scholarly journals Expression of IL-1 Family Cytokines in Patients Before and After Cutaneous Leishmaniasis Cure

2021 ◽  
Author(s):  
Ester Amorim ◽  
Marton Kaique Andrade Cavalcante ◽  
Ailton Alvaro Silva ◽  
Vanessa Lucília Silveira Medeiros ◽  
Maria Edileuza Felinto Brito ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Immune Response ◽  
Cutaneous Leishmaniasis ◽  
Mechanisms Of Resistance ◽  
Marked Inhibition ◽  
Gene And Protein Expression ◽  
Th2 Responses ◽  
Before And After ◽  
Response Profiles ◽  
Effector Immune Response

Abstract Cutaneous leishmaniasis is an infectious disease that presents an immune response marked by the activation of lymphocytes and production of cytokines, including those of the IL-1 family, which act as an important trigger for the activation of an effector immune response. Despite this, inflammation exacerbation is sometimes also attributed to IL-1 cytokines, although some others down-regulate inflammation or produce Th2 responses, which need to be further clarified in the CL. Assessing the gene and protein expression of IL-1 cytokines associated with different immune response profiles in PBMCs from patients with active and healed lesions, this study demonstrated that stimulation by L. braziliensis positively regulates inflammatory and anti-inflammatory IL-1 cytokines, as IL-1α/β and IL-37, while there was a marked inhibition of IL-1Ra and IL-18 genes in patients treated with antimony, which perhaps contributes to the mechanisms of resistance that control Leishmania infection.

scholarly journals Intestinal helminthiasis as a relevant factor on immunological markers status of cutaneous leishmaniasis patients

2020 ◽  
Author(s):  
ALEIDA VERDUGUEZ-ORELLANA ◽  
Ernesto Rojas Cabrera ◽  
Mery Arteaga Terrazas ◽  
Fidelia Barrientos Laura ◽  
Miguel Guzman-Rivero
Keyword(s):  
Immune Response ◽  
Cutaneous Leishmaniasis ◽  
Sand Fly ◽  
Intestinal Helminths ◽  
Sanitation Services ◽  
Immunological Markers ◽  
Tnf Α ◽  
Before And After ◽  
The Status ◽  
Basic Sanitation

Abstract Background: The intestinal helminths and the tegumentary leishmaniasis are frequent in rain forest area of Bolivia by absence of basic sanitation services and the natural presence of sand fly, vector of Leishmania parasites. Each one of these infections triggers a specific immune response by the host, nevertheless there is scant information regarding the behaviour of immune response during simultaneous Leishmania and intestinal helminths infections. The purpose of this study was contributing to the knowledge on this matter. Results: Forty-four cutaneous leishmaniasis patients and thirty controls entered in the study. The percentage of eosinophils from peripheral blood and plasma concentration of IgE and TNF-α were increased at after antimony treatment, respect the values presented before treatment in Albendazole and Non Albendazole groups, those increases were not statically significant. A decrease between before and after antimony treatment was observed in the ratio CD4/CD8 in both groups, but only in the receiving Albendazole group it was presented differences statistically significant.Conclusions: Several changes in the status of immunological markers including the number of eosinophils were found after the antimony treatment of patients. No additional clinical, neither immunological benefit of Albendazole treatment could be documented probably because the contact of individuals with helminths is long-standing.

scholarly journals Cellular immune response evaluation of cutaneous leishmaniasis patients cells stimulated with Leishmania (Viannia) braziliensis antigenic fractions before and after clinical cure

2012 ◽  
Vol 279 (2) ◽  
pp. 180-186 ◽  
Author(s):  
Maria Carolina Accioly Brelaz-de-Castro ◽  
Amanda Ferreira de Almeida ◽  
Andresa Pereira de Oliveira ◽  
Marina de Assis-Souza ◽  
Lucas Ferreira da Rocha ◽  
...  
Keyword(s):  
Immune Response ◽  
Cutaneous Leishmaniasis ◽  
Cellular Immune Response ◽  
Clinical Cure ◽  
Response Evaluation ◽  
Before And After ◽  
Cellular Immune

Oral Immune Activation by Disgust and Disease-Related Pictures

2015 ◽  
Vol 29 (3) ◽  
pp. 119-129 ◽  
Author(s):  
Richard J. Stevenson ◽  
Deborah Hodgson ◽  
Megan J. Oaten ◽  
Luba Sominsky ◽  
Mehmet Mahmut ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Innate Immune Response ◽  
Negative Control ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Immune Markers ◽  
Before And After ◽  
Secondary Analyses ◽  
Image Set

