Lipid Profile of Postmenopausal Women with Central Obesity

Background: Following menopause there are changes in values of lipid profile parameters. Abdominal obesity has also been linked to significant metabolic abnormalities including changes in lipid parameter values. So, we designed this study to observe the pattern of lipid profile parameters in postmenopausal central obese women.Objective: To assess the lipid profile status of postmenopausal women with central obesity. Materials and Methods: This cross sectional study was carried out in the department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh during the period of January 2005 to December 2005. Seventy four postmenopausal women with central obesity and age matched 56 nonobese postmenopausal women were included in the study. Central obesity was defined having waist hip ratio more than 0.8. All statistical analyses were done by SPSS 12.0. p values <0.05 were considered significant. Results: Statistically no significant difference was observed between the central obese women and nonobese women in total cholesterol and LDL-cholesterol levels. But HDL-cholesterol was found lower and triacylglycerol was found higher in postmenopausal central obese women. Conclusion: Dyslipidaemia is a feature of postmenopausal women with central obesity. DOI: http://dx.doi.org/10.3329/jemc.v3i1.13836 J Enam Med Col 2013; 3(1): 08-12

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Comparison of Atherogenic Index of Plasma (AIP) Between Postmenopausal Women with Central Obesity and Postmenopausal Nonobese Women

Chattagram Maa-O-Shishu Hospital Medical College Journal ◽

10.3329/cmoshmcj.v13i2.21064 ◽

2014 ◽

Vol 13 (2) ◽

pp. 47-50 ◽

Cited By ~ 1

Author(s):

Monowara Khanam ◽

Md Aminul Haque Khan ◽

Md Rewanur Rahman ◽

Rukhsana Parvin ◽

Selima Akhter ◽

...

Keyword(s):

Lipid Profile ◽

Postmenopausal Women ◽

Central Obesity ◽

Cross Sectional Study ◽

Atherogenic Index ◽

Obese Women ◽

Lipid Parameter ◽

Cross Sectional ◽

Atherogenic Index Of Plasma ◽

Significant Difference

Background: Following menopause there are changes in values of lipid profile parameters. Abdominal obesity has also been linked to significant metabolic abnormalities including changes in lipid parameter values. Atherogenic index of plasma (AIP) calculated as log (TG/HDL-C) has been used as some practitioners as a significant predictor of atherosclerosis. So, we designed this study to observe the pattern of lipid profile parameters and to find out AIP in postmenopausal central obese women and to compare these between postmenopausal women with central obesity and postmenopausal nonobese women. Objectives: To assess the lipid profile status and AIP of postmenopausal women with central obesity and to compare these parameters with that of postmenopausal nonobese women.Materials & Methods: This cross sectional study was carried out in the department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. Sixty six postmenopausal women with central obesity and age matched 56 nonobese postmenopausal women were included in the study. Central obesity was defined having waist hip ratio more than 0.8 and BMI <25.0. All statistical analyses were done by SPSS 18.0. p values <0.05 were considered significant.Results: Statistically no significant difference was observed between the central obese women and nonobese women in lipid profile parameters. But AIP was found significantly higher in postmenopausal central obese women.Conclusion: Central obese postmenopausal women may be at higher risk of cardiovascular events compared with postmenopausal nonobese women in spite of no difference in lipid profile parameters as their AIP values are significantly different.DOI: http://dx.doi.org/10.3329/cmoshmcj.v13i2.21064

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perbandingan kadar HDL dan LDL akseptor Depo Medroksi Progesteron Asetat dengan IUD

HEALTH CARE : JURNAL KESEHATAN ◽

10.36763/healthcare.v7i2.7 ◽

2019 ◽

Vol 7 (2) ◽

pp. 47-51

Author(s):

Suci Syahril ◽

Meldafia Idaman ◽

Dewi Fransisca

Keyword(s):

