A study to assess select risk factors for carcinoma cervix among patients attending Kidwai Memorial Institute of Oncology

Background: Cervical cancer is an important public health problem worldwide; it is second most common cancer among women aged 15-44 years globally (Globocan 2012). The objective of the study was to study the association between select risk factors and carcinoma cervix among patients attending Kidwai Memorial Institute of Oncology, Bangalore.Methods: Hospital based case- control study was carried among newly diagnosed cases of cervical cancer, cases and apparently healthy controls were selected. Statistical analysis was performed using, Chi square test of significance, logistic regression were preformed.Results: Univariate analysis revealed the following variables as significant risk factors these were Age at consummation of marriage <18 years OR 5.9 (2.6-19.4), Age 1st pregnancy <18 years OR 3.4 (2.2-5.2), live births delivered >5 OR 2.9 (1.7-5.8), marital status other than those who were married OR 1.7 (1.2-2.6), education of study subject being uneducated OR 3.9 (2.9-5.7), not washing genitals after sex OR 2.8 (1.6-4.9), material used during menstruation other than sanitary pads OR 6 (3.1-11.7), sex during menstruation OR 3 (1.1-7.9), not washing of private parts daily OR 10.8 (6.4-18.2), not taking bath daily OR 4.4 (2.8-7), open air defecation 7.6 (5.4-11.7), tobacco use OR 3.3 (2.2-5.6), never use of any contraceptive OR 3.7 (1.0-8.3) were significant at 0.05 level. Following backward multiple logistic regression analysis the following variables were independently associated with the development of cancer cervix, these were, age at 1st pregnancy <18 years OR 2.2 (1.2-3.8), use of material other than sanitary pads OR 3 (1.3-6.5), having sex during menstruation OR 4.3 (1.2-15), not washing of private parts daily OR 5.5 (2.9-10.4), open air defecation OR 2.6 (1.4-4.7), attained significance at 0.05 level.Conclusions: The study has revealed that age at 1st pregnancy <18 years, use of material other than sanitary pads, having sex during menstruation, not washing of private parts daily, open air defecation, as an independent risk factor for the development of cancer cervix. It can be noted that all the risk factor mentioned above is highly amenable for primary prevention.

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Risk factors for hypertensive crisis in children with acute glomerulonephritis

Paediatrica Indonesiana ◽

10.14238/pi56.2.2016.101-6 ◽

2016 ◽

Vol 56 (2) ◽

pp. 101

Author(s):

Sherly Yuniarchan ◽

Risky Vitria Prasetyo ◽

Ninik Asmaningsih Soemyarso ◽

Mohammad Sjaifullah Noer

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Risk Factor ◽

Pediatric Population ◽

Hypertensive Crisis ◽

Significant Risk ◽

Significant Risk Factor ◽

P Value ◽

Acute Glomerulonephritis ◽

Female Ratio

Background Hypertensive crisis occurs in 1-4% of the hypertensive pediatric population, mostly due to acute glomerulonephritis (AGN). Some factors have been suggested to affect blood pressure (BP) in children, such as age, sex, race/ethnicity, obesity, and socioeconomic status, but little is known for risk factors for hypertensive crisis in AGN.Objective To analyze the risk factors for hypertensive crisis in children with AGN.Methods Retrospectively, we studied possible risk factors for hypertensive crisis in children with AGN at Dr. Soetomo Hospital from 2007 to 2011. Hypertensive crisis was defined as systolic BP ≥180 mmHg or diastolic BP ≥120 mmHg (for children ≥ 6 years of age); and systolic and/or diastolic BP >50% above the 95th percentile (for children aged <6 years). We evaluated the demographic and clinical characteristics as potential risk factors. Statistical analysis was done with Chi-square, Fisher’s exact, and logistic regression tests. Variables with P <0.25 in the univariable analysis were further analyzed by the multivariable logistic regression model. A P value of < 0.05 was considered statistically significant.Results There were 101 children included (mean age 9.7 (SD 2.17) years), with a male-to-female ratio of 2.7:1. Hypertensive crisis occurred in 42 (41.6%) children, of whom 8 had hypertensive urgency and 34 had hypertensive emergency. Proteinuria was seen in 53 children with AGN (52.5%) and was the significant risk factor for hypertensive crisis in our subjects (OR=2.75; 95%CI 1.16 to 6.52; P=0.021). Gender, clinical profiles, ethnicity, nutritional status, blood urea nitrogen (BUN), and glomerular filtration rate (GFR) were not significant risk factors for hypertensive crisis.Conclusion Proteinuria is the significant risk factor for hypertensive crisis in children with AGN.

