Age-Specific Trend and Birth Cohort Effect on Different Histologic Types of Uterine Corpus Cancers

2021 ◽  
Author(s):  
Yi-Jou Tai ◽  
Chun-Ju Chiang ◽  
Ying-Cheng Chiang ◽  
Chia-Ying Wu ◽  
Wen-Chung Lee ◽  
...  
Keyword(s):  
Birth Cohort ◽  
Cancer Incidence ◽  
Incidence Rates ◽  
Endometrioid Carcinoma ◽  
Birth Cohorts ◽  
Cancer Specific Survival ◽  
Uterine Corpus ◽  
Incidence Trends ◽  
Histologic Types ◽  
Cancer Incidence Rates

Abstract To evaluate the uterine corpus cancer incidence rates, age-specific trends and birth cohort patterns by different histologic types. From the Taiwan Cancer Registry, we identified women with a primary diagnosis of uterine corpus cancer (n=28 769) from1998 to 2017. We analyzed the incidences, stages of disease at diagnosis and prognostic factors in endometrioid and non-endometrioid carcinoma. During the study period, uterine corpus cancer incidence rates increased over time from 5.3 to 15.21 per 100 000 woman-years. Incidence trends for endometrioid carcinoma increased in all age groups and the rise was steeper in women age 40 years and younger. For non-endometrioid carcinomas, incidence rates increased in women over 50 years. Women diagnosed after 2013 had significantly better cancer-specific survival (CSS) (hazard ratio [HR] =0.81, 95% confidence interval [CI] 0.73-0.89) compared with those at the period of 2009-2012. CSS also improved in stage I (HR=0.81, 95% CI 0.49-0.63) and stage III (HR 0.90, 95% CI 0.58-0.72) endometrioid carcinomas after 2013. Whereas CSS remained unchanged for non-endometrioid carcinomas. We found the incidences of both endometrioid and non-endometrioid carcinomas continued to increase among contemporary birth cohorts. Etiologic research is mandatory to explain the causes for these trends.

scholarly journals Hysterectomy-Corrected Uterine Corpus Cancer Incidence Trends and Differences in Relative Survival Reveal Racial Disparities and Rising Rates of Nonendometrioid Cancers

2019 ◽  
Vol 37 (22) ◽  
pp. 1895-1908 ◽  
Author(s):  
Megan A. Clarke ◽  
Susan S. Devesa ◽  
Summer V. Harvey ◽  
Nicolas Wentzensen
Keyword(s):  
Cancer Incidence ◽  
Race And Ethnicity ◽  
Survival Rates ◽  
Relative Survival ◽  
Incidence Rates ◽  
Pacific Islanders ◽  
Endometrioid Carcinoma ◽  
Histologic Subtype ◽  
Uterine Corpus ◽  
Cancer Incidence Rates

PURPOSE Uterine corpus cancer incidence rates have been projected to increase, a prediction often attributed to the obesity epidemic. However, correct estimation of these rates requires accounting for hysterectomy prevalence, which varies by race, ethnicity, and region. Here, we evaluated recent trends in hysterectomy-corrected rates by race and ethnicity and histologic subtype and estimated differences in relative survival by race and ethnicity, subtype, and stage. METHODS We estimated hysterectomy prevalence from the Behavioral Risk Factor Surveillance System. Hysterectomy-corrected age-standardized uterine corpus cancer incidence rates from 2000 to 2015 were calculated from the SEER 18 registries. Incidence rates and trends were estimated separately by race and ethnicity, region, and histologic subtype. Five-year relative survival rates were estimated by race and ethnicity, histologic subtype, and stage. RESULTS Hysterectomy-corrected incidence rates of uterine corpus cancer were similar among non-Hispanic whites and blacks and lower among Hispanics and Asians/Pacific Islanders. Endometrioid carcinoma rates were highest in non-Hispanic whites, whereas nonendometrioid carcinoma and sarcoma rates were highest in non-Hispanic blacks. Hysterectomy-corrected uterine corpus cancer incidence increased among non-Hispanic whites from 2003 to 2015 and among non-Hispanic blacks, Hispanics, and Asians/Pacific Islanders from 2000 to 2015. Overall incidence rates among non-Hispanic blacks surpassed those of non-Hispanic whites in 2007. Endometrioid carcinoma rates rose among non-Hispanic blacks, Hispanics, and Asians/Pacific Islanders but were stable among non-Hispanic whites; however, nonendometrioid carcinoma rates rose significantly among all women. Non-Hispanic blacks had the lowest survival rates, irrespective of stage at diagnosis or histologic subtype. CONCLUSION Among all women, rates of nonendometrioid subtypes have been rising rapidly. Our analysis shows profound racial differences and disparities indicated by higher rates of nonendometrioid subtypes and poorer survival among non-Hispanic black women.

