scholarly journals Effects of Sarcopenia and Sarcopenic Obesity on Joint Pain and Degenerative Osteoarthritis in Postmenopausal Women

Author(s):  
Hye In Kim ◽  
So Hyun Ahn ◽  
Yup Kim ◽  
Ji Eun Lee ◽  
Seok Kyo Seo

Abstract This study aimed to identify the prevalence of sarcopenia, obesity, and sarcopenic obesity and examine their association with radiographic knee osteoarthritis (OA) and knee pain in Korean menopausal women. This cross-sectional study utilized the data from Korean National Health and Nutrition Examination Surveys 2009–2011. The participants were categorized based on body composition. The prevalence of radiographic knee OA and knee pain was calculated. The effect of hormone therapy (HT) was also evaluated. The prevalence of radiographic knee OA, knee pain, and both were all highest in the sarcopenic obese group and lowest in the non-sarcopenic non-obese group. Without sarcopenia, obese women showed higher ratio of radiographic knee OA. With sarcopenia, the coexistence of obesity presented higher ratio of radiographic knee OA, knee pain, and both compared to sarcopenia without obesity. The use of HT for more than one year was not associated with radiographic knee OA, knee pain, or both. Obesity with sarcopenia had greater effect on knee OA compared to obesity without sarcopenia. Moreover, HT use for more than one year was not associated with the prevalence of knee OA. Therefore, more efforts should focus on reducing body fat and increasing muscle in postmenopausal women with knee OA.

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 198-198
Author(s):  
Dohyun Yoo ◽  
Yongsoon Park

Abstract Objectives Sodium is known to positively relate with hypertension risk; however, the association of fermented soy products, a major source of salt in Korea, with hypertension risk and blood pressure (BP) has not been reported. The present study aimed to investigate the hypothesis that hypertension risk and BP were inversely associated with the intake of fermented soy products but not with the intake of sodium from fermented soy products. Methods This cross-sectional study was performed using data from the Korea National Health and Nutrition Examination Survey (2013–2018). In total, 11,566 men and postmenopausal women aged ≥50 years were divided according to quintiles of sodium or fermented soy product intake. Results In multivariable adjusted models, the intake of fermented soy products was negatively associated with hypertension risk (odds ratio: 0.81, 95% confidence interval: 0.66–0.98; p-trend = 0.023) and systolic BP (SBP; p-trend = 0.043) in postmenopausal women. Mediation analysis showed significant total and direct effects between the intake of fermented soy products and SBP; however, there was no indirect effect because soy nutrients, such as protein, fiber, calcium, and potassium, had no significant effects on SBP. Among men, fermented soy product intake was not associated with hypertension risk and BP. Additionally, the intake of sodium from fermented soy products was not significantly associated with hypertension risk and BP in both postmenopausal women and men. Conclusions This study suggested that hypertension risk and BP were not associated with the intake of sodium from fermented soy products; further, hypertension risk and BP were inversely associated with fermented soy product intake in postmenopausal women. Further clinical studies are needed to confirm the effect of fermented soy product intake on hypertension risk and BP. Funding Sources This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT).


2014 ◽  
Vol 13 (2) ◽  
pp. 47-50 ◽  
Author(s):  
Monowara Khanam ◽  
Md Aminul Haque Khan ◽  
Md Rewanur Rahman ◽  
Rukhsana Parvin ◽  
Selima Akhter ◽  
...  

Background: Following menopause there are changes in values of lipid profile parameters. Abdominal obesity has also been linked to significant metabolic abnormalities including changes in lipid parameter values. Atherogenic index of plasma (AIP) calculated as log (TG/HDL-C) has been used as some practitioners as a significant predictor of atherosclerosis. So, we designed this study to observe the pattern of lipid profile parameters and to find out AIP in postmenopausal central obese women and to compare these between postmenopausal women with central obesity and postmenopausal nonobese women. Objectives: To assess the lipid profile status and AIP of postmenopausal women with central obesity and to compare these parameters with that of postmenopausal nonobese women.Materials & Methods: This cross sectional study was carried out in the department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. Sixty six postmenopausal women with central obesity and age matched 56 nonobese postmenopausal women were included in the study. Central obesity was defined having waist hip ratio more than 0.8 and BMI <25.0. All statistical analyses were done by SPSS 18.0. p values <0.05 were considered significant.Results: Statistically no significant difference was observed between the central obese women and nonobese women in lipid profile parameters. But AIP was found significantly higher in postmenopausal central obese women.Conclusion: Central obese postmenopausal women may be at higher risk of cardiovascular events compared with postmenopausal nonobese women in spite of no difference in lipid profile parameters as their AIP values are significantly different.DOI: http://dx.doi.org/10.3329/cmoshmcj.v13i2.21064


