scholarly journals The Research on Perioperative Blood Glucose and Insulin Levels of Patients with Single Insulinoma

2021 ◽  
Author(s):  
Lin Cong ◽  
Rui Jiang ◽  
Xinqi Cheng ◽  
Yingying Hu ◽  
Xiafei Hong ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Response Time ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Venous Blood ◽  
Insulin Level ◽  
Biochemical Parameter ◽  
Glucose Infusion ◽  
Intravenous Glucose ◽  
Insulin Levels

Abstract Background The blood glucose level is an important biochemical parameter for evaluating the resection effectiveness of insulinomas. However, whether other biochemical parameters have better evaluating ability remains unclear. The current study aims to compare the evaluating capability of blood glucose and insulin levels at several aspects, such as the accuracy and response time. Methods Between September 2017 and July 2018, 21 insulinoma patients with single tumor who underwent surgical resection were enrolled. Peripheral venous blood samples were assayed for blood glucose and insulin levels on the day of surgery and at 30 minutes, 60 minutes, 1 day, and 7 days after surgery. The evaluating abilities of blood glucose and insulin levels for resection effectiveness were recorded and compared. Results The evaluating performance of the insulin level was better than that of the blood glucose level (100% for 21 patients vs 82.4% for 17 patients), as well as the response time ( p<0.0001). Furthermore, the insulin level was not effected by intravenous glucose infusion compared to the blood glucose level. Conclusions Comparing with blood glucose level, insulin level is a better parameter for evaluating resection effectiveness of insulinomas with faster response and regardless of perioperative intravenous glucose infusion.

Anti-diabetic activity of diphenhydramine in diabetic rats

2020 ◽  
Vol 11 (4) ◽  
pp. 5067-5070
Author(s):  
Pang Jyh Chayng ◽  
Nurul Ain ◽  
Kaswandi Md Ambia ◽  
Rahim Md Noah
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Insulin Level ◽  
Diabetic Rats ◽  
Group Iv ◽  
Diabetic Rat ◽  
Control Group ◽  
Group I

The purpose of this project is to study the anti-diabetic effect of on a diabetic rat model. A total of Twenty male Sprague rats were used and it randomly distributed into four groups which are Group I: , Group II: negative control, Group III: and Group IV: and . In diabetic model were induced with via injection at the dosage of 65mg/kg. and FBG (Fasting Blood Glucose) level of diabetic rats were assessed every three days. Blood was collected via cardiac puncture at day 21 after the induction of treatment. Insulin level of the rats was assessed with the Mercodia Rat Insulin ELISA kit. FBG level of group I (12.16 ±3.96, p&lt;0.05) and group IV (11.34 ±3.67, p&lt;0.05) were significantly decreased. Meanwhile, the for all rats did not show any significant increase. However, the insulin level was escalated in group IV (0.74+0.25, p&lt;0.05) significantly. The present study shows that the and the combination of and lowered blood glucose level and enhanced insulin secretion.

scholarly journals Effect of Sago Analog Rice and Red Bean Diet to β Cells Pancreas Refinement in STZ-NA Induced Diabetic Rats

2020 ◽  
pp. 667-673
Author(s):  
Sri Budi Wahjuningsih ◽  
Haslina Haslina ◽  
Agus Tri Putranto ◽  
Mita Nurul Azkia
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Insulin Level ◽  
Diabetic Rats ◽  
Diabetic Group ◽  
Pancreatic Β Cell ◽  
Β Cells ◽  
Β Cell ◽  
Red Bean

