The Relationship Between Genetic Variants Associated with Premature Menopause and Lipid Profile in Women Recruited from MASHAD Cohort Study

Abstract Background and aim: Premature menopause (PM) is defined by the occurrence of the menopause before the age of 40 years. It is often associated with cardiovascular disease (CVD). The purpose of this study was to explore the relationship between PM-associated genotypes cardio metabolic disorder risk factors. Methods: One hundred seventeen women with PM and one hundred eighty-three healthy women without PM were recruited in this study. DNA was extracted and analyzed using ASO-PCR or Tetra ARMS-PCR. Lipid profiles were also assessed.Results: Multivariate logistic regression analysis showed that individuals with GG vs. TT genotype of the rs1046089 SNP were more likely to have high serum LDL risk (p = 0.03) compared to the control group. There was also a significant association between low serum HDL risk and rs2303369 and rs4806660 SNP genotypes in the PM group. In the PM group, the percentage of those with a high total cholesterol was lower in those with a CC genotype compared to those with a TT genotype (p = 0.03).Conclusion: Some SNPs reported to be associated with PM appear to be independently associated with dyslipidemia. These results may be helpful to identify subjects with PM who may be susceptible to CVD.

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The relationship between genetic variants associated with primary ovarian insufficiency and lipid profile in women recruited from MASHAD cohort study

BMC Women s Health ◽

10.1186/s12905-021-01550-8 ◽

2022 ◽

Vol 22 (1) ◽

Author(s):

Mohammad Reza Mirinezhad ◽

Hamideh Ghazizadeh ◽

Maliheh Aghsizadeh ◽

Mohammad Zamiri Bidary ◽

Alireza Naghipour ◽

...

Keyword(s):

Genetic Variants ◽

Multivariate Logistic Regression Analysis ◽

Primary Ovarian Insufficiency ◽

Control Group ◽

High Total Cholesterol ◽

Multivariate Logistic Regression ◽

Ovarian Insufficiency ◽

Cardiometabolic Disorder ◽

The Relationship ◽

Low Serum

Abstract Background and aim Primary Ovarian Insufficiency (POI) is defined by the occurrence of menopause before the age of 40 years. It is often associated with cardiovascular disease (CVD). The purpose of this study was to explore the relationship between POI-associated genotypes cardiometabolic disorder risk factors. Methods One hundred seventeen women with POI and one hundred eighty-three healthy women without POI were recruited in this study. DNA was extracted and analyzed using ASO-PCR or Tetra ARMS-PCR. Lipid profiles were also assessed. Results Multivariate logistic regression analysis showed that individuals with GG vs. TT genotype of the rs1046089 SNP were more likely to have a higher serum LDL (p = 0.03) compared to the control group. There was also a significant association between low serum HDL and rs2303369 and rs4806660 SNP genotypes in the POI group. In the POI group, the percentage of those with high total cholesterol was lower in those with a CC genotype compared to those with a TT genotype (p = 0.03). Conclusion Some SNPs reported to be associated with POI appear to be independently associated with dyslipidemia. These results may be helpful to identify subjects with POI who may be susceptible to CVD.

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Evaluation of the nature and etiologies of risk factors for diaphyseal atypical femoral fractures

Medical Principles and Practice ◽

10.1159/000517484 ◽

2021 ◽

Author(s):

Hiroyuki Tsuchie ◽

Naohisa Miyakoshi ◽

Yuji Kasukawa ◽

Koji Nozaka ◽

Kimio Saito ◽

...

Keyword(s):

