A Study on the Short-Term Mortality and Related Risk Factors of Fragile Hip Fracture

Abstract BackgroundThis study aimed to observe the mortality of patients with fragile hip fractures and assess the death-associated risk factors.MethodsSix hundred and ninety patients with osteoporotic hip fractures(aged 50-103-years-old) that were treated from January 2010 to December 2015 were enrolled in this study and followed-up and the clinical data were retrospectively examined. Three months, one year, and the total mortality during the follow-up time were measured. Mortality-related risk factors were assessed including age, gender, surgery, the duration from injury to operation, pulmonary infection, and the number and type of complications.ResultsThe 286 patients were followed up between 6 months and 42 months, with an average of 21.42±9.88 months. The three-month mortality was 7.69%, the number of patients who were followed up over one year was 231, the one-year mortality was 16.02%, and the total mortality of the follow-up time was 17.48%. The higher mortality was related to age over 75 years, associated cardio-respiratory diseases, male gender, non-operative treatment, surgery delayed over 5 days. Binary Logistic regression analysis showed that the independent risk factors affecting mortality included age (OR=5.385, P=0.003), surgery (OR=21.217, P=0.000), the number of complications (OR=9.038, P=0.000), and pre-injury cardiovascular disease (OR=3.201, P=0.041).ConclusionThe early mortality of fragile hip fractures was high and was also related to many risk factors. Age, surgery, the number of complications, and pre-injury cardiovascular disease were the independent risk factors affecting the mortality of patients with fragile hip fractures. Effective treatment without complications and early surgery can lower early mortality in patients with fragile hip fractures.

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Impact of Metabolic Syndrome on the Development of Cardiovascular Disease among Kazakhs in Remote Rural Areas of Xinjiang, China: A Cohort Study

10.21203/rs.3.rs-34700/v1 ◽

2020 ◽

Author(s):

Wenwen Yang ◽

Shuxia Guo ◽

Haixia Wang ◽

Yu Li ◽

Xianghui Zhang ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Metabolic Syndrome ◽

Rural Areas ◽

Cox Regression ◽

Baseline Survey ◽

Minority Populations ◽

Cox Regression Analysis ◽

Independent Risk Factors

Abstract Background: Metabolic syndrome (MS) could promote the development of cardiovascular disease(CVD). The aim of this study was to examine the association of MS and its components with CVD among Kazakhs in Xinjiang. Methods: According to the geographical distribution of the minority populations in Xinjiang, we selected the representative prefecture (Yili). A total of 2,644 participants completed the baseline survey between April 2010 and December 2012. The follow-up survey was conducted from April 2016 to December 2016. Only 2,286 out of 2,644 participants were followed-up on, with a follow-up rate of 86.46%. Cox regression was used to evaluate the association of each component and the number of combinations of MS components on the development of CVD. Results: Multivariate Cox regression analysis showed that blood pressure (BP), waist circumference (WC), and triglycerides (TG) were independently associated with CVD. Participants with 1–5 MS components had an increased hazard ratio for developing CVD, from 1.82 to 8.59 (trend P<0.001), compared with those without any MS components. This trend persisted after adjusting for other general risk factors. The risk of developing CVD increased when TG and WC coexisted, or when TG/WC and BP coexisted. However, no significant interactions were found between BP , WC , and TG. Conclusions: BP , WC, and TG were independent risk factors for CVD in Kazakhs. In clinical practice, a more informative assessment may be obtained by taking into account the number of MS components.

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Factors Affecting the Outcome of Multiple Intracranial Aneurysm Surgery

Indian Journal of Neurosurgery ◽

10.1055/s-0038-1668493 ◽

2018 ◽

Vol 07 (02) ◽

pp. 116-121 ◽

Cited By ~ 4

Author(s):

Anas Abdallah ◽

Murad Asiltürk ◽

Erhan Emel ◽

Betül Güler Abdallah

Keyword(s):

