Association of serum uric acid levels with suicide risk in female patients with major depressive disorder: a comparative cross-sectional study

Abstract Background Individuals with major depressive disorder (MDD) have a high suicide risk. Some evidence suggests that uric acid (UA) may be involved in the pathophysiology of MDD. The purpose of this study was to evaluate whether serum UA levels were associated with suicide risk in MDD patients. Methods One hundred four female patients with MDD (52 patients with suicide risk and 52 patients without suicide risk) and 52 healthy individuals were included in this study. The suicide risk was evaluated by Mini International Neuropsychiatric Interview (M.I.N.I.). Fasting serum levels of UA, as well as glucose, lipid and renal function indicators were measured. Results Serum UA levels in MDD patients with suicide risk (245.01 ± 55.44 μmol/L) were significantly lower than those in MDD patients without suicide risk (274.17 ± 72.65 μmol/L) (p = 0.017) and healthy controls (271.42 ± 55.25 μmol/L) (p = 0.030). There was no difference in serum UA levels between the MDD patients without suicide risk and healthy controls (p = 0.821). Binary logistic regression analysis revealed a significant relationship between suicide risk and decreased serum UA levels (OR = 0.989, p = 0.010) in MDD patients. Conclusion Decreased serum UA levels were associated with suicide risk in MDD patients. Purinergic system dysfunction may be involved in the neurobiological basis of suicide risk in these patients.

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Association of serum uric acid levels with suicide risk in female patients with major depressive disorder: a comparative cross-sectional study

10.21203/rs.3.rs-15810/v3 ◽

2020 ◽

Author(s):

Jing-Xu Chen ◽

Jun-Hui Feng ◽

Li-Gang Zhang ◽

Yan Liu ◽

Fu-De Yang ◽

...

Keyword(s):

Major Depressive Disorder ◽

Uric Acid ◽

Depressive Disorder ◽

Suicide Risk ◽

Serum Levels ◽

Binary Logistic Regression Analysis ◽

Healthy Controls ◽

Major Depressive ◽

Cross Sectional ◽

Female Patients

Abstract Background: Individuals with major depressive disorder (MDD) have a high suicide risk. Some evidence suggests that uric acid (UA) may be involved in the pathophysiology of MDD. The purpose of this study was to evaluate whether serum UA levels were associated with suicide risk in MDD patients.Methods: One hundred four female patients with MDD (52 patients with suicide risk and 52 patients without suicide risk) and 52 healthy individuals were included in this study. The suicide risk was evaluated by Mini International Neuropsychiatric Interview (M.I.N.I.). Fasting serum levels of UA, as well as glucose, lipid and renal function indicators were measured.Results: Serum UA levels in MDD patients with suicide risk (245.01 ± 55.44 μmol/L) were significantly lower than those in MDD patients without suicide risk (274.17 ± 72.65 μmol/L) (p = 0.017) and healthy controls (271.42 ± 55.25 μmol/L) (p = 0.030). There was no difference in serum UA levels between the MDD patients without suicide risk and healthy controls (p = 0.821). Binary logistic regression analysis revealed a significant relationship between suicide risk and decreased serum UA levels (OR = 0.989, p = 0.010) in MDD patients.Conclusion: Decreased serum UA levels were associated with suicide risk in MDD patients. Purinergic system dysfunction may be involved in the neurobiological basis of suicide risk in these patients.

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Association of serum uric acid levels with suicide risk in female patients with major depressive disorder: a comparative cross-sectional study

10.21203/rs.3.rs-15810/v4 ◽

2020 ◽

Author(s):

Jing-Xu Chen ◽

Jun-Hui Feng ◽

Li-Gang Zhang ◽

Yan Liu ◽

Fu-De Yang ◽

...