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Case control study of gastrointestinal complications after cardiopulmonary bypass heart surgery

Perfusion ◽

10.1177/0267659109346665 ◽

2009 ◽

Vol 24 (3) ◽

pp. 173-178 ◽

Cited By ~ 3

Author(s):

Guowei Zhang ◽

Naishi Wu ◽

Hongyu Liu ◽

Hang Lv ◽

Zhifa Yao ◽

...

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Cardiopulmonary Bypass ◽

Heart Surgery ◽

Perfusion Pressure ◽

Multiple Logistic Regression Analysis ◽

Univariate Analysis ◽

Multiple Logistic Regression ◽

Gastrointestinal Complications ◽

Preoperative Serum

Background: Gastrointestinal complications (GIC) after cardiopulmonary bypass (CPB) surgery are rare, but, nevertheless, extremely dangerous.The identification of risks for GIC may be helpful in planning appropriate perioperative management strategies. The aim of the present study was to analyze perioperative factors of GIC in patients undergoing CPB surgery. Methods: We retrospectively analysed 206 patients who underwent GIC after cardiopulmonary bypass surgery from 2000 to 2007 and compared them with 206 matched control patients (matched for surgery, temperature, hemodilution and date). Univariate analysis and multiple logistic regression analysis were performed on 12 risk factors. Result: Sex and types of cardioplegia perfusate did not significantly influence the GIC after CPB surgery. Multiple logistic regression revealed that CPB time, preoperative serum creatinine (PSC) ≥ 179 mg/dL, emergency surgery, perfusion pressure ≤40mmHg, low cardiac output syndrome (LCOS), age ≥ 61, mechanical ventilation ≥96 h, New York Heart Association (NYHA) class III and IV were predictors of the occurrence of GIC after CPB surgery. Perfusion pressure and aprotinin administration were protective factors. Conclusion: Gastrointestinal complications after CPB surgery could be predictive in the presence of the above risk factors. This study suggests that GIC can be reduced by maintenance of higher perfusion pressure and shortening the time on CPB and ventilation.

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Risk Factors for Silent Cerebral Infarcts in a Pediatric Sickle Cell Anemia (SCA) Cohort

Blood ◽

10.1182/blood.v112.11.2487.2487 ◽

2008 ◽

Vol 112 (11) ◽

pp. 2487-2487 ◽

Cited By ~ 1

Author(s):

Francoise Bernaudin ◽

Suzanne Verlhac ◽

Annie Kamdem ◽

Cécile Arnaud ◽

Lena Coïc ◽

...