The study aims to determine the effect of sago analogue rice and red beans in diabetic rats to repair pancreatic β-cells. Thirty-five males Wistar rats were divided into 5 groups: normal group diet (STD), the diabetic group (STDD) with a standard feed diet, the diabetic group with mentik wangi rice (MWRD), the diabetic group with sago analogue rice (SARD) and the diabetic group with sago analogue rice with the addition of 10% red bean flour (SARKBD). All groups were analysed for dietary interventions, blood glucose level, insulin level for HOMA-β and HOMA S indices and measurement of insulin level by using IHC analysis. In addition, short-chain fatty acids (SCFA) analysis was performed in the caecum. This study showed that decreasing blood glucose level shown in SARD and RASKBD groups. The pancreatic β-cell number indicated an increase in the SARD group compares to the STDD group. The pool total of SCFA in SARD group was the highest among of all groups, as well as the acetate, propionate and butyrate pools. These results indicate that the sago analogue rice diet could repair and increase the expression of pancreatic β-cell through absorption inhibition mechanisms and by increasing insulin sensitivity and the SCFA level.

scholarly journals Consecutive Low Doses of Streptozotocin Induce Polycystic Ovary Syndrome Features in Mice

2021 ◽  
Vol 22 (3) ◽  
pp. 1299
Author(s):  
Youngjae Ryu ◽  
Yong Jin Kim ◽  
Yoon Young Kim ◽  
Jungwoo Kim ◽  
Sung Woo Kim ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Polycystic Ovary ◽  
Insulin Level ◽  
Experimental Period ◽  
Reproductive Age ◽  
Total Testosterone ◽  
Low Doses ◽  
Glucose Levels

Polycystic ovarian syndrome (PCOS) is a common reproductive endocrine disorder in reproductive-age women. Due to its various pathophysiological properties and clinical heterophenotypes, the mechanism of PCOS pathogenesis is still unclear. Several animal models have been used to study PCOS and allow the exploration of the specific mechanism underlying PCOS. We focused on streptozotocin (STZ) to develop a non-steroidal and non-diabetic PCOS model. We administered multiple STZ injections to female C57BL/6 mice (3–4 weeks old) at different concentrations: STZ-15 (15 mg/kg), STZ-30 (30 mg/kg), and STZ-60 (60 mg/kg) treatments. During the experimental period, we analyzed body weight, blood glucose levels, and estrous cycle pattern. Furthermore, five weeks after STZ administration, we examined hormone levels and the morphology of ovarian tissues. Mice in the STZ-15 group did not show differences in body weights, blood glucose level, insulin level, and insulin tolerance compared to wild-type and control groups whereas those in the STZ-60 group presented a typical diabetes phenotype. In the case of the STZ-30 group, only increased blood glucose level was observed. Total testosterone levels were significantly elevated in STZ-15 and STZ-30 groups. Luteinizing hormone (LH) and estradiol levels were not significantly changed in the STZ-treated groups. The number of ovarian antral follicles and atretic follicles significantly increased in the ovary of mice in the STZ-15 and STZ-30 groups. All STZ-treated groups manifested irregular estrus cycles. However, the patterns of estrous cycles were different between mice treated with different STZ concentrations. We found that PI3K-AKT and IRS-1 signaling in the ovary was enhanced by low doses of STZ treatment. Taken together, our finding indicates that multiple injections of STZ at low doses induce PCOS features in mice without induction of diabetes features.

scholarly journals Correlation of Estrogen with Serum Insulin and Blood Glucose Levels in Post-menopausal Women

2017 ◽  
Vol 46 (1) ◽  
pp. 32-37
Author(s):  
Nahid Yeasmin ◽  
Qazi Shamima Akhter ◽  
Sayeeda Mahmuda ◽  
Mahmudul Hasan ◽  
Rukhshana Rabbani ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Postmenopausal Women ◽  
Glucose Level ◽  
Serum Insulin ◽  
Fasting Blood Glucose ◽  
Insulin Level ◽  
Fasting Insulin ◽  
Glucose Levels ◽  
Estrogen Level