Risk Factors ◽

Surgical Outcomes ◽

Medical Records ◽

Core Sample ◽

Morbidity Rate ◽

Factors Affecting ◽

Unruptured Aneurysms ◽

History Of ◽

Independent Risk Factors

Abstract Objectives Multiple intracranial aneurysms (MIAs) are fairly common entities. Unless MIAs are incidentally diagnosed, they remain asymptomatic until they rupture. In this study, the authors investigated factors affecting the surgical outcomes in patients with MIA by evaluating the surgical outcomes of 90 consecutive cases. Material and Methods Medical records were retrospectively reviewed for 409 consecutive cerebral aneurysm cases that underwent surgery in the hospital from 2011 to 2013. The patients’ data were prospectively collected. All MIA patients (n = 90) constituted the core sample for this study. Results The authors detected 221 aneurysms in 90 patients (49 females and 41 males; mean age: 50.8 ± 11.9 years; range: 25–82 years). Of the patients, 67 presented with subarachnoid hemorrhage, whereas 23 were incidentally diagnosed with unruptured aneurysms. The mortality rate was 13.3% (n = 12). The morbidity rate was 18.8% (n = 17). Of the patients, 67.8% (n = 61) had returned to their jobs and normal daily activities by their last follow-up (average: 52.3 months). History of coronary artery diseases (CADs) and low neurologic grade at presentation (Hunt-Hess grade 4/5) are independent risk factors for increasing morbidity and mortality in patients with MIA (odds ratio [OR]: 18.46; p = 0.007); (OR: 30.0; p = 0.002) and (OR: 0.06; p = 0.0001); (OR: 0.07; p = 0.002), respectively. Conclusion History of CADs and high Hunt-Hess grade are independent risk factors for poor surgical outcomes of patients with MIA.

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Cardiovascular diseases and related risk factors accelerated cognitive deterioration in patients with late-life depression: a one-year prospective study

International Psychogeriatrics ◽

10.1017/s1041610218002041 ◽

2019 ◽

Vol 31 (10) ◽

pp. 1483-1489 ◽

Cited By ~ 1

Author(s):

Xiaomei Zhong ◽

Zhangying Wu ◽

Cong Ouyang ◽

Wanyuan Liang ◽

Ben Chen ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Diseases ◽

Late Life ◽

Reliable Change Index ◽

Cognitive Deterioration ◽

Late Life Depression ◽

Short Term ◽

Related Risk ◽

One Year

ABSTRACTObjectives:Cognitive impairment in late-life depression is common and associated with a higher risk of all-cause dementia. Late-life depression patients with comorbid cardiovascular diseases (CVDs) or related risk factors may experience higher risks of cognitive deterioration in the short term. We aim to investigate the effect of CVDs and their related risk factors on the cognitive function of patients with late-life depression.Methods:A total of 148 participants were recruited (67 individuals with late-life depression and 81 normal controls). The presence of hypertension, coronary heart disease, diabetes mellitus, or hyperlipidemia was defined as the presence of comorbid CVDs or related risk factors. Global cognitive functions were assessed at baseline and after a one-year follow-up by the Mini-Mental State Examination (MMSE). Global cognitive deterioration was defined by the reliable change index (RCI) of the MMSE.Results:Late-life depression patients with CVDs or related risk factors were associated with 6.8 times higher risk of global cognitive deterioration than those without any of these comorbidities at a one-year follow-up. This result remained robust after adjusting for age, gender, and changes in the Hamilton Depression Rating Scale (HAMD) scores.Conclusions:This study suggests that late-life depression patients with comorbid CVDs or their related risk factors showed a higher risk of cognitive deterioration in the short-term (one-year follow up). Given that CVDs and their related risk factors are currently modifiable, active treatment of these comorbidities may delay rapid cognitive deterioration in patients with late-life depression.

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Venous Thromboembolism (VTE) in Patients with Hematologic and Non-Hematologic Malignancies: Incidence and Risk Factors for Recurrent VTE

Blood ◽

10.1182/blood.v118.21.2303.2303 ◽

2011 ◽

Vol 118 (21) ◽

pp. 2303-2303

Author(s):

Saroj Vadhan-Raj ◽

Xiao Zhou ◽

Jatin J Shah ◽

Robert S Benjamin ◽

Gregory Gladish

Keyword(s):

