scholarly journals Prognostic Value of Preoperative Neutrophil-to -Lymphocyte Ratio in Adenoid Cystic Carcinoma of the Head and Neck

2021 ◽  
Author(s):  
XIN-RAN LI ◽  
LIN ZHOU ◽  
YU-XIN CHEN ◽  
NA LI ◽  
JIAN MENG
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Head And Neck ◽  
Prognostic Value ◽  
Cox Regression ◽  
Neutrophil To Lymphocyte Ratio ◽  
Cutoff Value ◽  
Lymphocyte Ratio ◽  
Adenoid Cystic ◽  
Kaplan Meier ◽  
Chi Squared

Abstract BackgroundStudies in recent years have shown that the neutrophil-to-lymphocyte ratio (NLR) is associated with the survival and prognosis of patients with malignant tumors.However, the utility of the NLR in predicting outcomes in patients with adenoid cystic carcinoma (ACC) of the head and neck remains unclear. Here, we examined the prognostic value of the preoperative NLR in patients with ACC of the head and neck.MethodsThis study retrospectively analyzed 71 patients with a histopathological diagnosis of ACC from August 2005 to November 2020.The optimal cutoff value was obtained by receiver operating characteristic (ROC) analysis. The characteristics of the patients were evaluated using chi-squared tests.The value of the NLR used in predicting the outcomes of these patients was analyzed using Kaplan-Meier curves and Cox regression models.ResultsThe cutoff value of the NLR was 2.071. The chi-squared tests showed that a high NLR(>2.071)was associated with tumor stage and lymph node metastasis(LNM). Kaplan-Meier survival analysis showed that the NLR>2.071 group was correlated with a shorter Overall survival(P<0.05). In multivariate Cox regression analysis, high NLR (>2.071) and high age (>54 years) were independent risk factors predicting poorer outcomes in patients with ACC.ConclusionsWe suggest that the preoperative NLR is a useful biomarker for the prognosis of patients with ACC.

Prognostic value of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with colorectal cancer.

2017 ◽  
Vol 35 (4_suppl) ◽  
pp. 551-551 ◽  
Author(s):  
Jae Hyun Kim ◽  
Seun Ja Park
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Value ◽  
Cox Regression ◽  
Neutrophil To Lymphocyte Ratio ◽  
Platelet To Lymphocyte Ratio ◽  
Poor Overall Survival ◽  
Cox Regression Analysis ◽  
Lymphocyte Ratio ◽  
Kaplan Meier ◽  
Independent Risk Factors

551 Background: Inflammatory response plays an important role in the pathogenesis of cancer. Some evidence has suggested that elevations in the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are associated with decreased survival in various types of cancer. In this study, we aimed to evaluate the prognostic value of the NLR and PLR in patients with colorectal cancer (CRC). Methods: Between August 1995 and December 2010, medical records from a total of 2,004 patients with CRC were retrospectively reviewed. The values of simple inflammatory markers including NLR and PLR in predicting the long-term outcomes of these patients were evaluated using Kaplan-Meier curves and multivariate Cox regression models. Results: The median follow-up duration was 42 months (interquartile range, 19 – 69). The estimation of NLR and PLR was based on the time of diagnosis. In multivariate Cox regression analysis, high NLR ( ≥ 2.6) [hazard ratio (HR) 2.251, 95% confidence interval (CI) 1.570-3.228, p < 0.001] and high PLR ( ≥ 155) [HR 1.473, 95% CI 1.019 – 2.128, p = 0.039] were independent risk factors predicting poor overall survival (OS) in CRC patients. Combined high NLR and PLR was also an independent risk factor predicting poor OS in patients with CRC [HR 2.316, 95% CI 1.529 – 3.508, p < 0.001]. Conclusions: In this study, we identified that high NLR ( ≥ 2.6), high PLR ( ≥ 155), and combined high NLR and PLR are useful prognostic factors to predict OS in CRC patients.

scholarly journals The prognostic value of platelet-to-lymphocyte ratio on the long-term renal survival in patients with IgA nephropathy