Risk Factors ◽

Multivariate Analyses ◽

Femoral Fractures ◽

Japanese Patients ◽

High Serum ◽

Control Group ◽

Atypical Femoral Fractures ◽

Factors Affecting ◽

Lateral Curvature ◽

Low Serum

Objectives: Differences in the mechanisms of subtrochanteric and diaphyseal atypical femoral fractures (AFFs) have been speculated in studies that have analyzed differences in the patients’ backgrounds. However, the etiologies of each type of AFF have not been investigated in detail. Therefore, this study aimed to investigate the nature and etiologies of the risk factors for diaphyseal AFFs. Materials and Methods: Eighty consecutive Japanese patients with 91 diaphyseal AFFs (the AFF group) and 110 age-matched female patients with osteoporosis (the non-AFF control group) were included. Their clinical data were compared and the factors affecting AFFs were investigated. Furthermore, the etiologies of the risk factors for diaphyseal AFFs were examined. Results: Multivariate analysis revealed that femoral serrated changes, bisphosphonate or denosumab usage, and lateral and anterior femoral curvatures were the risk factors for diaphyseal AFFs (p<0.0011, p=0.0137, and p<0.0001, respectively). Multivariate analyses also revealed that serrated changes and low serum 25(OH)D levels affected the lateral curvature (p=0.0088 and 0.0205, respectively), while serrated changes affected the anterior curvature (p=0.0006); each significantly affected the femoral curvature. In addition, a high serum calcium (Ca) level, lateral femoral curvature, and anterior femoral curvature were the predictors of serrated changes (p=0.0146, 0.0002, and 0.0098, respectively). Conclusion: The risk factors for diaphyseal AFFs were bone resorption inhibitor usage, a strong femoral curvature, and serrated changes. A low serum 25(OH)D level and serrated changes are the risk factors for lateral curvature, while a high serum Ca level is a risk factor for serrated changes.

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P692Chemoradiation therapy to patients with lung cancer exacerbates thoracic aortic calcification

European Heart Journal ◽

10.1093/eurheartj/ehz747.0297 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

T Miki ◽

T Miyoshi ◽

K Ichikawa ◽

S Miyauchi ◽

J Soh ◽

...

Keyword(s):

Risk Factors ◽

Lung Cancer ◽

Cardiovascular Events ◽

Multivariate Logistic Regression Analysis ◽

Aortic Calcification ◽

Control Group ◽

Multivariate Logistic Regression ◽

Annual Percent Change ◽

Percent Change ◽

Thoracic Aortic Calcification

Abstract Introduction Development of chemoradiation therapy (CRT) has improved mortality in patients with cancer. Whereas, it is emerging problem that cancer-survivors suffer from cardiovascular diseases, and the association between modern CRT and the increase in future cardiovascular events is suggested. Meanwhile, previous studies showed that thoracic aortic calcification (TAC) detected by computed tomography (CT), a marker of atherosclerosis, was associated with all-cause mortality and cardiovascular events. However, the influence of CRT on TAC progression remains unclear. Purpose The purpose of this study was to evaluate whether CRT would exacerbate TAC. Methods A total of 68 patients who treated lung cancer at our hospital between 2011 and 2015 were retrospectively analyzed (mean 62 year-old, male 78%): 35 patients underwent surgical treatment after induction CRT (CRT group) and 33 patients underwent surgical treatment alone (control group), extracted by propensity score matching by age, sex, smoking status, and diseased side. The volume of TAC between 2nd and 12th thoracic vertebrae was quantitatively measured with CT imaging, at baseline and at 1 year follow-up. The annual percent change in TAC was compared between the CRT and the control group. Moreover, the independent relationship between implementation of CRT and the progression of TAC was assessed by multivariate logistic regression analysis, adjusting for age, gender, conventional atherosclerotic risk factors and baseline aortic calcification volume. Results Patients in the CRT group received radiation (mean 47.3±4.0 Gy) and chemotherapy: 2 courses of cisplatin with docetaxel (34 cases) or vinorelbine (1 case). The prevalence of dyslipidemia, taking statins and diabetes drugs were significantly higher in the control groups (17% vs. 39%; p=0.041, 11% vs. 33%; p=0.029, 3% vs. 18%; p=0.044, respectively). Baseline C-reactive protein level was significantly higher in the CRT group (0.255 vs. 0.115; p=0.034). In univariate analysis, the annual percent change in TAC volume was significantly increased in the CRT group compared with the control group (37.6% vs. 23.3%; p=0.006). Multivariate logistic regression analysis demonstrated that CRT was an independent factor associated with the progression of TAC volume, even after adjustment for baseline calcification volume and coronary risk factors (OR, 3.90; 95% CI, 1.32–11.47; p=0.014). Conclusion CRT to patients with lung cancer exacerbates thoracic aortic calcification, which may result in future cardiovascular events.

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Increased Overall Heart Rate Irregularity Risk by Hyperuricemia in the General Population: Results from the Korean National Health and Nutrition Examination Survey

Medicina ◽

10.3390/medicina56100501 ◽

2020 ◽

Vol 56 (10) ◽

pp. 501

Author(s):

Yeonghee Eun ◽

Kyung-Do Han ◽

Da Hye Kim ◽

In Young Kim ◽

Eun-Jung Park ◽

...

