scholarly journals Persisting Hypolipoproteinaemia Following Multiple Wasp Stings

2021 ◽  
Author(s):  
Zhenglin Quan ◽  
Huanchao Zeng ◽  
Zhicheng Fang ◽  
Xianyi Yang
Keyword(s):  
Large Scale ◽  
Lipid Level ◽  
Blood Lipid ◽  
Multiple Organ ◽  
Organ Injury ◽  
Severe Allergic Reaction ◽  
Lipid Levels ◽  
Life Threatening ◽  
Wasp Stings

Abstract Background Severe allergic reactions and life-threatening multiple organ injury or failure are common after severe stings. However, reports on wasp stings complicated with continual hypolipoproteinaemia are scarce in the literature and there is no consensus for its therapeutic management. Methods This case is a 49-year-old female patient who developed severe allergic reaction and multiple organ failure after severe wasp stings and complicated with sustained hypolipoproteinaemia. Her clinical characteristics and the change of lipid levels are described. During the hospitalization, we did not perform any intervention for dyslipidemia. Results The patient’s blood lipid levels were decreased after numerous wasp stings. In particular, the HDL-C was linear over all five days(nadir, 0.21mmol/L on day 5), and the level gradually recovered to normal till day 17. At the same time, the patient occurs severe inflammatory response and multiple organ dysfunction syndrome, especially liver failure. The 3 months follow-up of the patient was remarkable with normal lipid level and she was doing well in normal daily activities. Conclusion We highlight the hypolipoproteinaemia that might occur in the patient who after severe wasp stings. This study initially confirmed that there is some correlation between abnormal blood lipid metabolism and the evolution of the condition. Whether dyslipidemia in wasp stings is associated with hemolysis and inflammatory reaction is unclear, and further investigation would be required. As far as we know, this is the first report of persisting hypolipoproteinaemia after wasp stings. The clinical research and prolonged follow-up are yet to be concluded, and large-scale clinical studies need to be performed.

scholarly journals The effects of almond consumption on fasting blood lipid levels: a systematic review and meta-analysis of randomised controlled trials

2016 ◽  
Vol 5 ◽  
Author(s):  
Kathy Musa-Veloso ◽  
Lina Paulionis ◽  
Theresa Poon ◽  
Han Youl Lee
Keyword(s):  
Systematic Review ◽  
Heart Disease ◽  
Randomised Controlled Trials ◽  
Large Scale ◽  
Meta Analysis ◽  
Blood Lipid ◽  
Controlled Trials ◽  
Lipid Levels ◽  
Randomised Controlled ◽  
Blood Lipid Levels

AbstractA systematic review and meta-analysis of randomised controlled trials was undertaken to determine the effects of almond consumption on blood lipid levels, namely total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), TAG and the ratios of TC:HDL-C and LDL-C:HDL-C. Following a comprehensive search of the scientific literature, a total of eighteen relevant publications and twenty-seven almond-control datasets were identified. Across the studies, the mean differences in the effect for each blood lipid parameter (i.e. the control-adjusted values) were pooled in a meta-analysis using a random-effects model. It was determined that TC, LDL-C and TAG were significantly reduced by −0·153 mmol/l (P < 0·001), −0·124 mmol/l (P = 0·001) and −0·067 mmol/l (P = 0·042), respectively, and that HDL-C was not affected (−0·017 mmol/l; P = 0·207). These results are aligned with data from prospective observational studies and a recent large-scale intervention study in which it was demonstrated that the consumption of nuts reduces the risk of heart disease. The consumption of nuts as part of a healthy diet should be encouraged to help in the maintenance of healthy blood lipid levels and to reduce the risk of heart disease.

scholarly journals Pathogenesis of Multiple Organ Injury in COVID-19 and Potential Therapeutic Strategies