Keyword(s):

Major Depressive Disorder ◽

Uric Acid ◽

Depressive Disorder ◽

Suicide Risk ◽

Serum Levels ◽

Binary Logistic Regression Analysis ◽

Healthy Controls ◽

Major Depressive ◽

Cross Sectional ◽

Female Patients

Abstract Background: Individuals with major depressive disorder (MDD) have a high suicide risk. Some evidence suggests that uric acid (UA) may be involved in the pathophysiology of MDD. The purpose of this study was to evaluate whether serum UA levels were associated with suicide risk in MDD patients.Methods: One hundred four female patients with MDD (52 patients with suicide risk and 52 patients without suicide risk) and 52 healthy individuals were included in this study. The suicide risk was evaluated by Mini International Neuropsychiatric Interview (M.I.N.I.). Fasting serum levels of UA, as well as glucose, lipid and renal function indicators were measured.Results: Serum UA levels in MDD patients with suicide risk (245.01 ± 55.44 μmol/L) were significantly lower than those in MDD patients without suicide risk (274.17 ± 72.65 μmol/L) (p = 0.017) and healthy controls (271.42 ± 55.25 μmol/L) (p = 0.030). There was no difference in serum UA levels between the MDD patients without suicide risk and healthy controls (p = 0.821). Binary logistic regression analysis revealed a significant relationship between suicide risk and decreased serum UA levels (OR = 0.989, p = 0.010) in MDD patients.Conclusion: Decreased serum UA levels were associated with suicide risk in MDD patients. Purinergic system dysfunction may be involved in the neurobiological basis of suicide risk in these patients.

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Association of serum uric acid levels with suicide risk in female patients with major depressive disorder: a comparative cross-sectional study

10.21203/rs.3.rs-15810/v1 ◽

2020 ◽

Author(s):

Jing-Xu Chen ◽

Jun-Hui Feng ◽

Li-Gang Zhang ◽

Yan Liu ◽

Fu-De Yang ◽

...

Keyword(s):

Major Depressive Disorder ◽

Uric Acid ◽

Depressive Disorder ◽

Suicide Risk ◽

Serum Levels ◽

Binary Logistic Regression Analysis ◽

Healthy Controls ◽

Major Depressive ◽

Cross Sectional ◽

Female Patients

Abstract Background: Individuals with major depressive disorder (MDD) have a high suicide risk. Some evidence suggests that uric acid (UA) may be involved in the pathophysiology of MDD. The purpose of this study was to evaluate whether serum UA levels were associated with suicide risk in MDD patients.Methods: One hundred four female patients with MDD (52 patients with suicide risk and 52 patients without suicide risk) and 52 healthy individuals were included in this study. The suicide risk was evaluated by Mini International Neuropsychiatric Interview (M.I.N.I). Fasting serum levels of UA, as well as glucose, lipid and renal function indicators were measured.Results: Serum UA levels in MDD patients with suicide risk (245.01 ± 55.44 μmol/L) were significantly lower than those in MDD patients without suicide risk (274.17 ± 72.65 μmol/L) (p = 0.017) and healthy controls (271.42 ± 55.25 μmol/L) (p = 0.030). There was no difference in serum UA levels between the MDD patients without suicide risk and healthy controls (p = 0.821). Binary logistic regression analysis revealed a significant relationship between suicide risk and decreased serum UA levels (OR = 0.989, p = 0.010) in MDD patients.Conclusion: Decreased serum UA levels were associated with suicide risk in MDD patients. Purinergic system dysfunction may be involved in the neurobiological basis of suicide risk in these patients.

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Projective Technique Testing Approach to the Understanding of Psychological Pain in Suicidal and Non-Suicidal Psychiatric Inpatients

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17010284 ◽

2019 ◽

Vol 17 (1) ◽

pp. 284

Author(s):

Isabella Berardelli ◽

Salvatore Sarubbi ◽

Alessandra Spagnoli ◽

Chiara Fina ◽

Elena Rogante ◽

...

Keyword(s):

Bipolar Disorder ◽

Major Depressive Disorder ◽

Depressive Disorder ◽

Suicide Risk ◽

Cross Sectional Study ◽

Psychological Pain ◽

Major Depressive ◽

Clinical Factor ◽

Cross Sectional ◽

Significant Difference

Psychological pain is a core clinical factor for understanding suicide, independently from depression. The aim of this study is to assess the role of psychological pain on suicide risk and to evaluate the relationship between psychache and different psychiatric disorders. We conducted the present cross-sectional study on 291 inpatients with a diagnosis of major depressive disorder, bipolar disorder, and schizophrenia. We administered Shneidman’s Psychological Pain Assessment Scale (PPAS) for the assessment of mental pain and the Mini International Neuropsychiatric Interview (MINI) for the assessment of suicide risk. There was a significant association between current psychache and worst-ever psychache and suicide risk in inpatients affected by a depressive disorder, bipolar disorder and schizophrenia. Furthermore, we found a significant difference in current psychache between inpatients with major depressive disorder and inpatients with schizophrenia and in worst-ever psychache between inpatients with bipolar disorder and inpatients with schizophrenia, with lower scores in inpatients with schizophrenia. The assessment of psychache appears to be useful for predicting suicidal risk and should be used routinely for identifying and treating suicide risk in clinical practice.