Keyword(s):

Risk Factors ◽

Heart Rate ◽

Representative Sample ◽

Multivariate Logistic Regression Analysis ◽

Nutrition Examination Survey ◽

Multivariate Logistic Regression ◽

Health And Nutrition ◽

Sample Data ◽

Highly Correlated ◽

The Relationship

Background and objectives: Hyperuricemia is one of the well-known cardiovascular risk factors. There is a growing interest in the association between hyperuricemia and arrhythmia. We used the representative sample data of Korean population to study the association between hyperuricemia and heart rate irregularity (HRI) that reflects total arrhythmia. Materials and Methods: We performed weighted multivariate logistic regression analysis to assess the association between hyperuricemia and HRI. Results: Of the 10,827 subjects, 1308 (13.2%) had hyperuricemia and 130 (1%) had HRI. In the presence of hyperuricemia, HRI was three times higher than that in the absence of hyperuricemia (OR 2.98, 95% CI 1.71–5.18). The risk of HRI was highest in subjects with both hypertension and hyperuricemia. In the subgroup analysis, the association of hyperuricemia with HRI was most pronounced in the smoker group. Conclusions: Hyperuricemia was highly correlated with HRI in adult Korean representative sample data. Hyperuricemia was associated with a nearly tripled risk for HRI. Hypertension has a synergistic effect with hyperuricemia on HRI. Further research is warranted to clarify the relationship between hyperuricemia and arrhythmia and its mechanism.

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Operative wound-related complications after cranial revascularization surgeries

Journal of Neurosurgery ◽

10.3171/2014.12.jns132602 ◽

2015 ◽

Vol 123 (5) ◽

pp. 1145-1150 ◽

Cited By ~ 21

Author(s):

Keisuke Takanari ◽

Yoshio Araki ◽

Sho Okamoto ◽

Hideyoshi Sato ◽

Shunjiro Yagi ◽

...

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Regression Analysis ◽

Blood Supply ◽

Operative Technique ◽

Multivariate Logistic Regression Analysis ◽

Wound Complication ◽

Wound Complications ◽

Multivariate Logistic Regression ◽

The Relationship

OBJECT Intracranial revascularization surgeries are an effective treatment for moyamoya disease and other intracranial vascular obliterative diseases. However, in some cases, wound-related complications develop after surgery. Although the incidence of wound complication is supposed to be higher than that with a usual craniotomy, this complication has rarely been the focus of studies in the literature that report the outcomes of revascularization surgeries. Here, the relationship between intracranial revascularization surgeries and their complications is statistically assessed. METHODS Between October 2004 and February 2010, 71 patients were treated using cerebral revascularization surgeries on 98 sides of the head. The relationship between wound complications and operative technique was retrospectively assessed. Multivariate logistic regression analysis was performed to identify the risk factors of wound complication, including operative technique, age, sex, diabetes mellitus (DM), hypertension, hyperlipidemia, and smoking history. RESULTS In total, there were 21 (21.4%) operative wound complications. Of these 21 complications, there were 14 (66.7%) minor complications and 7 (33.3%) major complications. No statistically significant relationship was found between wound complications and any surgical procedure. A trend toward severer complications was demonstrated for the procedures that used both STA branches (“double” procedures) in comparison with the procedures that used only 1 STA branch (“single” procedures, p = 0.016, Cochran-Armitage trend test). Multivariate logistic regression analysis also revealed that double procedures demonstrated a significantly higher incidence of wound complications than single procedures (OR 3.087, p = 0.048). DM was found to be a risk factor for wound complication (OR 9.42, p = 0.02), but age, sex, hypertension, and hyperlipidemia were not associated with the incidence of complications. Even though the blood supply to the scalp is abundant due to 5 arteriovenous systems, sometimes cutaneous necrosis develops after intracranial revascularization surgeries. The galeal blood supply is thought to be crucial for preventing wound-related complications. Special care is also thought to be required for DM patients. CONCLUSIONS Revascularization surgeries seemed to demonstrate a higher risk of wound-related complications. Double-type procedures, which use both branches of the STA, and a history of DM were found to be risk factors for wound-related complications. Attention should be paid to the design of the galeal incision and vessel harvest line. Also, special attention should be paid to patients with DM.