Author(s):  
Sungwoo Choi ◽  
Sangun Nah ◽  
Hae-Dong Jang ◽  
Seung-Hee Cheon ◽  
Ji-Eun Moon ◽  
...  

The knee is a hinge joint that provides stability and control, which are essential in daily life. Obesity is a major cause of knee pain and its incidence continues to increase worldwide. In this study, we analyzed Korea National Health and Nutrition Examination Survey data on the general population, and showed an association between weight change and knee pain. A total of 22,948 participants were enrolled; those under the age of 50 and those who did not answer the questions about knee pain or weight change were excluded. In all, 8480 patients were analyzed, 7001 (82.56%) of whom indicated that they did not have knee pain, versus 1479 (17.44%) who did experience knee pain. Multivariate regression analysis was performed to analyze the association between knee pain and weight change. With full adjustment for covariates, weight gain per se (OR 1.37; p = 0.002), and gains of 3–6 kg (OR 1.28; p = 0.029) and ≥6 kg (OR 1.62; p = 0.012), showed significant associations with knee pain. This cross-sectional study confirmed a significant association between knee pain and weight change. Therefore, when evaluating patients with knee pain, it is necessary to evaluate weight gain.


2021 ◽  
Vol 10 (4) ◽  
pp. 668
Author(s):  
Elisabeth Ginnerup-Nielsen ◽  
Robin Christensen ◽  
Berit L Heitmann ◽  
Roy D. Altman ◽  
Lyn March ◽  
...  

Knee pain is an early sign of later incident radiographic knee osteoarthritis (OA). However, the prevalence of knee pain in the general population is unknown. Additionally, it is unknown how people with knee pain choose to self-manage the condition and if the perception of the illness affects these choices. In this study, 9086 citizens between 60–69 years old in the municipality of Frederiksberg, Copenhagen, Denmark, were surveyed, of which 4292 responded. The prevalence of knee pain was estimated, and associations between illness perceptions (brief illness perception questionnaire [B-IPQ]), self-management strategies, and knee symptoms were assessed. The prevalence of knee pain was 21.4% of which 40.5% reported to use no self-management strategies (non-users). These non-users perceived their knee pain as less threatening and reported less severe symptoms than users of self-management strategies. Further, we found that a more positive illness perception was associated with less severe knee symptoms. In conclusion, among Danes aged 60–69 years, the knee pain prevalence is 21.4%, of which 40.5% use no treatment and perceive the condition as non-threatening. These non-users with knee pain represent a subpopulation being at increased risk of developing knee OA later in life, and there is a potential preventive gain in identifying these persons.


2013 ◽  
Vol 3 (1) ◽  
pp. 8-12
Author(s):  
Monowara Khanam ◽  
Md Aminul Haque Khan ◽  
Md Rezwanur Rahman ◽  
Selima Akhter ◽  
Md Mozammel Hoque

Background: Following menopause there are changes in values of lipid profile parameters. Abdominal obesity has also been linked to significant metabolic abnormalities including changes in lipid parameter values. So, we designed this study to observe the pattern of lipid profile parameters in postmenopausal central obese women.Objective: To assess the lipid profile status of postmenopausal women with central obesity. Materials and Methods: This cross sectional study was carried out in the department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh during the period of January 2005 to December 2005. Seventy four postmenopausal women with central obesity and age matched 56 nonobese postmenopausal women were included in the study. Central obesity was defined having waist hip ratio more than 0.8. All statistical analyses were done by SPSS 12.0. p values <0.05 were considered significant. Results: Statistically no significant difference was observed between the central obese women and nonobese women in total cholesterol and LDL-cholesterol levels. But HDL-cholesterol was found lower and triacylglycerol was found higher in postmenopausal central obese women. Conclusion: Dyslipidaemia is a feature of postmenopausal women with central obesity. DOI: http://dx.doi.org/10.3329/jemc.v3i1.13836 J Enam Med Col 2013; 3(1): 08-12


