scholarly journals Correlation between optic disc deformation and retinal vasculature in non-pathological high myopia

2019 ◽  
Author(s):  
Jiao Sun ◽  
Jialin Wang ◽  
Yanling Wang
Keyword(s):  
Optic Disc ◽  
High Myopia ◽  
Cross Sectional Study ◽  
Foveal Avascular Zone ◽  
Flow Density ◽  
Retinal Vasculature ◽  
Fiber Layer ◽  
Cross Sectional ◽  
Nerve Fiber Layer Thickness ◽  
Retinal Microvasculature

Abstract Background: The aim of this study was to investigate the correlation between optic disc deformation and retinal vasculature in high myopia.Methods: One hundred and thirty eyes with non-pathological high myopia were included in this cross-sectional study. The optic disc tilt ratio, and horizontal and vertical disc diameters were analyzed using fundus color photography. A 3 × 3 mm2 grid and a 4.5 × 4.5 mm2 grid were used to scan parafoveal and peripapillary regions, respectively, using optical coherence tomography angiography. Vessel flow density (VFD) and fractal dimension of the retina and the foveal avascular zone (FAZ) were analyzed and quantified using en face projection images. Optic disc parameters that were associated with vascular changes were determined using multiple linear regression analysis.Results: Results from the multivariate analysis revealed that the tilt ratio (β = -2.291, p = 0.025) was negatively correlated with three sectors in the deep layer. Age was negatively correlated with the VFD of the retina (β = -2.161; p < 0.034). Additionally, FAZ was not significantly correlated with any factors in the current study. Further, there was a positive correlation between retinal nerve fiber layer thickness and VFD of the optic nerve head (β = -2.146, p = 0.035).Conclusions: Overall, our results demonstrated that optic disc deformation was negatively correlated with the retinal microvasculature in non-pathological high myopia. Therefore, optic disc deformation may be used to predict the retinal vasculature in high myopia.

scholarly journals Measuring Hemoglobin Levels in the Optic Disc of Parkinson’s Disease Patients Using New Colorimetric Analysis Software

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Maria Pilar Bambo ◽  
Elena Garcia-Martin ◽  
Maria Satue ◽  
Susana Perez-Olivan ◽  
Silvia Alayon ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Optic Nerve ◽  
Optic Disc ◽  
Healthy Subjects ◽  
Cross Sectional Study ◽  
Fiber Layer ◽  
Cross Sectional ◽  
Color Changes ◽  
Good Ability

Objective.To evaluate a new method of measuring hemoglobin (Hb) levels and quantifying the color changes in the optic nerve head of Parkinson’s disease (PD) patients. We also compared differences in retinal nerve fiber layer (RNFL) thicknesses obtained using spectral domain optical coherence tomography (OCT) device between PD group and healthy group.Methods.One hundred and fifty-five PD patients and 91 sex- and age-matched healthy subjects were included in this cross-sectional study. OCT examinations and one photograph of the optic disc were performed. The Laguna ONhE (“optic nerve hemoglobin”; Insoft SL, Tenerife, Spain) software was used to analyze the Hb level on the acquired optic disc photographs.Results.PD patients exhibited significantly reduced mean optic disc Hb percentages (57.56% in PD, 67.63% in healthy subjects;P=0.001) as well as reduced Hb in almost all analyzed sectors, with the largest differences detected in the inferior and nasal sectors. RNFL parameters were significantly reduced in PD patients compared with healthy subjects, especially in the inferior quadrant.Conclusions.Measurements of optic disc Hb levels obtained with the Laguna ONhE software had good ability to detect optic nerve color changes (more papillary paleness and consequently this could suggest optic atrophy and axonal loss) in PD patients.

scholarly journals Ocular biomarkers for cognitive impairment in nonagenarians; a prospective cross-sectional study

2019 ◽  
Author(s):  
Jacoba Alida van de Kreeke ◽  
Nienke Legdeur ◽  
Maryam Badissi ◽  
H. Ton Nguyen ◽  
Elles Konijnenberg ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Layer Thickness ◽  
Cross Sectional Study ◽  
Fundus Photography ◽  
Cognitively Impaired ◽  
Retinal Layer ◽  
Sectional Study ◽  
Fiber Layer ◽  
Cross Sectional ◽  
Nerve Fiber Layer Thickness

Abstract Background: Ocular imaging receives much attention as a source of potential biomarkers for dementia. In the present study, we analyze these ocular biomarkers in cognitively impaired and healthy participants in a population aged over 90 years (= nonagenarian), and elucidate the effects of age on these biomarkers. Methods: For this prospective cross-sectional study, we included individuals from the EMIF-AD 90+ study, consisting of a cognitively healthy (N=67) and cognitively impaired group (N=33), and the EMIF-AD PreclinAD study, consisting of cognitively healthy controls aged ≥60 (N=198). Participants underwent Optical Coherence Tomography (OCT) and fundus photography of both eyes. OCT was used to asses total and individual inner retinal layer thickness in the macular region (Early Treatment Diabetic Retinopathy Study circles) as well as peripapillary retinal nerve fiber layer thickness, fundus images were analyzed with Singapore I Vessel Assessment to obtain 7 retinal vascular parameters. Values for both eyes were averaged. Differences in ocular biomarkers between the 2 nonagenarian groups were analyzed using linear regression, differences between the individual nonagenarian groups and controls were analyzed using generalized estimating equations. Results: Ocular biomarkers did not differ between the healthy and cognitively impaired nonagenarian groups. Both nonagenarian groups differed in most ocular biomarkers from the younger controls. Conclusion: Ocular biomarkers were not associated with cognitive impairment in nonagenarians, making their use as a screening tool for dementing disorders in this group limited. However, ocular biomarkers were significantly associated with chronological age, which were very similar to those ascribed to occur in Alzheimer’s Disease.

