Depression, anxiety, and associated factors in patients with diabetes: evidence from the Anxiety, Depression, and Personality Traits in Diabetes Mellitus (ADAPT-DM) study

Abstract Background Depression and anxiety are common psychiatric complications affecting patients with diabetes mellitus. However, data on the prevalence of depression, anxiety, and associated factors among Malaysian diabetic patients is scarce. The Anxiety, Depression, and Personality Traits in Diabetes Mellitus (ADAPT-DM) study aimed to determine the prevalence of depression and anxiety, and their associated factors in the Malaysian diabetic population. Methods This cross-sectional study recruited 300 diabetic patients via convenience sampling from the Endocrine outpatient clinic of Universiti Kebangsaan Malaysia Medical Centre, a tertiary referral healthcare facility in Kuala Lumpur. Socio-demographic characteristics and clinical history were obtained from each participant. The Generalised Anxiety Disorder-7 (GAD-7) was administered to assess anxiety symptoms, the Beck Depression Inventory (BDI) to assess depressive symptoms, the Big Five Inventory (BFI) to evaluate personality traits, and the World Health Organization Quality of Life-BREF (WHOQOL-BREF) to measure quality of life (QOL). Multivariate logistic regression analyses were performed to determine the association between various factors, and depression and anxiety. Results The prevalence of depression was 20% (n = 60) while anxiety was 9% (n = 27). Co-morbid depression (adjusted OR = 24.91, 95% CI = 5.67–109.42, p < 0.001), neuroticism (adjusted OR = 9.24, 95% CI = 2.03–42.03, p = 0.004), and greater physical health-related QOL (adjusted OR = 1.67, 95% CI = 1.07–2.59, p = 0.024) increased the odds of developing anxiety, while psychological QOL (adjusted OR = 0.41, 95% CI = 0.21–0.79, p = 0.008) was protective. Co-morbid anxiety (adjusted OR = 20.06, 95% CI = 4.70–85.57, p < 0.001) increased the odds of depression, while older age (adjusted OR = 0.96, 95% CI = 0.92–0.99, p = 0.012), regular religious practice (adjusted OR= 0.08, 95% CI= 0.01-0.56, p= 0.011) and physical health-related QOL (adjusted OR = 0.72, 95% CI = 0.59–0.89, p = 0.002) were protective. Conclusions The study findings signify the need to screen for co-morbid depression and anxiety, as well as personality traits and QOL, and to include psychosocial interventions when planning a multidisciplinary approach to managing diabetes.

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Depression, anxiety, and associated factors in patients with diabetes: evidence from the Anxiety, Depression, and Personality Traits in Diabetes Mellitus (ADAPT-DM) study

10.21203/rs.2.20390/v2 ◽

2020 ◽

Author(s):

Sy-Cherng Luke Woon ◽

Hatta Sidi ◽

Arun Ravindran ◽

Paula Junggar Gosse ◽

Roslyn Laurie Mainland ◽

...

Keyword(s):

Quality Of Life ◽

Diabetes Mellitus ◽

Personality Traits ◽

Associated Factors ◽

Diabetic Patients ◽

Depression And Anxiety ◽

Prevalence Of Depression ◽

Patients With Diabetes ◽

Anxiety Depression

Abstract Background: Depression and anxiety are common psychiatric complications affecting patients with diabetes mellitus. However, data on the prevalence of depression, anxiety, and associated factors among Malaysian diabetic patients is scarce. The Anxiety, Depression, and Personality Traits in Diabetes Mellitus (ADAPT-DM) study aimed to determine the prevalence of depression and anxiety, and their associated factors in the Malaysian diabetic population. Methods: This cross-sectional study recruited 300 diabetic patients via convenience sampling from the Endocrine outpatient clinic of Universiti Kebangsaan Malaysia Medical Centre, a tertiary referral healthcare facility in Kuala Lumpur. Socio-demographic characteristics and clinical history were obtained from each participant. The Generalised Anxiety Disorder-7 (GAD-7) was administered to assess anxiety symptoms, the Beck Depression Inventory (BDI) to assess depressive symptoms, the Big Five Inventory (BFI) to evaluate personality traits, and the World Health Organization Quality of Life-BREF (WHOQOL-BREF) to measure quality of life (QOL). Stepwise multiple logistic regression analyses were performed to determine the association between various factors, and depression and anxiety. Results: The prevalence of depression was 20% (n = 60) while anxiety was 9% (n = 27). Co-morbid depression (adjusted odds ratio [OR] = 9.89, 95% confidence interval [CI] = 2.63- 37.14, p = 0.001) and neuroticism (adjusted OR = 11.66, 95% CI= 2.69-50.47, p = 0.001) increased the odds of developing anxiety, while conscientiousness (adjusted OR = 0.45, 95% CI= 0.23-0.80, p = 0.004) and greater psychological-related QOL (adjusted OR = 0.47, 95% CI= 0.29-0.75, p = 0.002) were protective. Co-morbid anxiety (adjusted OR = 19.83, 95% CI = 5.63- 69.92, p < 0.001) increased the odds of depression, while older age (adjusted OR = 0.96, 95% CI = 0.93–0.98, p = 0.002), social relationship-related QOL (adjusted OR= 0.84, 95% CI = 0.71- .0.99, p= 0.047), and physical health-related QOL (adjusted OR = 0.69, 95% CI = 0.58-0.83, p < 0.001) were protective. Conclusions: The study findings signify the need to screen for co-morbid depression and anxiety, as well as personality traits and QOL, and to include psychosocial interventions when planning a multidisciplinary approach to managing diabetes.

