scholarly journals Access to Systemic Anti-cancer Therapies for Women With Secondary Breast Cancer - Protocol for a Mixed Methods Systematic Review

2020 ◽  
Author(s):  
Sally Anne Pearson ◽  
Sally Taylor ◽  
Antonia Marsden ◽  
Janelle Yorke
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Mixed Methods ◽  
Data Extraction ◽  
Contextual Factors ◽  
Cancer Therapies ◽  
Factors Associated ◽  
Anti Cancer ◽  
Unwarranted Variation ◽  
Secondary Breast Cancer

Abstract Background:It is well recognised that access and receipt of appropriate guideline recommended treatment with systemic anti-cancer therapies for secondary breast cancer is a key determinant in overall survival. Where there is disparity in access this may result in unwarranted variation and disparity in outcomes. Individual, clinical and wider contextual factors have been associated with these disparities, however this remains poorly understood for women with secondary breast cancer. The purpose of the review is to address this gap by bringing together the available quantitative and qualitative evidence to examine factors associated with access to systemic anti-cancer therapies for women with secondary breast cancer and explore barriers and facilitators in relation to women and clinicians experience of access.Methods: A mixed methods approach with a segregated design will be used to examine and explore factors which influence access to systemic anti-cancer therapies for women with secondary breast cancer. Quantitative and qualitative appraisal, analysis and syntheses will be conducted discretely prior to final integration of findings. The review will use a comprehensive search strategy to search published and gray literature. Titles and abstracts will be screened against the eligibility criteria and full text articles will be retrieved for all records that meet the inclusion criteria. A data extraction tool will be developed, piloted and refined prior to full data extraction. Methodological quality and risk of bias will be assessed using the Mixed Methods Appraisal Tool. Discussion:Understanding individual, clinical and wider contextual factors associated with access and receipt of systemic anti-cancer therapies for secondary breast cancer is a complex phenomenon. These will be examined to determine any association with access. Review findings will be used to guide future research in this area and the development of an evidence-based service level intervention designed to address unwarranted variation in access based upon the Medical Research Council (MRC) approach to the development, implementation and evaluation of complex interventions.Systematic review registration:The review protocol has been registered in PROSPERO CRD42020196490

scholarly journals Access to systemic anti-cancer therapies for women with secondary breast cancer—protocol for a mixed methods systematic review

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Sally Anne Pearson ◽  
Sally Taylor ◽  
Antonia Marsden ◽  
Janelle Yorke
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Mixed Methods ◽  
Contextual Factors ◽  
Cochrane Library ◽  
Evidence Based ◽  
Cancer Therapies ◽  
Anti Cancer ◽  
Unwarranted Variation ◽  
Secondary Breast Cancer

Abstract Background It is well recognised that access and receipt of appropriate guideline recommended treatment with systemic anti-cancer therapies for secondary breast cancer is a key determinant in overall survival. Where there is disparity in access this may result in unwarranted variation and disparity in outcomes. Individual, clinical and wider contextual factors have been associated with these disparities, however this remains poorly understood for women with secondary breast cancer. The purpose of the review is to examine individual, clinical and contextual factors which influence access to evidence-based systemic anti-cancer therapies for women with secondary breast cancer. This will include barriers and facilitators for access and receipt of treatment and an exploration of women and clinicians experience and perspectives on access. Methods A mixed methods approach with a segregated design will be used to examine and explore factors which influence access to systemic anti-cancer therapies for women with secondary breast cancer. Electronic databases to be searched from January 2000 onwards will be EBSCO CINAHL Plus, Ovid MEDLINE, Ovid EMBASE, PsychINFO and the Cochrane Library and JBI database. This will include NHS Evidence which will be searched for unpublished studies and gray literature. Title and abstract citations and full-text articles will be screened by the author and second reviewer. Data will be extracted by the author and validated by the second reviewer. An overarching synthesis will be produced which brings together quantitative and qualitative findings. Methodological quality and risk of bias will be assessed using the Mixed Methods Appraisal Tool. Discussion Understanding individual, clinical and wider contextual factors associated with access and receipt of systemic anti-cancer therapies for secondary breast cancer is a complex phenomenon. These will be examined to determine any association with access. Review findings will be used to guide future research in this area and the development of an evidence-based service level intervention designed to address unwarranted variation in access based upon the Medical Research Council (MRC) approach to the development, implementation and evaluation of complex interventions. Systematic review registration The review protocol has been registered in PROSPERO CRD42020196490.

scholarly journals SOCIODEMOGRAPHIC AND GEOGRAPHICAL VARIATION IN ACCESS TO SYSTEMIC ANTI-CANCER THERAPIES FOR WOMEN WITH ADVANCED BREAST CANCER: A SYSTEMATIC REVIEW

The Breast ◽  
2021 ◽  
Vol 59 ◽  
pp. S40-S41
Author(s):  
Sally Anne Pearson ◽  
Sally Taylor ◽  
Antonia Marsden ◽  
Jessica Dalton O’Reilly ◽  
Sacha Howell ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Advanced Breast Cancer ◽  
Geographical Variation ◽  
Advanced Breast ◽  
Cancer Therapies ◽  
Anti Cancer

scholarly journals Factors associated with breast cancer screening participation among women in mainland China: a systematic review

