Pan-cancer survey and evaluation of the oncogenic role of NF-κB1
Abstract Although emerging cells or animals based evidence supports an association between nuclear factor kappa-B1 (NF-κB1) cells and cancers, there has no pan-cancer analysis. Therefore, based on TCGA (The Cancer Genome Atlas) and GEO (Gene Expression Omnibus) data sets, we first studied the potential carcinogenic effect of NF-κB1 in 33 tumors. As we not only found high expression of NF-κB1 in most tumors, but also found that NF-κB1 expression is closely related to the prognosis of tumor patients. Enhanced phosphorylation of S893 was observed in several tumors, such as breast cancer, uterine corpus endometrial carcinoma or lung adenocarcinoma. In thymoma, NF-κB1 expression was relevant to CD8+ T-cell infiltration levels, and tumor-associated fibroblast infiltration has also seen in other tumors, such as uterine corpus endometrial carcinoma or glioblastoma multiforme. In addition, the functional mechanism of NF-κB1 also involves the related functions of protein processing and RNA metabolism. In this study, NF-κB1 was pan-cancer study in order to have a systematic and comprehensive understanding of the carcinogenic effect of NF-κB1 in different tumors.