scholarly journals Gynecology Cancer in Relationship with Obesity

2016 ◽  
Author(s):  
Gracia M R G Rauw ◽  
Bismarck J Laihad ◽  
Biran Affandi
Keyword(s):  
Obstet Gynecol ◽  
Case Control Study ◽  
Multivariate Logistic Regression Analysis ◽  
Normal Weight ◽  
Control Group ◽  
Multivariate Logistic Regression ◽  
Obese Subjects ◽  
Cancer Multiple ◽  
The Relationship ◽  
Control Study

Objective: To know the relationship between obesity and gynecology cancer. Method: This study use case control study design for 250 gynecology patients (125 controls and 125 cases) in Prof. Dr. R. D. Kandou Manado Hospital from 1 July to 30 November 2015. The data was collected by measuring Body Mass Index (BMI) and filing out selfadministered questioners. Result: From the 250 subjects, the study group (125 subjects), 72 subjects have obesity (57.6%) and 97 subjects have multiple parities (77.6%) with 58 subjects diagnosed with cervical cancer (46.4%). In the control group (125 subjects), 71 subjects have normal weight (56.8%) and 67 subjects have multiple parities (53.6%) with 64 subjects diagnosed with ovarium cysts (51.2%). Using multivariate logistic regression, the overweight and obese subjects have 7 folds higher risk to develop gynecology cancer compared to those with normal or underweight subjects. Those with multiple parities and grande multipara subjects have 3 folds higher risk to develop gynecology cancer compared with those who are nullipara and primipara. Conclusion: A significant correlation is found between obesity and gynecology cancer using multivariate logistic regression analysis (p=0.000, OR=6.9 (95% CI = 3.62-13.13). [Indones J Obstet Gynecol 2016; 1: 23-30] Keywords: gynecology cancer, multiple parities, obesity

scholarly journals Some risk factors for hypertension in the United Arab Emirates

2004 ◽  
Vol 10 (4-5) ◽  
pp. 610-619
Author(s):  
S. Sabri ◽  
A. Bener ◽  
V. Eapen ◽  
M. S. O. Abu Zeid ◽  
A. M. Al Mazrouei ◽  
...  
Keyword(s):  
Physical Activity ◽  
United Arab Emirates ◽  
Low Income ◽  
Case Control Study ◽  
Multivariate Logistic Regression Analysis ◽  
Multivariate Logistic Regression ◽  
Al Ain ◽  
History Of ◽  
The Relationship ◽  
Control Study

A case-control study evaluated the relationship between hypertension and socioeconomic and lifestyle factors in Al-Ain city. The survey included 426 hypertensive adults aged 20-65 years attending urban and semi-urban clinics and a randomly selected sample of 436 normotensive controls. Hypertension among cases was higher for men, age 40-49 years, non-UAE nationals, urban living, currently married, having children, illiterate, administrative/professional job, living in traditional house and low income. There were significant differences between cases and controls with regard to obesity, raised cholesterol level, low physical activity and family history of heart disease, kidney disease or diabetes. Multivariate logistic regression analysis revealed that obesity, medium/high income, history of diabetes, low physical activity and having 3+ children were significantly associated with hypertension

scholarly journals Erosive Esophagitis in the Obese: The Effect of Ethnicity and Gender on Its Association

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Albin Abraham ◽  
Seth Lipka ◽  
Rabab Hajar ◽  
Bhuma Krishnamachari ◽  
Ravi Virdi ◽  
...  
Keyword(s):  
Erosive Esophagitis ◽  
Multivariate Logistic Regression Analysis ◽  
Normal Weight ◽  
Morbidly Obese ◽  
Multivariate Logistic Regression ◽  
Black Patients ◽  
Obese Subjects ◽  
Race Ethnicity ◽  
And Gender ◽  
Ethnicity And Gender

Background.Data examining the association between obesity and erosive esophagitis (ErE) have been inconsistent, with very little known about interracial variation.Goals.To examine the association between obesity and ErE among patients of different ethnic/racial backgrounds.Methods.The study sample included 2251 patients who underwent esophagogastroduodenoscopy (EGD). The effects of body mass index (BMI) on ErE were assessed by gender and in different ethnic groups. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariate logistic regression analysis.Results.The prevalence of ErE was 29.4% (661/2251). Overweight and obese subjects were significantly more likely to have ErE than individuals with a normal BMI, with the highest risk seen in the morbidly obese (OR 6.26; 95% CI 3.82–10.28;p<0.0001). Normal weight Black patients were less likely to have ErE as compared to Caucasians (OR 0.46; 95% CI 0.27–0.79;p=0.005), while the odds ratio comparing normal weight Hispanics to normal weight Whites was not statistically significant. No effect modification was seen between BMI and race/ethnicity or BMI and gender. Significant trends were seen in each gender and ethnicity.Conclusions.The effect of BMI on ErE does not appear to vary by race/ethnicity or gender.

