scholarly journals Research on the Correlation Between Activating Transcription Factor 3 Expression in the Human Coronary Artery and Atherosclerotic Plaque Stability

2021 ◽  
Author(s):  
J. Peng ◽  
C. Y. Le ◽  
B. Xia ◽  
J. W. Wang ◽  
J. J. Liu ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Coronary Artery ◽  
Necrotic Core ◽  
Inflammatory Factors ◽  
Lesion Group ◽  
Control Group ◽  
Atherosclerotic Plaques ◽  
Activating Transcription Factor 3 ◽  
Fibrous Cap ◽  
Activating Transcription Factor

Abstract Background: Activating transcription factor 3 (ATF3) is an early response gene that is activated in response to atherosclerotic stimulation and may be an important factor in inhibiting the progression of atherosclerosis. In this study, we directly measured the expression of ATF3 and inflammatory factors in human coronary atherosclerotic plaques to examine the relationship between ATF3 expression, inflammation and structural stability in human coronary atherosclerotic plaques. Methods: A total of 68 coronary artery specimens were collected from the autopsy group, including 36 cases of sudden death from coronary heart disease (SCD group) and 32 cases of acute death caused by mechanical injury with coronary atherosclerosis (CHD group). Twenty-two patients who had no coronary heart disease were collected as the control group (CON group). Haematoxylin-eosin staining was used to observe changes in arterial structure. Western blotting and immunohistochemistry were used to measure the expression and distribution of ATF3, Full list of author information is available at the end of the article-2-inflammatory factors and matrix metalloproteinase-9 (MMP-9) and vascular cell adhesion molecule 1 (VCAM1) in the coronary artery. The Pearson correlation coefficient was used to analyse the correlation between ATF3 protein expression and inflammatory factors and between ATF3 protein expression and structure-related indexes in the lesion group. Results: Compared with those in the control group, the intima and necrotic core in the coronary artery were thickened, the fibrous cap became thin and the degree of vascular stenosis was increased in the lesion group, while the intima and necrotic core became thicker and the fibrous cap became thinner in the SCD group than in the CHD group (P < 0.05). There was no or low expression of ATF3, inflammatory factors, VCAM1 and MMP-9 in the control group, and the expression of inflammatory factors, VCAM1 and MMP-9 in the SCD group was higher than that in CHD group, while the expression of ATF3 in the SCD group was significantly lower than that in CHD group (P < 0.05). In the lesion group, the expression of ATF3 was negatively correlated with intimal and necrotic focus thickness, positively correlated with fibrous cap thickness (P < 0.01), and negatively correlated with inflammatory factors, VCAM1 and MMP-9 (P < 0.01). Conclusions: The expression of ATF3 may be related to the progression and stability of atherosclerotic plaques, and may affect the structural stability of atherosclerotic plaques by regulating the inflammatory response, thus participating in the regulation of atherosclerotic progression.

scholarly journals Research on the correlation between activating transcription factor 3 expression in the human coronary artery and atherosclerotic plaque stability

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
J. Peng ◽  
C. Y. Le ◽  
B. Xia ◽  
J. W. Wang ◽  
J. J. Liu ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Necrotic Core ◽  
Inflammatory Factors ◽  
Lesion Group ◽  
Control Group ◽  
Atherosclerotic Plaques ◽  
Activating Transcription Factor 3 ◽  
Fibrous Cap ◽  
Fibrous Cap Thickness ◽  
Activating Transcription Factor