scholarly journals Melanoma Incidence Among Non-Hispanic Whites in All 50 US States From 2001 Through 2015

2019 ◽  
Vol 112 (5) ◽  
pp. 533-539 ◽  
Author(s):  
Aaron P Thrift ◽  
Franciska J Gudenkauf
Keyword(s):  
Incidence Rate ◽  
Birth Cohort ◽  
Sun Exposure ◽  
The United States ◽  
Incidence Rates ◽  
Birth Cohorts ◽  
Annual Percent Change ◽  
Incidence Trends ◽  
Percent Change ◽  
Melanoma Incidence

Abstract Background The United States has large regional variation in primary prevention campaigns for skin cancer. We collected data from all 50 states to examine changes in melanoma incidence and performed age-period-cohort analyses to describe the simultaneous effects of age, period, and cohort on incidence rates. Methods Annual melanoma incidence rates for non-Hispanic whites from 2001 to 2015 were extracted from the US Cancer Statistics registry. Secular trends were examined overall and by sex and state. We used joinpoint regression to compute annual percent change and average annual percent change and corresponding 95% confidence intervals (CIs). We also analyzed incidence trends by 5-year age group and birth cohort using incidence rate ratios and age-period-cohort modeling. Results Melanoma incidence increased from 20.7 per 100 000 (95% CI = 20.5 to 20.9) in 2001 to 28.2 per 100 000 (95% CI = 28.0 to 28.5) in 2015, increasing by 3.90% (95% CI = 2.36% to 5.48%) annually between 2001 and 2005 and 1.68% (95% CI = 1.37% to 1.99%) annually from 2005 through 2015. The average annual percent change in melanoma incidence rates were similar for men (2.34%, 95% CI = 1.91 to 2.78) and women (2.25%, 95% CI = 1.60 to 2.91). Age-specific relative risk by birth cohort increased from circa 1921 to 1981 before decreasing. Compared with adults born circa 1956, those born circa 1991 had lower melanoma risk (incidence rate ratio  = 0.85; 95% CI = 0.77 to 0.94). Geographic variation was observed; some states still have melanoma rates trending upwards in all birth cohorts. Conclusions The continued increase in melanoma incidence among non-Hispanic whites, particularly in states where rates continue to rise among recent and current birth cohorts, underscores the need for increased public health campaigns aimed at reducing sun exposure.

Oral cancer incidence rates from 1997 to 2016 among men in Taiwan: Association between birth cohort trends and betel nut consumption

Oral Oncology ◽  
2020 ◽  
Vol 107 ◽  
pp. 104798
Author(s):  
Shih-Yung Su ◽  
Wei-Ting Chen ◽  
Chun-Ju Chiang ◽  
Ya-Wen Yang ◽  
Wen-Chung Lee
Keyword(s):  
Oral Cancer ◽  
Birth Cohort ◽  
Cancer Incidence ◽  
Incidence Rates ◽  
Betel Nut ◽  
Cancer Incidence Rates

scholarly journals State-Level Uterine Corpus Cancer Incidence Rates Corrected for Hysterectomy Prevalence, 2004 to 2008

2012 ◽  
Vol 22 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Rebecca L. Siegel ◽  
Susan S. Devesa ◽  
Vilma Cokkinides ◽  
Jiemin Ma ◽  
Ahmedin Jemal
Keyword(s):  
Cancer Incidence ◽  
State Level ◽  
Incidence Rates ◽  
Uterine Corpus ◽  
Cancer Incidence Rates

scholarly journals Disparities in the Increases of Cervical Cancer Incidence Rates: Observations from a City-wide Population-based Study