scholarly journals Siesta and Risk for Ischemic Stroke: Results from a Case-Control Study

Medicina ◽  
2020 ◽  
Vol 56 (5) ◽  
pp. 222
Author(s):  
Yousef Mohammad
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Ischemic Stroke ◽  
Protective Effect ◽  
Case Control Study ◽  
Multivariate Logistic Regression Analysis ◽  
Case Control ◽  
Multivariate Logistic Regression ◽  
Neurology Clinic ◽  
Control Study

Background and objectives: Siesta, which is a short afternoon nap, is a habit that is commonly practiced in the Mediterranean and tropical areas. Data on the association between siesta and coronary artery disease has been conflicting. A protective effect has been demonstrated in the countries that commonly practice siesta, but a harmful effect has been observed in the countries that infrequently practice the siesta habit. Information on the association between siesta and ischemic stroke has been, however, lacking. Hence, the purpose of our study was to determine the effect of siesta on ischemic stroke. Materials and Methods: This was a case-control study, conducted on the patients with acute ischemic stroke who came for their first follow-up visit to the neurology clinic. Controls were randomly selected from the patients visiting the neurology clinic on the same day as the patients with ischemic stroke. In addition to basic demographics and the occurrence of established stroke risk factors, information about siesta practice was also collected from both groups. A multivariate logistic regression analysis was utilized to determine the relationship between siesta practice and ischemic stroke. Results: A total of 206 patients were recruited from the neurology clinic of King Khalid university hospital; of which only 194 subjects were included in the analysis (98 ischemic stroke cases and 96 controls). The mean age of the participants was 59.68 ± 13.75 years and 98 (50.52%) were male. Interestingly, 43% of the whole study cohort practiced regular siesta. However, when compared to the stroke population, the control group practiced siesta more frequently (30% vs. 56%). In a multivariate logistic regression analysis, hypertension, diabetes mellitus, excess body weight (body mass index > 25 kg/m2) and dyslipidemia were found to increase the risk of ischemic stroke (OR 2.12, 95% CI: 1.02–4.66, p = 0.005; OR 2.72, 95% CI: 1.94–4.88, p = 0.014; OR 2.94, 95% CI: 1.5164–5.7121 p = 0.0014; OR 3.27, 95% CI: 2.42–5.199, p ≤ 0.001, respectively). On the contrary, the practice of regular siesta lowered the risk of ischemic stroke (OR 0.58, 95% CI: 0.3551–0.9526, p = 0.031). Conclusions: Siesta was associated with a reduced risk for the occurrence of ischemic stroke. Large prospective longitudinal studies should be conducted to verify the protective effect of siesta on stroke.

Lumbar Posterior Muscle and Local Kyphosis in Patients with Degenerative Thoracolumbar Kyphosis: A Case-Control Study

2020 ◽  
Author(s):  
Shuai Xu ◽  
Chen Guo ◽  
Yan Liang ◽  
Zhenqi Zhu ◽  
Haiying Liu
Keyword(s):  
Normal Weight ◽  
Overweight And Obesity ◽  
Control Group ◽  
Thoracolumbar Kyphosis ◽  
Local Kyphosis ◽  
The Mean ◽  
Whole Spine ◽  
The Relationship ◽  
T2 Mri ◽  
Control Study