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Regression Analysis ◽

Risk Factor ◽

Logistic Regression Analysis ◽

G6pd Deficiency ◽

Significant Risk ◽

Significant Risk Factor ◽

History Of ◽

Independent Risk Factors

Abstract Background Silent infarcts are associated with impaired cognitive functioning and have been shown to be predictors of stroke (Miller ST J Pediatr 2001). Until now, reported risk factors for silent infarcts were low pain event rate, history of seizures, high leukocyte count and Sen bS haplotype (Kinney TR Pediatrics 1999). Here, we seek to define the prevalence and risk factors of silent infarcts in the Créteil SCA pediatric cohort comprising patients assessed at least yearly by transcranial doppler (TCD) since 1992, and by MRI/MRA. Methods This study retrospectively analyzed data from the Créteil cohort stroke-free SS/Sb0 children (280; 134 F, 146 M), according to institutional review board. Time-averaged mean of maximum velocities higher than 200 cm/sec were considered as abnormal, resulting in initiation of a transfusion program (TP). A switch to hydroxyurea was proposed to patients with normalized velocities (< 170 cm/sec) and normal MRA on TP, although TP was re-initiated in case of abnormal velocities recurrence. Patients with “conditional” velocities (170–199 cm/sec) were assessed by TCD 4 times yearly. Alpha genes and beta-globin haplotypes were determined. Baseline biological parameters (G6PD activity; WBC, PMN, Reticulocytes, Platelets counts; Hemoglobin, Hematocrit, HbF, LDH levels; MCV; SpO2) were obtained a minimum of 3 months away from a transfusion, one month from a painful episode, after 12 months of age, before the first TCD, and always before therapy intensification. Results. Patients were followed for a total of 2139 patient-years. Alpha-Thal was present in 114/254 patients (45%) and 27/241 (11.2%) had G6PD deficiency. Beta genotype, available in 240 patients, was BaBa in 102 (42.5%), BeBe in 54 (22.5%), SeSe in 19 (7.9%) and “other” in 65 (27.1%); TCD was abnormal in 52 of 280 patients (18.6%). MRA showed stenoses in 30 of 226 evaluated patients (13.3%) while MRI demonstrated presence of silent infarcts in 81/280 patients (28.9%). Abnormal TCD (p<0.001), G6PD deficiency (p=0.008), high LDH (p=0.03), and low Hb (p=0.026) were significant risk factors for stenoses by univariate analysis while multivariate analysis retained only abnormal TCD as a significant risk factor for stenoses ([OR= 10.6, 95% CI (4.6–24.4)]; p<0.001). Univariate logistic regression analysis showed that the risk of silent infarcts was not related to alpha-Thal, beta genotype, abnormal TCD, WBC, PMN, platelets, reticulocyte counts, MCV, LDH level, HbF %, pain or ACS rates but was significantly associated with stenoses detected by MRA (p<0.001), gender (male; p=0.04), G6PD deficiency (p=0.05), low Hb (p=0.016) and Hct (p=0.012). Multivariate logistic regression analysis showed that gender ([OR= 2.1, 95% CI (1.03–4.27)]; p=0.042), low Hb ([OR= 1.4, 95% CI (1.0–1.1)]; p=0.05) and stenoses ([OR= 4.8, 95% CI (1.88–12.28)]; p=0.001) were all significant independent risk factors for silent infarcts. The presence of stenoses was the only significant risk factor for silent infarcts in patients with a history of abnormal TCD ([OR= 5.9, 95% CI (1.6–21.7)]; p=0.008). Conclusion We recently showed that G6PD deficiency, absence of alpha-Thal, and hemolysis are independent significant risk factors for abnormal TCD in stroke-free SCA patients (Bernaudin et al, Blood, 2008, in press). Here, we report that an abnormal TCD is the most significant risk factor for stenoses and, expanding previous studies, we demonstrate that stenoses, low Hb and gender are significant independent risk factors for silent infarcts.

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Prevalence and risk factors of depression and anxiety for inpatients with lung cancer in China: A hospital-based cross-sectional study

10.21203/rs.3.rs-1149458/v1 ◽

2022 ◽

Author(s):

Xueqian Wang ◽

Xuejiao Ma ◽

Mo Yang ◽

Yan Wang ◽

Yi Xie ◽

...

