scholarly journals A Case of Choriocarcinoma with Lung Metastasis as the First Symptom

2020 ◽  
Author(s):  
Jin Tian ◽  
YaNan Xiao ◽  
TengLong Zhang ◽  
Jie Wang ◽  
CaiLong Jin ◽  
...  
Keyword(s):  
Clinical Diagnosis ◽  
Clinical Manifestations ◽  
Primary Lung Cancer ◽  
Diagnosis And Treatment ◽  
Clinical Feature ◽  
Rapid Progression ◽  
Immunohistochemical Examination ◽  
Case Presentation ◽  
History Of ◽  
Timely Treatment

Abstract Background: Pure testicular choriocarcinoma is very rare in clinic and the patient's age is 20-39 years (median age 29 years). Because of its polymorphic manifestations, it is not always suspected and patients are sometimes misdiagnosed. The case should be reported due to the rarity of the disease ,the onset age and the rapid progression of the disease. This case with primary lung cancer as the first diagnosis is a misdiagnosis. We hope we can provide some experience for clinical diagnosis and treatment. Case presentation: We report the case of a 46-year-old man who was admitted to our hospital with bloodshot sputum. Histopathological and immunohistochemical examination revealed pure choriocarcinoma. The patient had received radiotherapy, chemotherapy, immunotherapy, Over the next 5 months, the patient developed symptoms of multiple system metastases and died soon. Conclusions: Testicular choriocarcinoma is progressing rapidly. The clinical feature of choriocarcinoma is hemorrhaging at the metastatic site. Early diagnosis and timely treatment should be combined with the clinical manifestations and medical history of patients to strive for a longer survival time. We hope this case can provide guidance for the clinical diagnosis and treatment of the disease.

scholarly journals Progress in the Pathogenesis, Diagnosis, and Treatment of TSH-Secreting Pituitary Neuroendocrine Tumor

2020 ◽  
Vol 11 ◽  
Author(s):  
Peiqiong Luo ◽  
Lin Zhang ◽  
Lidan Yang ◽  
Zhenmei An ◽  
Huiwen Tan
Keyword(s):  
Neuroendocrine Tumor ◽  
Clinical Manifestations ◽  
High Sensitivity ◽  
Mass Effect ◽  
Pituitary Hormones ◽  
Diagnosis And Treatment ◽  
Detection Methods ◽  
Thyroid Goiter ◽  
Magnetic Resonance Imaging Mri ◽  
Timely Treatment

TSH-secreting pituitary neuroendocrine tumor (PitNET) is one of the causes of central hyperthyroidism. The incidence of TSH PitNET is far lower than that of other PitNETs. The clinical manifestations of TSH PitNETs mainly include thyrotoxicosis or thyroid goiter, secretion disorders of other anterior pituitary hormones, and mass effect on the pituitary gland and its surrounding tissues. The application of high-sensitivity TSH detection methods contributes to the early diagnosis and timely treatment of TSH PitNETs. Improvements in magnetic resonance imaging (MRI) have advanced the noninvasive visualization of smaller PitNETs. Treatments for TSH PitNETs include surgery, drugs, and radiotherapy. This review focuses on the progress in pathogenesis, diagnosis, and treatment of TSH PitNETs to provide more information for the clinician.

scholarly journals A Solitary Giant Neurofibroma of Inguinal Region—A Case Report

2020 ◽  
Author(s):  
Haiying Zhou ◽  
Hui Lu
Keyword(s):  
Tumor Resection ◽  
Clinical Manifestations ◽  
Inguinal Region ◽  
Case Presentation ◽  
Neurogenic Tumors ◽  
Long Time ◽  
Giant Neurofibroma ◽  
History Of ◽  
Recurrence Tendency

Abstract Background:Neurofibroma is a rare nerve sheath tumorofneuroectodermal origin, especially the huge and isolated neurofibroma located in the inguinal region. To our knowledge, no such case has previously been reported.Case presentation:We report a case of 34-year-old male patient with a 4-year history of progressive enlargement of the medial root mass in his left thigh with sitting and standing disorders along with pain. The tumor was completely removed by operation, and pathological diagnosisshowed neurofibroma. There was no obvious neurologic defect after surgery, and no recurrence tendency was found in the follow-up of 2years.Conclusions:For a large solitary mass with slow growth and no malignant clinical manifestations for a long time, clinicians can not rule out the hypothetical diagnosis of neurofibroma, even though its growth site is very rare, such as this case of a huge tumor located in the groin. For neurogenic tumors, early operation should be performed, and the prognosis of patients after tumor resection isexcellent.