Abstract Purpose: To explore the relationship between thoracolumbar kyphosis (TLK), body mass index (BMI) and the content of lumbar posterior muscles in patients with degenerative thoracolumbar kyphosis (DTLK) combined with lumbar stenosis syndrome (LSS).Methods: 126 patients with DTLK and LSS (DTLK group) and 87 patients with simple LSS (control group) were retrospectively included with well-matched demographics. TLK and lumbar lordosis (LL) were obtained on the X-ray of the whole spine. Lumbar crossing indentation value (LCIV) was introduced to evaluate the content of the lumbar muscles, with was measured from T12-L1 to L4-L5 at T2-MRI axial imaging. Three subgroups of normal weight, overweight and obesity were respectively divided into in both groups according to BMI. Three subgroups of increased LL, normal LL normal and decreased LL were also divided into in DTLK group.Results: The mean LCIV (mLCIV) of the DTLK group was less than control group and LCIV showed an increasing trend in DTLK group from T12-L1 to L4-L5. Different from control group, there were no significances in gender and BMI distribution of mLCIV in DTLK group (P>0.05). LCIV in increased LL subgroup was larger than that of normal LL and less LL subgroup (P<0.01). There were no relationship between TLK and BMI in both groups. BMI was positively correlated with mLCIV in control group(P=0.004). TLK and LCIV were negatively correlated (P<0.001) in DTLK group with LCIV=13.75-0.48×TLK.Conclusion: LCIV in DTLK group was less than control group with no gender- and BMI-difference. LCIV and TLK were mutually predictable in DTLK with LCIV=13.75-0.48×TLK.

scholarly journals Analyzing the Relationship between Cohort and Case-Control Study Results Based on Model for Multiple Pathogenic Factors

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Hui Liu
Keyword(s):  
Cohort Study ◽  
Cohort Studies ◽  
Case Control Study ◽  
Case Control ◽  
Control Group ◽  
Case Control Studies ◽  
Definite Relationship ◽  
Study Results ◽  
The Relationship ◽  
Control Study

Objective. Although the relative risk from a prospective cohort study is numerically approximate to the odds ratio from a case-control study for a low-probability event, a definite relationship between case-control and cohort studies cannot be confirmed. In this study, we established a different model to determine the relationship between case-control and cohort studies. Methods. Two analysis models (the cross-sectional model and multiple pathogenic factor model) were established. Incidences in both the exposure group and the nonexposure group in a cohort study were compared with the frequency of the observed factor in each group (diseased and nondiseased) in a case-control study. Results. The relationship between the results of a case-control study and a cohort study is as follows: Pe=Pd∗m/Pc∗1−m+Pd∗m; Pn=m∗1−Pd/1−Pc∗1−m−Pd∗m, where Pe and Pn represent the incidence in the exposed group and nonexposed group, respectively, from the cohort study, while Pd and Pc represent the observed frequencies in the disease group and the control group, respectively, for the case-control study; finally, m represents the incidence in the total population. Conclusions. There is a definite relationship between the results of case-control and cohort studies assessing the same exposure. The outcomes of case-control studies can be translated into cohort study data.

scholarly journals What is the relationship between obesity and new circadian rhythm parameters in Turkish children and adolescents? A case-control study

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Mehmet Karadag ◽  
Gulay Can Yilmaz
Keyword(s):  
Circadian Rhythm ◽  
Children And Adolescents ◽  
Sleep Duration ◽  
Case Control Study ◽  
Case Control ◽  
Normal Weight ◽  
Turkish Children ◽  
Social Jetlag ◽  
The Relationship ◽  
Control Study

Abstract Background Although the relationship between circadian rhythm parameters and obesity in children and adolescents is recognized, there are few studies on this topic. The concept of sleep-corrected social jetlag (SJLsc) has been formulated recently, but its relationship with childhood obesity has not yet been established. Therefore, we thought that SJL might play an important role in the etiology of obesity. Accordingly, we aimed to compare circadian rhythm parameters between obese and normal-weight children and adolescents. Methods Seventy-nine obese and eighty-two normal-weight children and adolescents aged between 8 and 17 years participated in this case-control study, which took place in the Mardin province of Turkey. Data were collected with a sociodemographic information form, the Childhood Chronotype Questionnaire, and anthropometric measurements. Results The average ages of the obese participants and controls were 12.3 ± 2.3 and 12.4 ± 2.2 years, respectively. Obese young people had greater evening preference, longer sleep debt duration, SJL duration and SJLsc duration, and higher Morningness–Eveningness Scale (MeScale) scores; and shorter mean sleep duration (p<0.005). In regression analyses, BMI z scores were significantly correlated with all circadian rhythm parameters, except SJLsc duration, while WC z scores were significantly correlated with all circadian rhythm parameters, except mean sleep duration. After adjustment, the high MeScale scores (OR: 1.142, p<0.05) and the presence of psychiatric disorder in the mother (OR: 15.075, p<0.05) were associated with obesity. Conclusions Circadian rhythm parameters can play an important role in the etiology of obesity. Future studies with larger samples and fewer confounding factors are needed to clarify the etiological factors.