Keyword(s):

Risk Factors ◽

Lung Cancer ◽

Logistic Regression ◽

Risk Factor ◽

Univariate Analysis ◽

Multivariate Logistic Regression Analysis ◽

Multivariate Logistic Regression Model ◽

Depression And Anxiety ◽

Multivariate Logistic Regression ◽

Cross Sectional

Abstract Background Lung cancer was often accompanied by depression and anxiety. Nowadays, most investigations for depression and anxiety were concentrated in western medical hospitals, while few related studies have been carried out in the tradition Chinese medicine (TCM) ward. It was necessary to understand the prevalence and risk factors of depression and anxiety in the inpatients with lung cancer in TCM hospital. Methods This study adopted cross-sectional research method, which enrolled a total of 222 inpatients with lung cancer in TCM hospital. PHQ-9 and GAD-7 scales were used to assess depression and anxiety for the inpatients, respectively. Demographic and clinical data were also collected. Statistical methods of the univariate analysis and the multivariate logistic regression model were used. Results The prevalence of depression and anxiety in the inpatients with lung cancer were 58.1% and 34.2%, respectively. Multivariate logistic regression analysis prompted that the common risk factor of depression and anxiety was the symptom of insomnia. Constipation and gender were the two anther risk factors of depression. Conclusion Depression and anxiety were common for the inpatients with lung cancer in TCM hospital. Gender, insomnia and constipation were risk factors for depression, and insomnia was risk factor for anxiety. Therefore, medical workers should pay close attention to the emotional changes of these high-risk patients and intervene the symptoms as early as possible.

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Underweight increases the risk of pulmonary tuberculosis in adult

Zinc supplementation improves heme biosynthesis in rats exposed to lead ◽

10.18051/univmed.2017.v36.4-10 ◽

2017 ◽

Vol 36 (1) ◽

pp. 4

Author(s):

Galuh Chandra Irawan ◽

Ani Margawati ◽

Ali Rosidi

Keyword(s):

Risk Factors ◽

Body Mass Index ◽

Logistic Regression ◽

Risk Factor ◽

Pulmonary Tuberculosis ◽

Body Mass ◽

Low Income ◽

Smoking Behavior ◽

Significant Risk ◽

Low Body Mass Index

Background Tuberculosis (TB) is a leading cause of morbidity and mortality, especially in middle- and low-income countries. The risk of developing TB may be related to nutritional status. Socioeconomic and behavioral factors are also shown to increase the susceptibility to TB infection. The objective of this study was to determine nutritional factors as risk factors of pulmonary TB in adult.Methods This was an observational study of case control design. The study subjects were community members consisting of 19 adult cases of pulmonary tuberculosis and 38 controls. Data on nutritional intakes were obtained by semiquantitative food frequency questionnaire (FFQ), while smoking behavior, history of DM, body mass index, education, and income were obtained by structured interviews. The data were analyzed by independent t-test and logistic regression for calculation of the odds ratio (OR).Results The bivariate test showed that the adequacy levels for energy (OR=6.8; 95% CI: 1.51-30.54), protein (OR=5.1; 95% CI: 1.52-17.14), vitamin A (OR=4.2; 5% CI: 1.31-13.54), vitamin C (OR=3.8;95% CI: 1.21-12.36), selenium (OR=4.2; 95% CI: 1.34-13.58), body mass index (OR=4.4; 95% CI: 1.32-14.35) and smoking behavior (OR=3.7; 95% CI: 1.15-11.9), were significant risk factors for pulmonary tuberculosis. Multiple logistic regression test showed that low body mass index (<18.5 kg/m2) (OR=6.0; 95% CI: 1.32-27.18) was a the most influential risk factor of pulmonary tuberculosis.Conclusion Low body mass index is the most influential risk factor for pulmonary tuberculosis incidence in adult. Nutrition profile in adult is an important determinant of TB incidence.

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Risk factors and prophylaxis of irinotecan induced cholinergic syndrome in sight of supportive care.

Journal of Clinical Oncology ◽

10.1200/jco.2017.35.31_suppl.216 ◽

2017 ◽

Vol 35 (31_suppl) ◽

pp. 216-216

Author(s):

Hiroyuki Fujii ◽

Taizo Hirata ◽

Takuya Mura ◽

Yuko Okada ◽

Takuo Ito ◽

...