Risk Factors ◽

Recurrent Events ◽

Conflicts Of Interest ◽

Hematologic Malignancies ◽

Cancer Center ◽

Index Event ◽

Independent Risk Factors ◽

Recurrent Vte ◽

One Year

Abstract Abstract 2303 The incidence of VTE and risk for recurrence is known to be higher in patients (pt) with malignancy than in other patients. However, the exact incidence and risk factors predictive of recurrent VTE in patients with hematologic malignancies (Hem) and solid tumors (ST) are not well defined. A retrospective study was conducted to evaluate the incidence of VTE and the recurrent events during one year period at MD Anderson Cancer Center. The medical records of all patients with VTE confirmed by the radiologic studies in 2006 were reviewed. The data were collected for the incidence and type of VTE, the recurrent events during a one year follow-up from the time of primary event, and the risk factors for recurrent events, including, the pt demographics, diagnosis, prior history of VTE, transfusions, use of erythropoiesis-stimulating agents, and the laboratory parameters at the time of the index VTE event. Cox proportional hazard models were established to determine the independent predictive factors for recurrent VTE. There were 24,806 unique patients (each patient counted once) in active treatment at the Cancer Center between January 2006 and December 2006. Of the 980 pts diagnosed with VTE (480 DVT, 477 PE, and 23 DVT/PE) during this period, there were 770 ST, 208 Hem, and 2 benign conditions. The incidence of VTE was higher in Hem pts than in ST pts [208/3603 (6%) vs. 770/20212 (4%), p<0.0001]. Among Hem pts, the incidence was significantly higher in myeloma as compared to lymphoma and leukemia (9%, 6%, and 4%, respectively, p<0.0001). The proportion of VTE pts with PE was significantly higher among ST pts compared with Hem pts (55% vs 37%, p<0.0001). The incidence of recurrent VTE, as defined by any new event or progression of the index event, was 14% (140/978 pts) during one year follow-up period, and it was not different for Hem (16%) vs. ST (14%). Among Hem pts, the recurrence was higher for myeloma (19%) than lymphoma (16%) and leukemia (13%). Majority of the recurrent events (100/140, 71%) were seen during the initial 3 month period from the index event. The independent risk factors for recurrent VTE during 3 months, 6 months and 1 year were summarized in the following table:3 months6 months1 yearRisk factorsHazard ratio (95% CI)PHazard ratio (95% CI)PHazard ratio (95%CI)PPE vs. non-PE1.86 (1.20–2.88)0.0051.67 (1.12–2.42)0.0061.74 (1.20–2.51)0.003Age (<60 vs. ≥60 years)2.05 (1.34–3.15)0.0011.55 (1.08–2.23)0.0171.62 (1.14–2.32)0.008Men vs. women1.70 (1.10–2.63)0.0181.44 (0.994–2.07)0.054PE, pulmonary embolism; CI, confidence interval. Conclusions: The incidence of VTE is higher in Hem pts, especially in myeloma. Younger age (<60 years) and PE are independent risk factors predictive of recurrence during 3 month, 6 month and 1 year period. Disclosures: No relevant conflicts of interest to declare.

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Incidence and Risk Factors for L5-S1 Complications After Long-level Floating Fusion in Adult Degenerative Scoliosis

10.21203/rs.3.rs-546988/v1 ◽

2021 ◽

Author(s):

Tinghua Jiang ◽

Yunzhong Cheng ◽

Yong Hai ◽

Xinuo Zhang ◽

Qingjun Su ◽

...

Keyword(s):

Risk Factors ◽

Sacral Slope ◽

Multivariate Logistic Regression ◽

Degenerative Scoliosis ◽

Instrumented Fusion ◽

Adult Degenerative Scoliosis ◽

Related Risk ◽

Potential Risk Factors ◽

Independent Risk Factors

Abstract Background Whether to preserve L5-S1 with no pre-existing pathology in the fusion for patients with adult degenerative scoliosis (ADS) remains controversial. This study is to determine the predictors of L5-S1 diseases for the distal fusion to L5 in the long instrumented fusion for ADS. Methods A total of 159 patients with ADS who had undergone long floating fusion were evaluated with a minimum 2 year follow-up between 2014 to 2018. The patient- and surgical-related risk factors for each individual were identified by using univariate testing. All patients were divided into groups with and without L5-S1 diseases. Univariate testing was used to identify the potential risk factors. Independent risk factors of L5-S1 diseases were identified using multivariate logistic regression. Results BMD of the patients with L5-S1 diseases were much higher than that without L5-S1 diseases (P = 0.003). Postoperative sacral slope in L5-S1 diseases group was much higher than that without L5-S1 diseases group (P = 0.000). Patient-related independent risk factors for the development of L5-S1 diseases included gender (OR = 0.41, P = 0.016) and BMD (OR = 0.42, P = 0.000). Surgical-related independent risk factors for the development of L5-S1 diseases included fusion level (OR = 2.64, P = 0.033) and postoperative sacral slope (OR = 1.43, P = 0.000).ConclusionsGender and BMD were the most common patient-related independent risk factors, Fusion levels and postoperative sacral slope were the most common surgical-related independent risk factors. Prevention of these risk factors can reduce the incidence of L5-S1 diseases in patients with long floating fusion.