Hyperglycemia is a major risk factor for cardiovascular diseases in postmenopausal women. Increased incidence of cardiovascular diseases in postmenopausal women may be due to hyperglycemia caused by lower level of estrogen hormone. This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka, Bangladesh during the period of January to December 2011 to observe the correlation of estrogen with fasting serum insulin (FSI) and fasting blood glucose (FBG) levels in postmenopausal women. A total of 90 women were selected from different areas of Dhaka city, among them, 60 postmenopausal women of age group 50 to 60 years were taken as study group and 30 apparently healthy premenopausal women of age group 20 to 30 years were included as comparison group. The study parameters fasting blood glucose level was estimated by enzymatic method in both groups. Serum insulin level was estimated by Enzyme Linked Immunosorbent Assay (ELISA) and serum estrogen level by RIA method in order to assess the hormonal level of both groups. Data was analyzed by Unpaired Student’s‘t’ test and Pearson's correlation co-effcient (r) test as applicable. Mean serum fasting insulin level and mean blood glucose level was higher in postmenopausal women than premenopausal and result was statistically significant. In postmenopausal women serum estrogen level was lower than premenopausal and serum estrogen level showed negative correlation with serum fasting insulin level. Blood glucose level also showed negative correlation with serum estrogen level. All these correlation were statistically non-significant. It may be concluded that the serum fasting insulin and blood glucose levels are significantly higher in postmenopausal women that may be due to low level of estrogen.Bangladesh Med J. 2017 Jan; 46 (1): 32-37

Insulin-like effect of vanadyl ion on streptozotocin-induced diabetic rats

1990 ◽  
Vol 126 (3) ◽  
pp. 451-459 ◽  
Author(s):  
H. Sakurai ◽  
K. Tsuchiya ◽  
M. Nukatsuka ◽  
M. Sofue ◽  
J. Kawada
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Plasma Insulin ◽  
Active Form ◽  
Insulin Level ◽  
Plasma Insulin Level ◽  
High Concentration ◽  
Vanadyl Ion ◽  
Vanadyl Sulphate

ABSTRACT Recent studies have indicated that the blood glucose level of rats with streptozotocin (STZ)-induced diabetes (type 1) is normalized without an increase in the plasma insulin level by administration of sodium orthovanadate in the drinking water. The mechanism of this insulin-like effect of vanadate is unknown. In this study, we investigated whether vanadyl ion, which is less toxic than vanadate to rats, also has an insulin-like effect in rats with STZ-induced diabetes. When rats with STZ-induced diabetes were given a daily i.p. injection of vanadyl sulphate (9·3 and 4·6 mg vanadium/kg body weight), their blood glucose level decreased from about 22·2 to about 7·2 mmol glucose/l within 2 days and remained low for at least 12 weeks. This treatment did not affect their low plasma insulin level. Quantitative electron spin resonance (ESR) spectrometry showed that most of the vanadium (about 90%) in their tissues was present as a vanadyl form (VO2+). ESR analysis also showed that the vanadyl ion in tissues was bound endogenously with four oxygen ligands from either water or oxyamino acid residues in proteins. Vanadyl sulphate accelerated glucose incorporation into adipocytes of rats, suggesting that the action of vanadyl ion is peripheral. Interestingly, vanadyl sulphate at a high concentration (about 10 mmol/l) was more effective than insulin in enhancing glucose uptake. This study demonstrated that: (1) vanadyl sulphate (+ 4 oxidation state), like vanadate ion, normalizes the blood glucose levels of rats with STZ-induced diabetes; (2) the action of vanadyl ion is peripheral; and (3) the active form of vanadium for an insulin-like effect may be a vanadyl form, not vanadate. Journal of Endocrinology (1990) 126, 451–459

scholarly journals Effects of Ganoderma lucidum Extract on Diabetic Rats

2018 ◽  
Vol 10 (3) ◽  
pp. 642-647 ◽  
Author(s):  
Nuniek Ina Ratnaningtyas ◽  
Hernayanti Hernayanti ◽  
Suci Andarwanti ◽  
Nuraeni Ekowati ◽  
Endang Sri Purwanti ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Ganoderma Lucidum ◽  
Glycosylated Hemoglobin ◽  
Insulin Level ◽  
Negative Control ◽  
Diabetic Rats ◽  
Treatment Groups ◽  
Randomized Design