scholarly journals Pneumoconiosis with a Sarcoid-Like Reaction Other than Beryllium Exposure: A Case Report and Literature Review

Medicina ◽  
2020 ◽  
Vol 56 (11) ◽  
pp. 630
Author(s):  
Fumiko Hayashi ◽  
Takashi Kido ◽  
Noriho Sakamoto ◽  
Yoshiaki Zaizen ◽  
Mutsumi Ozasa ◽  
...  
Keyword(s):  
Chest Radiography ◽  
Analytical Electron Microscopy ◽  
Clinical Manifestations ◽  
Dust Exposure ◽  
Dust Deposition ◽  
High Resolution Computed Tomography ◽  
Case Presentation ◽  
Old Japanese ◽  
History Of ◽  
Beryllium Disease

Background: Chronic beryllium disease (CBD) is a granulomatous disease that resembles sarcoidosis but is caused by beryllium. Clinical manifestations similar to those observed in CBD have occasionally been reported in exposure to dusts of other metals. However, reports describing the clinical, radiographic, and pathological findings in conditions other than beryllium-induced granulomatous lung diseases, and detailed information on mineralogical analyses of metal dusts, are limited. Case presentation: A 51-year-old Japanese man with rapidly progressing nodular shadows on chest radiography, and a 10-year occupation history of underground construction without beryllium exposure, was referred to our hospital. High-resolution computed tomography showed well-defined multiple centrilobular and perilobular nodules, and thickening of the intralobular septa in the middle and lower zones of both lungs. No extrathoracic manifestations were observed. Pathologically, the lung specimens showed 5–12 mm nodules with dust deposition and several non-necrotizing granulomas along the lymphatic routes. X-ray analytical electron microscopy of the same specimens revealed aluminum, iron, titanium, and silica deposition in the lung tissues. The patient stopped smoking and changed his occupation to avoid further dust exposure; the chest radiography shadows decreased 5 years later. Conclusion: The radiological appearances of CBD and sarcoidosis are similar, although mediastinal or hilar lymphadenopathy is less common in CBD and is usually seen in the presence of parenchymal opacities. Extrathoracic manifestations are also rare. Despite limited evidence, these findings are similar to those observed in pneumoconiosis with a sarcoid-like reaction due to exposure to dust other than of beryllium. Aluminum is frequently detected in patients with pneumoconiosis with a sarcoid-like reaction and is listed as an inorganic agent in the etiology of sarcoidosis. It was also detected in our patient and may have contributed to the etiology. Additionally, our case suggests that cessation of dust exposure may contribute to improvement under the aforementioned conditions.

Deceptive Giant Dedifferentiated Liposarcoma of the Esophagus: An Extremely Rare Surgical Case

2019 ◽  
Vol 28 (2) ◽  
pp. 200-205
Author(s):  
Xiao-Xin Shi ◽  
Meng-Ying Liao ◽  
Li-Li Tao ◽  
Xin-Gen Wang ◽  
Wei-Hua Yin
Keyword(s):  
Clinical Diagnosis ◽  
Poor Prognosis ◽  
Clinical Manifestations ◽  
Accurate Diagnosis ◽  
Diagnosis And Treatment ◽  
Dedifferentiated Liposarcoma ◽  
Surgical Case ◽  
Pathologic Features

Dedifferentiated liposarcoma rarely occurs in the esophagus. It always has atypical clinical manifestations and different pathologic features, which usually lead to misdiagnosis and mistreatment. Given its poor prognosis, early and accurate diagnosis is of the utmost importance. The accumulation of similar cases is critical for surgeons and pathologists to raise awareness of such tumors. This report aims to discuss the diagnosis and provide a reference for the clinical diagnosis and treatment for pathologists and clinicians.

scholarly journals Alport's Syndrome in Pregnancy

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Suchita Mehta ◽  
Chadi Saifan ◽  
Marie Abdellah ◽  
Rita Choueiry ◽  
Rabih Nasr ◽  
...  
Keyword(s):  
Kidney Injury ◽  
Adverse Outcomes ◽  
Rapid Progression ◽  
Alport's Syndrome ◽  
Case Presentation ◽  
Alport’S Syndrome ◽  
History Of ◽  
Stage Renal Disease ◽  
End Stage ◽  
In Pregnancy