BMJ Open ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. e028705 ◽  
Author(s):  
Zijing Wu ◽  
Yu Liu ◽  
Xiaohan Li ◽  
Bing Song ◽  
Cuiping Ni ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Cancer Screening ◽  
Breast Cancer Screening ◽  
Data Extraction ◽  
Mainland China ◽  
Breast Disease ◽  
Factors Associated ◽  
Screening Participation ◽  
Cancer Screening Participation

ObjectivesAlthough detecting breast cancer at an early stage through screening has been clearly shown to be an effective strategy, the screening participation rate in China remains low. This systematic review sought to synthesise the current evidence to identify factors associated with breast cancer screening participation among women in mainland China.DesignThis study was a systematic review.Data sourcesStudies were collected from PubMed, PsycINFO, CINAHL, EMBASE and three major Chinese databases, specially China National Knowledge Infrastructure, Chongqing VIP and Wanfang Data.Eligibility criteriaAll included papers were original research studies with a longitudinal or cross-sectional study design that considered associated factors of breast cancer screening participation among women in mainland China.Data extraction and synthesisStudy selection, data extraction and quality assessment were conducted independently by two reviewers, involving a third to help reach a consensus when necessary. Primary outcomes of interest included factors associated with breast cancer screening participation.ResultsA total of 19 studies were included in this review. Based on these studies, geographical region, a personal history of breast disease, past screening behaviours for breast disease, physical examination and the availability of medical specialists/equipment for breast examination were consistently associated with participation in breast cancer screening, while residential area, ethnicity and attitude towards breast cancer screening appeared to be associated with participation in breast cancer screening. There were additionally some factors with even more limited evidence with which to ascertain their association with screening participation.ConclusionsThere exists a wide range of factors that influence breast cancer screening participation in mainland China. These findings could help to inform future research and policy efforts.

The need for effective digital solutions to enhance adherence to oral anti-cancer medicines in adults: a systematic review of reviews (Preprint)

2021 ◽  
Author(s):  
Thu Ha Dang ◽  
Abdur Rahim Mohammad Forkan ◽  
Nilmini Wickramasinghe ◽  
Prem Prakash Jayaraman ◽  
Marliese Alexander ◽  
...  
Keyword(s):  
Systematic Review ◽  
Data Extraction ◽  
Critical Role ◽  
Future Research ◽  
Cancer Therapies ◽  
Seamless Integration ◽  
Study Selection ◽  
Adult Cancer Survivors ◽  
Anti Cancer ◽  
Adherence Interventions

BACKGROUND Adherence to anti-cancer medicines is critical for the success of cancer treatments, however, non-adherence is still challenging while evidence of adherence interventions in cancer is limited. OBJECTIVE This systematic review aimed to synthesise evidence of available reviews of interventions to improve adherence to oral anti-cancer medicines in adult cancer survivors. METHODS A comprehensive search was undertaken on seven electronic databases and three oncology journals. Two reviewers independently conducted study selection, quality assessment using AMSTAR 2, and data extraction of selected reviews. The PRISMA-2020 checklist was adapted to report results. RESULTS Twenty-eight reviews were included for a narrative synthesis. The overall quality of systematic reviews was low. Four main adherence-promoting strategies were education, reminder, behaviour and monitoring, and multi-component. Digital technology-based interventions were reported in most reviews (n=26). Few interventions applied theories (n=10), design frameworks (n=2), or engaged stakeholders (n=1) in the development processes. The effectiveness of interventions was inconsistent between and within reviews. However, interventions using multiple adherence-promoting strategies were more likely to be effective than single-strategy interventions (11 reviews). Unidirectional communication (7 reviews) and technology alone (11 reviews) were not sufficient to demonstrate improvement in adherence outcomes. Nurses and pharmacists play a critical role in promoting patients’ adherence to oral cancer therapies, especially with the support of digital technologies (6 reviews). CONCLUSIONS Multi-component interventions are potentially effective in promoting patients’ adherence to oral-anti cancer medicines. The seamless integration of digital solutions with direct clinical contacts is likely to be effective in promoting adherence. It is important for future research in developing comprehensive digital adherence interventions to be evidence-based, theory-based, and rigorously evaluated.

