scholarly journals First report of rapid, non-invasive, and reagent-free detection of malaria through the skin of patients with a beam of infrared light

Author(s):  
Gabriela Garcia ◽  
Tharanga Kariyawasam ◽  
Anton Lord ◽  
Cristiano Costa ◽  
Lana Chaves ◽  
...  

Abstract We describe the first application of the Near-infrared spectroscopy (NIRS) technique to detect Plasmodium falciparum and P. vivax malaria parasites through the skin of malaria positive and negative human subjects. NIRS is a rapid, non-invasive and reagent free technique which involves rapid interaction of a beam of light with a biological sample to produce diagnostic signatures in seconds. We used a handheld, miniaturized spectrometer to shine NIRS light on the ear, arm and finger of P. falciparum (n=7) and P. vivax (n=20) positive people and malaria negative individuals (n=33) in a malaria endemic setting in Brazil. Supervised machine learning algorithms for predicting the presence of malaria were applied to predict malaria infection status in independent individuals (n=12). Separate machine learning algorithms for differentiating P. falciparum from P. vivax infected subjects were developed using spectra from the arm and ear of P. falciparum and P. vivax (n=108) and the resultant model predicted infection in spectra of their fingers (n=54).NIRS non-invasively detected malaria positive and negative individuals that were excluded from the model with 100% sensitivity, 83% specificity and 92% accuracy (n=12) with spectra collected from the arm. Moreover, NIRS also correctly differentiated P. vivax from P. falciparum positive individuals with a predictive accuracy of 93% (n=54). These findings are promising but further work on a larger scale is needed to address several gaps in knowledge and establish the full capacity of NIRS as a non-invasive diagnostic tool for malaria. It is recommended that the tool is further evaluated in multiple epidemiological and demographic settings where other factors such as age, mixed infection and skin colour can be incorporated into predictive algorithms to produce more robust models for universal diagnosis of malaria.

Author(s):  
Christian Knaak ◽  
Moritz Kröger ◽  
Frederic Schulze ◽  
Peter Abels ◽  
Arnold Gillner

An effective process monitoring strategy is a requirement for meeting the challenges posed by increasingly complex products and manufacturing processes. To address these needs, this study investigates a comprehensive scheme based on classical machine learning methods, deep learning algorithms, and feature extraction and selection techniques. In a first step, a novel deep learning architecture based on convolutional neural networks (CNN) and gated recurrent units (GRU) is introduced to predict the local weld quality based on mid-wave infrared (MWIR) and near-infrared (NIR) image data. The developed technology is used to discover critical welding defects including lack of fusion (false friends), sagging and lack of penetration, and geometric deviations of the weld seam. Additional work is conducted to investigate the significance of various geometrical, statistical, and spatio-temporal features extracted from the keyhole and weld pool regions. Furthermore, the performance of the proposed deep learning architecture is compared to that of classical supervised machine learning algorithms, such as multi-layer perceptron (MLP), logistic regression (LogReg), support vector machines (SVM), decision trees (DT), random forest (RF) and k-Nearest Neighbors (kNN). Optimal hyperparameters for each algorithm are determined by an extensive grid search. Ultimately, the three best classification models are combined into an ensemble classifier that yields the highest detection rates and achieves the most robust estimation of welding defects among all classifiers studied, which is validated on previously unknown welding trials.


Sepsis is a life-threatening disease that causes tissue damage, organ failure and results in the death of millions of people. Sepsis is one of the highest risky diseases identified globally. A large proportion of these deaths occur in developing countries due to inaccessibility of hospitals or lack of resources. Blood samples are taken to confirm sepsis, but it requires the presence of laboratory and is time-consuming. The aim and objective of this study is to develop a practical, non-invasive sepsis prediction model that can be used to detect sepsis using supervised machine Learning algorithms. For this retrospective analysis, we used the data available from Physio-Net database.