Abstract Background Activating transcription factor 3 (ATF3) is an early response gene that is activated in response to atherosclerotic stimulation and may be an important factor in inhibiting the progression of atherosclerosis. In this study, we directly measured the expression of ATF3 and inflammatory factors in human coronary atherosclerotic plaques to examine the relationship between ATF3 expression, inflammation and structural stability in human coronary atherosclerotic plaques. Methods A total of 68 coronary artery specimens were collected from the autopsy group, including 36 cases of sudden death from coronary heart disease (SCD group) and 32 cases of acute death caused by mechanical injury with coronary atherosclerosis (CHD group). Twenty-two patients who had no coronary heart disease were collected as the control group (Con group). The histological structure of the coronary artery was observed under a light microscope after routine HE staining, and the intimal and lesion thicknesses, thickness of the fibrous cap, thickness of necrosis core, degree of lumen stenosis were assessed by image analysis software. Western blotting and immunohistochemistry were used to measure the expression and distribution of ATF3, inflammatory factors (CD45, IL-1β, TNF-α) and matrix metalloproteinase-9 (MMP-9) and vascular cell adhesion molecule 1 (VCAM1) in the coronary artery. The Pearson correlation coefficient was used to analyse the correlation between ATF3 protein expression and inflammatory factors and between ATF3 protein expression and structure-related indexes in the lesion group. Results Compared with those in the control group, the intima and necrotic core in the coronary artery were thickened, the fibrous cap became thin and the degree of vascular stenosis was increased in the lesion group, while the intima and necrotic core became thicker and the fibrous cap became thinner in the SCD group than in the CHD group (P < 0.05). There was no or low expression of ATF3, inflammatory factors, VCAM1 and MMP-9 in the control group, and the expression of inflammatory factors, VCAM1 and MMP-9 in the SCD group was higher than that in CHD group, while the expression of ATF3 in the SCD group was significantly lower than that in CHD group (P < 0.05). In the lesion group, the expression of ATF3 was negatively correlated with intimal and necrotic focus thickness, positively correlated with fibrous cap thickness (P < 0.01), and negatively correlated with inflammatory factors, VCAM1 and MMP-9 (P < 0.01). Conclusions The expression of ATF3 may be related to the progression and stability of atherosclerotic plaques, and may affect the structural stability of atherosclerotic plaques by regulating the inflammatory response, thus participating in the regulation of atherosclerotic progression.

scholarly journals Aspirin Resistance as a Result of Impaired Interaction of Platelets and Neutrophils in Patients with Coronary Heart Disease

2021 ◽  
Vol 17 (1) ◽  
pp. 16-22
Author(s):  
M. D. Goncharov ◽  
A. A. Savchenko ◽  
Yu. I. Grinshtein ◽  
I. I. Gvozdev ◽  
A. A. Kosinova ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Artery ◽  
Superoxide Radical ◽  
Maximum Intensity ◽  
Control Group ◽  
Platelet Activity ◽  
Before And After ◽  
Artery Disease ◽  
The Relationship

Aim. To study the relationship between the levels of synthesis of reactive oxygen species (ROS) by platelets and neutrophils in patients with coronary heart disease (CHD) before and after coronary artery bypass grafting (CABG), depending on sensitivity to acetylsalicylic acid (ASA).Material and methods. The study included 95 patients with coronary artery disease who are indicated for CABG surgery. The control group consisted of 30 healthy donors. The antiplatelet therapy was stopped for at least 5 days before CABG. In the postoperative period, from the first day, all patients were received 100 mg of an enteric form of acetylsalicylic acid (ASA). Resistance to ASA was determined at the level of platelet aggregation with arachidonic acid ≥20% by optical agregometry at least at one observation point: before CABG, on 1-3 day and on 8-10 day after surgery. We evaluated the spontaneous and induced lucigenin-dependent chemiluminescence (CL) of platelets (ADP induction) and neutrophils (zymosan induction) by the exit time to maximum intensity (Tmax), maximum intensity (Imax) and area (S) under the CL curve.Results. 70.5% sensitive (sASA) and 29.5% resistant (rASA) to ASA patients were revealed. Prior to CABG, in sASA patients, the Imax of spontaneous and zymosan-induced neutrophil CL and CL platelet activity was increased relative to control values. Tmax of spontaneous platelet CL, Imax and S under the ADP-induced platelet CL curve were lower in sASA patients, if to compare with rASA patients. On the 1st and 8-10th day after CABG in sASA patients, the CL indicators of neutrophil and platelet activity also remained elevated compared to control values. On the 1st day after CABG decreased levels of S under the spontaneous CL curve of neutrophils in rASA patients was established compared with sASA patients, and increased levels of Imax and S under the curve of induced neutrophil CL were detected in comparison with the control range. In rASA patients, the values of Tmax of spontaneous platelet CL decreased in relation to the values detected in the control group and sASA patients. On the 8–10th day after CABG, most indicators of spontaneous and zymosan-induced CL neutrophils in rASA patients were also increased compared to control values. In rASA patients a positive correlation of Imax-induced CL was found (r=0.83) on the 1st day after CABG and negative correlations of Tmax of spontaneous CL (r=- 0.75) and S under the curve induced CL (r=-0.70) on the 8-10th day were detected between platelets and neutrophils.Conclusion. In sASA patients with coronary heart disease before and after CABG, a high level of synthesis of superoxide radical by neutrophils and platelets was detected. The relationship between the levels of the synthesis of superoxide radical by neutrophils and platelets was found only after CABG in rASA patients. Increased synthesis of superoxide radical due to metabolic and regulatory relationships in neutrophils and platelets stimulates pro-inflammatory processes in coronary artery disease and determines the sensitivity of platelets to ASA.