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Analysis of the short-term prognosis and risk factors of elderly acute kidney injury patients in different KDIGO diagnostic windows

Aging Clinical and Experimental Research ◽

10.1007/s40520-019-01261-z ◽

2019 ◽

Vol 32 (5) ◽

pp. 851-860 ◽

Cited By ~ 1

Author(s):

Qinglin Li ◽

Zhi Mao ◽

Pan Hu ◽

Hongjun Kang ◽

Feihu Zhou

Keyword(s):

Risk Factors ◽

Diagnostic Criteria ◽

Kidney Injury ◽

Short Term ◽

Factors Affecting ◽

Kdigo Guidelines ◽

Diagnostic Window ◽

Independent Risk Factors ◽

Low Serum

Abstract Background and aims Follow-up observation was performed on elderly acute kidney injury (AKI) patients to analyze the short-term prognosis and risk factors of AKI patients in the 48-h diagnostic window and 7-day diagnostic window of the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines. Methods Inpatients aged ≥ 75 years in the geriatric ward of the People’s Liberation Army General Hospital, China, between January 2007 and December 2015 were selected as the research subjects. According to two diagnostic criteria in the KDIGO guidelines, patients were divided into a 48-h diagnostic window group and a 7-day diagnostic window group. The medical data of the patients were divided into the death group and the survival group for analysis based on the survival condition of the patients after 90 days of AKI. Factors that affected the 90-day survival of patients in the 48-h diagnostic window and 7-day diagnostic window groups were analyzed using multivariate Cox regression. Results During the follow-up period, a total of 652 patients were enrolled in this study. Among them, 623 cases were men, accounting for 95.6% of the patients. The median age was 87 (84–91) years. According to the KDIGO staging criteria, there were 308 (47.2%) cases in AKI stage 1, 164 (25.2%) cases in stage 2, and 180 (27.6%) cases in stage 3. Among the 652 patients, 334 (51.2%) were diagnosed with AKI based on the 48-h diagnostic criteria window, and 318 (48.8%) were diagnosed with AKI based on the baseline 7-day diagnostic criteria. The 90-day mortality of AKI patients was 42.5% in the 48-h diagnostic window and 24.2% in the 7-day diagnostic window. The multivariate Cox analysis results showed that low mean arterial pressure (HR = 0.966; P < 0.001), low serum prealbumin level (HR = 0.932; P < 0.001), infection (HR = 1.448; P = 0.047), mechanical ventilation (HR = 1.485; P = 0.038), high blood urea nitrogen (BUN) level (HR = 1.026; P < 0.001), blood magnesium level (HR = 2.560; P = 0.024), and more severe AKI stage (stage 2: HR = 3.482; P < 0.001 and stage 3: HR = 6.267; P < 0.001) were independent risk factors affecting the 90-day mortality of elderly patients in the 48-h diagnostic window, whereas low body mass index (HR = 0.851; P < 0.001), low mean arterial pressure (HR = 0.980; P = 0.036), low serum prealbumin level (HR = 0.950; P = 0.048), low serum albumin level (HR = 0.936; P = 0.015), high BUN level (HR = 1.046; P < 0.001), and more severe AKI stage (stage 2: HR = 4.249; P = 0.001 and stage 3: HR = 9.230; P < 0.001) were independent risk factors affecting the 90-day mortality of elderly patients in the 7-day diagnostic window. Conclusions The clinical differences of AKI and risk factors for 90-day mortality in elderly AKI individuals vary depending on the definition used. An increment of Scr ≥ 26.5 μmol/L in 48 h (48-h KDIGO window) alone predicts adverse clinical outcomes.

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Lifestyle-Related Risk Factors, Smoking Status and Cardiovascular Disease

High Blood Pressure & Cardiovascular Prevention ◽

10.2165/11632140-000000000-00000 ◽

2012 ◽

Vol 19 (2) ◽

pp. 85-92

Author(s):

Renata Giudice ◽

Raffaele Izzo ◽

Maria Virgina Manzi ◽

Giampiero Pagnano ◽

Mario Santoro ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Smoking Status ◽

Related Risk

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THU0254 Risk factors for back pain in a cross sectional and in a one-year follow up study in nurses

10.1136/annrheumdis-2001.798 ◽

2001 ◽

Author(s):

M Brzosko ◽

I Fiedorowicz-Fabrycy ◽

J Fliciñski ◽

H Przepiera-Bêdzak ◽

K Prajs

Keyword(s):

Risk Factors ◽

Back Pain ◽

Cross Sectional ◽

Follow Up Study ◽

One Year

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Coronary endarterectomy in coronary artery disease: Factors affecting graft patency and survival

Asian Cardiovascular and Thoracic Annals ◽

10.1177/02184923211006851 ◽

2021 ◽

pp. 021849232110068

Author(s):

Simon CY Chow ◽

Jacky YK Ho ◽

Micky WT Kwok ◽

Takuya Fujikawa ◽

Kevin Lim ◽

...