2020 ◽  
Author(s):  
Dan Chang ◽  
Yichun Cheng ◽  
Ran Luo ◽  
Chunxiu Zhang ◽  
Meiying Zuo ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Prognostic Value ◽  
Cox Regression ◽  
Independent Prognostic Factor ◽  
Renal Survival ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Female Patients ◽  
Kaplan Meier

Abstract Purpose Platelet-to-lymphocyte ratio (PLR) was established showing the poor prognosis in several diseases, such as malignancies and cardiovascular diseases. But limited study has been conducted about the prognostic value of PLR on the long-term renal survival of patients with Immunoglobulin A nephropathy (IgAN). Methods We performed an observational cohort study enrolling patients with biopsy-proven IgAN recorded from November 2011 to March 2016. The definition of composite endpoint was eGFR decrease by 50%, eGFR < 15 mL/min/1.73 m2, initiation of dialysis, or renal transplantation. Patients were categorized by the magnitude of PLR tertiles into three groups. The Kaplan–Meier curves and multivariate Cox models were performed to determine the association of PLR with the renal survival of IgAN patients. Results 330 patients with a median age of 34.0 years were followed for a median of 47.4 months, and 27 patients (8.2%) had reached the composite endpoints. There were no differences among the three groups (PLR < 106, 106 ≤ PLR ≤ 137, and PLR > 137) in demographic characteristics, mean arterial pressure (MAP), proteinuria, and estimated glomerular filtration rate (eGFR) at baseline. The Kaplan–Meier curves showed that the PLR > 137 group was significantly more likely to poor renal outcomes than the other two groups. Using univariate and multivariate cox regression analyses, we found that PLR > 137 was an independent prognostic factor for poor renal survival in patients with IgAN. Subgroup analysis revealed that the PLR remained the prognostic value for female patients or patients with eGFR less than 60 mL/min/1.73 m2. Conclusions Our results underscored that baseline PLR was an independent prognostic factor for poor renal survival in patients with IgAN, especially for female patients or those patients with baseline eGFR less than 60 mL/min/1.73 m2.

scholarly journals High Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio Are Associated with Poor Survival in Patients with Hemodialysis

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Jialing Zhang ◽  
Xiangxue Lu ◽  
Shixiang Wang ◽  
Han Li
Keyword(s):  
Cox Regression ◽  
Pearson Correlation ◽  
Neutrophil To Lymphocyte Ratio ◽  
Poor Survival ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Kaplan Meier ◽  
Stage Renal Disease ◽  
End Stage ◽  
The Relationship

Background. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are markers for systemic inflammation condition. Although NLR has emerged as a risk factor for poor survival in end-stage renal disease (ESRD) patients, the relationship between PLR and mortality is still unknown. We aimed to explore the interaction of NLR and PLR in predicting mortality in hemodialysis (HD) patients. Method. We enrolled 360 HD patients for a 71-month follow-up. The endpoint was all-cause and cardiovascular (CV) mortality. Pearson correlation analysis was conducted to evaluate the relationship between factors and NLR or PLR. Kaplan-Meier curves and Cox proportional analysis were used to assess the prognostic value of NLR and PLR. Results. NLR was positively correlated with neutrophil and negatively correlated with lymphocyte, hemoglobin, and serum albumin. PLR was positively correlated with neutrophil and platelet and negatively correlated with lymphocyte and hemoglobin. In multivariate Cox regression, a higher NLR level was independently associated with all-cause mortality (OR 2.011, 95% CI 1.082-3.74, p = 0.027 ), while a higher PLR level might predict CV mortality (OR 2.768, 95% CI 1.147-6.677, p = 0.023 ) in HD patients. Conclusion. NLR and PLR are cheap and reliable biomarkers for all-cause and CV mortality to predict survival in HD patients.

scholarly journals The Neutrophil-to-lymphocyte Ratio at the Time of Admission: A New Prognostic Indicator for Hospital Mortality of Trauma Patients

