scholarly journals Clinical Outcomes Observation in Stage IIB–III Cervical Cancer Treated by Adjuvant Surgery Following Concurrent Chemoradiotherapy

2020 ◽  
Author(s):  
Yong Li ◽  
Zhiying Chen ◽  
Xiang Wang ◽  
Xiumei Li ◽  
Jie Zhou ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Logistic Regression ◽  
Operation Time ◽  
Residual Tumor ◽  
Postoperative Recurrence ◽  
Surgery Complications ◽  
Combined Surgery ◽  
Adjuvant Surgery ◽  
Completion Surgery

Abstract Objective: To explore the feasibility of adjuvant surgery following concurrent chemoradiation therapy (CCRT) in stage ⅡB–Ⅲ cervical cancer. And analyze risk factors of recurrence after surgery. Methods: Forty-nine patients diagnosed with stage ⅡB–Ⅲ cervical cancer were reviewed retrospectively. Investigated the risk factors of recurrence after surgery using Chi-squared Test and further analyzed multiple factors affecting postoperative recurrence using the multi-factor logistic regression. Furthermore, the correlation of surgery outcomes (including operation time, bleeding, and hospitalization date and surgery complications) with the time which carried out between CCRT and completion surgery was analyzed. Results: Tumor histology and residual tumor in the cervix were significantly associated with postoperative recurrence (P = 0.014 and P = 0.040, respectively). Logistic regression analysis demonstrated that the independent risk factors of postoperative recurrence were age and residual tumor in the cervix (P = 0.017 and P = 0.030, respectively). Compared with completion surgery was carried out ≤ 6 weeks after CCRT, the operation time, bleeding, hospitalization date and surgery complications were more than > 6 weeks group. Moreover, bleeding and surgery complications were statistically significant (P = 0.019 and P = 0.044, respectively). Conclusion: CCRT combined surgery for stage ⅡB–Ⅲ cervical cancer was feasible, reduced the rate of postoperative recurrence and surgery complications were tolerated. CCRT combined surgery might improve the local control of lesion.

scholarly journals Clinical Outcomes Observation in Stage IIB–III Cervical Cancer Treated by Adjuvant Surgery Following Concurrent Chemoradiotherapy

2020 ◽  
Author(s):  
Yong Li ◽  
Zhiying Chen ◽  
Xiang Wang ◽  
Xiumei Li ◽  
Jie Zhou ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Logistic Regression ◽  
Operation Time ◽  
Residual Tumor ◽  
Postoperative Recurrence ◽  
Surgery Complications ◽  
Combined Surgery ◽  
Adjuvant Surgery ◽  
Completion Surgery

Abstract Objective: To explore the feasibility of adjuvant surgery following concurrent chemoradiation therapy (CCRT) in stage ⅡB–Ⅲ cervical cancer. And analyze risk factors of recurrence after surgery. Methods: Forty-nine patients diagnosed with stage ⅡB–Ⅲ cervical cancer were reviewed retrospectively. Investigated the risk factors of recurrence after surgery using Chi-squared Test and further analyzed multiple factors affecting postoperative recurrence using the multi-factor logistic regression. Furthermore, the correlation of surgery outcomes (including operation time, bleeding, and hospitalization date and surgery complications) with the time which carried out between CCRT and completion surgery was analyzed. Results: Tumor histology and residual tumor in the cervix were significantly associated with postoperative recurrence (P = 0.014 and P = 0.040, respectively). Logistic regression analysis demonstrated that the independent risk factors of postoperative recurrence were age and residual tumor in the cervix (P = 0.017 and P = 0.030, respectively). Compared with completion surgery was carried out ≤ 6 weeks after CCRT, the operation time, bleeding, hospitalization date and surgery complications were more than > 6 weeks group. Moreover, bleeding and surgery complications were statistically significant (P = 0.019 and P = 0.044, respectively).Conclusion: CCRT combined surgery for stage ⅡB–Ⅲ cervical cancer was feasible, reduced the rate of postoperative recurrence and surgery complications were tolerated. CCRT combined surgery might improve the local control of lesion.