2021 ◽  
Author(s):  
A lum Han

Abstract Osteoarthritis of the knee (knee OA) is on the rise due to the aging population and increasing obesity. In addition to mechanical stress attributed to weight and age, osteoarthritis is associated with obesity and metabolic dysregulation. Here, a cross-sectional study targeting retrospectively registered 17,476 adults aged 50 years or older who were enrolled in the National Health and Nutrition Survey (2010–2011) was performed to analyze the association between the newly named metabolic associated fatty liver disease (MAFLD) and knee OA. Fatty liver index (FLI) ≥ 60 confirmed the presence of MAFLD, and FLI < 30 indicated the absence of MAFLD. Knee OA was diagnosed according to the Kellgren–Lawrence scale based on knee radiography results. A complex sample logistic regression analysis was performed. Statistically significant factors were adjusted to estimate probability ratios, and 95% confidence intervals were used to investigate the association between knee OA and MAFLD. The probability of knee OA was 1.479 times higher in the presence of MAFLD than that in the normal group. The results indicate that MAFLD is significantly associated with knee OA, suggesting that these two disorders should be managed simultaneously.


2017 ◽  
Vol 6 (2) ◽  
pp. 32-37
Author(s):  
Batool Hassan ◽  
Anum Haidar ◽  
Nida Kanwal ◽  
Mehak Yaseen

BACKGROUND AND AIM Hip and knee OA has been ranked as eleventh maximum contributor to global incapacity. The prevalence is expected to increase up to 25.9% by 2040. Hip arthritis reduces the mobility at the hip joint limiting flexion extension, abduction, and adduction, internal and external rotation. Similarly knee pain causes considerable disability among middle adult population affecting both proximal and distal joint (hip and ankle) respectively. Hence the present study aims to find out a correlation between Hip Rotation Dysfunction and Knee Pain METHODOLOGY A cross sectional study was conducted on patient with hip and knee pain of age in between 45 to 60 years. Ranges at the level of hip joints were assessed using goniometer. Knee pain was assessed using Visual Analog Scale. RESULT The result obtained from the study shows a moderate negative correlation between knee pain and hip internal rotation, r= -0.67 showing no significant correlation p=0.45. There is also a weak negative correlation between knee pain and hip external rotation, r= -0.37 with a p> 0.05. CONCLUSION The result obtained from the study concluded that no significant co-relationship exist between hip rotation dysfunction and knee pain, however more researches with larger number of sample size is required to further evaluate the causal relationship between the two variables.


Author(s):  
Sangun Nah ◽  
Seong-San Park ◽  
Sungwoo Choi ◽  
Hae-Dong Jang ◽  
Ji-Eun Moon ◽  
...  

Chronic knee pain (CKP) can degrade the quality of life and cause dysfunction, resulting in the loss of independence. Psychological stress not only affects physical and mental health but is also a risk factor for CKP. In this cross-sectional study, we analyzed data from the sixth Korea National Health and Nutrition Examination Survey (2013–2015), and investigated the association between CKP and psychological stress of the Korean general population. The CKP status was determined based on survey responses of self-reported knee pain lasting for more than 30 days during the last 3 months. Psychological stress was classified as none, mild, moderate, or severe. The association between CKP and psychological stress was analyzed using multiple logistic regression analysis considering co-variables and demographic data. Logistic regression analysis adjusting for co-variables indicated that the risk of CKP increased with an increasing degree of stress, from mild (OR = 1.65, 95% CI 1.35–2.03, p < 0.001) to moderate (OR = 2.00, 95% CI 1.56–2.57, p < 0.001) and severe (OR = 3.02, 95% CI 2.08–4.37, p < 0.001). A significant association between the risk of CKP and psychological stress was identified. Therefore, when evaluating patients with CKP, it may be helpful for clinicians to check the degree of stress.


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