2021 ◽  
Vol 12 ◽  
Author(s):  
Miquéias Lopes-Pacheco ◽  
Pedro Leme Silva ◽  
Fernanda Ferreira Cruz ◽  
Denise Battaglini ◽  
Chiara Robba ◽  
...  
Keyword(s):  
Respiratory Disease ◽  
Biological Activities ◽  
Case Fatality ◽  
Cell Types ◽  
Multiple Organ ◽  
Organ Injury ◽  
Downstream Effects ◽  
Threatening Condition ◽  
Life Threatening ◽  
Novel Coronavirus

Severe acute respiratory disease coronavirus 2 (SARS-CoV-2, formerly 2019-nCoV) is a novel coronavirus that has rapidly disseminated worldwide, causing the coronavirus disease 2019 (COVID-19) pandemic. As of January 6th, 2021, there were over 86 million global confirmed cases, and the disease has claimed over 1.87 million lives (a ∼2.2% case fatality rate). SARS-CoV-2 is able to infect human cells by binding its spike (S) protein to angiotensin-conversing enzyme 2 (ACE2), which is expressed abundantly in several cell types and tissues. ACE2 has extensive biological activities as a component of the renin-angiotensin-aldosterone system (RAAS) and plays a pivotal role as counter-regulator of angiotensin II (Ang II) activity by converting the latter to Ang (1-7). Virion binding to ACE2 for host cell entry leads to internalization of both via endocytosis, as well as activation of ADAM17/TACE, resulting in downregulation of ACE2 and loss of its protective actions in the lungs and other organs. Although COVID-19 was initially described as a purely respiratory disease, it is now known that infected individuals can rapidly progress to a multiple organ dysfunction syndrome. In fact, all human structures that express ACE2 are susceptible to SARS-CoV-2 infection and/or to the downstream effects of reduced ACE2 levels, namely systemic inflammation and injury. In this review, we aim to summarize the major features of SARS-CoV-2 biology and the current understanding of COVID-19 pathogenesis, as well as its clinical repercussions in the lung, heart, kidney, bowel, liver, and brain. We also highlight potential therapeutic targets and current global efforts to identify safe and effective therapies against this life-threatening condition.

Traumatic Rupture of the Ureter: 10 Cases

2002 ◽  
Vol 38 (2) ◽  
pp. 188-192 ◽  
Author(s):  
Chick Weisse ◽  
Lillian R. Aronson ◽  
Ken Drobatz
Keyword(s):  
Retrospective Study ◽  
Physical Examination ◽  
Radiographic Finding ◽  
Abdominal Distension ◽  
Multiple Organ ◽  
Organ Injury ◽  
Traumatic Rupture ◽  
Gross Hematuria ◽  
Multiple Organ Injury

A retrospective study was performed on eight dogs, one cat, and one ferret with ruptured ureters secondary to blunt trauma. The most common physical examination findings were abdominal distension/discomfort (in five of 10 animals) and gross hematuria (in five of six animals). Multiple organ injury was also common (in seven of 10 animals). Loss of retroperitoneal and peritoneal detail was the most common radiographic finding (in four of six animals). Ureteronephrectomy was the most common surgical procedure (performed in five out of seven procedures). Three of the five cases discharged were available for follow-up and have had no evidence of associated problems.

scholarly journals Rare coding variants in 35 genes associate with circulating lipid levels – a multi-ancestry analysis of 170,000 exomes

2020 ◽  
Author(s):  
George Hindy ◽  
Peter Dornbos ◽  
Mark D. Chaffin ◽  
Dajiang J. Liu ◽  
Minxian Wang ◽  
...  
Keyword(s):  
Complex Traits ◽  
Drug Target ◽  
Large Scale ◽  
Target Genes ◽  
Genome Wide Association Study ◽  
Sequence Data ◽  
Blood Lipid ◽  
Nucleotide Polymorphisms ◽  
Lipid Levels ◽  
Blood Lipid Levels