scholarly journals Clinical outcomes observation in stage IIB–IIIB cervical cancer treated by adjuvant surgery following concurrent chemoradiotherapy

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yong Li ◽  
Zhiying Chen ◽  
Xiang Wang ◽  
Xiumei Li ◽  
Jie Zhou ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Logistic Regression ◽  
Operation Time ◽  
Residual Tumor ◽  
Postoperative Recurrence ◽  
Surgery Complications ◽  
Factors Affecting ◽  
Adjuvant Surgery ◽  
Chi Squared

Abstract Background To explore the feasibility of adjuvant surgery following concurrent chemoradiation therapy (CCRT) in stage IIB–IIIB (according to FIGO staging of 2009) cervical cancer and analyze risk factors of recurrence after surgery. Methods Forty-nine patients diagnosed with stage IIB–IIIB cervical cancer were reviewed retrospectively. We investigated the risk factors of recurrence after surgery using Chi-squared Test and further analyzed multiple factors affecting postoperative recurrence using the multi-factor logistic regression. Furthermore, the correlation of surgery outcomes (including operation time, bleeding, and hospitalization date and surgery complications) with the time which carried out between CCRT and completion surgery was analyzed. Results Tumor histology and residual tumor in the cervix were significantly associated with postoperative recurrence (P = 0.014 and P = 0.040, respectively). Logistic regression analysis demonstrated that the independent risk factors of postoperative recurrence were age and residual tumor in the cervix (P = 0.017 and P = 0.030, respectively). Complications (operation time, bleeding, hospitalization date) were compared between patients with an interval with radiotherapy less than 6 weeks and patients with an interval longer than 6 weeks. There were statistical differences in the amount of bleeding and postoperative complications between the two groups (P = 0.019 and P = 0.044, respectively). Conclusion CCRT combined with surgery for stage IIB–IIIB cervical cancer was feasible, reduced the rate of postoperative recurrence and surgery complications were tolerated.

scholarly journals Risk Factors for Dysphagia After Anterior Cervical Discectomy and Fusion With the Zero-P Implant System: a Retrospective Study With Minimum of 2 Years Follow-up

2021 ◽  
Author(s):  
Rong Xue ◽  
Ningdao Li ◽  
Zhurong Ji ◽  
Xingdong Cheng ◽  
Zhuqiu Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Operation Time ◽  
Anterior Cervical Discectomy ◽  
Postoperative Dysphagia ◽  
Chi Square ◽  
Chi Square Test ◽  
Implant System ◽  
Segmental Angle

Abstract Background: Dysphagia is one of the most common complications after anterior cervical spine surgery. The study aimed to evaluate the risk factors for dysphagia after anterior cervical discectomy and fusion (ACDF) with the Zero-P Implant System by multidimensional analysis and investigated the predictive values of these risk factors for dysphagia. Methods: A retrospective analysis of 260 patients who underwent ACDF with the Zero-P Implant System and had at least 2 year of follow-up ware performed. All patients were divided into a non-dysphagia group and a dysphagia group. Sex, age, body mass index (BMI), intraoperative time, estimated blood loss, diabetes mellitus, hypertension, smoking, alcohol consumption, prevertebral soft-tissue thickness, the levels of surgery, O-C2 angle, C2–7 angle, T1 slope and segmental angle were analyzed. Chi-square test and logistic regression were performed to analyze the predictive value of each dimension for dysphagia. Results: In total, the non-dysphagia group comprised 170 patients and the dysphagia group comprised 90 patients. Chi-square test results indicated that number of operated levels, operation time dT1 slope, dO-C2 angle, dC2–7 angle, segmental angle and dPSTT were associated with a high incidence of dysphagia. Multivariate logistic regression analysis showed that number of operated levels, operation time, dC2–7 angle and dPSTT were significantly associated with postoperative dysphagia.Conclusions: Number of operated levels, operation time, dC2–7 angle and dPSTT were significantly associated with postoperative dysphagia. In additionally, sufficient preoperative preparation, evaluation combining with proficient and precise treatment measures are suggested to reduce the incidence of postoperative dysphagia when ACDF is performed.