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Depression, anxiety, and associated factors in patients with diabetes: evidence from the anxiety, depression, and personality traits in diabetes mellitus (ADAPT-DM) study

BMC Psychiatry ◽

10.1186/s12888-020-02615-y ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Luke Sy-Cherng Woon ◽

Hatta Bin Sidi ◽

Arun Ravindran ◽

Paula Junggar Gosse ◽

Roslyn Laurie Mainland ◽

...

Keyword(s):

Diabetes Mellitus ◽

Personality Traits ◽

Associated Factors ◽

Patients With Diabetes ◽

Anxiety Depression

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Depression and Anxiety among Patients with Type II Diabetes Mellitus in Chitwan Medical College Teaching Hospital, Nepal

Nursing Research and Practice ◽

10.1155/2021/8846915 ◽

2021 ◽

Vol 2021 ◽

pp. 1-8

Author(s):

Kalpana Sharma ◽

Govinda Dhungana ◽

Shailendra Adhikari ◽

Archana Bista Pandey ◽

Muna Sharma

Keyword(s):

Diabetes Mellitus ◽

College Teaching ◽

Educational Status ◽

Current Treatment ◽

Depression And Anxiety ◽

Medical College ◽

Prevalence Of Depression ◽

Patients With Diabetes ◽

History Of ◽

Diabetes Patients

The prevalence of depression and anxiety disorders is common among people with diabetes mellitus. Coexistence of diabetes and depression/anxiety increases the risk of diabetes complications and reduces the overall quality of life. Hence, this study aimed to assess the depression and anxiety among patients with type 2 diabetes mellitus in Chitwan. Descriptive survey was carried out among 296 purposively selected clinically diagnosed type 2 diabetes patients admitted in the Chitwan Medical College Teaching Hospital from 15th June 2018 to 17th September 2019. Patients were interviewed using the Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorders-7 (GAD-7). Data were analyzed using descriptive and inferential statistics. Of 296 diabetic patients, 48.6% were 60 years and above, 59.5% female and 61.5% literate; their common occupation was agriculture (38.2%) followed by household work (26.4%). Nearly two-thirds (62.8%) of diabetes patients had other chronic comorbid conditions. Depression and anxiety were observed among 57.8% and 49.7% of diabetes patients, respectively. While observing the severity, 27.4%, 19.6%, 8.4%, and 2.4% of patients had mild, moderate, moderately severe, and severe depression, respectively. Likewise, 24.7%, 20.3%, and 4.7% of patients had mild, moderate, and severe anxiety, respectively. Current living status, educational status, medicine adherence, satisfaction toward current treatment, and history of mental illness in the family were found to be significant factors associated with the anxiety of patients with diabetes. Further, educational status, smoking habit, satisfaction towards current treatment, and history of diabetes in family were the factors associated with depression. Prevalence of depression and anxiety is high among admitted patients with diabetes mellitus, and many factors are associated with it. Hence, regular screening services are essential along with diabetes management plan for timely identification and treatment of the vulnerable groups in the healthcare centers.