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Response Rate ◽

Univariate Analysis ◽

Significant Risk ◽

Significant Risk Factor ◽

Anticancer Therapy ◽

Cancer Type ◽

Chemotherapeutic Regimen ◽

Cholinergic Syndrome

216 Background: Irinotecan Induced Cholinergic Syndrome (IICS), manifesting in such events as early diarrhea and diaphoresis, is well-known adverse effect of irinotecan. These symptoms occur within the first 24 hours of irinotecan administration and can be ameliorated with anticholinergic agents. Although IICS is transient and tends to be underestimated, diarrhea and abdominal pain during drug infusion are inflictive and make patients reluctant to undergo anticancer therapy. Methods: First, to identify the risk factors that are associated with IICS, 132 consecutive patients who were treated with a chemotherapeutic regimen that included irinotecan at Kure Medical Center between 2012 and 2017 were retrospectively analyzed from the aspect of sex, age, dose, cancer type, regimen, kidney function, and renal function. Secondly, to determine the response rate of butylscopolamine bromide for IICS, we injected butylscopolamine bromide 20mg into the irinotecan infusion bag and administered both agents through the intravenous line together to patients who experienced IICS. Results: IICS occurred 14 of 132 patients (10.6%); these 14 patients were given butylscopolamine bromide by coinjection for total 119 cycles. Univariate analysis indicated that dose (p = 0.0029), cancer type (p = 0.0023) and regimen (p = 0.0005) was associated with IICS. Patients with symptoms tended to be administered a higher irinotecan dose than those without symptoms (127.9±20.4mg/m2 and 99.6±34.1mg/m2). By logistic regression analysis, a higher dose (dose > 105mg/m2) was identified a significant risk factor for IICS (Odds Ratio = 10.9; 95% Confidence Interval: 2.0 to 96.7; p = 0.0121). 13 patients (105 cycles) of 14 patients (119 cycles) who were administered butylscopolamine bromide, experienced complete or partial improvement of IICS. The response rate was nearly 90%. Conclusions: A higher dose of irinotecan is a significant risk factor for IICS. To avoid creating a disincentive for patients to undergo anticancer therapy, the prevention of IICS is paramount. As prophylaxis of IICS, mixing butylscopolamine bromide into the irinotecan infusion bag was remarkably effective.

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Use of carbapenems and glycopepdides is significant risk for multidrug resistant Acinetobacter baumannii infections

The Journal of Infection in Developing Countries ◽

10.3855/jidc.8081 ◽

2018 ◽

Vol 12 (02) ◽

pp. 67-72

Author(s):

Salih Hosoglu ◽

Eyup Arslan ◽

Emel Aslan ◽

Özcan Deveci

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Acinetobacter Baumannii ◽

Univariate Analysis ◽

Tertiary Care ◽

Significant Risk ◽

Significant Risk Factor ◽

Control Group ◽

Time Interval ◽

And Control

Introduction: Multi-drug resistant Acinetobacter baumannii (MDR-Ab) infections are an important healthcare problem globally. The aim of this study was to evaluate risk factors associated with MDR-Ab infections in hospitalized patients in Turkey. Methodology: A case-control study was performed in a tertiary care 1,303-bed university hospital, among case patients with MDR-Ab infections. The hospital records of case and control patients were retrospectively evaluated over a year. Patients who were hospitalized in the same department and in the same time interval as the case patients, without MDR-Ab infection or colonization, were chosen for control group. Demographic characteristics, Acute Physiology And Chronic Health Evaluation II (APACHE II) scores, comorbid diseases, use of invasive tools and duration of usage, and duration of use of antibiotics were recorded for all patients. Comparisons between case and control groups for possible risk factors were performed. Results: In total, 95 cases and 95 controls were included in the study. Univariate analysis highlighted several variables as risk factors for MDR-Ab infections. Multivariate analysis showed that only antibiotic usage over seven days (OR = 2.38, CI = 1.18-4.83, p = 0.016) was found to be a significant risk factor. When antibiotic treatment patterns in both groups were compared, the use of carbapenems (p = 0.001) and glycopeptide antibiotics (p=0.001) in patient treatment were found significantly higher in the MDR-Ab case group. Conclusion: This study showed us that previous antibiotic use is a significant risk factor for MDR-Ab infections. The use of carbapenems and glycopeptides should be considered as primary risk factors for developing MDR-Ab infection.