scholarly journals Risk Factors for Dysphagia after Anterior Cervical Discectomy and Fusion with the Zero-P Implant system: A Study with Minimum of 2 Years Follow-up

2021 ◽  
Author(s):  
Rong Xue ◽  
Yang Yu ◽  
Mengchen Yin ◽  
Zhuyong Ji ◽  
Xingdong Cheng ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Operation Time ◽  
Anterior Cervical Discectomy ◽  
Postoperative Dysphagia ◽  
Chi Square ◽  
Chi Square Test ◽  
Implant System ◽  
Segmental Angle

Abstract ObjectiveDysphagia is one of the most common complications after anterior cervical spine surgery. The study aimed to evaluate the risk factors for dysphagia after anterior cervical discectomy and fusion (ACDF) with the Zero-P Implant System by multidimensional analysis and investigated the predictive values of these risk factors for dysphagia.MethodsA retrospective analysis of 260 patients who underwent ACDF with the Zero-P Implant System and had at least 2 year of follow-up ware performed. All patients were divided into a non-dysphagia group and a dysphagia group. Sex, age, body mass index (BMI), intraoperative time, estimated blood loss, diabetes mellitus, hypertension, smoking, alcohol consumption, prevertebral soft-tissue thickness, the levels of surgery, O-C2 angle, C2–7 angle, T1 slope and segmental angle were analyzed. Chi-square test and logistic regression were performed to analyze the predictive value of each dimension for dysphagia.ResultsIn total, the non-dysphagia group comprised 70 patients and the dysphagia group comprised 190 patients. Chi-square test results indicated that number of operated levels, operation time dT1 slope, dO-C2 angle, dC2–7 angle, segmental angle and dPSTT were associated with a high incidence of dysphagia. Multivariate logistic regression analysis showed that number of operated levels, operation time, dC2–7 angle and dPSTT were significantly associated with postoperative dysphagia.ConclusionsNumber of operated levels, operation time, dC2–7 angle and dPSTT were significantly associated with postoperative dysphagia. In additionally, sufficient preoperative preparation, evaluation combining with proficient and precise treatment measures are suggested to reduce the incidence of postoperative dysphagia when ACDF is performed.

scholarly journals A study to assess select risk factors for carcinoma cervix among patients attending Kidwai Memorial Institute of Oncology

2017 ◽  
Vol 4 (11) ◽  
pp. 4238
Author(s):  
Swapnajaswanth M. ◽  
Suryanarayana S. P. ◽  
Suman G. ◽  
Murthy N. S.
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Logistic Regression ◽  
Risk Factor ◽  
Multiple Logistic Regression Analysis ◽  
Univariate Analysis ◽  
Significant Risk ◽  
Cancer Cervix ◽  
Carcinoma Cervix ◽  
Sanitary Pads

Background: Cervical cancer is an important public health problem worldwide; it is second most common cancer among women aged 15-44 years globally (Globocan 2012). The objective of the study was to study the association between select risk factors and carcinoma cervix among patients attending Kidwai Memorial Institute of Oncology, Bangalore.Methods: Hospital based case- control study was carried among newly diagnosed cases of cervical cancer, cases and apparently healthy controls were selected. Statistical analysis was performed using, Chi square test of significance, logistic regression were preformed.Results: Univariate analysis revealed the following variables as significant risk factors these were Age at consummation of marriage <18 years OR 5.9 (2.6-19.4), Age 1st pregnancy <18 years OR 3.4 (2.2-5.2), live births delivered >5 OR 2.9 (1.7-5.8), marital status other than those who were married OR 1.7 (1.2-2.6), education of study subject being uneducated OR 3.9 (2.9-5.7), not washing genitals after sex OR 2.8 (1.6-4.9), material used during menstruation other than sanitary pads OR 6 (3.1-11.7), sex during menstruation OR 3 (1.1-7.9), not washing of private parts daily OR 10.8 (6.4-18.2), not taking bath daily OR 4.4 (2.8-7), open air defecation 7.6 (5.4-11.7), tobacco use OR 3.3 (2.2-5.6), never use of any contraceptive OR 3.7 (1.0-8.3) were significant at 0.05 level. Following backward multiple logistic regression analysis the following variables were independently associated with the development of cancer cervix, these were, age at 1st pregnancy <18 years OR 2.2 (1.2-3.8), use of material other than sanitary pads OR 3 (1.3-6.5), having sex during menstruation OR 4.3 (1.2-15), not washing of private parts daily OR 5.5 (2.9-10.4), open air defecation OR 2.6 (1.4-4.7), attained significance at 0.05 level.Conclusions: The study has revealed that age at 1st pregnancy <18 years, use of material other than sanitary pads, having sex during menstruation, not washing of private parts daily, open air defecation, as an independent risk factor for the development of cancer cervix. It can be noted that all the risk factor mentioned above is highly amenable for primary prevention.