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Hypoglycemia Prevention Practice and Associated Factors Among Patients with Diabetes Mellitus Following at Public Hospitals of Central Zone, Tigray, Ethiopia, 2018

10.21203/rs.2.11704/v1 ◽

2019 ◽

Author(s):

Gebrewahd Bezabh Gebremichael ◽

Teklewoini Mariye Zemichael

Keyword(s):

Diabetes Mellitus ◽

Associated Factors ◽

Central Zone ◽

Public Hospitals ◽

P Value ◽

Diabetic Patients ◽

Binary Logistic Regression Model ◽

Cross Sectional ◽

Patients With Diabetes ◽

At Home

Abstract Background Hypoglycemia is an acute medical situation that occurs when blood sugar falls below the recommended level. Even though, hypoglycemia prevention practice in the management of diabetes mellitus is one cornerstone in controlling the effect of hypoglycemia, hypoglycemia prevention practice among patients with diabetes mellitus is insufficiently studied. Moreover, the existed scarce literature in Ethiopia revealed hypoglycemia prevention practice is inadequate. Thus, this study tried to assess hypoglycemia prevention practices and associated factors among diabetic patients. Methods Hospital-based, cross-sectional study design was employed from April one to March one 2018 in Central Zone of Tigray Regional state of Ethiopia. A total of 272 diabetes mellitus patients were selected by systematic random sampling method from study area. The collected data was checked for its completeness and then entered into Epi data version 3.1 then cleaned and analyzed using SPSS version 23. Binary logistic regression model (AOR, 95% CI and p-value < 0.05) was used to determine the predictors of hypoglycemia prevention practice. Results the mean age of respondents was 52.19 years and about 100 (63.2%) had good hypoglycemia prevention practice. Knowledge regarding hypoglycemia [AOR = 10.34; 95% CI [5.41, 19.89]], having a glucometer at home [AOR=3. 02; 95% CI [1.12, 8.12]], attitude regarding diabetes mellitus [AOR = 2.36 CI [1.26, 4.39]], being governmental employee [AOR=5. 19, 95% CI [1.63, 16.58]] and being divorced [AOR = 0.13, 95% CI [0.32, 0.53]] were found significantly associated with good hypoglycemia prevention practice. Conclusion Around two third of the study participants were found to have good hypoglycemia prevention practice. Good knowledge and favorable attitude toward diabetes mellitus, having glucometer at home, being governmental employee and divorced were found to be the predictors of good hypoglycemia prevention practice.

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Prevalence of Depression and Associated Factors among Diabetic Patients in an Outpatient Diabetes Clinic

Psychiatry Journal ◽

10.1155/2019/2083196 ◽

2019 ◽

Vol 2019 ◽

pp. 1-6 ◽

Cited By ~ 8

Author(s):

Zahra D. Khan ◽

Janet Lutale ◽

Sibtain M. Moledina

Keyword(s):

Associated Factors ◽

Diabetic Patients ◽

Mild Depression ◽

Diabetes Clinic ◽

Cross Sectional ◽

Adequate Treatment ◽

Moderate Depression ◽

Prevalence Of Depression ◽

Patients With Diabetes ◽

Diabetes Patients

Despite adequate treatment for diabetes, it is estimated that 15%- 20% of people with diabetes are struggling with a moderate to severe form of depression daily. Little is known about depression in diabetes in East Africa, particularly in Tanzania. The study is aimed at determining the prevalence of depression and associated factors among patients with diabetes. A descriptive cross-sectional study was carried out at the diabetes clinic of Muhimbili National Hospital. The 9-item Patient Health Questionnaire (PHQ 9) scale was used to assess presence of depressive symptoms among diabetes patients at the clinic. In addition, patient’s sociodemographic and clinical characteristics were obtained and analysed for their association with depression. A total of 353 participants were recruited, of whom 229 (64.9%) patients were female and 156 (44.2%) were aged between 41 and 60 years. The overall prevalence of depression among diabetes patients at the diabetes clinic was 87%. Most (56.7%) had minimal depression, 22.1% had mild depression, and 8.2% had moderate depression. None had severe depression. Factors independently associated with a diagnosis of mild to moderate depression were being on insulin therapy and being a current smoker. There was a high prevalence of depression in this diabetic population. Majority of patients had minimal depression but about 30% had either mild or moderate depression. A holistic approach that focuses on the identification and management of depression among patients with diabetes is recommended.