2018 ◽  
Author(s):  
Nazmul Hossain ◽  
Fumihiko Yokota ◽  
Akira Fukuda ◽  
Ashir Ahmed

BACKGROUND Predictive analytics through machine learning has been extensively using across industries including eHealth and mHealth for analyzing patient’s health data, predicting diseases, enhancing the productivity of technology or devices used for providing healthcare services and so on. However, not enough studies were conducted to predict the usage of eHealth by rural patients in developing countries. OBJECTIVE The objective of this study is to predict rural patients’ use of eHealth through supervised machine learning algorithms and propose the best-fitted model after evaluating their performances in terms of predictive accuracy. METHODS Data were collected between June and July 2016 through a field survey with structured questionnaire form 292 randomly selected rural patients in a remote North-Western sub-district of Bangladesh. Four supervised machine learning algorithms namely logistic regression, boosted decision tree, support vector machine, and artificial neural network were chosen for this experiment. A ‘correlation-based feature selection’ technique was applied to include the most relevant but not redundant features into the model. A 10-fold cross-validation technique was applied to reduce bias and over-fitting of the data. RESULTS Logistic regression outperformed other three algorithms with 85.9% predictive accuracy, 86.4% precision, 90.5% recall, 88.1% F-score, and AUC of 91.5% followed by neural network, decision tree and support vector machine with the accuracy rate of 84.2%, 82.9 %, and 80.4% respectively. CONCLUSIONS The findings of this study are expected to be helpful for eHealth practitioners in selecting appropriate areas to serve and dealing with both under-capacity and over-capacity by predicting the patients’ response in advance with a certain level of accuracy and precision.


2021 ◽  
Vol 1916 (1) ◽  
pp. 012042
Author(s):  
Ranjani Dhanapal ◽  
A AjanRaj ◽  
S Balavinayagapragathish ◽  
J Balaji

2021 ◽  
Vol 11 (15) ◽  
pp. 6728
Author(s):  
Muhammad Asfand Hafeez ◽  
Muhammad Rashid ◽  
Hassan Tariq ◽  
Zain Ul Abideen ◽  
Saud S. Alotaibi ◽  
...  

Classification and regression are the major applications of machine learning algorithms which are widely used to solve problems in numerous domains of engineering and computer science. Different classifiers based on the optimization of the decision tree have been proposed, however, it is still evolving over time. This paper presents a novel and robust classifier based on a decision tree and tabu search algorithms, respectively. In the aim of improving performance, our proposed algorithm constructs multiple decision trees while employing a tabu search algorithm to consistently monitor the leaf and decision nodes in the corresponding decision trees. Additionally, the used tabu search algorithm is responsible to balance the entropy of the corresponding decision trees. For training the model, we used the clinical data of COVID-19 patients to predict whether a patient is suffering. The experimental results were obtained using our proposed classifier based on the built-in sci-kit learn library in Python. The extensive analysis for the performance comparison was presented using Big O and statistical analysis for conventional supervised machine learning algorithms. Moreover, the performance comparison to optimized state-of-the-art classifiers is also presented. The achieved accuracy of 98%, the required execution time of 55.6 ms and the area under receiver operating characteristic (AUROC) for proposed method of 0.95 reveals that the proposed classifier algorithm is convenient for large datasets.


Author(s):  
Charalambos Kyriakou ◽  
Symeon E. Christodoulou ◽  
Loukas Dimitriou

The paper presents a data-driven framework and related field studies on the use of supervised machine learning and smartphone technology for the spatial condition-assessment mapping of roadway pavement surface anomalies. The study explores the use of data, collected by sensors from a smartphone and a vehicle’s onboard diagnostic device while the vehicle is in movement, for the detection of roadway anomalies. The research proposes a low-cost and automated method to obtain up-to-date information on roadway pavement surface anomalies with the use of smartphone technology, artificial neural networks, robust regression analysis, and supervised machine learning algorithms for multiclass problems. The technology for the suggested system is readily available and accurate and can be utilized in pavement monitoring systems and geographical information system applications. Further, the proposed methodology has been field-tested, exhibiting accuracy levels higher than 90%, and it is currently expanded to include larger datasets and a bigger number of common roadway pavement surface defect types. The proposed system is of practical importance since it provides continuous information on roadway pavement surface conditions, which can be valuable for pavement engineers and public safety.


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