Mediating Effect of C-reactive Protein and Aspartate Aminotransferase on Diabetes Mellitus and Myocardial Infarction Risk

2020 ◽  
Author(s):  
Hui Zhao ◽  
Miao-miao Jiang ◽  
Sang Hu ◽  
Chang Su ◽  
Li Zhang ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Mediation Analysis ◽  
Mediating Effect ◽  
Total Effect ◽  
Mediation Effect ◽  
Risk Level ◽  
Mediation Model ◽  
Reactive Protein ◽  
Unit Increase ◽  
The Relationship

Abstract Background: The relationship between diabetes and myocardial infarction has always been the focus of research, but it is not clear whether the DM-MI association is direct or mediated by other factors. Our hypothesis is that part of the risk of MI in DM patients may be mediated by CRP and AST. We examined this hypothesis in the mediation analysis and tried to assess the extent to which CRP and AST could explain the MI risk caused by DM.Methods: This case-control study was conducted on 130 patients with MI and 130 patients with no-MI. We compared the relevant biochemical indicators of MI and no-MI patients, and applied mediation analysis to test the association of CRP and AST with DM-MI Potential adjustment effect.Results: The study found that individuals who suffered MI were more likely to have DM as compared with Non-MI (OR = 2.117, 95%CI = 1.130-4.195, P = 0.020), and CRP and AST are positively correlated with the occurrence of MI, For every unit increase in CRP and AST levels, the risk level of MI Significantly increased by 1%, 3.1% respectively. The direct effect of DM and MI is 0.847, the mediating effect of CRP is 7.69% of the total effect, and the mediating effect of AST is 52.79% of the total effect. The mediation effect of the CRP-AST path is 0.386, accounting for 12.36% of the total effect. In the mediation model we verified, CRP and AST play a part of the mediation effect between DM with MI, and the total mediation effect accounts for 72.84%.Conclusions: CRP and AST play an important role in the risk of DM-induced MI. This provides evidence for the mechanism and is of great significance for the exploration of therapeutic targets.

Mediation effect of C-reactive protein in the relationship between abdominal obesity and intermediate hyperglycemia in Kuwaiti adolescents

2020 ◽  
Vol 14 (15) ◽  
pp. 1427-1437
Author(s):  
Hend Alqaderi ◽  
Ebaa Al-Ozairi ◽  
Saadoun Bin-Hasan ◽  
Mary Tavares ◽  
Jo M Goodson ◽  
...  
Keyword(s):  
Abdominal Obesity ◽  
Fasting Blood Glucose ◽  
High Sensitivity ◽  
Mediating Effect ◽  
Mediation Effect ◽  
Multilevel Regression ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
The Relationship

Aim: This study aimed to investigate the mediating effect of C-reactive protein (CRP) on obesity and hyperglycemia. Materials & methods: Fasting blood glucose, high-sensitivity CRP (hs-CRP) levels and waist circumference (WC) were measured on 353 participants. Multilevel regression modeling and mediation analyses were used to investigate the link between abdominal obesity, hs-CRP and hyperglycemia. Results: Elevation in hs-CRP was predictive of hyperglycemia in nonobese individuals (OR = 1.3, p = 0.03). With every 1-mg/l increase in hs-CRP, there was a 1-cm increase in WC (B = 0.87, p = 0.001). hs-CRP was a full mediator in the relationship between WC and hyperglycemia. Conclusion: hs-CRP predicts hyperglycemia development in nonobese individuals and the effect of increased WC on hyperglycemia was fully mediated by hs-CRP.

Effect of Charitable Behavior on Life Satisfaction: a Parallel Multivariable Mediation Model

2019 ◽  
Vol 47 (3) ◽  
pp. 1-8 ◽  
Author(s):  
Jingjing Song ◽  
Chuanhua Gu ◽  
Bin Zuo
Keyword(s):  
Life Satisfaction ◽  
Positive Affect ◽  
Mediation Analysis ◽  
Mediating Effect ◽  
Mediation Model ◽  
Charitable Behavior ◽  
Self Acceptance ◽  
The Relationship

We aimed to determine how charitable behavior affects life satisfaction through the multiple mediating roles of self-acceptance and positive affect. We recruited 4,048 adults in China who voluntarily completed a survey on the frequency of their charitable behavior, self-acceptance, positive affect, and life satisfaction. Results of a parallel multivariable mediation analysis showed that more frequent charitable behavior was positively associated with greater life satisfaction. Also, self-acceptance and positive affect mediated the relationship between charitable behavior and life satisfaction. Implications for the mediating effect of charitable behavior on life satisfaction are discussed.