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Analysis of Risk Factors for Non-Union After Surgery for Limb Fractures: A Case-Control Study of 669 Subjects

10.21203/rs.3.rs-74785/v1 ◽

2020 ◽

Author(s):

Qiang Xu ◽

Bin Zhang ◽

Min Dai ◽

Xuqiang Liu

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Internal Fixation ◽

Weight Bearing ◽

Multivariate Logistic Regression Analysis ◽

Control Group ◽

Fracture Type ◽

Multivariate Logistic Regression ◽

Non Union ◽

Limb Fractures

Abstract Objective: Although a large number of clinical and animal experimental studies have explored factors affecting fracture healing, there are only a few examples of systematic research on these factors for limb fractures. The purpose of this study was to analyse the risk factors for limb fracture non-union in order to improve non-union prevention and early detection.Methods: A total of 223 patients with non-union after surgery for limb fractures performed at our institution from January 2005 to June 2017 were included as the case group, while a computer-generated random list was created to select 446 patients with successful bone healing who were treated during the same period as the control group, thus achieving a ratio of 1:2. The medical records of these patients were reviewed retrospectively. Age, sex, body mass index, obesity, smoking, alcohol, diabetes, hypertension, osteoporosis, fracture type, multiple fractures, non-steroidal anti-inflammatory drugs (NSAIDs) use, delayed weight bearing, internal fixation failure, and infection data were analysed and compared between the two groups. A multivariate logistic regression model was constructed to determine relevant factors associated with non-union.Results: The multivariate logistic regression analysis revealed that osteoporosis, open fractures, NSAIDs use, delayed weight bearing, failed internal fixation, and infection were independent risk factors for non-union after surgery for limb fractures.Conclusions: Osteoporosis, open fracture type, NSAIDs use, delayed weight bearing, failed internal fixation, and infection were found to be the main causes of bone non-union; clinicians should, therefore, take targeted measures to intervene in high-risk groups early.

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Gynecology Cancer in Relationship with Obesity

Indonesian Journal of Obstetrics and Gynecology ◽

10.32771/inajog.v4i1.68 ◽

2016 ◽

Author(s):

Gracia M R G Rauw ◽

Bismarck J Laihad ◽

Biran Affandi

Keyword(s):

Obstet Gynecol ◽

Case Control Study ◽

Multivariate Logistic Regression Analysis ◽

Normal Weight ◽

Control Group ◽

Multivariate Logistic Regression ◽

Obese Subjects ◽

Cancer Multiple ◽

The Relationship ◽

Control Study

Objective: To know the relationship between obesity and gynecology cancer. Method: This study use case control study design for 250 gynecology patients (125 controls and 125 cases) in Prof. Dr. R. D. Kandou Manado Hospital from 1 July to 30 November 2015. The data was collected by measuring Body Mass Index (BMI) and filing out selfadministered questioners. Result: From the 250 subjects, the study group (125 subjects), 72 subjects have obesity (57.6%) and 97 subjects have multiple parities (77.6%) with 58 subjects diagnosed with cervical cancer (46.4%). In the control group (125 subjects), 71 subjects have normal weight (56.8%) and 67 subjects have multiple parities (53.6%) with 64 subjects diagnosed with ovarium cysts (51.2%). Using multivariate logistic regression, the overweight and obese subjects have 7 folds higher risk to develop gynecology cancer compared to those with normal or underweight subjects. Those with multiple parities and grande multipara subjects have 3 folds higher risk to develop gynecology cancer compared with those who are nullipara and primipara. Conclusion: A significant correlation is found between obesity and gynecology cancer using multivariate logistic regression analysis (p=0.000, OR=6.9 (95% CI = 3.62-13.13). [Indones J Obstet Gynecol 2016; 1: 23-30] Keywords: gynecology cancer, multiple parities, obesity

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Prognostic Analysis and Risk Factors Associated with Fetal Ventriculomegaly

Pediatric Neurosurgery ◽

10.1159/000516378 ◽

2021 ◽

pp. 1-9

Author(s):

Qi-Ming Li ◽

Hong-Zhan Liao ◽

Wen-Bo Wang ◽

Shi-Yi Zeng ◽

Xian-Sheng Qiu ◽

...

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Multivariate Logistic Regression Analysis ◽

Control Group ◽

Width Ratio ◽

Case Group ◽

Multivariate Logistic Regression ◽

Prognostic Analysis ◽

Fetal Ventriculomegaly

Background: This study aimed to investigate the clinical outcome and related risk factors of fetal lateral ventriculomegaly (VM). Methods: A retrospective analysis was performed on 255 cases diagnosed as fetal VM. Prenatal imaging examination was carried out. The pregnancy outcomes were investigated through follow-up. According to the prognosis of children, they were divided into case group and control group. Multivariate logistic regression was used to analyze the factors influencing the prognosis of hydrocephalus. Results: After excluding the cases with either loss of follow-up or incomplete information, 102 cases were followed up. Twelve cases with poor prognosis were set as the case group. According to the maternal age, gestational age, gender of children, and follow-up time, 3 cases were selected from the other 90 cases for each child in the case group, respectively, and selected as the control group. Paired comparative analysis was performed on 48 cases. Using prognosis as a dependent variable, multivariate logistic regression analysis of the statistically significant factors indicated that the change speed of width ratio (CSWR) and maximum lateral ventricular width (MW) were associated with fetal prognosis. Conclusions: Our results suggested that CSWR and MW may have the value of predicting fetal prognosis.