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Serum interferon-gamma level is associated with drug-naïve major depressive disorder

SAGE Open Medicine ◽

10.1177/2050312120974169 ◽

2020 ◽

Vol 8 ◽

pp. 205031212097416

Author(s):

Sohel Daria ◽

Maliha Afrin Proma ◽

Mohammad Shahriar ◽

Sardar Mohammad Ashraful Islam ◽

Mohiuddin Ahmed Bhuiyan ◽

...

Keyword(s):

Risk Assessment ◽

Major Depressive Disorder ◽

Major Depression ◽

Depressive Disorder ◽

Serum Levels ◽

Enzyme Linked Immunosorbent Assay ◽

Healthy Controls ◽

Major Depressive ◽

Early Risk ◽

Ifn Γ

Objectives: Major depressive disorder is a leading heterogeneous psychiatric illness manifested by persistent low mood, a feeling of sadness, and diminished interest in daily activities. Many biological, genetic, and social factors are thought to be linked with depression. But any suitable early risk assessment markers are absent for this illness. Therefore, we aimed to investigate the serum levels of IFN-γ in major depressive disorder patients to further investigate the association between serum levels of this cytokine and major depression. Methods: This prospective case-control study enrolled 120 major depressive disorder patients and 100 healthy controls matched by age, sex, and body mass index. A qualified psychiatrist diagnosed the major depressive disorder patients and evaluated healthy controls according to the Diagnostic and Statistical Manual of Mental Health Disorders (5th ed.; DSM-5). The Hamilton depression rating scale was applied for all the study participants to measure the severity of depression. Serum IFN-γ levels were measured by a commercially available enzyme-linked immunosorbent assay kit (Boster Biological Technology, Pleasanton, CA, USA). Results: This study observed that serum IFN-γ levels were significantly decreased in major depressive disorder patients compared to healthy controls. A significant negative correlation ( r = −0.375; p < 0.001) was obtained between serum IFN-γ levels and Hamilton depression scores. Receiver operating characteristic analysis showed good diagnostic performance of lowered serum IFN-γ levels in depression with an area under the curve at 0.790. Conclusion: We suggest the altered serum IFN-γ levels are associated with the pathophysiology of depression. The reduced levels of serum IFN-γ might be used as an early risk assessment tool for major depression.

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Lysophosphatidic acid and lysophosphatidylcholine levels in serum samples of patients with major depressive disorder

10.1101/2020.10.04.20206490 ◽

2020 ◽

Author(s):

Sumaia Bari ◽

Sharmin Sultana ◽

Sohel Daria ◽

Maliha Afrin Proma ◽

Md. Rabiul Islam ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Lysophosphatidic Acid ◽

Rating Scale ◽

Serum Levels ◽

Enzyme Linked Immunosorbent Assay ◽

Healthy Controls ◽

Serum Samples ◽

Major Depressive ◽

Medical University

ABSTRACTMajor depressive disorder (MDD) is a heterogeneous condition featured with a continuous low mood, feeling of sadness, lack of interest to perform daily activities. Many factors including genetic, physiological, biological, social, and environmental are thought to be connected with the pathophysiology of depression. Several previous studies failed to identify the favorable biomarkers for MDD. Lysophosphatidic acid (LPA) and lysophosphatidylcholine (LPC)showed important roles in the regulation of emotion among experimental animals. The current study aimed to measure the serum levels of LPA and LPC in MDD patients and healthy controls (HCs) to explore their roles and relationship with depression. This case-control study enrolled 53 MDD patients and 50 healthy controls (HCs). The patients were recruited from the department of psychiatry, Bangabandhu Sheikh Mujib Medical University whereas the controls was from different locations of Dhaka city. Both the cases and controls were strictly matched by gender, age, and body mass index. A qualified psychiatrist diagnosed patients and evaluated controls based on the diagnostic and statistical manual of mental disorders, 5th edition. The severity of depression in MDD patients was measured by using the Hamilton depression rating scale (Ham-D). Enzyme-linked immunosorbent assay kits were used to measure serum levels LPA and LPC. We found no alterations of these parameters in serum levels of MDD patients compared to HCs. A significant positive correlation was found between serum LPA and LPC levels in MDD patients. Moreover, the present study showed no significant associations between target markers and either diagnosis of depression or Ham-D scores, or management of depression. The present study suggests that LPA and LPC levels probably would not serve as potential biomarkers of MDD. Thus, further studies with large and more homogeneous populations are recommended to explore the exact relationship between targeted serum lipids and major depression.