Conventional cardiac risk factors associated with trastuzumab-induced cardiotoxicity in breast cancer: Systematic review and meta-analysis

2021 ◽  
pp. 100723
Author(s):  
George Koulaouzidis ◽  
Amanda E. Yung ◽  
Diana E. Yung ◽  
Karolina Skonieczna-Żydecka ◽  
Wojciech Marlicz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Systematic Review ◽  
Meta Analysis ◽  
Cardiac Risk ◽  
Factors Associated ◽  
Cardiac Risk Factors

Prevascularized, Co-Culture Model for Breast Cancer Drug Development

2012 ◽  
Author(s):  
Lauren Marshall ◽  
Isabel Löwstedt ◽  
Paul Gatenholm ◽  
Joel Berry
Keyword(s):  
Breast Cancer ◽  
Drug Development ◽  
Three Dimensional ◽  
Human Tumor ◽  
3D Models ◽  
Cancer Drug ◽  
Cancer Therapies ◽  
Anti Cancer

The objective of this study was to create 3D engineered tissue models to accelerate identification of safe and efficacious breast cancer drug therapies. It is expected that this platform will dramatically reduce the time and costs associated with development and regulatory approval of anti-cancer therapies, currently a multi-billion dollar endeavor [1]. Existing two-dimensional (2D) in vitro and in vivo animal studies required for identification of effective cancer therapies account for much of the high costs of anti-cancer medications and health insurance premiums borne by patients, many of whom cannot afford it. An emerging paradigm in pharmaceutical drug development is the use of three-dimensional (3D) cell/biomaterial models that will accurately screen novel therapeutic compounds, repurpose existing compounds and terminate ineffective ones. In particular, identification of effective chemotherapies for breast cancer are anticipated to occur more quickly in 3D in vitro models than 2D in vitro environments and in vivo animal models, neither of which accurately mimic natural human tumor environments [2]. Moreover, these 3D models can be multi-cellular and designed with extracellular matrix (ECM) function and mechanical properties similar to that of natural in vivo cancer environments [3].

scholarly journals Terapia Física Descongestiva no tratamento do linfedema secundário ao câncer de mama: uma revisão sistemática / Decongestive Physical Therapy in the treatment of secondary breast cancer lymphedema: a systematic review

2020 ◽  
Vol 14 (53) ◽  
pp. 330-340
Author(s):  
Marilange Araújo de Almeida Souza ◽  
Aline Marques Piloto ◽  
Rosana Porto Cirqueira
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Physical Therapy ◽  
Cáncer De Mama ◽  
Secondary Breast Cancer ◽  
De Medicina

Resumo: O linfedema secundário é disfunção linfática crônica caraterizado como uma consequência do processo cirúrgico do câncer de mama que pode ser tratado por procedimento cirúrgico ou conservador. O objetivo foi realizar uma revisão sistemática da literatura sobre a utilização da terapia física descongestiva no tratamento do linfedema secundário e seus efeitos na redução do linfedema. Trata-se de uma revisão sistemática de literatura com artigos publicados nas bases de dados do Scientific Eletronic Library Online, Biblioteca Nacional de Medicina, Literatura Latino-Americana e Google Acadêmico, nos anos de 2010 a 2019. Foram selecionados 10 estudos que demonstraram efeitos positivos da terapia física descongestiva no tratamento do linfedema secundário e seus efeitos benefícios na redução do linfedema. A revisão sistemática comprovou os terapia física descongestiva é uma aliada no tratamento conservador do linfedema secundário de câncer de m

scholarly journals Factors Associated with Disease Severity and Mortality among Patients with Coronavirus Disease 2019: A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Vignesh Chidambaram ◽  
Nyan Lynn Tun ◽  
Waqas Haque ◽  
Marie Gilbert Majella ◽  
Ranjith Kumar Sivakumar ◽  
...  
Keyword(s):  
Systematic Review ◽  
Disease Severity ◽  
English Language ◽  
Clinical Decision Making ◽  
Clinical Laboratory ◽  
Data Extraction ◽  
Meta Analysis ◽  
Severe Disease ◽  
Factors Associated ◽  
Risk Of Mortality

Background: Understanding the factors associated with disease severity and mortality in Coronavirus disease (COVID19) is imperative to effectively triage patients. We performed a systematic review to determine the demographic, clinical, laboratory and radiological factors associated with severity and mortality in COVID-19. Methods: We searched PubMed, Embase and WHO database for English language articles from inception until May 8, 2020. We included Observational studies with direct comparison of clinical characteristics between a) patients who died and those who survived or b) patients with severe disease and those without severe disease. Data extraction and quality assessment were performed by two authors independently. Results: Among 15680 articles from the literature search, 109 articles were included in the analysis. The risk of mortality was higher in patients with increasing age, male gender (RR 1.45; 95%CI 1.23,1.71), dyspnea (RR 2.55; 95%CI 1.88,2.46), diabetes (RR 1.59; 95%CI 1.41,1.78), hypertension (RR 1.90; 95%CI 1.69,2.15). Congestive heart failure (OR 4.76; 95%CI 1.34,16.97), hilar lymphadenopathy (OR 8.34; 95%CI 2.57,27.08), bilateral lung involvement (OR 4.86; 95%CI 3.19,7.39) and reticular pattern (OR 5.54; 95%CI 1.24,24.67) were associated with severe disease. Clinically relevant cut-offs for leukocytosis(>10.0 x109/L), lymphopenia(< 1.1 x109/L), elevated C-reactive protein(>100mg/L), LDH(>250U/L) and D-dimer(>1mg/L) had higher odds of severe disease and greater risk of mortality. Conclusion: Knowledge of the factors associated of disease severity and mortality identified in our study may assist in clinical decision-making and critical-care resource allocation for patients with COVID-19.

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