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Pharmacist-Led Interventions on Improving Outcomes in Patients with Diabetes Mellitus: Evidence from the Literature

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v10i4.4195 ◽

2020 ◽

Vol 10 (4) ◽

pp. 49-58

Author(s):

Sini T Inasu ◽

MV Kumudavalli

Keyword(s):

Diabetes Mellitus ◽

Self Management ◽

Diabetic Patients ◽

Health Related Quality ◽

Randomized Controlled ◽

Chd Risk ◽

Patients With Diabetes ◽

Related Quality ◽

Health Related

Diabetes mellitus is a rapidly growing major health problem world-wide. The management of type 2 diabetes mellitus is complex, requiring continuous medical care by health care professionals and considerable self-care efforts by patients. A collaborative and integrated team approach in which pharmacists can play a pivotal role should be sought when managing patients with diabetes. Pharmacist-led care programs have been shown to help patients with diabetes succeed in achieving treatment goals and improving outcomes. Hence, the aim of this narrative review is to address and summarize the effectiveness of pharmacist interventions in the management of diabetic patients. A comprehensive literature search was conducted in PubMed/Medline, Scopus, web of Science and the Cochrane Library were searched from the date of database inception to June 2019. All randomized controlled trials evaluating the effectiveness of pharmacist-based interventions on diabetic patients in comparison with usual care were included in study. Outcomes of interest included short-term and long-term measures such as glycated haemoglobin (HbA1c), and secondary outcomes were blood glucose level, blood pressure (BP), lipid profile, body mass index (BMI), 10-year coronary heart disease (CHD) risk, medication adherence, health related quality of life (HRQoL), and economic outcomes. Twenty-five studies were included in this systematic study. They were heterogeneous in terms of interventions, participants, settings and outcomes. Pharmacist-led self-management interventions included education on diabetes and its complications, medication adherence, lifestyle and education of self-management skills. Few studies even focussed on patients need through a tailored intervention. We found that those who received the pharmacist care had a statistically significant improvement in HbA1C, blood pressure, lipid profile, health-related quality of life, and CHD risk. These results underline the added value of pharmacists in patient-related care. Hence this review supports the involvement of pharmacists as a member of health- care teams in managing diabetic patients at diverse settings worldwide. Keywords: diabetes, self-management, HbA1C, pharmaceutical care, randomized controlled trial

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Knowledge about diabetic retinopathy, eye check-up practice and associated factors among patients with diabetes mellitus attending Debark hospital, northwest Ethiopia

10.21203/rs.2.16562/v1 ◽

2019 ◽

Author(s):

Mebratu Muusew Tegegne ◽

Abel Sinshaw Assem ◽

Destaye Shiferaw Alemu ◽

Asamere Tsegaw Woredekal ◽

Tsehay Kassa Alemu

Keyword(s):

Diabetes Mellitus ◽

Diabetic Retinopathy ◽

Associated Factors ◽

Northwest Ethiopia ◽

Good Knowledge ◽

Eye Disease ◽

Diabetic Patients ◽

Duration Of Diabetes ◽

Patients With Diabetes ◽

History Of

Abstract Background: Routine eye examination plays a vital role in detecting diabetic retinopathy in its earliest stage before the onset of blindness. Patients’ knowledge about the nature and the consequences of diabetic retinopathy and routine eye checkup helps in timely identification and early treatment. However, there is limited evidence on knowledge of patients with diabetes mellitus on diabetic retinopathy and their eye check-up practices in Ethiopia in general and the study area in particular. Purpose: The aim of this study was to assess knowledge, eye check-up practice and associated factors of diabetic retinopathy among diabetic patients at Debark hospital, Northwest Ethiopia. Materials and Methods: Institution based cross – sectional study was conducted at Debark hospital, Northwest Ethiopia, from April 20/2018- May 20/2018. A pretested interviewer administered structured questionnaire was used to collect data among 230 diabetic patients aged 18 years and above. Data were entered in to Epi Info version 7 and exported to SPSS version 20 for analysis. Bivariable and multivariable binary logistic regression analyses were done. Odds ratio with 95% confidence level was determined and variables with p–value of < 0.05 were considered as statistically significant. Result: Out of 238 sample 230 were participated, among this, 119 (51.7%) were males. The mean age of the respondents was 49 (SD ±17.6) years. One hundred nine (47.4%) participants had good knowledge and 91 (39.6%) had good eye check-up practice. Urban residence [AOR= 2.65;95% CI: 1.16-6.07)]), monthly income of 3501-8000 birr [AOR=4.54;(1.31-15.7)], type II diabetes mellitus [AOR=3.9;(1.6-9.6)], duration of diabetes (6-12 years[AOR=4.4;(1.4-13.5)]), history of eye disease [AOR=5.5;(2.3-13.0)] were associated with good knowledge. Similarly, longer duration of diabetes (13-25 years [AOR=3.77; (1.05-13.5)]) and history of eye disease [AOR=2.47;(1.09-5.62)] were associated with good eye check-up practice. Conclusion: The proportion of good knowledge about diabetic retinopathy among diabetic patients was fair (47.4%) in the study setting and good eye check-up practice was low (39.6%) Longer duration of diabetes and history of eye disease were identified as positive factors for good knowledge and eye check-up practice. Knowledge and regular eye check-up practice needs to be enhanced through provision of appropriate health education.