scholarly journals The lower methylation of RANK is associated with osteoporosis in male aged general population of Xinjiang: A Case-Control Study

2020 ◽  
Author(s):  
Junjing Shang ◽  
Hong xiang ◽  
Xue Bai ◽  
Buluhan Halan ◽  
Hongmei Wang
Keyword(s):  
Blood Pressure ◽  
General Population ◽  
Case Control Study ◽  
Statistical Significance ◽  
Multivariate Logistic Regression Analysis ◽  
Case Control ◽  
Control Group ◽  
Case Group ◽  
Methylation Rate ◽  
Control Study

Abstract Background RANK is a candidate gene for osteoporosis on both functional and genetic grounds. The study is to investigate the relationships between the methylation of RANK and osteoporosis in aged general population. Methods On the basis of an epidemiological investigation, we detect for methylation CpGs in promoter of RANK in 32 aged subjects (16 males and 16 females) firstly. Secondly, after considering the relationships among osteoporosis and the methylation rate of identified CpGs in male and female subjects, the selected representatives CpGs were detected in 90 male aged general subjects (43 controls and 47 cases) by bisulfite sequencing. Then a case-control study is conducted. Results Age and the prevalence of diabetes were significantly difference between the case patients and control individuals (P = 0. 025, P = 0. 005)., There was no statistical significance between the case group and the control group for the following values: systolic blood pressure, diastolic blood pressure, body mass index, 25-dihydroxyvitaminD3, folic acid, testosterone, creatinine, serum calcium concentration, and the prevalence of smoking, drinking and hypertension (P > 0.05). The methylation rate of RANK in control group was significant higher than that in osteoporosis group (P < 0.001). In addition, by covariance analysis to adjust age, prevalence of smoking, drinking, hypertension, and diabetes, the methylation rate of RANK in control group was significant higher than that in osteoporosis group in male aged general population of Xinjiang (P = 0.001). After adjusting for confounding factors (age, smoking, drinking, and diabetes), multivariate logistic regression analysis also showed that lower methylation of RNAK gene were significantly associated with osteoporosis (OR = 0.930, 95% CI = 0.886–0.976) Conclusions The lower methylation rate of RANK was associated with osteoporosis in male aged general population of Xinjiang. This confirms that lower methylation of RANK might be involved in the pathogenesis of osteoporosis

scholarly journals Association between Serum Adiponectin and Atrial Fibrillation: A Case-Control Study Stratified by Age and Gender

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Tongjian Zhu ◽  
Zhuo Wang ◽  
Songyun Wang ◽  
Wei Hu ◽  
Hui Chen ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Regression Analysis ◽  
Case Control Study ◽  
Multivariate Logistic Regression Analysis ◽  
Case Control ◽  
Serum Adiponectin ◽  
Multivariate Logistic Regression ◽  
Age And Gender ◽  
And Gender ◽  
Control Study

Background. Circulating adiponectin has been suggested to be associated with atrial fibrillation (AF). However, whether the association differs by age and gender remains unknown. We performed a case-control study to evaluate the above association. Methods. AF patients who underwent 24-hour long-range 12-channel electrocardiogram examination at our center were included in this study, and people with normal sinus rhythm (NSR) were included as controls. All participants underwent echocardiography and heart rate variability tests. Biochemical parameters and adiponectin levels were also evaluated. Receiver operating characteristic (ROC) analyses were used to determine the predictive efficacy of adiponectin for AF, and multivariate logistic regression analysis was performed to evaluate the potential independent predictors of AF. Results. Overall, 84 patients with AF and 84 people with NSR were included. Serum adiponectin was significantly higher in AF patients compared to that in controls ( P < 0.001 ). ROC analysis showed that higher serum adiponectin (>6.098 μg/mL) had predictive efficacy for AF, with an area under the curve of 0.660 (95% confidence interval [CI]: 577–0.742). The results of multivariate logistic regression analysis showed that higher adiponectin was an independent predictor of AF in the overall participants (odds ratio [OR] 1.224, 95% CI 1.018–1.471, P = 0.032 ). Subgroup analysis showed that higher adiponectin was independently associated with AF in women (OR 1.893, 95% CI 1.160–3.089, P = 0.011 ) and in patients aged < 65 years (OR 1.453, 95% CI 1.023–2.064, P = 0.037 ), but not in men or those aged ≥ 65 years. Conclusions. Higher serum adiponectin level was independently associated with higher odds for AF in women and in participants <65 years old, but not in men or those aged ≥65 years.