scholarly journals The Effect of Social Support on Athlete Burnout in Weightlifters: The Mediation Effect of Mental Toughness and Sports Motivation

2021 ◽  
Vol 12 ◽  
Author(s):  
Yao Shang ◽  
Shi-Yong Yang
Keyword(s):  
Social Support ◽  
Confidence Interval ◽  
Mediation Analysis ◽  
Athletic Performance ◽  
Mediating Effect ◽  
Mediation Effect ◽  
Mental Toughness ◽  
Athlete Burnout ◽  
Important Solution ◽  
The Relationship

Objectives: Athlete burnout is a crucial concern affecting the development and athletic performance of young weightlifters. To reduce or relieve the prevalence of athlete burnout, this study examined the relationship across social support, sports motivation, mental toughness, and athlete burnout in weightlifters.Methods: A total of 315 weightlifters aged 17–28 years old (151 males, 164 females; Mage = 18.89 years, SD = 3.66) from Sichuan, Chongqing, and Shanxi in China participated in this survey. The Perceived Available Support in Sport Questionnaire (PASS-Q), Sports Motivation Questionnaire (SMQ), Sports Mental Toughness Questionnaire (SMTQ), and Athlete Burnout Questionnaire (ABQ) were used in this study. SPSS Statistics 19.0, AMOS 21.0, and PROCESS 3.0 macro were used to analyze the collected data.Results: The results indicated that weightlifters’ social support could negatively significantly affect athlete burnout [beta = −0.398; 95% confidence interval (CI): −0.3699, −0.2184; P < 0.05) via mental toughness and sports motivation. The mediation analysis revealed that they had partial mediating effect, including three paths: First, social support had a direct effect on athlete burnout (beta = −0.150; 95% CI: −0.1824, −0.0397; P < 0.05); second, sport mental toughness had a mediating effect on athlete burnout (beta = −0.113; 95% CI: −0.1703, −0.0631; P < 0.05); and finally, sports motivation had a mediating effect on athlete burnout (beta = −0.124; 95% CI: −0.1751, −0.0793; P < 0.05).Conclusion: The findings revealed that social support could inhibit or prevent athlete burnout via mental toughness and sports motivation; thus, to decrease or relieve the prevalence of burnout in weightlifters, it is an important solution to enhance their social support.

scholarly journals Bachelor Status and the Sleep Quality Among Chinese Men: A Moderated Mediation Model

2021 ◽  
Vol 15 (3) ◽  
pp. 155798832110184
Author(s):  
Qian Liu ◽  
Yalin Zhu ◽  
Yaolin Pei
Keyword(s):  
Life Satisfaction ◽  
Sleep Quality ◽  
Mediating Effect ◽  
Mediation Effect ◽  
Poor Sleep ◽  
Mediation Model ◽  
Chinese Men ◽  
Value Of Children ◽  
The Relationship

Research has identified the status of being unmarried as a risk factor for poor sleep quality. Few studies have focused on the relationship between bachelor status and sleep quality. Moreover, little is known about the underlying mechanisms that may mediate or moderate this relationship. This study tested the mediating role of life satisfaction and moderating role of traditional value of children in the relationship between bachelor status and sleep quality among Chinese men. Data were derived from the 2018 wave of China Family Panel Studies (CFPS). The working sample included 12,102 Chinese men. The moderate mediation model was used to examine the mechanisms between bachelor status and sleep quality. Results showed that life satisfaction partially mediated the association between bachelor status and sleep quality. The mediating effect of life satisfaction was moderated by traditional value of children. Specially, the mediation effect was stronger for men with higher traditional value of children. The implications for future studies and practices are also discussed in this study.

scholarly journals Development of Structural Mediation Model of Innovative Strategy, Employees’ Job Performance and Technology for UAE Government Sector

2020 ◽  
Vol 11 (2) ◽  
Author(s):  
Mohamed Ahmed Darwish Abdulla Lari ◽  
◽  
Norhadilah Abdul Hamid ◽  
Darwish Ahmed Darwish Abdulla Lari ◽  
◽  
...  
Keyword(s):  
Job Performance ◽  
Simple Random Sampling ◽  
Mediating Effect ◽  
Mediation Effect ◽  
Mediation Model ◽  
Innovative Strategy ◽  
Government Sector ◽  
Innovation Strategies ◽  
The Government ◽  
The Relationship