Background. Alport's syndrome is an X-linked hereditary disorder affecting the glomerular basement membrane associated with ocular and hearing defects. In women, the disease is much less severe compared to that in men. However, women with Alport's syndrome can have an accelerated form of their disease during pregnancy with worsening of kidney function and can also develop preeclampsia. There are only four described cases of Alport's syndrome in pregnancy.Case Presentation. 20-year-old woman with a history of Alport's syndrome, which during pregnancy worsened resulting in hypertension, proteinuria, and acute kidney injury. Fortunately, there was complete resolution of the proteinuria and kidney injury with delivery, and the patient did not require any renal replacement therapy.Conclusion. One of the four reported cases had an accelerated form of the disease during pregnancy with rapid progression of kidney injury and end-stage renal disease. There are no definite guidelines to monitor these patients during pregnancy. Further studies are required to understand the exact pathophysiology of kidney damage that occurs in pregnant women with Alport's syndrome. This may give us some insight into the prognostic predictors, so that we can monitor these women more thoroughly and prevent adverse outcomes.

scholarly journals Association of COVID-19 infection with large thrombi in left and right atrial appendages

2021 ◽  
Vol 73 (1) ◽  
Author(s):  
Saeed Ghodsi ◽  
Sara Taghi ◽  
Zahra Alizadeh-Sani ◽  
Yaser Jenab ◽  
Zahra Hosseini ◽  
...  
Keyword(s):  
Right Atrial ◽  
Surgical Removal ◽  
Rapid Progression ◽  
Imaging Features ◽  
Case Presentation ◽  
Acute Thrombosis ◽  
Prosthetic Valves ◽  
Cardiac Devices ◽  
Progressive Dyspnea ◽  
History Of

Abstract Background Multiple intra-atrial thrombi are found rarely except in the presence of prosthetic valves, intra-cardiac devices, structural connections like foramen ovale and thrombophilia. Case presentation We reported acute thrombosis formation in right and left atrial appendages of a 66-year old man admitted due to progressive dyspnea since 7 days earlier. He had a history of prior laryngeal Squamous Cell Carcinoma, apical hypertrophic cardiomyopathy (HCM), and atrial fibrillation (AF). Infection with COVID-19 was confirmed thereafter. Cardiac Magnetic Resonance Imaging (CMR) suggested the diagnosis of atrial clot superior to neoplasm. After surgical removal of the thrombi, symptoms as well as imaging features of pneumonia were resolved. Conclusions We should focus on different presentations and complications of systemic inflammation especially in the setting of COVID-19 infection. Although risk factors of thrombosis are present in some of these patients, rapid progression as well as unusual types of involvement may indicate to a new trigger.

scholarly journals Diagnosis of hereditary hemorrhagic telangiectasia in a pediatric patient admitted with diabetes: the utility of genetic testing

2021 ◽  
Vol 2 (3) ◽  
pp. 01-02
Author(s):  
Alvaro E. Galvis ◽  
Beatrice Batoczki ◽  
Iris S. Pecson ◽  
Evan Vidal ◽  
Craig T. Nakamura
Keyword(s):  
Genetic Testing ◽  
Pediatric Patient ◽  
Hereditary Hemorrhagic Telangiectasia ◽  
Autosomal Dominant ◽  
Wide Spectrum ◽  
Clinical Manifestations ◽  
Autosomal Dominant Disorder ◽  
Case Presentation ◽  
History Of ◽  
Vascular Dysplasia

Background: Hereditary hemorrhagic telangiectasia (HHT) formerly known as Osler-Weber-Rendu syndrome is a rare autosomal dominant disorder characterized by vascular dysplasia and a wide spectrum of clinical manifestations. Case presentation: We report the case of an undiagnosed pediatric patient who presented hypoxemia on clinical exam as the only suggestive feature for the presence of HHT. Conclusions: Although HHT diagnosis is based on the finding of characteristic clinical features genetic testing should also be implemented when a family history of the disease is present to help confirm or refute the diagnosis.

scholarly journals A case report of Sino-orbital Mucormycosis in a COVID-19 patient from eastern India: a “Red-alert” to physicians emphasizing the importance of early microbiological diagnosis