2021 ◽  
Author(s):  
Hamed Fouladseresht ◽  
Shahram Bolandparvaz ◽  
Hamid Reza Abbasi ◽  
Hossein Abdolrahimzadeh Fard ◽  
Shahram Paydar
Keyword(s):  
Survival Analysis ◽  
Hospital Mortality ◽  
Regression Models ◽  
Cox Regression ◽  
Prognostic Indicator ◽  
Neutrophil To Lymphocyte Ratio ◽  
Trauma Patients ◽  
Lymphocyte Ratio ◽  
Kaplan Meier ◽  
Time Of Admission

The elevated neutrophil-to-lymphocyte ratio (NLR) is associated with poor clinical outcomes, especially in pro-inflammatory states such as surgical injuries and severe hemorrhages. Therefore, it was hypothesized whether NLR value at the time of admission could be a prognostic indicator of hospital mortality in trauma patients. This retrospective cohort study was conducted on 865 trauma patients referred to Rajaee Hospital between April 2016 and July 2019. The NLR value was calculated at the time of admission, and receiver operating characteristics (ROC) curve analysis was used to determine the cut-off point value of admission NLR related to hospital mortality of trauma patients. Furthermore, Kaplan-Meier survival analysis and Cox regression models have been applied to determine the effectiveness and prognostic potential of the admission NLR in the hospital mortality of trauma patients. The median age of the trauma patients was 32 years with an interquartile range (IQR) of 23 to 48 years, and most of them were male (83.9%). Also, trauma patients had a median injury severity score (ISS) of 9 (IQR=4-16) and a median Glasgow coma scale (GCS) of 14 (IQR=9-15). The cut-off value for admission NLR was 5.27 (area under the curve: 0.642, 95%CI: 0.559-0.726, p=0.001). In Kaplan-Meier survival analysis, the admission NLR>5.27 was an indicator of hospital mortality in trauma patients (p=0.001). Multivariate Cox regression models demonstrated that trauma patients with an admission NLR>5.27 had a 2.33-fold risk of hospital mortality (hazard ratio=2.33, 95%CI: 1.02-5.38, p=0.041). Furthermore, the admission NLR>5.27 was associated with a higher risk of hospital mortality in trauma patients with age≥65 years, systolic blood pressure≤90 mmHg, blood potassium>4.5 mmol/L, blood sodium>144 mEq/L, blood potential hydrogen (pH)≤7.28, GCS≤8, ISS>24 and blood base excess≤-6.1 mEq/L. The NLR value greater than 5.27 at the time of admission was associated with poorer outcomes, and it can be considered an independent prognostic indicator of hospital mortality in trauma patients.

scholarly journals Prognostic Value and Optimal Candidates of Primary Tumor Surgery in Metastatic Adenoid Cystic Carcinoma of the Head and Neck: First Evidence from a Population-Based Study

2021 ◽  
Author(s):  
Di Zhang
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Head And Neck ◽  
Primary Tumor ◽  
Prognostic Value ◽  
Univariate Analysis ◽  
Initial Diagnosis ◽  
Prognostic Impact ◽  
Tumor Surgery ◽  
Adenoid Cystic ◽  
The Impact