scholarly journals Intelligent Algorithm-Based Multislice Spiral Computed Tomography to Diagnose Coronary Heart Disease

2022 ◽  
Vol 2022 ◽  
pp. 1-10
Author(s):  
Shaowen Tan ◽  
Zili Xu
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Artery ◽  
Expectation Maximization ◽  
Spiral Ct ◽  
Ct Images ◽  
Control Group ◽  
Observation Group ◽  
Research Subjects ◽  
Number Of Iterations

In this study, dictionary learning and expectation maximization reconstruction (DLEM) was combined to denoise 64-slice spiral CT images, and results of coronary angiography (CAG) were used as standard to evaluate its clinical value in diagnosing coronary artery diseases. 120 patients with coronary heart disease (CHD) confirmed by CAG examination were retrospectively selected as the research subjects. According to the random number table method, the patients were divided into two groups: the control group was diagnosed by conventional 64-slice spiral CT images, and the observation group was diagnosed by 64-slice spiral CT images based on the DLEM algorithm, with 60 cases in both groups. With CAG examination results as the standard, the diagnostic effects of the two CT examination methods were compared. The results showed that when the number of iterations of maximum likelihood expectation maximization (MLEM) algorithm reached 50, the root mean square error (RMSE) and peak signal to noise ratio (PSNR) values were similar to the results obtained by the DLEM algorithm under a number of iterations of 10 when the RMSE and PSNR values were 18.9121 dB and 74.9911 dB, respectively. In the observation group, 28.33% (17/60) images were of grade 4 or above before processing; after processing, it was 70% (42/60), significantly higher than the proportion of high image quality before processing. The overall diagnostic consistency, sensitivity, specificity, and accuracy (88.33%, 86.67%, 80%, and 85%) of the observation group were better than those in the control group (60.46%, 62.5%, 58.33%, and 61.66%). In conclusion, the DLEM algorithm has good denoising effect on 64-slice spiral CT images, which significantly improves the accuracy in the diagnosis of coronary artery stenosis and has good clinical diagnostic value and is worth promoting.

scholarly journals Tianeptine Reduces Mechanical Allodynia in Spinal Nerve-ligated and Chemotherapyinduced Neuropathic Mice

2017 ◽  
Vol 4 (20;4) ◽  
pp. E593-E600
Author(s):  
Hue Jung Park
Keyword(s):  
Transcription Factor ◽  
Mechanical Allodynia ◽  
Tricyclic Antidepressants ◽  
Spinal Nerve ◽  
Control Group ◽  
Activating Transcription Factor 3 ◽  
Mechanical Stimuli ◽  
Activating Transcription Factor ◽  
Trial Setting ◽  
Transcription Factor 3