Abstract. Both disgust and disease-related images appear able to induce an innate immune response but it is unclear whether these effects are independent or rely upon a common shared factor (e.g., disgust or disease-related cognitions). In this study we directly compared these two inductions using specifically generated sets of images. One set was disease-related but evoked little disgust, while the other set was disgust evoking but with less disease-relatedness. These two image sets were then compared to a third set, a negative control condition. Using a wholly within-subject design, participants viewed one image set per week, and provided saliva samples, before and after each viewing occasion, which were later analyzed for innate immune markers. We found that both the disease related and disgust images, relative to the negative control images, were not able to generate an innate immune response. However, secondary analyses revealed innate immune responses in participants with greater propensity to feel disgust following exposure to disease-related and disgusting images. These findings suggest that disgust images relatively free of disease-related themes, and disease-related images relatively free of disgust may be suboptimal cues for generating an innate immune response. Not only may this explain why disgust propensity mediates these effects, it may also imply a common pathway.

scholarly journals Role of costimulatory molecules in immune response of patients with cutaneous leishmaniasis

2005 ◽  
Vol 7 (1) ◽  
pp. 86-92 ◽  
Author(s):  
Cecilia Favali ◽  
Dirceu Costa ◽  
Lilian Afonso ◽  
Viviane Conceição ◽  
Andréa Rosato ◽  
...  
Keyword(s):  
Immune Response ◽  
Cutaneous Leishmaniasis ◽  
Costimulatory Molecules

scholarly journals Antibody response to Salmonella typhi lw human Schistosomiasis mansoni

1996 ◽  
Vol 29 (5) ◽  
pp. 441-445 ◽  
Author(s):  
Maria Imaculada Muniz-Junqueira ◽  
José Tavares-Neto ◽  
Aluizio Prata ◽  
Carlos Eduardo Tosta
Keyword(s):  
Immune Response ◽  
Antibody Response ◽  
Blood Stream ◽  
Salmonella Typhi ◽  
Healthy Individuals ◽  
Typhoid Vaccine ◽  
Schistosomiasis Mansoni ◽  
Positive Antibody ◽  
Before And After ◽  
Hepatosplenic Schistosomiasis

Antibody response to Salmonella typhi O and H antigens was evaluated in 24 individuals with either hepatointestinal or hepatosplenic schistosomiasis mansoni before and after typhoid vaccination, and compared with that of non-infected controls. Before vaccination, Schistosoma-infected patients showed a higher frequency of positive antibody to O antigen and the same frequency to H antigen when compared with that of healthy individuals. However, those with hepatosplenic schistosomiasis showed higher titres of antibody to H antigen than those with hepatointestinal disease or healthy individuals. Infected subjects, particularly those with hepatointestinal disease, showed a decreased response after typhoid vaccine. Tins diminished ability to mount an immune response towards typhoid antigens dining schistosomiasis may interfere ivith the clearance of the bacteria from blood stream and, therefore, play a role in the prolonged survival of salmonella as obsewed in some patients with chronic salmonellosis associated with schistosomiasis.

scholarly journals Immunochemotherapy in American cutaneous leishmaniasis: immunological aspects before and after treatment

2001 ◽  
Vol 96 (1) ◽  
pp. 89-98 ◽  
Author(s):  
VPCP Toledo ◽  
W Mayrink ◽  
KJ Gollob ◽  
MAP Oliveira ◽  
CA da Costa ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
American Cutaneous Leishmaniasis ◽  
Before And After

scholarly journals Molecular and Immunological Mechanisms of Miana Leaf (Coleus Scutellariodes [L] Benth) in Infectious Diseases

2020 ◽  
Vol 13 (4) ◽  
pp. 1607-1618
Author(s):  
Theo Audi Yanto ◽  
Mochammad Hatta ◽  
Agussalim Bukhari ◽  
Rosdiana Natzir
Keyword(s):  
Infectious Disease ◽  
Immune Response ◽  
Premature Mortality ◽  
Antimicrobial Effect ◽  
Immunological Mechanism ◽  
Mortality And Morbidity ◽  
Immunological Mechanisms ◽  
To Come ◽  
Antibiotic Efficacy ◽  
Anti Inflammation