Weight Gain ◽

Lipid Profile ◽

Medroxyprogesterone Acetate ◽

Colorimetric Method ◽

Cross Sectional Study ◽

First Year ◽

Sectional Study ◽

Normal Range ◽

Cross Sectional ◽

Significant Difference

Abstract The use of contraceptive depot medroxyprogesterone acetate (DMPA) increasing lately, but some studies suggest has the side effects of weight gain and contraceptives that have side effect in lipid metabolism. Therefore, about 35% of acceptors of DMPA in the first year to stop the use of DMPA. The objective of this study was to determine the differences of lipid profile between acceptors DMPA with acceptors IUD. This was a obcervational study with cross sectional study. The study wasdone at health center Lubuk Buaya in Padang and at laboratory of Biochemistry Departement in Medical Faculty of Andalas University from Januari until September 2016. The subjects were consisted of two groups, each group had 26 subjects. The examination for LDL and HDL used an enzymatic colorimetric method CHOD-PAP. Data was analyzed using analysis of t-test with p < 0.05 was considered to be significantly different. HDL levels average in Depo Medroxyprogesterone Acetate was 87,54±14,28 mg/dl and IUD was 75,90±8,67 mg/dl with p < 0.05 (significantly difference). Levels of LDL means there is no significantly difference between DMPA and IUD acceptors (p> 0.05). This research concluded that there isa significant difference on average levels of HDL in the Depo Medroxyprogesterone Acetate and IUD but levels of LDL there is no significantly difference. The clinically lipid profile in the two groups is in normal range.

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Breast density in women with premature ovarian failure or postmenopausal women using hormone therapy: analytical cross-sectional study

Sao Paulo Medical Journal ◽

10.1590/s1516-31802010000400007 ◽

2010 ◽

Vol 128 (4) ◽

pp. 211-214 ◽

Cited By ~ 9

Author(s):

Patrícia Magda Soares ◽

César Cabello ◽

Luis Alberto Magna ◽

Eduardo Tinois ◽

Cristina Laguna Benetti-Pinto

Keyword(s):

Hormone Therapy ◽

Postmenopausal Women ◽

Breast Density ◽

Premature Ovarian Failure ◽

Cross Sectional Study ◽

Ovarian Failure ◽

Sectional Study ◽

Cross Sectional ◽

Significant Difference ◽

The Impact

CONTEXT AND OBJECTIVE: Studies on postmenopausal women have reported increased risk of breast cancer relating to the type and duration of hormone therapy (HT) used. Women with premature ovarian failure (POF) represent a challenge, since they require prolonged HT. Little is known about the impact of prolonged HT use on these women's breasts. This study aimed to evaluate the effects of one type of HT on the breast density of women with POF, compared with postmenopausal women. DESIGN AND SETTING: Cross-sectional study at the Department of Obstetrics and Gynecology, Universidade Estadual de Campinas (Unicamp). METHODS: 31 women with POF and 31 postmenopausal women, all using HT consisting of conjugated equine estrogen combined with medroxyprogesterone acetate, and matched according to HT duration, were studied. Mammography was performed on all subjects and was analyzed by means of digitization or Wolfe's classification, stratified into two categories: non-dense (N1 and P1 patterns) and dense (P2 and Dy). RESULTS: No significant difference in breast density was found between the two groups through digitization or Wolfe's classification. From digitization, the mean breast density was 24.1% ± 14.6 and 18.1% ± 17.2 in the POF and postmenopausal groups, respectively (P = 0.15). Wolfe's classification identified dense breasts in 51.6% and 29.0%, respectively (P = 0.171). CONCLUSION: There was no difference in breast density between the women with POF and postmenopausal women, who had used HT for the same length of time. These results may help towards compliance with HT use among women with POF.