2021 ◽  
Author(s):  
Ke Li ◽  
Huan Xu ◽  
Suixiang Wang ◽  
Pengzhe Qin ◽  
Boheng Liang
Keyword(s):  
Cervical Cancer ◽  
Birth Cohort ◽  
Cancer Incidence ◽  
Incidence Rates ◽  
Cohort Effects ◽  
Age Group ◽  
Cervical Cancer Incidence ◽  
Rural Regions ◽  
Urban Regions ◽  
Cancer Incidence Rates

Abstract Background: Globally cervical cancer incidence rate has been declining continuously. However, an unfavorable trend has been observed in China during the past decades, and the underlying reasons remain unclear. We hereby explore the recent trends of cervical cancer incidence, as well as the underlying determinants using data from Guangzhou, one of biggest cities in China. Methods：City-wide cancer registration data were obtained from the Guangzhou Center for Disease Prevention and Control from 2004 to 2018. We used the Joinpoint regression models to estimate the average annual percentage change (AAPC) of age-standardized and age-specific incidence rates by regions and by histological subtype. Age-period-cohort models were applied to analyze the period and birth cohort effects on the time trends. Results: The age-standardized rates (ASRs) of cervical cancer incidence increased at an annual rate of 2.1% [95% confidence interval (CI): 1.0%-3.2%] during 2004-2018. The largest increase in ASRs was found for rural regions, with AAPC of 6.6% [95% CI: 3.7%-9.5%], followed by the suburbs (2.2% [95% CI: 1.0%-3.4%]), while there was no statistically significant increase in urban regions. The ASRs of adenocarcinoma increased faster than those of the squamous cell carcinoma (AAPC=6.53% [95% CI: 5.0%-8.1%] versus 1.79% [95% CI: 0.8%-2.8%]). A downward trend in urban regions was found in the 20-49 age group, whereas an upward trend was found in the 50+ age group, especially in rural regions. An inverted V-shape was found for cohort effects, with the peak varied by regions, i.e., peaked in the 1966 and 1971 birth cohort in the urban and suburb regions, respectively. Period effects kept increasing during the study period. Conclusions: We systematically examine the disparities in the increases of cervical cancer incidence rates using city-wide data from Guangzhou. Extensive efforts are warranted to address the large urban-rural disparities in cervical cancer prevention. The combined strategies of vaccination, screening, and health education should be reinforced and locally customized.

scholarly journals Thyroid Cancer Incidence in New Jersey: Time Trend, Birth Cohort and Socioeconomic Status Analysis (1979–2006)

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Lisa M. Roche ◽  
Xiaoling Niu ◽  
Karen S. Pawlish ◽  
Kevin A. Henry
Keyword(s):  
Socioeconomic Status ◽  
Thyroid Cancer ◽  
New Jersey ◽  
Birth Cohort ◽  
Cancer Incidence ◽  
Age Groups ◽  
Incidence Rates ◽  
Population Exposure ◽  
Thyroid Cancer Incidence ◽  
Cancer Incidence Rates

The study's purpose was to investigate thyroid cancer incidence time trends, birth cohort effects, and association with socioeconomic status (SES) in New Jersey (NJ), a high incidence state, using NJ State Cancer Registry data. Thyroid cancer incidence rates in each sex, nearly all age groups, two major histologies and all stages significantly increased between 1979 and 2006. For each sex, age-specific incidence rates began greatly increasing in the 1924 birth cohort and, generally, the highest thyroid cancer incidence rate for each five-year age group occurred in the latest birth cohort and diagnosis period. Thyroid cancer incidence rates were significantly higher in NJ Census tracts with higher SES and in counties with a higher percentage of insured residents. These results support further investigation into the relationship between rising thyroid cancer incidence and increasing population exposure to medical (including diagnostic) radiation, as well as widespread use of more sensitive diagnostic techniques.

scholarly journals Ovarian Cancer Incidence Trends in Relation to Changing Patterns of Menopausal Hormone Therapy Use in the United States

2013 ◽  
Vol 31 (17) ◽  
pp. 2146-2151 ◽  
Author(s):  
Hannah P. Yang ◽  
William F. Anderson ◽  
Philip S. Rosenberg ◽  
Britton Trabert ◽  
Gretchen L. Gierach ◽  
...  
Keyword(s):  
United States ◽  
Ovarian Cancer ◽  
Cancer Incidence ◽  
The United States ◽  
Incidence Rates ◽  
Ovarian Cancer Risk ◽  
Histologic Subtype ◽  
Incidence Trends ◽  
Cancer Incidence Rates