SummaryLarge-scale gene sequencing studies for complex traits have the potential to identify causal genes with therapeutic implications. We performed gene-based association testing of blood lipid levels with rare (minor allele frequency<1%) predicted damaging coding variation using sequence data from >170,000 individuals from multiple ancestries: 97,493 European, 30,025 South Asian, 16,507 African, 16,440 Hispanic/Latino, 10,420 East Asian, and 1,182 Samoan. We identified 35 genes associated with circulating lipid levels. Ten of these: ALB, SRSF2, JAK2, CREB3L3, TMEM136, VARS, NR1H3, PLA2G12A, PPARG and STAB1 have not been implicated for lipid levels using rare coding variation in population-based samples. We prioritize 32 genes identified in array-based genome-wide association study (GWAS) loci based on gene-based associations, of which three: EVI5, SH2B3, and PLIN1, had no prior evidence of rare coding variant associations. Most of the associated genes showed evidence of association in multiple ancestries. Also, we observed an enrichment of gene-based associations for low-density lipoprotein cholesterol drug target genes, and for genes closest to GWAS index single nucleotide polymorphisms (SNP). Our results demonstrate that gene-based associations can be beneficial for drug target development and provide evidence that the gene closest to the array-based GWAS index SNP is often the functional gene for blood lipid levels.

scholarly journals The Relationships Between Lipid Accumulation Product Levels and Cognitive Decline Over 4 Years in a Rural Area of Xi’an, China

2021 ◽  
Vol 13 ◽  
Author(s):  
Yanyu Wang ◽  
Shan Wei ◽  
Rong Zhou ◽  
Suhang Shang ◽  
Liangjun Dang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cognitive Impairment ◽  
Cognitive Decline ◽  
Mmse Score ◽  
Blood Lipid ◽  
Normal Blood Pressure ◽  
Lipid Levels ◽  
Lipid Accumulation Product ◽  
Blood Lipid Levels

Background and Aims: The relationships between blood lipid levels and obesity and cognitive impairment have not been fully determined. Considering that the lipid accumulation product (LAP) is a composite index of blood lipid levels and obesity, we investigated the relationships between LAP levels at baseline and cognitive decline over 4 years.Methods: A total of 983 subjects (≥40 years) from a longitudinal cohort in a village of Xi’an, China, who completed the baseline survey were followed-up for 4 years. All participants underwent face-to-face interviews and cognitive assessments at baseline and at the 4-year follow-up. The Mini-Mental State Examination (MMSE) was used to assess cognitive function, and an MMSE score dropping ≥ 2 points from baseline was defined as cognitive decline. The relationships between LAP and cognitive decline were analyzed by linear regression models.Results: During the 4-year follow-up, 172 patients exhibited cognitive decline (17.5%). Univariate analysis showed that the rate of change in MMSE score was significantly different between the low-LAP group and the high-LAP group (t = −2.26, p = 0.024). Multiple linear regression indicated that a high LAP was positively associated with cognitive decline (β = 0.564, p = 0.012). Stratified multivariate analysis showed that LAP was positively associated with cognitive decline in the normal blood pressure female subgroup (β = 1.29, p = 0.002) but not in the high blood pressure group or the male group.Conclusions: High LAP is associated with cognitive decline in females with normal blood pressure but not in those with high blood pressure or males. This indicates that the relationships between blood lipid levels and obesity and cognitive impairment may be affected by blood pressure and sex.

Does cisplatin-based chemotherapy effect on blood lipid levels of patients with germ cell testicular tumor in long-term follow-up?