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Demographic and Biochemical Parameters of Community Survey Participants with Metabolic Syndrome from Terai Region of Nepal

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2021/50730.15577 ◽

2021 ◽

Author(s):

Birendra Kumar Jha ◽

Mingma Lhamu Sherpa ◽

Binod Kumar Dahal ◽

Jitendra Kumar Singh ◽

Chamma Gupta

Keyword(s):

Metabolic Syndrome ◽

Glucose Tolerance ◽

Biochemical Parameters ◽

Central Obesity ◽

Hdl Cholesterol ◽

Cross Sectional Study ◽

Atherogenic Dyslipidemia ◽

Sectional Study ◽

Cross Sectional ◽

The Mean

Introduction: The Metabolic Syndrome (MS) is a multifactorial disease associated with central obesity, hypertension, atherogenic dyslipidemia and impaired glucose tolerance. Low grade inflammatory and a prothrombotic state are also involved in MS. Aim: To explore the demographic and biochemical parameters of participants with MS in Terai region of Nepal using community based cross-sectional study. Materials and Methods: A cross-sectional study was carried out during September 2019-December 2019 in adult participants with central obesity (n=378) selected from three districts of Terai region of Nepal. International Diabetes Federation (IDF) criteria were used to define MS. The C-reactive protein-ultra sensitive, fibrinogen, and apolipoprotein-B were estimated as inflammatory, prothrombotic, and atherogenic dyslipidemia markers, respectively. Results: The MS was present in 283 participants with central obesity. The mean (±SD) age, height, weight, and BMI of the participants with MS were 46.36±12.52 years, 5.56±0.11 feet, 66.54±13.45 kg and 27.28±4.98 kg/m2, respectively. The mean (±SD) of biochemical factors were significantly different than their respective normal ranges: decreased serum High Density Lipoprotein (HDL) cholesterol in mg/dL (male: 34.50±9.93, p<0.001, female: 36.77±7.28, p<0.001), raised serum triglycerides level- 184.96±85.72 mg/dL (p<0.001), and impaired fasting serum glucose level 108.14±48.27 mg/dL (p=0.002). Significant increase in inflammatory (CRP-US: 1.12±2.17 mg/L, p<0.001), prothrombotic (fibrinogen: 3.42±1.04 gm/L, p<0.001) and atherogenic dyslipidemia marker (Apo-B: 149.35±59.13 mg/dL, p=0.003) from normal values were observed in subjects with MS. Conclusion: Lowered serum HDL cholesterol, increased triglycerides followed with impaired fasting glucose tolerance were observed as the major abnormal biochemical parameters and increased inflammatory and prothrombotic activities were present among participants with MS.

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Perbedaan Profil Lipid pada Akseptor Depo Medroksi Progesteron Asetat dengan Implant Levonorgestrel di Wilayah Kerja Puskesmas Air Tawar Padang Tahun 2014

Jurnal Kesehatan Andalas ◽

10.25077/jka.v4i1.186 ◽

2015 ◽

Vol 4 (1) ◽

Author(s):

Rafika Oktova ◽

Desmiwarti Desmiwarti ◽

Arni Amir

Keyword(s):