Infectious disease is still a massive world burden of disease. It causes premature mortality and morbidity. Regardless of antibiotic therapy, the increased numbers of antibiotic resistance bring emerging problems in infectious disease. Several pathogens have unique roles to deactivate host immune response causing difficulty to treat the infection. Alack of antibiotic efficacy is crucial to modulate the immune response as a brilliant strategy to face infectious disease in years to come. Various herbal medicine has been known to have a pivotal role in enhancing immune response at the molecular level. Miana leaves extract (MLE) has a potential role in regulating the immune response to the infection. Besides its antimicrobial effect, MLE has other properties such as anti-inflammation, antioxidant. Several studies have revealedthe molecular mechanism of MLE in immune response, such as enhancing IL 37, IL 10, regulating TLR 4, and IFN-g. The objectives of this article are to review the molecular and immunological mechanism of Miana in treating various infective diseases comprehensively.

scholarly journals Immune Response Profiles During Asthma Attacks and Intercritical Periods In Children

2015 ◽  
pp. 26-33
Author(s):  
Lima JS ◽  
◽  
Santos RS ◽  
Ribeiro BM ◽  
Maria HC Silva ◽  
...  
Keyword(s):  
Immune Response ◽  
Response Profiles

scholarly journals Label-free quantitative proteomic analysis reveals potential biomarkers for early healing in cutaneous leishmaniasis

PeerJ ◽  
2019 ◽  
Vol 6 ◽  
pp. e6228 ◽  
Author(s):  
Andrés Montoya ◽  
Manuel Carlos López ◽  
Ivan D. Vélez ◽  
Sara M. Robledo
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Differential Expression ◽  
Calcium Binding ◽  
Therapeutic Response ◽  
Label Free ◽  
Early Biomarkers ◽  
Parasitological Diagnosis ◽  
Pcr Rflp ◽  
Before And After ◽  
Globally Distributed

Background Leishmaniasis is a parasitic disease caused by more than 20 species of the Leishmania genus. The disease is globally distributed and is endemic in 97 countries and three territories in the tropical and subtropical regions. The efficacy of the current treatments is becoming increasingly low either due to incomplete treatment or resistant parasites. Failure of treatment is frequent, and therefore, the search for early biomarkers of therapeutic response in cutaneous leishmaniasis (CL) is urgently needed. Objective The aim of this study was to compare the proteomic profiles in patients with CL before and after 7 days of treatment and identify early biomarkers of curative response. Methods Four patients with a parasitological diagnosis of leishmaniasis with confirmation of species by PCR-RFLP were recruited. All patients had a single lesion, and a protein from the middle of the ulcer was quantified by liquid chromatography and mass spectrometry. Results A total of 12 proteins showed differential expression in the comparative LC-electrospray ionization MS/MS (LC-ESI-MS/MS) triplicate analysis. Seven of them were up-regulated and five of them were down-regulated. Calcium binding proteins A2, A8, and A9 and hemoglobin subunits alpha-2 and delta showed high correlation with epidermis development and immune response. Conclusion We identified changes in the profiles of proteins that had a positive therapeutic response to the treatment. The proteins identified with differential expression are related to the reduction of inflammation and increased tissue repair. These proteins can be useful as biomarkers for early monitoring of therapeutic response in CL.

scholarly journals Protective and Pathogenic Immune Responses to Cutaneous Leishmaniasis

2021 ◽  
Author(s):  
Elina Panahi ◽  
Danielle I. Stanisic ◽  
Christopher S. Peacock ◽  
Lara J. Herrero
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Cutaneous Leishmaniasis ◽  
Adaptive Immune Response ◽  
Leishmania Parasite ◽  
Host Immune System ◽  
Phagocytic Cells ◽  
Host Immune Responses ◽  
Outcome Severity ◽  
Common Clinical Presentation

Leishmania (Kinetoplastida: Trypanosomatidae) parasites are known to cause a broad spectrum of clinical diseases in humans, collectively known as the leishmaniases. Cutaneous leishmaniasis is the most common clinical presentation with varying degrees of severity largely driven by host immune responses, specifically the interplay between innate and adaptive immune response. The establishment of a T lymphocyte driven cell-mediated immune response, leading to activated phagocytic cells, leading to Leishmania parasite killing and control of infection. Alternatively, the Leishmania parasite manipulates the host immune system, enabling parasite proliferation and clinical disease. Here we review how the cumulative interactions of different aspects of the host immune response determines disease outcome, severity, and immunity to re-infection.

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