scholarly journals Retinal and Choroidal Changes in Children with Moderate-to-High Hyperopia

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Yu Qian ◽  
Yingyan Ma ◽  
Qiurong Lin ◽  
Zhaoyu Xiang ◽  
Jun Qiang ◽  
...  
Keyword(s):  
Optic Disc ◽  
Axial Length ◽  
Choroidal Thickness ◽  
Cross Sectional Study ◽  
Fiber Layer ◽  
Cross Sectional ◽  
Swept Source ◽  
Uncorrected Visual Acuity ◽  
Spherical Equivalent Refraction ◽  
High Hyperopia

Purpose. This study aimed to investigate the characteristics of retinal nerve fiber layer (RNFL) thickness, ganglion cell layer (GCL) thickness, and choroidal thickness in children with moderate-to-high hyperopia (MHH). Methods. This was a cross-sectional study that enrolled 53 children with MHH and 53 emmetropic children. Subjects with a spherical equivalent refraction (SER) of +4.0 D or higher were included in the MHH group, and subjects with SER between −1.0 D and +1.0 D were included in the emmetropic group. Ophthalmic examinations, including uncorrected visual acuity, cycloplegic refraction, slit-lamp examination, axial length, and swept-source optical coherence tomography (SS-OCT; DRI OCT Triton-1, Topcon, Tokyo, Japan), were performed. Results. The RNFL and GCL in the temporal and inferior quadrants in 1–3 mm of the macular fovea were thinner in the MHH group than in the emmetropic group (all P < 0.05 ). The MHH group also had a thicker choroidal thickness in all regions (all P < 0.05 ). The SER was independently correlated with the average choroidal thickness in the optic disc and fovea (coefficient = 4.853, P < 0.001 for the optic disc; coefficient = 5.523, P = 0.004 for the fovea), while axial length was negatively correlated with choroidal thickness (coefficient = −12.649, P < 0.001 ). Axial length was positively associated with RNFL and GCL thickness in the temporal quadrant in 1–3 mm of the macular fovea (coefficient = 0.966, P = 0.007 for RNFL and coefficient = 1.476, P = 0.011 for the macular fovea). Conclusion. Compared with emmetropic children, MMH children had greater choroidal thickness. The characteristics of the RNFL and GCL thickness in MMH children were different from those in emmetropic children.

scholarly journals Ocular biomarkers for cognitive impairment in nonagenarians; a prospective cross-sectional study

2020 ◽  
Author(s):  
Jacoba Alida van de Kreeke ◽  
Nienke Legdeur ◽  
Maryam Badissi ◽  
H. Ton Nguyen ◽  
Elles Konijnenberg ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Layer Thickness ◽  
Cross Sectional Study ◽  
Fundus Photography ◽  
Cognitively Impaired ◽  
Retinal Layer ◽  
Sectional Study ◽  
Fiber Layer ◽  
Cross Sectional ◽  
Nerve Fiber Layer Thickness

Abstract Background: Ocular imaging receives much attention as a source of potential biomarkers for dementia. In the present study, we analyze these ocular biomarkers in cognitively impaired and healthy participants in a population aged over 90 years (= nonagenarian), and elucidate the effects of age on these biomarkers. Methods: For this prospective cross-sectional study, we included individuals from the EMIF-AD 90+ study, consisting of a cognitively healthy (N=67) and cognitively impaired group (N=33), and the EMIF-AD PreclinAD study, consisting of cognitively healthy controls aged ≥60 (N=198). Participants underwent Optical Coherence Tomography (OCT) and fundus photography of both eyes. OCT was used to asses total and individual inner retinal layer thickness in the macular region (Early Treatment Diabetic Retinopathy Study circles) as well as peripapillary retinal nerve fiber layer thickness, fundus images were analyzed with Singapore I Vessel Assessment to obtain 7 retinal vascular parameters. Values for both eyes were averaged. Differences in ocular biomarkers between the 2 nonagenarian groups were analyzed using linear regression, differences between the individual nonagenarian groups and controls were analyzed using generalized estimating equations. Results: Ocular biomarkers did not differ between the healthy and cognitively impaired nonagenarian groups. Both nonagenarian groups differed in most ocular biomarkers from the younger controls. Conclusion: Ocular biomarkers were not associated with cognitive impairment in nonagenarians, making their use as a screening tool for dementing disorders in this group limited. However, ocular biomarkers were significantly associated with chronological age, which were very similar to those ascribed to occur in Alzheimer’s Disease.

Sign in / Sign up

Export Citation Format

Share Document