Lipid Profile ◽

Total Cholesterol ◽

Medroxyprogesterone Acetate ◽

Colorimetric Method ◽

Cross Sectional Study ◽

Hormonal Contraceptives ◽

P Value ◽

Sectional Study ◽

Cross Sectional ◽

Significant Difference

AbstrakDepo Medroksiprogesteron Asetat dan Implant Levonorgestrel merupakan kontrasepsi hormonal progestin sintetik yang memiliki efek samping yaitu peningkatan berat badan dan mempengaruhi metabolisme lipid. Tujuan penelitian ini adalah untuk mengetahui perbedaan profil lipid pada akseptor Depo Medroksiprogesteron Asetat dengan Implant Levonorgestrel. Ini adalah studi observasional dengan desain cross sectional comparative. Penelitian dilakukan di laboratorium Bagian Biokimia Fakultas Universitas Andalas dari Maret sampai Mei 2014. Subjek penelitian terdiri dari dua kelompok, masing-masing 20 subjek. Pemeriksaan dengan metode enzimatis kolorimetri yaitu GPO-PAP untuk trigliserida, dan CHOD-PAP untuk kolesterol total, HDL dan LDL. Data dianalisis menggunakan uji t dengan nilai p<0.05 dianggap bermakna secara statistik. Rerata kadar LDL pada Depo Medroksiprogesteron Asetat lebih tinggi (95,51 ± 20,47) mg/dl daripada Implant Levonorgestrel (79,35 ± 12,55) mg/dl dengan nilai p<0,05 artinya terdapat perbedaan yang bermakna sedangkan kadar trigliserida, kolesterol total dan HDL tidak bermakna. Kesimpulan penelitian in adalah terdapat perbedaan yang bermakna rerata kadar LDL pada Depo MedroksiprogesteronAsetat dan Implant Levonorgestrel, sedangkan kadar trigliserida, kolesterol total dan HDL tidak bermakna. Secara klinis profil lipid pada kedua kelompok dalam keadaan normal.Kata kunci: profil lipid, depo medroksiprogesteron asetat, implant levonorgestrelAbstractDepo Medroxyprogesterone Acetate and Levonorgestrel Implants are synthetic progestine hormonal contraceptives that have side effect in body weight and lipid metabolism. The objective of this study was to determine the differences of lipid profile between acceptors Depo Medroxyprogesterone Acetate and Levonorgestrel Implants. This was a comparative cross sectional study. The study was done at laboratory of Biochemistry Departement in Medical Faculty of Andalas University from March until May 2014. The subjects were consisted of two groups, each group had 20 subjects. The examination used an enzymatic colorimetric method GPO-PAP for trygliserides and CHOD-PAP for total cholesterol, HDL and LDL. Data was analyzed using analysis of t-test with p<0.05 was considered to be significantly different. LDL levels average in Depo Medroxyprogesterone Acetate was (95,51 ± 20,47) mg/dl and Levonorgestrel Implants was (79,35 ± 12,55) mg/dl with p-value, it means there is a significantly difference, but levels of trygliserides, total cholesterol and HDL means there is no significantly difference. This research concluded that there is a significant difference on average levels of LDL in the Depo Medroxyprogesterone Acetate and Levonorgestrel Implants but levels of trygliserides, total cholesterol and HDL there is no significantly difference. The clinically lipid profile in the two groups is in normal range.Keywords: lipid profile, depo medroxyprogesterone acetate and levonorgestrel implants

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Senam aerobik dan konsumsi zat gizi serta pengaruhnya terhadap kadar kolesterol total darah wanita

Jurnal Gizi Klinik Indonesia ◽

10.22146/ijcn.17727 ◽

2011 ◽

Vol 8 (1) ◽

pp. 23

Author(s):

Siti Fatimah ◽

Apoina Kartini

Keyword(s):

Total Cholesterol ◽

Cholesterol Level ◽

Total Cholesterol Level ◽

Hdl Cholesterol ◽

Cross Sectional Study ◽

Adult Women ◽

Chi Square ◽

Cross Sectional ◽

Nutrient Adequacy ◽

Significant Difference

Background: Hypercholesterolemia is a condition in which levels of cholesterol in the blood above normal levels (≥ 240 mg/dl). Physical exercises done regularly useful in the regulation of cholesterol, is total cholesterol, LDL cholesterol and triglycerides in the blood decreased, while HDL cholesterol increased. Food has an important role in association with the incident hypercholesterolemia.Objective: The purpose of this study was to determine the effect of aerobic exercise on blood total cholesterol level of adult women in the city of Semarang.Method: This research was explanatory research with cross sectional study. Subject was women aged 20-49 years gymnastic participants, as a comparison group was a housewife who was not doing gymnastics. Twenty three samples for group2 by matching on nutritional status and age and with the sampling purposive sampling. Adequacy levels of carbohydrates, proteins, fats, and also vitamins A and C were obtained through 2x24-hour recall was not a sequence, and processed using NutriSurvey. Results of independent t-test used to determine the effect of cholesterol levels between groups, and chi square test was used to determine association with nutrient adequacy levels of total cholesterol.Results: The results showed no significant difference in mean total cholesterol level between groups of gymnastic participants (201.2 g/dl) with housewife group (208.3 g/dl). Housewife group was belonging to hypercholesterolemia by 52.2%, while in group of exercise participants at 43.5%. Sufficiency level of protein showed a role in the total cholesterol level of adult women.Conclusion: The aerobic gymnastics did not affect total cholesterol. Moderate level of protein adequacy contributes to the total cholesterol level of adult women.