Background: Spinal nerve-ligated neuropathy and chemotherapy-induced neuropathy produce a persistent tactile allodynia in mice. Tianeptine is an antidepressant that exhibits structural similarities to tricyclic antidepressants but has distinct neurochemical properties. Objective: Here we examined the effects of intraperitoneal (i.p.) tianeptine on allodynia in spinal nerve-ligated and chemotherapy-induced neuropathic mice. Study Design: A randomized, experimental trial. Setting: Laboratory animal study. Methods: Spinal nerve-ligated neuropathy was induced in a Chung model made by ligating the L5 spinal nerve. Chemotherapy-induced neuropathy was induced by injecting vincristine (0.1 mg/kg/day; i.p.) on the following schedule: 5 days on, 2 days off, for14 days. Tianeptine (10, 30, and 50 mg/kg) and saline were administered, respectively, to both groups of neuropathic mice (n = 5 for each group). We evaluated mechanical allodynia using von Frey hairs prior to drug injections and at 30, 60, 90, 120, 180, and 240 minutes, and 24 hours after injections. We also measured the changes in activate transcription factor 3 (ATF3) level in the dorsal root ganglion (DRG) in each group in order to understand the analgesic mechanism of tianeptine. Results: Both spinal nerve-ligated and chemotherapy-induced neuropathic mice showed prominent allodynia. The control group showed no differences in mechanically induced allodynia compared to the experimental groups. For the tianeptine groups, paw-withdrawal thresholds in response to mechanical stimuli were significantly lower than the pre-administration values and values from the control group (P < 0.05). The increase in DRG ATF3 in neuropathic mice was reduced by tianeptine (P < 0.05). Limitations: Less is known about the transcription factors that affect inflammation signaling. Conclusions: Tianeptine administered i.p. reduces mechanical allodynia in spinal nerveligated and chemotherapy-induced neuropathic mice models. These effects were confirmed by attenuation of previously increased DRG ATF3. Key words: Tianeptine, spinal-nerve ligation, chemotherapy-induced neuropathic, activating transcription factor 3

Myocardial bridge analysis by multidetector computed tomography and its association with coronary atherosclerosis

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Mohamed Ismail Ahmed Abd El Ati Mousa ◽  
Yasser Gomaa Mohamed ◽  
Ahmed Mohamed Onsy
Keyword(s):  
Coronary Artery ◽  
Coronary Angiography ◽  
Atherosclerotic Plaque ◽  
Significant Risk ◽  
Atherosclerotic Lesion ◽  
Lesion Group ◽  
Atherosclerotic Plaques ◽  
Myocardial Bridge ◽  
Group A ◽  
Group B

Abstract Background Myocardial Bridging an inborn coronary abnormality, is defined as a segment of a major epicardial coronary artery, the tunneled artery, that goes intramurally through the myocardium beneath the muscle bridge. Objective To evaluate noninvasively the presence and distribution of atherosclerotic plaques in relation to myocardial bridge coronary segments and to determine the prevalence of myocardial bridges and their location and morphology by using MDCT. Patients and Methods The study population consisted of 55 patients presented with chest pain, referred for MDCT coronary angiography and found to have myocardial bridge at during the period from April 2018 and August 2019. 23 patients was found having Myocardial Bridge and coronary artery atherosclerotic plaques included in Group (A), 29 persons found having Myocardial Bridge without CAD included in Group (B). All patients were subjected to detailed history taking, clinical evaluation, ECG analysis and MSCT coronary angiography. Results In the present study, patients with atherosclerotic plaque (group A) (n = 29), mean age was 52.41 ± 10.55 years ranged from 35.0 to 73.0 years, 41.4% were males, while in Myocardial bridge without atherosclerotic lesion group (group B) (n = 26), mean age was 51.65 ± 7.58 ranged from 38.0 to 65.0 years., 30.8% were males. Conclusion Our study showed that diabetes mellitus and dyslipidemia are a significant risk factor for developing atherosclerotic plaque in the segment proximal to myocardial bridge. Myocardial bridge were usually located over the Mid segment of the left anterior descending coronary artery

Distribution Patterns of Uric Acid in Coronary Artery Disease

1967 ◽  
Vol 13 (2) ◽  
pp. 132-141 ◽  
Author(s):  
Morris London ◽  
Mary Hums
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Heart Disease ◽  
Uric Acid ◽  
Coronary Artery ◽  
Distribution Patterns ◽  
Normal Subjects ◽  
Acute Stage ◽  
Control Group ◽  
Male Patients ◽  
Artery Disease