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Nidhi Dawar Pal ◽  
Anirban Pal ◽  
Debi Kundu ◽  
Puspendu Dutta
Keyword(s):  
Case Report ◽  
Clinical Diagnosis ◽  
Microbiological Diagnosis ◽  
Eastern India ◽  
Fatal Disease ◽  
Direct Smear ◽  
History Of ◽  
Timely Treatment

A 65 years old diabetic female, presented with swelling of left eye and multiple discharging sinuses near the inner canthus of the left eye. She had a history of recent COVID-19 infection and was treated with steroids. The pus from peri-orbital sinuses, in KOH stain showed presence of broad, non-septate, right-angle branching fungal filaments. An early microbiological diagnosis of Mucormycosis, based on the direct smear findings substantiated the clinical diagnosis and helped the patient to get timely treatment. We emphasize that a request for an early microbiological diagnosis may affect the outcome in this highly invasive fatal disease.

scholarly journals Glucose-6-phosphate dehydrogenase gene Ala365Thr mutation in an Iraqi family with confusing clinical differences

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Yasemin Ardicoglu Akisin ◽  
Zafer Arslan ◽  
Serdar Ceylaner ◽  
Nejat Akar
Keyword(s):  
Clinical Presentation ◽  
Clinical Manifestations ◽  
Recessive Inheritance ◽  
Case Presentation ◽  
The People ◽  
Dehydrogenase Gene ◽  
Severe Clinical Presentation ◽  
History Of ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Three Sisters

Abstract Objectives Glucose-6-phosphate dehydrogenase (G6PD) has role in the Embden Meyerhof road. Any loss of its function causes NADPH to cease, leaving erythrocytes susceptible to oxidative damage resulting in acute hemolytic anemia attacks secondary to drugs or infection and favism. Because of X-linked recessive inheritance males are mainly affected. Being heterozygous, females have less severe clinical presentation. Case presentation G6PD deficiency was suspected in a six-year-old girl from an Iraqi family with a history of yellowing of skin and darkening of urine after eating broad beans. Besides the patient, G6PD levels were found low in the father and in two sisters who showed no symptoms. The father was found hemizygous and the three sisters were found heterozygous for NM_000402.4c.1093G>A(p.A365T)(6.Ala365Thr) mutation while the mother was normal. Conclusions G6PD enzyme deficiency can be seen in both genders, and it may be presented with different clinical manifestations even within the people having the same mutation.

Outcomes of spontaneous regression of retinopathy of prematurity

2021 ◽  
pp. 167-169
Author(s):  
O.M. Zнukova ◽  
◽  
A.V. Tereshchenko ◽  
I.G. Trifanenkova ◽  
M.S. Tereshchenkova ◽  
...  
Keyword(s):  
Retinopathy Of Prematurity ◽  
Spontaneous Regression ◽  
Age Groups ◽  
Clinical Manifestations ◽  
Ophthalmological Examination ◽  
History Of ◽  
Varying Length ◽  
Long Term Observation ◽  
Timely Treatment

Purpose. To analyze postnatal outcomes in children with spontaneous ROP regression. Material and methods. The study included 37 children (74 eyes) with spontaneous ROP regression. Gestational age was ranged from 23 to 32 weeks, body weight - from 493 to 1660 g at birth. Depending on the observation period, the children were divided into 2 age groups: 1 - from 1 month to 4 years old - 31 children (62 eyes), 2 - from 9 to 13 years old - 6 children (12 eyes). The diagnostics included standard ophthalmological examinations and additional methods. Results. In the first group, upon reaching the age of 1-year, complete retinal vascularization was observed in 26 (83%) cases (52 eyes). 5 children (10 eyes) had a narrow retinal avascular zone in the temporal segment. In the second group, in cases of postponed 3-rd stage of ROP, more severe disorders in the peripheral parts of the retina were revealed: compaction of the posterior hyaloid membrane with fixation and zones of traction retinoschisis of varying length. In the first years of life, all patients with ROP had a history of predominantly hyperopic refraction (94%). However, myopic refraction prevailed (82%) in the second group of children reaching school age. Conclusion. Considering the significant variability of the clinical manifestations of the cicatricial stage of ROP with spontaneous regression, long-term observation and a comprehensive ophthalmological examination of this group of patients are necessary for timely treatment. Key words: retinopathy of prematurity, spontaneous regression, cicatricial phase.

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