scholarly journals The Analysis of Risk Factors for Hemorrhage Associated with Minimally Invasive Percutaneous Nephrolithotomy

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Xiangjun Meng ◽  
Juan Bao ◽  
Qiwu Mi ◽  
Shaowei Fang
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Minimally Invasive ◽  
Logistic Regression Analysis ◽  
Percutaneous Nephrolithotomy ◽  
Operation Time ◽  
Stone Size ◽  
Minimally Invasive Percutaneous Nephrolithotomy ◽  
Staghorn Stone

Objective. This study investigated the risk factors for bleeding during minimally invasive percutaneous nephrolithotomy, so as to prevent the occurrence of bleeding and improve the surgical effect. Patients and Methods. The data of 396 patients who underwent percutaneous nephrolithotomy by an experienced surgeon between May 2014 and December 2017 were retrospectively analyzed. To identify the risk factors for bleeding during percutaneous nephrolithotomy, each group was stratified according to the decrease in median hemoglobin. Age, gender, body mass index, stone size, operation time, stone type, degree of hydronephrosis, number of accesses, puncture guidance, underlying disease (diabetes; hypertension), and previous surgical history were evaluated. Univariate analysis was performed to calculate the potential factors. In order to determine the independence of each factor, we finally selected stone size, staghorn stone, degree of hydronephrosis, and operation time. Multivariate logistic regression analysis was used to identify the risk factors for bleeding during minimally invasive percutaneous nephrolithotomy. Results. A total of 396 patients were successfully treated with percutaneous nephrolithotomy. The univariate analysis demonstrated that the potential risk factors for bleeding during percutaneous nephrolithotomy included stone size, type of stone, operative time, and degree of hydronephrosis. According to the previous studies, stone size, staghorn stone, degree of hydronephrosis, and operation time were ultimately selected. Multivariate logistic regression analysis was used to identify the risk factors for bleeding during percutaneous nephrolithotomy. According to the outcome of logistic regression analysis, stone size, staghorn stone, operation time, and degree of hydronephrosis were the risk factors for bleeding during minimally invasive percutaneous nephrolithotomy. Conclusions. Percutaneous nephrolithotomy is an effective method for the treatment of upper urinary calculi with few complications. According to the results achieved by an experienced surgeon, the size of stone, staghorn stone, operation time, and degree of hydronephrosis were associated with the bleeding during minimally invasive percutaneous nephrolithotomy.

scholarly journals Prevalence and Risk Factors Associated with Precancerous Cervical Cancer Lesions among HIV-Infected Women in Resource-Limited Settings

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Peter Memiah ◽  
Wangeci Mbuthia ◽  
Grace Kiiru ◽  
Solomon Agbor ◽  
Francesca Odhiambo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Logistic Regression ◽  
Precancerous Lesions ◽  
Multivariate Logistic Regression Model ◽  
Cervical Lesions ◽  
Resource Limited Settings ◽  
Resource Limited ◽  
Cervical Precancerous Lesions ◽  
Associated Risk Factors