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Association of Subclinical Hypothyroidism and Dyslipidemia in Children and Adolescents

10.21203/rs.2.21501/v1 ◽

2020 ◽

Author(s):

Ashkan Habib ◽

Asadollah Habib

Keyword(s):

Lipid Profile ◽

Total Cholesterol ◽

Subclinical Hypothyroidism ◽

Cross Sectional Study ◽

Specific Pattern ◽

Cross Sectional ◽

Lipid Disorder ◽

Significant Difference ◽

Sh Group ◽

Tsh Levels

Abstract Background: Correlation of higher levels of TSH and dyslipidemia in children is controversial. This study was designed to assess the relation between lipid profile components and TSH levels in children. Method: This cross-sectional study was performed in a growth assessment clinic in Shiraz. Children aged between 2 to 18 years that came to the clinic from January till April 2018 were considered. TSH levels equal or above 5 and lower than 10 mIU/L with normal FT4 were considered as subclinical hypothyroidism. Results: 666 children were euthyroid while 181 had subclinical hypothyroidism. Mean total cholesterol in euthyroid children was 160.50 ± 29.070 mg/dl and in SH group 161.39 ± 28.694 mg/dl (P=0.713). Mean LDL-C in euthyroid children was 90.96 ± 24.996 mg/dl and in SH group 89.10 ± 23.852 mg/dl (P=0.369). Mean HDL-C in euthyroid children was 47.94 ± 10.560 mg/dl and in SH group 49.04 ± 10.361 mg/dl. (P=0.211). Mean non HDL-C in euthyroid children was 112.56 ± 27.696 mg/dl and in SH group 112.35 ± 28.136 mg/dl. (P=0.929). Mean triglyceride in euthyroid children was 104.98 ± 54.934 mg/dl and in SH group 113.83 ± 91.342 mg/dl (P=0.215). There was no significant difference in mean serum total cholesterol, LDL, HDL, non-HDL and triglyceride levels between euthyroid and subclinical hypothyroid. Adjusted correlation was not significant between TSH levels and any lipid profile component. Conclusion: By comparing the results of this study with other studies, it is evident that lipid disorder in subclinical hypothyroid children does not have a specific pattern.

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Association between Lipid Profile and Glycemic Status in Iraqi patients with Acromegaly Receiving Depot Long-Acting Octreotide

Al-Rafidain Journal of Medical Sciences ( ISSN: 2789-3219 ) ◽

10.54133/ajms.v1i.48 ◽

2021 ◽

Vol 1 ◽

pp. 140-144

Author(s):

Omar Mohammed Al-Juboori

Keyword(s):

Glycemic Control ◽

Lipid Profile ◽

Ldl Cholesterol ◽

Hdl Cholesterol ◽

Cross Sectional Study ◽

Treatment Modalities ◽

Cross Sectional ◽

Octreotide Lar ◽

Profile Changes ◽

Long Acting

Background: Treatment modalities of acromegaly and disease control impact differently on glucose homeostasis and lipid changes, and consequently on cardiometabolic risk. Aim: To investigate the possible association of lipid profile changes with the glycemic control status in acromegaly patients treated with octreotide LAR. Methods: This cross-sectional study included 52 Iraqi patients with acromegaly treated with octreotide LAR and not using statins. Demographic, anthropometric, and clinical data were collected, as well as the duration of Octreotide LAR administration. The glycemic state was assessed and classified as DM, prediabetes, or normal. Plasma levels of triglycerides, LDL cholesterol, HDL cholesterol, and non-HDL were evaluated using standard methods. Results: Most of the participants presented with low levels of triglycerides, LDL cholesterol, and HDL cholesterol. The lipid profile variables were not significantly correlated with the glycemic control status after treatment with octreotide LAR. Conclusion: Lipid profile parameters were not associated with the different glycemic control status of acromegaly patients treated with octreotide LAR.