Abstract Objective: The prognostic value of primary tumor surgery (PTS) for patients with metastatic adenoid cystic carcinoma of the head and neck (HNACC) at initial diagnosis has never been studied. The aims of this study were to determine the prognostic significance and identify optimal candidates of PTS.Materials and Methods: Patients with metastatic HNACC (stage IVC) at initial diagnosis were identified from the Surveillance, Epidemiology and End Results (SEER) database between 2004 and 2015. Correlated variables, including age, sex, race, tumor stage, metastatic site, treatment, and survival information were extracted. Kaplan-Meier analysis, log-rank test, and multivariate Cox regression model were performed to evaluate the impact of PTS on survival outcomes, including overall survival (OS) and cancer-specific survival (CSS).Results: Overall, 155 patients were identified from database. Of those, 93 (60%) patients underwent palliative PTS. Patients with lung metastasis alone were more likely undergo PTS (c2=15.042, P=0.002). The univariate analysis showed that PTS were associated with significantly improved survival than no-PTS (P=0.001 for CSS; P＜0.001 for OS). The median CSS for patients who received PTS and those who did not receive PTS were 64.0 and 22.0 months, respectively. The median OS for patients who received PTS and those without PTS were 43.0 and 16.0 months, respectively. Notably, in multivariate model, the OS of patients who underwent PTS was better than that of patients who did not (HR=0.586, P=0.017), but there was no significantly improvement in CSS. In addition, subgroup analyses further revealed that patients with T3-4 or N0 stage might benefit from PTS.Conclusion: PTS signifi­cantly improved OS in patients with metastatic HNACC. Besides, PTS had a favorable prognostic impact on highly-selected patients, namely T3-4 and N0 stage, which could be adopted in future clinical practice. Further multicenter prospective studies are still needed to verify these outcomes.

Prognostic value of neutrophil-to-lymphocyte ratio in older patients with head and neck cancer

2020 ◽  
Vol 11 (3) ◽  
pp. 417-422 ◽  
Author(s):  
Ja Yoon Ku ◽  
Jong-Lyel Roh ◽  
Sung-Bae Kim ◽  
Seung-Ho Choi ◽  
Soon Yuhl Nam ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Older Patients ◽  
Prognostic Value ◽  
Neutrophil To Lymphocyte Ratio ◽  
Lymphocyte Ratio

scholarly journals The Potential Prognostic Value of a Novel Hematologic Marker Fibrinogen-to-Lymphocyte Ratio in Head and Neck Adenoid-Cystic Carcinoma

2021 ◽  
Vol 11 (11) ◽  
pp. 1228
Author(s):  
Faris F. Brkic ◽  
Stefan Stoiber ◽  
Marlene Friedl ◽  
Tobias Maier ◽  
Gregor Heiduschka ◽  
...  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Head And Neck ◽  
Disease Free Survival ◽  
Threshold Value ◽  
Late Recurrence ◽  
Study Cohort ◽  
Lymphocyte Ratio ◽  
Adenoid Cystic ◽  
Long Term Survivors

Many patients with adenoid-cystic carcinoma (ACC) experience an indolent course of disease over many years but face late recurrence, and long-term survivors are rare. Due to its infrequent occurrence, it is hard to predict outcome in these patients. The fibrinogen-to-lymphocyte ratio (FLR) was recently proposed as an outcome prognosticator in different cancer entities. We aimed to investigate its prognostic relevance in patients with head and neck ACC. This retrospective analysis was performed including all patients treated for ACC between 1998 and 2020. The FLR ratio was calculated based on pretreatment values (0–7 days). The study cohort was dichotomized based on optimized threshold value and compared for differences in outcome (overall survival (OS) and disease-free survival (DFS)). In the cohort of 39 included patients, the OS was significantly longer in the low (n = 28) compared to the high pretreatment FLR group (n = 11) (median OS 150.5 months, 95% confidence intervals (CI) 85.3–215.7 months vs. 29.4 months, 95% CI not reached; p = 0.0093). Similarly, the DFS was significantly longer in the low FLR group (median DFS 74.5 months, 95% CI 30.6–118.4 months vs. 11.0 months, 95% CI 5.1–16.9 months; p = 0.019). The FLR is an easily obtainable and simple marker and may be a valuable outcome prognosticator in patients with ACC. Further studies are needed for validation of our results.

PROGNOSTIC VALUE OF NUCLEAR VOLUME IN ADENOID CYSTIC CARCINOMA OF THE HEAD AND NECK

1994 ◽  
Author(s):  
X XIE ◽  
TC STENERSEN ◽  
PL LARSEN ◽  
OPF CLAUSEN ◽  
M BOYSEN
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Head And Neck ◽  
Prognostic Value ◽  
Nuclear Volume ◽  
Adenoid Cystic
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