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Association between increased serum interleukin-6 levels and sustained attention deficits in patients with major depressive disorder

Psychological Medicine ◽

10.1017/s0033291718000090 ◽

2018 ◽

Vol 48 (15) ◽

pp. 2508-2514 ◽

Cited By ~ 8

Author(s):

Gang Ye ◽

Guang Zhong Yin ◽

Zhen Tang ◽

Jia Lin Fu ◽

Jie Chen ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Sustained Attention ◽

Interleukin 6 ◽

Visual Information ◽

Serum Levels ◽

Multivariate Regression Analysis ◽

Healthy Controls ◽

Major Depressive ◽

Control Study

AbstractBackgroundThe pathophysiology of cognitive impairment in patients with the major depressive disorder (MDD) may involve neuroinflammation mediated by cytokines.ObjectiveThe aim of this study was to examine the serum interleukin-6 (IL-6) levels, sustained attention, and their association in patients with MDD.MethodsThirty patients with MDD and 30 healthy controls were enrolled in this case-control study. Sustained attention was measured using the Rapid Visual Information Processing (RVP) task in the Cambridge Neuropsychological Tests Automated Battery. The serum IL-6 levels of all subjects were assessed by sandwich enzyme-linked immunosorbent assays.ResultsThere were significant differences in the log10RVP total hits, log10RVP total misses, and log10RVP mean latency between patients with MDD and healthy controls (F= 6.04,p= 0.017;F= 19.77,p< 0.0001;F= 14.42,p< 0.0001, respectively). The serum levels of Log10IL-6 were significantly higher in patients with MDD than in healthy controls (F= 192.27,p< 0.0001). The log10IL-6 levels were also positively correlated with the log10RVP mean latency in patients with MDD (r= 0.45,p= 0.013). A further stepwise multivariate regression analysis indicated that the log10IL-6 levels were significantly associated with the log10RVP mean latency in patients with MDD (β= 0.31,t= 2.41,p= 0.025).ConclusionsOur data suggested that increased IL-6 levels were associated with the psychopathology of MDD, and that abnormal IL-6 levels were implicated in the impairment of sustained attention in patients with MDD.

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Study on Thyroid Dysfunction in Patients with Major Depressive Disorder

Journal of Evidence Based Medicine and Healthcare ◽

10.18410/jebmh/2020/639 ◽

2020 ◽

Vol 7 (52) ◽

pp. 3137-3141

Author(s):

Tonjam Hemchand Singh ◽

Haobijam Nirendrakumar Singh ◽

Nongthonbam Surajkumar Singh

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Low Socioeconomic Status ◽

Depressive Disorders ◽

Economic Status ◽

Serum Levels ◽

Cross Sectional Study ◽

Major Depressive ◽

Cross Sectional ◽

Study Results

BACKGROUND We wanted to evaluate serum levels of thyroid hormones (FT3, FT4 and TSH) among the patients with major depressive disorder (MDD) and determine the prevalence of hypothyroidism among MDD patients. METHODS This cross-sectional study was conducted in the Department of Psychiatry, JNIMS for a period of one year from Nov. 2017 to Oct. 2018. After obtaining informed consent, confirmed cases of MDD who attended JNIMS psychiatry OPD were selected for study. RESULTS Prevalence of hypothyroidism among MDD patients was found to be 24 % and more in females, patients from low-socio-economic status and in older age group. CONCLUSIONS Considering the higher prevalence of hypothyroidism in females and low socioeconomic status among the major depressive disorder patients, attention has to be paid to screening thyroid hormone testing in all major depressive disorders and early treatment of hypothyroidism. KEYWORDS Euthyroid, Hypothyroidism, Major Depressive Disorder

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