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A Cross Sectional Survey on Musculoskeletal Pain Among Postmenopausal Women with Overall and Central Obesity

10.53350/pjmhs211551369 ◽

2021 ◽

Vol 15 (5) ◽

pp. 1369-1371

Author(s):

Q. Kiran ◽

S. Riaz ◽

Z. Hashmi ◽

R. R. Khan ◽

Z. R. Athar ◽

...

Keyword(s):

Postmenopausal Women ◽

Musculoskeletal Pain ◽

Central Obesity ◽

Sampling Technique ◽

Cross Sectional Study ◽

Cross Sectional Survey ◽

Cross Sectional ◽

Post Menopause ◽

Convenience Sampling ◽

Waist Height Ratio

Objective: To find out the frequency of Musculoskeletal Pain among Postmenopausal women with Overall and Central Obesity. Methods: A Cross-Sectional study was carried out at Jinnah Hospital, Lahore, for six months. A sample size of 250 patients with generalized obesity and central obesity was taken. Non-Probability, Convenience Sampling technique was used. The Nordic questionnaire was used as a data collection tool. Data was analyzed on SPSS version 21. Results: Results showed that majority respondents were in the age group of 51-60 i.e. 43.6% (N=109), respondents with BMI >30 were 50.8% (N=127), waist/height ratio 99.2% (N=248) were > 0.5, waist/hip ratio 86.8% (N=217) were >0.85, 90% (N=225) were present with waist circumference >88cm. Conclusion: This study concludes that musculoskeletal pain is high in postmenopausal women with overall obesity and has shown more pain in the neck, back, shoulder and lower extremities, while postmenopausal women with central obesity have suffered more with back pain. Keywords: Body Mass Index, Obesity, Post menopause, Musculoskeletal pain.

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No association between 25-hydroxyvitamin D levels and prediabetes in Brazilian patients. A cross-sectional study

Sao Paulo Medical Journal ◽

10.1590/1516-3180.2013.7180005 ◽

2014 ◽

Vol 133 (2) ◽

pp. 73-77 ◽

Cited By ~ 6

Author(s):

Guilherme de Vieira Giorelli ◽

Lívia Nascimento de Matos ◽

Amir Saado ◽

Vera Lúcia Soibelman ◽

Cristiane Bitencourt Dias

Keyword(s):

Density Lipoprotein ◽

Hdl Cholesterol ◽

Cross Sectional Study ◽

Large For Gestational Age ◽

Oral Glucose ◽

Sectional Study ◽

Cross Sectional ◽

Hydroxyvitamin D ◽

Significant Difference ◽

25 Hydroxyvitamin D

CONTEXT AND OBJECTIVE: Several studies have evaluated the role of low 25-hydroxyvitamin D (25OHD3) in the pathogenesis of type 2 diabetes (T2DM) and have presented controversial results. The metabolic processes that culminate in T2DM begin under prediabetic conditions. Our aim was to analyze the association between 25OHD3 and glucose metabolism in individuals who were free from but at elevated risk of diabetes. DESIGN AND SETTING: Cross-sectional study at a tertiary hospital. METHODS: Anthropometric and laboratory profiles were determined in patients with one or more of the following risk factors: hypertension; body mass index (BMI) ≥ 25 kg/m2; waist circumference > 80 cm for women and > 94 cm for men; first-degree relatives with diabetes; women with large-for-gestational-age newborns or with gestational T2DM; HDL-cholesterol (high density lipoprotein) < 35 mg/dl; and triglycerides > 250 mg/dl. The patients were divided into two groups: one with prediabetes (abnormal fasting plasma glucose or oral glucose tolerance test) and the other with normal glucose (euglycemic). RESULTS: There was no statistically significant difference between the prediabetic group (n = 38) and euglycemic group (n = 15) regarding age (66.4 ± 10.6 versus 62.6 ± 9.1 years), gender (52.6 versus 73.3% female) and BMI (30.1 ± 4.61 versus 27.9 ± 4.7 kg/m2). Low serum levels of 25OHD3 were found in both groups, without any statistically significant difference between them (29.1 ± 11.8 versus 26.87 ± 9.2 ng/dl). CONCLUSION: There was no association between 25OHD3 levels and the clinical or laboratorial variables analyzed.

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