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Hyperglycemia but not Glycated Albumin, is Linked to Retinopathy of Prematurity

10.21203/rs.3.rs-100965/v1 ◽

2020 ◽

Author(s):

Ana C Almeida ◽

Gabriela A Silva ◽

Gabriele Santini ◽

Margarida Brízido ◽

Miguel Correia ◽

...

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Risk Factor ◽

Retinopathy Of Prematurity ◽

Glycated Albumin ◽

Significant Risk ◽

Significant Risk Factor ◽

The Other ◽

Reference Ranges ◽

Extremely Preterm

Abstract Background: Retinopathy of prematurity (ROP) is a neovascular disorder of the immature retina. Neonatal hyperglycemia is a common problem in extremely preterm infants. Several studies have also reported an association between hyperglycemia and ROPPurpose: Our goal was to determine the association between hyperglycemia, glycated albumin (GlyA) and retinopathy of prematurity (ROP).Methods: Prospective study of all infants under ROP screening from March 2017 to July 2019. All demographic, clinical and laboratory data were collected. Glucose was measured at birth and every 8h for the first week and serum GlyA was evaluated at birth, 1st, 2nd and 4th weeks after birth. Reference range for GlyA was obtained according to the CLSI EP28-A3C. Univariate logistic regression was used to examine risk factors for ROP followed by multivariate regression.Results: A total of 152 infants were included in the study. Median gestational age was 30 weeks and median birth weight 1,240g. Thirty-three infants (21,7%) had ROP. Hyperglycemia was present in 24 (72,7%) infants diagnosed with any ROP versus 6 (0,05%) in those without ROP. Median GlyA at birth, 1st, 2nd and 4th and respective reference ranges were 8.50% (6.00-12.65), 8.20% (5.32-11.67), 8.00% (5.32-10.00) and 7.90% (5.30-9-00) respectively. After multivariate logistic regression, hyperglycemia but not GlyA, remained a significant risk factor for ROP overpowering the other recognized risk factors (Exp (B)28.062, 95%CI for Exp(B) 7.881 - 99.924 p <0.001)Conclusions: In our cohort, hyperglycemia but not GlyA, remained a significant risk factor for ROP overpowering the other recognized risk factors.

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Risk factor analyses of severe cicatricial stricture after chemoradiotherapy for stage II/III (T3) esophageal carcinoma.

Journal of Clinical Oncology ◽

10.1200/jco.2017.35.4_suppl.190 ◽

2017 ◽

Vol 35 (4_suppl) ◽

pp. 190-190

Author(s):

Natsuko Tsushita ◽

Yoshitaka Honma ◽

Kengo Nagashima ◽

Takahiro Miyamoto ◽

Shoko Nakamura ◽

...

Keyword(s):