Objective. To assess the prevalence and identified associated risk factors for precancerous cervical cancer lesions among HIV-infected women in resource-limited settings in Kenya.Methods. HIV-infected women attending the ART clinic at the Nazareth Hospital ART clinic between June 2009 and September 2010. Multivariate logistic regression model with odds ratios and 95% confidence intervals (CI) were estimated after controlling for important covariates.Result. A total of 715 women were screened for cervical cancer. The median age of the participants was 40 years (range 18–69 years). The prevalence of precancerous lesions (CINI, CINII, CIN III, ICC) was 191 (26.7%). After controlling for other variables in logistic regression analysis, cervical precancerous lesions were associated with not being on ART therapy; whereby non-ART were 2.21 times more likely to have precancerous lesions than ART patients [(aOR)=2.21, 95% CI (1.28–3.83)].Conclusion. The prevalence of precancerous cervical lesions was lower than other similar settings. It is recommended that cancer screening of HIV-infected women should be an established practice. Availability and accessibility of these services can be done through their integration into HIV. Prompt initiation of HAART through an early enrollment into care has an impact on reducing the prevalence and progression of cervical precancerous lesions.

scholarly journals Evaluation of Pelvic Floor Muscle Function(PFMF) in Cervical Cancer Patients with Querleu-Morrow type C Hysterectomy：A Multicenter Study

2020 ◽  
Author(s):  
Shiyan Wang ◽  
Hongwu Wen ◽  
Yunong Gao ◽  
Qiubo Lv ◽  
Hongyu Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Logistic Regression ◽  
Pelvic Floor ◽  
Cancer Patients ◽  
Muscle Function ◽  
Pelvic Floor Muscle ◽  
Fibre Strength ◽  
Independent Risk Factors

Abstract Introduction and Hypothesis To evaluate the pelvic floor muscle function (PFMF) of cervical cancer patients after type QM-C hysterectomy and to explore the relationship between decreased PFMF and related factors.. Methods This was a multi-centered retrospective cohort study. 181 cervical cancer patients underwent type QM-C hysterectomy were enrolled from 9 tertiary hospitals. Strength of PFMF were measured by using neuromuscular apparatus (Phenix U8, French). Risk factors contributed to decreased PFMF was analyzed by univariate and multivariate ordinal ploytomous logistic regression. Results Totally 181 patients were investigated in this study.0-3 level of type I muscle fibre strength(MFSI) was 52.6%(95/181),0-3 level of type ⅡA muscle fibre strength(MFSⅡA) was 50%(91/181). Subjective stress urinary incontinence was 46%(84/181),urinary retention was 27.3%(50/181),dyschezia was 41.5%(75/181),fecal incontinence was 9%(18/181).①MFSI：Multivariate ordinal ploytomous logistic regression shows that the follow-up time(p<0.05),chemotherapy and radiotherapy (p=0.038) are independent risk factors of MFSI’s reduction after type QM-C hysterectomy.② MFSⅡA：Multivariate ordinal ploytomous logistic regression shows that the follow-up time(p<0.05) are independent risk factors of MFSⅡA’s reduction after type QM-C hysterectomy. The pelvic floor muscle strength(PFMS) increased after 9 months than in 9 months after operation, which showed that the PFMS could be recovered after operation. Conclusions We advocate for more attention and emphasis on the PFMF of Chinese female patients with cervical cancer postoperation. Contribution of the Paper The key messages of the article is that PFMF after QM-C hysterectomy have not been analyzed by current study.The new knowledge added by this study is that 3 months after radical hysterectomy patients’ should do pelvic floor rehabilitation exercises.

scholarly journals Salvage hysterectomy after radiotherapy for cervical cancer: literature review

2021 ◽  
Vol 17 (3) ◽  
pp. 121-127
Author(s):  
E. Zh. Shakirova ◽  
D. I. Zidikhanov
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cervical Cancer ◽  
Residual Disease ◽  
Residual Tumor ◽  
High Morbidity ◽  
Resonance Imaging ◽  
Recurrent Cervical Cancer ◽  
Point Of Interest ◽  
Completion Surgery ◽  
Difficult Challenge

Recurrent cervical cancer is a difficult challenge for gynecological oncologist. In this paper we review papers concerning incidence and surgical treatment of pelvic recurrences. A point of interest is studies evaluating completion surgery after radiotherapy/chemoradiotherapy. Surgery after definitive radiotherapy is associated with high morbidity and should be performed only in patients with residual tumor. Magnetic resonance imaging in special regimen can be useful in detecting residual disease.

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