Keyword(s):

Myocardial Infarction ◽

Graft Patency ◽

Complete Revascularization ◽

Coronary Endarterectomy ◽

Factors Affecting ◽

Early Results ◽

Cerebrovascular Events ◽

Obtuse Marginal ◽

One Year

Background Coronary endarterectomy aims to improve completeness of revascularization in patients with occluded coronary vessels. The benefits of coronary endarterectomy remain uncertain. The aim of this study was to evaluate short-term surgical outcomes and factors affecting graft patency post-coronary endarterectomy. Methods Between 2009 and 2019, 81 consecutive patients who had coronary endarterectomy done were evaluated for their perioperative and early results. A total of 36 patients with follow-up coronary studies were included in patency analysis. Mortality rates, major adverse cardiac and cerebrovascular events, and graft patency were outcomes of interest. Survival and risk factor analysis were performed with Kaplan–Meier and logistic regression analysis. Results The average age of the cohort was 61.9 ± 9.29 years. Complete revascularization rate was 95.4% post-coronary endarterectomy. The 30-day and 1-year mortality was 2.5 and 6.2%, respectively. One-year major adverse cardiac and cerebrovascular events rate was 11.1%. Periprocedural myocardial infarction rate was 7.4%. Three patients required repeat revascularization within a mean follow-up duration of 49.6 ± 36.5 months. Overall graft patency was 89.2% at 20.2 months and graft patency post-coronary endarterectomy was 85.4%. Arterial grafts showed 100% patency. Vein grafts to endarterectomized obtuse marginal branch had patency rates of 33.3%. Multiple endarterectomies were associated with worse one-year major adverse cardiac and cerebrovascular events (OR: 28.6 ± 1.16; P = 0.003). Conclusions Coronary endarterectomy facilitates completeness of revascularization and does not increase early mortality. Graft patency post-coronary endarterectomy on obtuse marginal artery was suboptimal. Judicious use of coronary endarterectomy should be practiced to balance the need of completeness of revascularization against the risk of myocardial infarction.

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Nasal symptoms increase the risk of snoring and snoring increases the risk of nasal symptoms. A longitudinal population study

Sleep And Breathing ◽

10.1007/s11325-020-02287-8 ◽

2021 ◽

Author(s):

Maria Värendh ◽

Christer Janson ◽

Caroline Bengtsson ◽

Johan Hellgren ◽

Mathias Holm ◽

...

Keyword(s):

Risk Factors ◽

Respiratory Health ◽

Smoking Status ◽

Northern Europe ◽

Nasal Breathing ◽

Nasal Symptoms ◽

Increased Risk ◽

Study Population ◽

Independent Risk Factors

Abstract Purpose Humans have a preference for nasal breathing during sleep. This 10-year prospective study aimed to determine if nasal symptoms can predict snoring and also if snoring can predict development of nasal symptoms. The hypothesis proposed is that nasal symptoms affect the risk of snoring 10 years later, whereas snoring does not increase the risk of developing nasal symptoms. Methods In the cohort study, Respiratory Health in Northern Europe (RHINE), a random population from Denmark, Estonia, Iceland, Norway, and Sweden, born between 1945 and 1973, was investigated by postal questionnaires in 1999–2001 (RHINE II, baseline) and in 2010–2012 (RHINE III, follow-up). The study population consisted of the participants who had answered questions on nasal symptoms such as nasal obstruction, discharge, and sneezing, and also snoring both at baseline and at follow-up (n = 10,112). Results Nasal symptoms were frequent, reported by 48% of the entire population at baseline, with snoring reported by 24%. Nasal symptoms at baseline increased the risk of snoring at follow-up (adj. OR 1.38; 95% CI 1.22–1.58) after adjusting for age, sex, BMI change between baseline and follow-up, and smoking status. Snoring at baseline was associated with an increased risk of developing nasal symptoms at follow-up (adj. OR 1.22; 95% CI 1.02–1.47). Conclusion Nasal symptoms are independent risk factors for development of snoring 10 years later, and surprisingly, snoring is a risk factor for the development of nasal symptoms.

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