Purpose After a report from the Women's Health Initiative (WHI) in 2002, a precipitous decline in menopausal hormonal therapy (MHT) use in the United States was linked to a decline in breast cancer incidence rates. Given that MHT use is also associated with increased ovarian cancer risk, we tested whether ovarian cancer incidence rates changed after 2002. Methods Using the North American Association of Central Cancer Registries database (1995 to 2008; N = 171,142 incident ovarian cancers), we applied standard analytic approaches and age-period-cohort (APC) models to estimate ovarian cancer incidence rate changes before (1995 to 2002) and after (2003 to 2008) the WHI report. Results Among women age ≥ 50 years, age-standardized ovarian cancer incidence declined by 0.8% per year (95% CI, −1.8% to −0.5% per year) before the WHI announcement; after the WHI report, the rate declined by 2.4% per year (95% CI, −2.5% to −2.2% per year). APC models confirmed an accelerated decline in ovarian cancer incidence after the WHI report, adjusted for age and birth cohort effects. This sudden change was notable among women most likely to have used MHT (ie, women age 50 to 69 years, white women, and residents of regions with highest MHT prescription frequency). The largest changes were found for the endometrioid histologic subtype. Conclusion After a marked reduction in MHT use around 2002, ovarian cancer incidence rates demonstrated an accelerated decline, with the largest changes for endometrioid carcinomas. This strong temporal association, although not proving a causal role of hormones in ovarian carcinogenesis, suggests that future analytic research supporting cancer control efforts should clarify the role of hormonal exposures on the development and behavior of subtypes of ovarian cancer.

scholarly journals 40 Years of Change in Age- and Stage-Specific Cancer Incidence Rates in US Women and Men

2019 ◽  
Vol 3 (3) ◽  
Author(s):  
Rebecca D Kehm ◽  
Wan Yang ◽  
Parisa Tehranifar ◽  
Mary Beth Terry
Keyword(s):  
Breast Cancer ◽  
Young Adults ◽  
Cancer Incidence ◽  
Age Groups ◽  
Incidence Rates ◽  
Permutation Testing ◽  
Incidence Trends ◽  
Specific Cancer ◽  
Old Men ◽  
Cancer Incidence Rates

Abstract Background Studies have documented a temporal increase in incidence for several cancers in US young adults aged 25 to 39-years, including noncardia gastric cancer, colorectal cancer, and distant-stage breast cancer. To further characterize trends in young adults, we assessed age-specific and stage-specific incidence trends from 1975 to 2015, overall (all malignant cancers combined), and for 18 and 16 cancer sites in women and men, respectively. Methods We used US population-based data from the Surveillance, Epidemiology, and End Results Program to obtain overall and site-specific cancer incidence rates by sex and age group. We individually analyzed cancer sites with an incidence rate of at least 5 per 100 000 in 2015, accounting for greater than 90% of all cancer diagnoses. We estimated annual percent changes (APCs) using segment log-linear regression performed with joinpoint software; multiple permutation testing was used to identify inflection points. We forecasted overall cancer incidence through 2030 using age-period-cohort regression models. Results Based on trends occurring after the most recent joinpoint inflection point, overall cancer incidence increased by 1.15% (95% CI = 1.01% to 1.28%) per year in 25- to 39-year-old women and by 0.46% (95% CI = 0.17% to 0.75%) per year in 25- to 39-year-old men; APCs were of much lower magnitude in the older age groups (eg, 70- to 84-year-old women APC = −0.31%, 95% CI = −0.42% to −0.20%). We forecasted that overall cancer incidence will increase by an additional 11% by 2030 in 25- to 39-year-old women, and by an additional 12% in 25- to 39-year-old men. Ten of the 18 cancers assessed in 25- to 39-year-old women and 7 of the 16 cancers in 25- to 39-year-old men have been statistically significantly increasing over time. We found that the increase in incidence for young adults is stage specific for some cancers (eg, only nonlocalized breast cancer has increased in 25- to 39-year-old women). Conclusion Cancer incidence is increasing in young adults, particularly in young women.

scholarly journals Rising and Falling Trends in Incidence Rates of Vulvar and Vaginal Cancers in the United States, 2000-2016