2011 ◽  
Vol 43 (4) ◽  
pp. 1095-1100 ◽  
Author(s):  
Gokhan Koc ◽  
Taner Rauf Divrik ◽  
Nuri Unlu ◽  
Volkan Bulut ◽  
Ferruh Zorlu
Keyword(s):  
Germ Cell ◽  
Testicular Tumor ◽  
Blood Lipid ◽  
Lipid Levels ◽  
Long Term Follow Up ◽  
Blood Lipid Levels

scholarly journals Toenail selenium levels and prevalence of dyslipidaemia among Korean adults

2017 ◽  
Vol 118 (6) ◽  
pp. 473-480 ◽  
Author(s):  
Jiyoung Jang ◽  
J. Steven Morris ◽  
Kyong Park
Keyword(s):  
Dietary Supplement ◽  
Large Scale ◽  
Antioxidant Properties ◽  
Blood Lipid ◽  
Epidemiological Data ◽  
The Body ◽  
Biomedical Science ◽  
Lipid Levels ◽  
Supplement Use ◽  
Dietary Supplement Use

AbstractMultiple studies have elucidated the antioxidant properties of Se, which are now well known among the nutrition and biomedical science communities. Recently, considerable interest has been focused on the possible association between Se exposure and risk of metabolic disease, such as lipid dysregulation; however, there is limited epidemiological data on this topic. The present study aimed to investigate associations between toenail Se levels and dyslipidaemia or individual lipid levels, and to examine the effect of dietary supplement use on these associations. We analysed baseline data from a cohort in the Yeungnam area, including 232 men and 269 women. Information on demographic, dietary and lifestyle characteristics was obtained through a self-reported questionnaire. Se levels in toenail specimens were measured using neutron activation analysis. Fasting blood lipid levels were measured during medical examinations. After adjusting for multiple confounding variables, we observed no association between toenail Se levels and dyslipidaemia or individual lipid profiles. However, the association was modified by dietary supplement use. Among the supplement users, higher toenail Se levels were associated with a higher prevalence of lipid dysregulation, whereas non-users exhibited a lower prevalence of lipid dysregulation. Associations between toenail Se levels, lipid levels and dyslipidaemia may be influenced by taking dietary supplements. Future large-scale, prospective cohort studies should be conducted to further evaluate the association between Se levels in the body and metabolic health effects in light of increasing rates of dietary supplement use.

scholarly journals IMMUNOMODULATING EFFECTS OF THE PURIFIED HEV B 13 FRACTION ON SEPTIC RATS

2017 ◽  
Vol 30 (2) ◽  
pp. 93-97 ◽  
Author(s):  
Maxley Martins ALVES ◽  
Lilhian Alves de ARAÚJO ◽  
Fátima MRUÉ ◽  
Clayson Moura GOMES ◽  
Milton Adriano Pelli de OLIVEIRA ◽  
...  
Keyword(s):  
Inflammatory Responses ◽  
Leukocyte Count ◽  
Multiple Organ ◽  
The Body ◽  
Organ Injury ◽  
Total Leukocyte Count ◽  
Histopathological Analysis ◽  
Differential Leukocyte Count ◽  
Sepsis Induction ◽  
Life Threatening

ABSTRACT Background: Sepsis is a potentially life-threatening complication of an infection that occurs when chemicals released into the bloodstream to fight the infection trigger inflammatory responses throughout the body, especially in the acute phase of the disease, producing excessive pro-inflammatory cytokines, leading to multiple organ injury and death. The Hev b 13 fraction has demonstrated biological activity capable of inducing IL-10 production and shrinking inflammatory disease lesions. Aim: To investigate the immunomodulating effects of the Hev b 13 fraction on septic rats. Methods: Acinetobacter baumannii was injected into the peritoneal cavity of the animals after sustaining a lesion in the pancreas, with the stomach as an entry point. After 10 h of infection, they were euthanized for blood and lung collection, followed by total and differential leukocyte count, determination of cytokine level and histopathological analysis. Results: Administering a single dose of the Hev b 13 fraction 2 h after sepsis induction significantly decreased total leukocyte count. Higher IL-10 and IL-4 and lower IL-6 production shrank the lung tissue lesions compared to the control groups. Conclusion: The Hev b 13 fraction exhibits an anti-inflammatory tendency, with potential for sepsis treatment.

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