Risk Factors ◽

Multivariate Analysis ◽

Risk Factor ◽

Esophageal Carcinoma ◽

Univariate Analysis ◽

Significant Risk ◽

Oral Intake ◽

Stage Ii ◽

Liquid Meal ◽

Cicatricial Stricture

190 Background: Severe benign cicatricial stricture (SBCS) is a major complication after chemoradiotherapy (CRT) for esophageal carcinoma (EC), and causes oral intake impairment leading to deterioration of quality of life even after being cured. Aim of this study was to investigate risk factors of SBCS. Methods: The subjects of this study were patients with stage II/III (T3) EC who received CRT and achieved complete response (CR) between 2000 and 2011. SBCS was determined as disability of passage by diameter-9mm endoscope. Results: Among 197 patients with Stage II/III (T3) treated by CRT, CR was obtained in 91 patients, who were included in this analysis. The median age was 63 years. Fifteen patients (16.5%) were female. The median follow-up time was 5.1 years. The cumulative incidence of SBCS was 15.0% (95%CI 9.0-24.5). Significant risk factors of SBCS were female (hazard ratio (HR) 3.3 (95%CI 1.1-10.0), p = 0.04), requirement of diced/liquid meal (HR 5.7 (95%CI 1.8-18.2), p = 0.003), tumor occupying 3/4 or grater of esophageal perimeter (HR 7.4 (95%CI 1.3-42.9), p = 0.03) and disability of endoscope passage (HR 12.7 (95%CI 4.2-38.5), p < 0.001) in univariate analysis. Hypoalbuminemia increased the risk of SBCS (HR 2.4 (95%CI 0.8-7.1), p = 0.12) marginally. As for the factors during CRT, grade 2-4 esophagitis significantly increased the risk of SBCS (HR 6.2 (95%CI 1.5-25.7), p = 0.01). Multivariate analysis showed that hypoalbuminemia (HR 3.5 (95%CI 1.1-11.1), p = 0.03) and disability of endoscope passage (HR 14.8 (95%CI 4.3-51.3), p < 0.001) were the significant risk factors of SBCS. Female (HR 1.5 (95%CI 0.5-4.9), p = 0.51) was not a significant risk factor in multivariate analysis. Conclusions: Obstructions before CRT, hypoalbuminemia and severe esophagitis during CRT are considered as risk factors of SBCS. Because SBCS occurred after completion of CRT, prophylactic treatment should be established especially for esophageal carcinoma patients with risk factors of SBCS.

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Risk factors of pulmonary complications after spine surgery and a risk assessment table was established: a retrospective cohort study

10.21203/rs.3.rs-278022/v1 ◽

2021 ◽

Author(s):

HuaXing Zhang ◽

Jingde Jia ◽

Jia Chen ◽

Suxing Wang ◽

Mengying Du ◽

...

Keyword(s):

Risk Factors ◽

Risk Assessment ◽

Logistic Regression ◽

Spine Surgery ◽

Univariate Analysis ◽

Significant Risk ◽

Pulmonary Complications ◽

Diabetes Type ◽

Spinal Diseases ◽

Postoperative Evaluation

Abstract Purpose To determine the risk factors for pulmonary complications after spine surgery and establish a risk assessment table. Methods A total of 627 patients, who underwent spine surgery at Hebei General Hospital from January 2018 to December 2019, were retrospectively collected and studied. Univariate analysis revealed significant variables. Risk factors and the effects of the model were determined by unconditional binary logistic regression analyses and the receiver operating characteristic (ROC) curve, respectively. A risk assessment scale for patients after spine surgery was also established based on the risk factors. Results 49 patients were diagnosed with pulmonary complications (49/627, 7.81 %). Logistic regression analysis showed that age, body mass index (BMI), smoking, diabetes, type of spinal diseases, type of operation, surgical site, American society of anesthesiologists (ASA) scores, type of anesthesia and total length of stay (LOS) were risk factors of pulmonary complications after spine surgery (P < 0.05) and area under the curve was 0.883, 95 % confidence intervals (CI): 0.843–0.923. The risk assessment table included preoperative and postoperative evaluation indicators. There were 8 preoperative evaluation indicators including age, BMI, smoking, hypertension, diabetes, chronic pulmonary diseases, type of spinal diseases, surgical site. Preoperative hospitalization days, ASA scores, type of anesthesia, type of operation and duration of operation were five postoperative evaluation indicators. The highest assessment score of preoperative is 21, postoperative is 18, and the total is 39 points of all these indicators. Conclusions Significant risk factors of pulmonary complications were age, BMI, smoking, diabetes, type of spinal diseases, type of operation, surgical site, ASA scores, type of anesthesia and total LOS after spine surgery. There were 13 evaluation indicators in our established risk assessment table including preoperative and postoperative evaluation indicators. The higher the score, the higher the risk of pulmonary complications after spine surgery.

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