Abstract The uric acid levels in each of 335 cardiac patients were studied over a period of more than 3 months from the onset of the acute stage of coronary heart disease. Comparison was made with uric acid values obtained from a group of 316 normal subjects. Male patients with arteriosclerotic coronary artery disease with infarction generally exhibited rising concentrations of serum uric acid during the first weeks after an attack and a gradual return toward normal levels after 3 months. Female patients of the two groups studied and male patients with arteriosclerotic coronary artery disease, but without infarction, had uric acid levels averaging much higher than those of the control group.

scholarly journals The relationship between arterial stiffness index and coronary heart disease and its severity

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Longjian Gao ◽  
Dasheng Lu ◽  
Guangwei Xia ◽  
Hao Zhang
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Artery ◽  
Arterial Stiffness ◽  
Roc Analysis ◽  
Stiffness Index ◽  
Control Group ◽  
Disease Group ◽  
Vessel Disease ◽  
Arterial Stiffness Index

Abstract Background Arterial stiffness index (ASI) is closely related to coronary atherosclerosis. This study aims to explore whether ASI can predict coronary heart disease (CHD) and its severity. Methods In this study, a total of 726 patients with suspected CHD were recruited. Based on coronary angiography results, the subjects were assigned into three groups: the control group (without obvious coronary artery disease), single-vessel disease group, and multi-vessel disease group (the number of vessels diseased ≥ 2). At the same time, according to the results of angiography, myocardial enzyme spectrum, electrocardiogram, color Doppler echocardiography and clinical manifestations, these patients were divided into four groups: the control group, stable angina (SA) Group, unstable angina (UA) group, and acute myocardial infarction (AMI) group. We have compared whether there were differences in ASI and related baseline data between groups. Receiver operating curve (ROC) analysis was conducted to determine whether ASI could predict CHD and evaluate the severity. Results ASI was positively correlated with the number of diseased branches of coronary artery. The value of ASI was increased as the number of the diseased branches increased. The ASI value in the SA group was significantly higher compared with the control group. Furthermore, the ASI value in the UA and AMI groups was remarkably increased compared with the control and SA groups. The results of ROC analysis indicated that the sensitivity and specificity of ASI was 71.0% and 85.4% in diagnosing CHD, respectively. While ASI was used in predicting the severity of CHD, the sensitivity was 72.1% and specificity 57.9%. Conclusion ASI is of great value in the diagnosis of coronary heart disease and the prediction of its severity.

scholarly journals Research on the changes and significance of serum RBP4 level in patients with senior coronary heart disease accompanying diabetes mellitus

2019 ◽  
Vol 6 (1) ◽  
pp. 26
Author(s):  
Qinxue Li ◽  
Biao Ge ◽  
Ruijing Yan ◽  
Yinlong Bai ◽  
Yan Liu
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Artery ◽  
Density Lipoprotein ◽  
Coronary Artery Lesion ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Significant Difference ◽  
Experimental Group

Objective: To explore the significance of serum Retinol binding protein 4 (RBP4) and its relationship with coronary artery lesion in patients with senior coronary heart disease accompanying T2DM by determining the level of serum RBP4 and Gensini score.Methods: 30 cases of patients who were 60 years old above with coronary heart disease accompanying T2DM were selected and included in the experimental group, and 30 cases of patients of 60 years old above with coronary heart disease alone were included in the control group. Both groups of patients were given CAG examinations. In addition, Gensini score was calculated according to different degrees and parts of coronary artery lesion. It was required to record each patient’s age, gender, fasting blood glucose (FPG), triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), glycated hemoglobin (HbA1c) and other laboratory examination indexes. ELISA was used to detect the level of serum RBP4 in each group, and statistical analysis was performed to the data in each group.Results: (1) RBP4 level, GS score, FPG and LDL-C in the experimental group were all higher than those in the control group, and the difference was of statistical significance (p < .05). There was no statistically significant difference in age, gender, TC, TG and HDL-C between two groups. (2) RBP4 was positively correlated to FPG and HbA1c. (3) In patients with senior coronary heart disease accompanying diabetes mellitus, HbA1c was positively correlated to GS score, RBP4 and FPG. (4) RBP4 was a risk factor for coronary artery stenosis in patients with senior coronary heart disease accompanying diabetes mellitus.Conclusions: The level of serum RBP4 in patients with senior coronary heart disease accompanying diabetes mellitus is higher than that in patients with coronary heart disease alone, with a deeper degree of coronary artery lesion. The level of serum RBP4 is increased with the degree of lesion deepened in patients with senior coronary heart disease, suggesting that the level of serum RBP4 is expected to be an early predictor of coronary artery lesion for patients with senior coronary heart disease.