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The relationship of depression and anxiety among diabetic patients with changes in the components of lipid profile

10.21203/rs.2.15557/v1 ◽

2019 ◽

Author(s):

Diaa Abdelfattah ◽

Abdulrahman Alduraywish

Keyword(s):

Diabetes Mellitus ◽

Lipid Profile ◽

Total Cholesterol Level ◽

Anxiety Symptoms ◽

High Density ◽

High Density Lipoproteins ◽

Diabetic Patients ◽

Depression And Anxiety ◽

Patients With Diabetes ◽

Anxiety Levels

Abstract Introduction our study aimed to investigate the presence of depression and anxiety symptoms in diabetic patients and their association with various components of lipid profile.Methods 428 patients with diabetes mellitus joined our study. Their de- mographic and lipid profile measurements were collected. The screening questionnaire HADS was used to evaluate level of depression and anxiety. An age matched control group consisting of 50 individuals were taken and their lipid profiles and depression and anxiety levels were determined.Results it was found that 22.4% of the sample showed marked depressive symptoms and 28.5% showed marked anxiety symptoms. We found that: depression was associated strongly but not significantly (P=0.057) with lower high density lipoproteins, and associated significantly (P=0.036) with lower total cholesterol level. In addition, anxiety was associated significantly (0.000) with lower high density lipoproteins and was associated significantly (P=0.004) with higher triglycerides level. There was insignificant association between all components of lipid profile and either depression or anxiety levels in the control group.Conclusion Depressive and anxiety symptoms were common among diabetic patients. Depression was related to lower high density lipoproteins, and to lower total cholesterol level. Anxiety was strongly related to lower high density lipoproteins and to higher triglycerides level. This relationship was specific to patients with diabetes mellitus in our study .

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Prevalence and Associated Factors of Depression among Patients with Diabetes at Jazan Province, Saudi Arabia: A Cross-Sectional Study

Psychiatry Journal ◽

10.1155/2019/6160927 ◽

2019 ◽

Vol 2019 ◽

pp. 1-6 ◽

Cited By ~ 2

Author(s):

Jnadi M. Madkhali ◽

Ammar A. Hakami ◽

Ali H. Dallak ◽

Ramzi M. Hakami ◽

Abdullah A. Yatimi ◽

...

Keyword(s):

Quality Of Life ◽

Risk Factors ◽

Associated Factors ◽

Cross Sectional Study ◽

Diabetic Patients ◽

Sectional Study ◽

Cross Sectional ◽

Prevalence Of Depression ◽

Patients With Diabetes

Context. Patients with diabetes mellitus (DM) have a poorer quality of life when compared with patients without DM. In fact, one in every five diabetic patients suffers from comorbid depression, which can lead to poor management, poor compliance with treatment, and low quality of life. Therefore, we assessed the prevalence of depression and identified its associated factors among diabetic patients at Jazan Province, KSA. Methods and Materials. A cross-sectional study was conducted among 500 diabetic patients attending a diabetic center in addition to four primary healthcare centers. We used a simple Arabic translation of the Beck Depression Inventory (BDI II) tool to evaluate the depression level among the subjects. We also evaluated the frequencies of certain sociodemographic characteristics and clinical information. Moreover, we performed univariate and multivariate analyses to identify the potential risk factors using adjusted odds ratios (AORs). Results. The prevalence of depression among DM patients was 20.6%. The majority of patients showed no depression (N = 285, 59.4%), one-fifth had mild depression (N = 96, 20.0%), some (N = 55, 11.4%) had moderate depression, and some had severe depression (N = 44, 9.2%). Depression was significantly more prevalent among uneducated patients (N = 27, 31.8%) (X2 = 17.627, P = 0.001) and patients with low monthly income (< 2500 SR/month) (N = 33, 22.8%) (X2 = 9.920, P = 0.019). Hypertension (AOR = 2.531, 95% CI [1.454, 4.406]) and ischemic heart diseases (AOR = 3.892, 95% CI [1.995, 7.593]) were considered as risk factors for depression among diabetic patients. Conclusions. Almost one in every five patients with DM is affected by depression coexisting with cardiovascular diseases. Therefore, screening for psychological problems, proper treatment, and educating patients with diabetes about DM self-management should be routine components of DM care.

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