cholesterol was not associated with hypertensive heart failure.

scholarly journals The Temporal Relationship Between Sleep Duration and Blood Lipids in Chinese Middle-aged and Elderly Individuals: Evidence From CHARLS

2021 ◽  
Author(s):  
Yilei Ma ◽  
Ziwei Chen ◽  
Yanran Duan ◽  
Tingting Mo ◽  
Wenli Liu ◽  
...  
Keyword(s):  
Sleep Duration ◽  
Temporal Relationship ◽  
Blood Lipids ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density Lipoprotein Cholesterol ◽  
Middle Aged ◽  
Elderly Individuals ◽  
Path Coefficients

Abstract Background: To explore the temporal relationship between blood lipids and sleep duration and clarify their potential causality in Chinese middle-aged and elderly individuals.Methods: We used medical examinations and questionnaire data of 5016 Chinese middle-aged and elderly individuals in 2011 and 2015. Cross-lagged path analysis was performed to examine the potential bidirectional relationships between blood lipids and sleep duration.Results: In total population, significant bidirectional relationship was observed between sleep duration and high-density lipoprotein cholesterol level and the path coefficients were -0.171 (P = 0.005) and -0.006 (P = 0.002). In contrast, there was a positive correlation between and sleep duration, and the path coefficient from triglycerides to sleep duration 4 year later (O = 0.001, P = 0.018) was greater than that from sleep duration to triglycerides 4 year later (b = 0.109, P = 0.847), with P = 0.030 for the difference between j and e. Longer sleep duration was associated lower levels of low-density lipoprotein cholesterol (c = -0.275, P = 0.097) and total cholesterol (t = -0.329, P = 0.096) 4 year later. In stratified analysis, effects of sleep duration on blood lipids were only observed among individuals aged < 60 years, while the effect in the opposite direction was observed in elderly individuals, and the cross-lagged path coefficients were more significant in adults with BMI > 25.Conclusions: Temporal relationships between sleep duration and high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total cholesterol, and triglycerides were different. The strength and direction of the relationships may be related to age and BMI.

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