Diabetes mellitus (DM) is a metabolic syndrome which occurs when insulin is insufficiently produced or insulin cannot well serve its function. Diabetes is marked with increase in blood glucose level followed by increase in glycosylated hemoglobin level and decrease in insulin level. This research aims to examining the effect of Ganoderma lucidum extract on the blood glucose, insulin and glycosylated hemoglobin (HbA1c) level of diabetic white rat and determining the most effective dose of extract to be a diabetic agent. This research was experimentally conducted by employing Completely Randomized Design (CRD) with 6 treatments and 4 repetitions. The treatment groups consisted of healthy rats group (K1), rats with diabetes as negative control (K2), diabetic rats with the administration of metformin 45 mg/kg BW as the comparison (K3) and diabetic rats with the administration of G. lucidum extract with dose of 250, 500 and 1000 mg /kg BW (K4, K5 and K6 respectively). Blood glucose level examination was conducted after the alloxan induction with single dose of 125 mg/kg BW by intraperitoneal injection. The results show that mushroom G. lucidum extract administration with dose of 1000 mg/kg BW (K6) is the best dose to be an anti-diabetic agent. The benefit of the research is developing anti-diabetic agent from herbal resources.

Influence of the oral cavity on insulin release in the rat

1976 ◽  
Vol 230 (5) ◽  
pp. 1411-1415 ◽  
Author(s):  
AB Steffens
Keyword(s):  
Blood Glucose ◽  
Oral Cavity ◽  
Insulin Release ◽  
Glucose Level ◽  
Insulin Level ◽  
Free Fluid ◽  
Second Phase ◽  
Oral Ingestion ◽  
Insulin Levels ◽  
Biphasic Pattern

Blood glucose and insulin levels were measured in undisturbed and free-moving rats. The insulin level rose in the 1st min after the start of food intake; the glucose level began to increase only in the 3rd min if a fluid carbohydrate-rich food was eaten. The insulin release followed a biphasic pattern. If the same quantity of food ingested orally was injected into the stomach in the same time as the animals needed to complete oral ingestion, delayed insulin release could be seen and the second phase of insulin release was exaggerated. The glucose level, which started to rise in the 3rd min, increased much more than during oral ingestion. With respect to insulin release the same phenomena could be observed if carbohydrate-free fluid food was used instead of carbohydrate-rich fluid food. It is argued that the oral cavity plays a major role in the first phase of insulin release, which in its turn seems to be important in the homeostasis of the blood glucose and insulin levels.

Parenteral Nutrition Effect on Serum Insulin in the Preterm Infant

PEDIATRICS ◽  
1987 ◽  
Vol 80 (5) ◽  
pp. 693-697
Author(s):  
S. Andronikou ◽  
I. Hanning
Keyword(s):  
Blood Glucose ◽  
Amino Acid ◽  
Preterm Infant ◽  
Serum Insulin ◽  
Insulin Level ◽  
Glucose Infusion ◽  
Amino Acid Infusion ◽  
Insulin Levels ◽  
Group A ◽  
Group B

Blood glucose and serum insulin levels were measured in two groups of preterm infants that had been matched for gestational age. Both groups were fed parenterally during the first 72 hours of life and were mechanically ventilated because of respiratory distress syndrome. Group A infants (n = 11) received 10% glucose (infusion rate 5 mg/kg/min) and group B infants (n = 12) received amino acid solution (1.2 g/kg/d) in addition to 10% glucose at the same rate as those in group A. Infants in both groups received 90 mL/kg of fluid per day. There was no difference in blood glucose or serum insulin levels between the two groups 24 hours after beginning the infusion; however, at 48 hours there was a significantly (P &lt; .01) higher insulin level in infants receiving amino acid and glucose infusion compared with those receiving only glucose. Blood glucose level remained stable in both groups. We conclude that, in the stable preterm infant, the higher insulin level associated with continuous amino acid infusion does not result in hypoglycemia.

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