2020 ◽  
Author(s):  
Yang-yang Yue ◽  
Wei-li Zhou ◽  
Dong-mei Pei
Keyword(s):  
Cancer Incidence ◽  
Vulvar Cancer ◽  
Relative Survival ◽  
Incidence Rates ◽  
Histological Type ◽  
Vaginal Cancer ◽  
Cancer Rate ◽  
Incidence Trends ◽  
Cancer Rates ◽  
Cancer Incidence Rates

Abstract Background: Few studies focus on incidence trends in vulvar and vaginal by histological type, race, age, and region. We aimed to evaluate the temporal incidence trends and survival for the two cancers.Methods: Cases with primary vulvar or vaginal carcinoma from 2000-2016 were identified from the Surveillance, Epidemiology, and End Results 18 registries. Annual percent change (APC) and average APC (AAPC) were calculated to evaluated trends. Relative survival was estimated to compare survival outcomes.Results: Vulvar cancer incidence rates were highest among non-Hispanic whites (20.9 per 1,000,000 person-years) and in the Midwest (27.7), while vaginal cancer rates were highest among non-Hispanic blacks (8.2) and in the South (6.7). Overall, vulvar cancer rate increased 0.4% annually (AAPC, 0.4%; 95% CI, 0.1% to 0.6%), but vaginal cancer rate decreased 1.4% annually (AAPC, -1.4%; 95% CI, -2.0% to -0.5%). The increased vulvar cancer rate was only observed for squamous cell carcinoma (APC, 1.0%), while the decreased vaginal cancer rate was only observed for other malignancies (APC, -1.7%). Vulvar cancer rates increased only among whites (APC, 1.2%), but vaginal cancer rates decreased only among whites (AAPC, -1.3%) and Asians (APC, -2.7%). Vulvar cancer rates increased among patients aged 50-59 (APC, 1.1%), 60-69 (APC, 1.3%), and 70-79 (APC, 1.2%) years, while vaginal cancer rates decreased among patients aged 50-59 (APC, -1.4%) and 80 (APC, -1.4%) years or older. Overall, whites had the highest five-year relative survival for both vulvar (72.22%) and vaginal (49.03%) cancers. Conclusion: There were profound disparities in vulvar and vaginal cancer incidence rates attributable to histological type, race, age, and region. The increased vulvar cancer rates and the declined vaginal cancer rate highlights the importance of further studies to investigate the reason for the disparities.

scholarly journals Ensemble forecasting of a continuously decreasing trend in bladder cancer incidence in Taiwan

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Bo-Yu Hsiao ◽  
Shih-Yung Su ◽  
Jing-Rong Jhuang ◽  
Chun-Ju Chiang ◽  
Ya-Wen Yang ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Incidence ◽  
Total Population ◽  
Incidence Rates ◽  
World Health ◽  
Cohort Model ◽  
Incidence Trends ◽  
Health Organization ◽  
Cancer Incidence Rates ◽  
Population Numbers

AbstractBladder cancer is one of the most common malignancies involving the urinary system of about 1.65 million cases worldwide. To attain the 25 by 25 goal set by the World Health Organization (25% reduction in non-communicable diseases between 2015 and 2025), developing strategies to reduce cancer burdens is essential. The data of the study comprised the age-specific bladder cancer cases and total population numbers from age 25 to 85 and above from 1997 to 2016 in Taiwan. An ensemble age–period–cohort model was used to estimate bladder cancer incidence trends and forecast the trends to 2025. For men, the projected age-standardized incidence rates per 100,000 people in 2020 and 2025 are 13.0 and 10.4, respectively, with a 16.1% and 32.9% decrease projected from 2016 to 2020 and 2025, respectively. For women, the projected age-standardized incidence rates per 100,000 people in 2020 and 2025 are 4.7 and 3.7, respectively, with a 16.1% and 33.9% decrease projected from 2016 to 2020 and 2025, respectively. The age-specific bladder cancer incidence rates demonstrated a consistently downward trend after 2003 for all ages and both sexes. This study projects that the incidence rates of bladder cancer in Taiwan will continue to decrease, and more than a 25% reduction can be achieved from 2016 to 2025.

Sign in / Sign up

Export Citation Format

Share Document