scholarly journals Association of Chlamydia pneumoniae Infection With Atherosclerotic Plaque Formation

2015 ◽  
Vol 8 (4) ◽  
pp. 260 ◽  
Author(s):  
Omid Assar ◽  
Azim Nejatizadeh ◽  
Farzaneh Dehghan ◽  
Mohammad Kargar ◽  
Nader Zolghadri
Keyword(s):  
Coronary Artery ◽  
Atherosclerotic Plaque ◽  
Chlamydia Pneumoniae ◽  
Artery Bypass ◽  
Cross Sectional Study ◽  
Control Group ◽  
Atherosclerotic Plaques ◽  
Nested Polymerase Chain Reaction ◽  
Cross Sectional ◽  
Artery Disease

<p>Atherosclerosis is a complex multifactorial disorder. Studies show that infectious microbial agents may play an important role in the development of atherosclerosis; however, these findings are conflicting. This study investigated the presence of <em>Chlamydia pneumoniae</em> DNA in atherosclerotic plaques of patients suffering from coronary artery disease. In a cross-sectional study, 85 patients (43 females and 42 males with mean age of 61±9.5, range 42-82 years) referred for coronary artery bypass grafting (CABG) and thoracic biopsy as the control groups were enrolled for this study. Standard questionnaires, including demographic and clinical evaluation were administered. Obtained specimens were processed and then nested polymerase chain reaction with primers for <em>Pst1</em> fragment was carried out to detect <em>Chlamydia pneumoniae</em> DNA. Statistical analysis was done using the SPSS software. Of note,<em> </em>in 25 out of the 85 patients (29.4%), <em>C. pneumoniae</em> was detected within atherosclerotic plaques, whereas, 5 out of the 85 thoracic biopsy (5.9%) were positive for the presence of the mentioned bacteria in internal thoracic artery. There was a statistically significant association between atherosclerotic plaque (study group) and thoracic biopsy (control group) in terms of <em>C. pneumoniae</em> positivity (P= 0.0001). The findings of this study support the hypothesis that <em>C. pneumoniae</em> is associated with atherosclerosis.</p>

scholarly journals Clinical Observation of Coronary Artery Bypass Grafting with Heart Valve Replacement for Coronary Heart Disease with Heart Valvular Disease

2018 ◽  
Vol 6 (2) ◽  
Author(s):  
Xiaoyu Zhou ◽  
Jiong Guo ◽  
Liliang Shu ◽  
Jing Xu
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Artery ◽  
Coronary Artery Bypass Grafting ◽  
Coronary Artery Bypass ◽  
Valve Replacement ◽  
Heart Valve ◽  
Artery Bypass ◽  
Control Group ◽  
Bypass Grafting

<p>Objective: To analyze and explore the clinical observation of coronary artery disease with coronary heart disease and coronary heart disease (CHD) undergoing coronary artery bypass grafting. Methods: From December 2015 to December 2016, 80 patients with coronary heart disease and heart valve were randomly divided into two groups: observation group and control group (40 cases). The observation group was treated with coronary artery bypass grafting combined with simultaneous heart valve replacement. The control group was treated with coronary stent implantation and non-synchronous valve replacement. The improvement of postoperative cardiac function, postoperative hospitalization, adverse events and bridge patency were compared between the two groups. Results: The improvement of cardiac function and the incidence of adverse events were significantly better in the observation group than in the control group (P &lt;0.05). The time of hospitalization and the time of ventilator were significantly shorter than those of the control group (P &lt;0.05). The patency rate of the bridge was significantly higher than that of the control group (P &lt;0.05). Conclusion: Coronary artery bypass grafting combined with heart valve replacement in patients with coronary heart disease complicated with valvular heart disease can achieve significant curative effect, which is more ideal and safer than coronary artery bypass surgery combined with non-synchronous valve replacement.</p>

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