This study established a relationship of innovations and employees’ job performance in the government sector and also the mediating effect of technology towards the relationship. It adopted quantitative approach where data was collected through questionnaires survey and analyzed statistically. The questionnaire survey utilized simple random sampling methods among UAE government employees. A total of 300 questionnaires were distributed randomly and 265 were returned indicates 88.3% response rate. The collected data was then used to develop and assess SEM-AMOS mediation model. The results found that all the direct relationships reported a positive effect. It also found that the innovation dimension constructs and technology mediating construct havingexplained 84% variation in employees’ job performance constructs. For indirect/mediation effect, it was found that technology does not show any mediation effect on the relationship between innovation and job performance constructs. This implies that technology does not mediate the relationship between innovation strategies and the employees’ job performance. It also implies that for an effective employees’ job performance core attention to building and managing an innovation approach is required in the UAE government sector. Thus, innovation strategies give more influence to employees’ job performance in the government sector through the distinctive capabilities of UAE ministry employees.

Structural Mediation Model of Information System and Sustainable Performance of UAE Manufacturing Sector

2020 ◽  
Vol 11 (2) ◽  
Author(s):  
Mohamed Ahmed Darwish Abdulla Larii ◽  
◽  
Fatma Ahmed Lari ◽  
Mohamed Ahmed Darwish Abdulla Lari ◽  
◽  
...  
Keyword(s):  
Information System ◽  
Manufacturing Sector ◽  
Organisational Culture ◽  
The Body ◽  
Mediating Effect ◽  
Operational Performance ◽  
Manufacturing Companies ◽  
Mediation Model ◽  
Sustainable Performance ◽  
The Relationship

This study intends to find out the mediating effect of organisational culture on the relationship between information system and sustainable performance of manufacturing sector in UAE. This study used AMOS-SEM software to develop mediation model that linking the mediating relationships between Information System, Organisational Culture and Sustainable operation Performance. Data was collected through questionnaire survey among the operation staff of Abu Dhabi manufacturing companies. A total 250 questionnaires were distributed however 205 were returned and only 200 are valid which indicates a response rate of 80%. The analysis found that TPS has positive but not significant effect to SP; OIS has positive but not significant effect to SP; FMW has a positive and significant effect on SP; SDS has a negative and not significant effect to SP and SP has positive but not significant effect OC. For the path relationship between the four exogenous variables (TPS, OIS, SDS, and FMW) and the mediator variable (OC), the results are TPS has positive and significant effect to OC; OIS has positive but not significant effect to OC; FMW has positive and significant effect to OC and SDS has positive and not significant effect to OC. Collectively, the five exogenous constructs (TPS, OIS, SDS, FMW and OC) explained 89% variation in operational performance and 86% of the variation in organisational culture. However, for a mediator, it was found that OC has no significant mediating effect on the relationship between TPS and SP; OC has no significant mediating effect on the relationship between OIS and SP; OC has no significant mediating effect on the relationship between SDS and SP and OC has no significant mediating effect on the relationship between FMW and SP. it can be concluded that there is a positive relationship between information system dimensions and operational performance. However organizational culture has no contributing any mediating effect to the relationship. These findings have contributed to the body of knowledge and could be shared among the UAE manufacturing practitioners.

scholarly journals Relationship between Competency to Consent to Treatment and Psychological Well-Being: Mediating Effect of Empowerment and Emotion

2021 ◽  
Vol 18 (15) ◽  
pp. 8170
Author(s):  
Yeun-Joo Hur ◽  
Joon-Ho Park ◽  
MinKyu Rhee
Keyword(s):  
Well Being ◽  
Treatment Evaluation ◽  
Mediating Effect ◽  
Mediation Effect ◽  
Psychiatric Outpatients ◽  
Psychological Well Being ◽  
Consent To Treatment ◽  
Study Participants ◽  
The Relationship

This study was conducted to evaluate the competency to consent to the treatment of psychiatric outpatients and to confirm the role of empowerment and emotional variables in the relationship between competency to consent to treatment and psychological well-being. The study participants consisted of 191 psychiatric outpatients who voluntarily consented to the study among psychiatric outpatients. As a result of competency to consent to treatment evaluation, the score of the psychiatric outpatient’s consent to treatment was higher than the cut-off point for both the overall and sub-factors, confirming that they were overall good. In addition, the effect of the ability of application on psychological well-being among competency to consent to treatment was verified using PROCESS Macro, and the double mediation effect using empowerment and emotional variables was verified to provide an expanded understanding of this. As a result of the analysis, empowerment completely mediated the relation between the ability of application and psychological well-being, and the relation between the ability of application and psychological well-being was sequentially mediated by empowerment and emotion-related variables. Based on these findings, the implications and limitations of this study were discussed.