scholarly journals The relationship between genetic variants associated with primary ovarian insufficiency and lipid profile in women recruited from MASHAD cohort study

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Mohammad Reza Mirinezhad ◽  
Hamideh Ghazizadeh ◽  
Maliheh Aghsizadeh ◽  
Mohammad Zamiri Bidary ◽  
Alireza Naghipour ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Multivariate Logistic Regression Analysis ◽  
Primary Ovarian Insufficiency ◽  
Control Group ◽  
High Total Cholesterol ◽  
Multivariate Logistic Regression ◽  
Ovarian Insufficiency ◽  
Cardiometabolic Disorder ◽  
The Relationship ◽  
Low Serum

Abstract Background and aim Primary Ovarian Insufficiency (POI) is defined by the occurrence of menopause before the age of 40 years. It is often associated with cardiovascular disease (CVD). The purpose of this study was to explore the relationship between POI-associated genotypes cardiometabolic disorder risk factors. Methods One hundred seventeen women with POI and one hundred eighty-three healthy women without POI were recruited in this study. DNA was extracted and analyzed using ASO-PCR or Tetra ARMS-PCR. Lipid profiles were also assessed. Results Multivariate logistic regression analysis showed that individuals with GG vs. TT genotype of the rs1046089 SNP were more likely to have a higher serum LDL (p = 0.03) compared to the control group. There was also a significant association between low serum HDL and rs2303369 and rs4806660 SNP genotypes in the POI group. In the POI group, the percentage of those with high total cholesterol was lower in those with a CC genotype compared to those with a TT genotype (p = 0.03). Conclusion Some SNPs reported to be associated with POI appear to be independently associated with dyslipidemia. These results may be helpful to identify subjects with POI who may be susceptible to CVD.

Determining the incidence and risk factors of congenital hypothyroidism based on the specifications of infants in Shadegan city in the period of 2006-2014: a case-control study

2021 ◽  
Vol 15 (5) ◽  
pp. 1641-1646
Author(s):  
Ehsan Keshavarzian ◽  
Yousef Khalifpour ◽  
Narges Biranvand
Keyword(s):  
Congenital Hypothyroidism ◽  
Case Control Study ◽  
Newborn Infants ◽  
Case Control ◽  
Thyroid Stimulating Hormone ◽  
Consanguineous Marriage ◽  
Control Group ◽  
Khuzestan Province ◽  
The Relationship ◽  
Control Study

Introduction: Congenital Hypothyroidism (CHT) is a condition in which the thyroid stimulating hormone (TSH) is equal to or more than 10 MU/L and the thyroxine hormone (T4) is less than 6.5 M/L. CHT is one of the most important preventable causes of mental retardation in infants. The present study aimed to determine the incidence of CHT and the associated factors. Method: At first, a descriptive research was done to examine the incidence of CHT in the period of 2006-2014 in Shadegan city, Khuzestan province. Then, a case-reference and a case-control study was done to investigate the relationship between CHT and demographic characteristics, environmental factors and medical factors. The cases in this study were neonates with CHT (transient and permanent). The results showed that the venous TSH score for these neonates was equal to or higher than 10 MU/L and their T4 level was lower than 6.5 MU/L. The subjects in the control group were infants that did not suffer from CHT whose venous TSH and T4 scores were lower than 10 MU/L and higher than 6.5 MU/L, respectively. The relationship between the aforementioned factors with the illness was determined using multiple logistic regression statistical model. The SPSS 18 software was used to analyze the findings of this research. Findings: In this study, the incidences of neonatal CHT in Shadegan were 17, 21.5 and 12.59 per thousand newborn infants in 2012, 2013 and 2014, respectively. Conclusion: The parents' record of consanguineous marriage increases the likelihood of developing CHT; therefore, couples that wish to marry have to be educated and made aware in marriage counseling centers, both in the field of consanguineous marriage and CHT. Keywords: incidence, screening, transient, permanent, congenital hypothyroidism

Sign in / Sign up

Export Citation Format

Share Document