Association Between Different Lipid Ratios and Diabetes in Chinese Adults With H-type Hypertension
Abstract Background: Previous studies have shown that lipid ratios [total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-C), atherogenic index of plasma (AIP, lg [triglyceride (TG)/HDL-C]), low-density lipoprotein cholesterol (LDL-C)/HDLC, non-HDL-C/HDL-C] were associated with the risk of diabetes in non-hypertension population. However, the relationship between different lipid ratios and diabetes is unclear in the H-type hypertension population. The purpose of this study is to investigate the relationship between lipid ratios and diabetes in Chinese adults with H- type hypertension.Methods: The current study included 13,581 H-type hypertension participants from the China hypertension registry study. Logistic regression analysis and smooth curve fitting were used to assess the association between different lipid ratios and diabetes.Results: Prevalence of diabetes was 17.8%. All lipid ratios (TC/HDL-C, AIP, LDL-C/HDL-C, and non-HDL-C/HDL-C) were positively and independently associated with diabetes. In the fully adjusted model, AIP manifested the largest ORs of diabetes (OR:2.84, 95%CI:2.37-3.41). However, the fully adjusted ORs (95%CI) of TC/HDL-C, LDL-C/HDL-C and non-HDL-C/HDL-C ratio was only 1.34 (1.27, 1.43), 1.40 (1.29, 1.51), 1.42 (1.35, 1.50), respectively. Comparing the area under receiver-operating characteristic curve (AUC), we found that AIP had the stronger ability to identify diabetes.Conclusions: all lipid ratios (TC/HDL-C, AIP, LDL-C/HDL-C, and non-HDL-C/HDL-C) were independently and positively correlated with the risk of diabetes in the Chinese population with H-type hypertension. Compared with other lipid ratios (TC/HDL-C, LDL-C/HDL-C, and non-HDL-C/HDL-C), AIP was superior in discriminating diabetes.