De relatie tussen herstel, werkdruk en slaap: een dagboekstudie

2010 ◽  
Vol 23 (4) ◽  
Author(s):  
Alicia L.T. Walkowiak ◽  
Ute R. Hülsheger ◽  
Fred R.H. Zijlstra
Keyword(s):  
Sleep Quality ◽  
Positive Influence ◽  
Mediating Effect ◽  
Mediation Effect ◽  
Diary Study ◽  
Work Pressure ◽  
Negative Effect ◽  
The Relationship ◽  
High Work

The relationship between recovery, work pressure and sleep quality: A diary study The relationship between recovery, work pressure and sleep quality: A diary study Alicia L.T. Walkowiak, Ute R.Hülsheger & Fred R.H. Zijlstra, Gedrag & Organisatie, volume 23, December 2010, nr. 4, pp. 316-332. Previous research showed that the experience of high work pressure can lead to fatigue and even to health complaints on the long term. This makes it very important, especially for people who experience high work pressure, to take sufficient time to recover after work. Sleep quality has a positive influence on recovery. The aim of this diary study was to investigate whether sleep quality has a mediating effect on the relationship between work pressure and recovery. Seventy-six people took part in the study and answered questions about work, recovery and sleep for 14 days. Results showed that work pressure indeed had a negative effect on recovery and sleep quality. Furthermore, we found a partial mediation effect: sleep quality mediated the relationship between work pressure and recovery. These results stress the importance of recovery and sleep quality, especially for people who experience high work pressure.

Effects of perceived social isolation, fear of social isolation and gratitude during COVID-19 pandemic on anxiety in Malaysia (Preprint)

2021 ◽  
Author(s):  
Cher Yi Tan ◽  
Jia Yi Ng ◽  
Mei-Hua Lin ◽  
Min Hooi Yong
Keyword(s):  
Older Adults ◽  
Young Adults ◽  
Social Isolation ◽  
Indirect Effect ◽  
Moderating Effect ◽  
Mediating Effect ◽  
Mediation Effect ◽  
Mediation Model ◽  
Middle Aged ◽  
Perceived Social Isolation

BACKGROUND The COVID-19 pandemic compelled many countries including Malaysia to impose movement restrictions to curb spreading the virus. Evidence shows that prolonged isolation has negative effects on both physical and mental health. OBJECTIVE Our aims were to examine (1) the mediating effect of perceived social isolation (SI) and fear of social isolation (FSI) on the relationship between gratitude and anxiety, and (2) to explore the moderating effect of age, education and socioeconomic status on the mediation model. METHODS We collected data from 427 participants currently living in Malaysia during the movement restriction order (Mage = 37.90, SD = 16.51, 313 females) from an online survey containing questions pertaining to isolation and gratitude. RESULTS Our mediation analysis showed that gratitude has a positive effect on overcoming anxiety as it also lowers feelings of SI and FSI (B = -.229, β = .128, bootstrap SE = .049, 95% bootstrap CI = [-.332, -.138]). The moderated mediation analyses revealed the indirect effect of gratitude on anxiety through SI was significant for young adults (B = -.148, β = .083, 95% bootstrap CI [-.274, -.042]) and middle-aged (B = -.099, β = -.055, 95% bootstrap CI [-.177, -.033]) but not for older adults (B = -.026, β = -.015, 95% bootstrap CI [-.129, .047]). Results were similar for FSI in that it was significant for middle aged and not significant for older adults (all CIs does not include zero). However the mediation effect was not significant for young adults (B = -.020, β = -.011, 95% bootstrap CI [-.066, .016]). When we examined the moderating effect of education and SES in the parallel mediation model, results showed that the mediation effect of SI and FSI for those with lower levels of education was significant for all SES levels (all CIs did not contain zero). As for those with medium levels of education, the conditional indirect effect of SI and FSI was significant only for low and medium levels of SES but not for high SES. CONCLUSIONS Our findings highlight the importance of having some coping mechanism and social connection during the pandemic to have higher wellbeing and quality of life, especially for middle-aged sample and people from low education and SES background. CLINICALTRIAL None

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