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Mortality Rate and Predictors of Mortality in Hospitalized COVID-19 Patients with Diabetes

Healthcare ◽

10.3390/healthcare8030338 ◽

2020 ◽

Vol 8 (3) ◽

pp. 338

Author(s):

Dilaram Acharya ◽

Kwan Lee ◽

Dong Seok Lee ◽

Yun Sik Lee ◽

Seong-Su Moon

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Mortality Rate ◽

South Korea ◽

Multivariate Logistic Regression Analysis ◽

High Serum ◽

Multivariate Logistic Regression ◽

Risk Of Mortality ◽

Patients With Diabetes ◽

The Mean

Studies have confirmed COVID-19 patients with diabetes are at higher risk of mortality than their non-diabetic counterparts. However, data-driven evidence of factors associated with increased mortality risk among hospitalized COVID-19 patients with diabetes is scarce in South Korea. This study was conducted to determine the mortality rate and identify risk factors of mortality among hospitalized COVID-19 patients with type 2 diabetes in Gyeongsangbuk-do province, South Korea. In this hospital-based, cross-sectional study, we enrolled a total of 324 patients with confirmed COVID-19, hospitalized at two of the tertiary level healthcare facilitates of Gyeongsangbuk-do, South Korea from 18 February to 30 June 2020. Demographic and clinical data and laboratory profiles were analyzed and multivariate logistic regression analysis was used to identify risk factors of mortality among diabetic patients with COVID-19. Of the 324 patients, 55 (16.97%) had diabetes mellitus. The mean age of all study subjects was 55 years, and the mean age of those with diabetes was greater than that of those without (69.8 years vs. 51.9 years). Remarkably, the mortality rate was much higher among those with diabetes (20.0% vs. 4.8%). Multivariate logistic regression analysis revealed that an older age (≥70 years) and a high serum lactate dehydrogenase (LDH) levels significantly predicted mortality among hospitalized COVID-19 patients with diabetes. Our study cautions more attention to be paid to patients with diabetes mellitus hospitalized for COVID-19, especially those aged ≥ 70 years and those with a high serum LDH level, to reduce the risk of mortality.

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Risk Factors Associated With Failure of Initial Treatment for Cesarean Scar Pregnancy

10.21203/rs.3.rs-155477/v1 ◽

2021 ◽

Author(s):

Lili Cao ◽

Jinyu Yan ◽

Yibo Tang ◽

Nanyu Cao ◽

Lili Huang

Keyword(s):

Risk Factors ◽

Initial Treatment ◽

Multivariate Logistic Regression Analysis ◽

Control Group ◽

Failure Model ◽

Multivariate Logistic Regression ◽

Artery Embolization ◽

Cesarean Scar Pregnancy ◽

Factors Associated ◽

Gestational Sac

Abstract This study aimed to provide reference for CSP treatment. It’s a cohort study. Ultrasound-guided evacuation, hysteroscopy-guided evacuation and uterine artery embolization were used during the initial treatment. The treatment methods failed in 77 of the CSP patients (study group). 1560 of the CSP patients were treated successfully (control group). Multivariate logistic regression analysis found that in model 1, distance between gestational sac and serosal layer (OR: 0.04, 95%CI: 0.00–0.82, p= 0.037) and fetal heartbeat (OR: 8.91, 95%CI: 3.81–20.81, p= 0.000) are risk factors for CSP initial treatment failure. Model 2 showed that gestational age (OR: 0.96, 95%CI: 0.92–1.00, p= 0.043) and fetal heartbeat (OR: 2.15, 95%CI: 1.02–4.52, p= 0.000) are the risk factors. Model 3 indicated that mean sac diameter (OR: 1.56, 95%CI: 1.21–2.01, p= 0.001), fetal heartbeat (OR: 4.75, 95%CI: 2.23–10.14, p= 0.000) and pretreated with UAE (OR: 5.05, 95%CI: 2.36–10.83, p= 0.000) are risk factors. In model 4, fetal heartbeat (OR: 2.87, 95%CI: 1.28–6.42, p= 0.010) and pretreated with UAE (OR: 4.24, 95%CI: 1.98–9.07, p= 0.000) are the risk factors. In conclusion, for CSP patients with different treatment, if the relevant risk factors exist, it should be more cautious.

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