scholarly journals The 100 most influential studies in CAR-T: a bibliometric analysis

2020 ◽  
Author(s):  
Beomjun Seo ◽  
Jeeyoon Kim ◽  
Seungwook Kim
Keyword(s):  
Bibliometric Analysis ◽  
Research Field ◽  
University Of Pennsylvania ◽  
Antigen Receptors ◽  
Non Profit ◽  
Funding Agencies ◽  
Car T ◽  
The Us ◽  
Us Government ◽  
The University

Abstract Background: Bibliometric analysis of mainly cited articles is used to provide information on trends in a specific research field and objective indicators of the scientific impact of the publication. With bibliometric and network analysis, we map the scientific landscape of chimeric antigen receptors T-cells (CAR-T) research. Methods: Extract 100 most cited articles published over the last decade (from January 1, 2009 to Dec 31, 2018; 10 years) from the Web of Science Core Collection with bibliographic details; year of publication, country of author, funding agencies, research organization, author information, and keywords. Results: Of the 100 papers identified, most (92%) were written in the US. US government agencies and non-profit organizations provided the most funding, and the papers funded by the NIH had the most citations, followed by those funded by the Alliance for Cancer Gene Therapy (US). 33 papers out of the top 100 most cited papers were published from the University of Pennsylvania. As for authors, Carl H. June participated in 30 papers, followed by Bruce L. Levine who participated in 11 papers. As for journals, Blood (n=20), published the most papers, followed by Science Translational Medicine (n=10). The most frequently used keyword was “adoptive immunotherapy” (n=37), followed by “lymphocytes” (n=27), and “antitumor-activity” (n=25). Conclusion: We performed the quantitative bibliometric analysis of funding bodies, countries, organizations, journals, authors, and keywords for the CAR-T research trends and landscape. Moving forward, Analysis of highly influential CAR-T articles provides insight into areas for future development.

scholarly journals Resecting the Dominant Lesion: Patient Outcomes after Surgery and Radiosurgery vs Stand-Alone Radiosurgery in the Setting of Multiple Brain Metastases

2021 ◽  
Author(s):  
Maria Punchak ◽  
Stephen P Miranda ◽  
Alexis Gutierrez ◽  
Steven Brem ◽  
Donald O'Rourke ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Surgical Resection ◽  
Gamma Knife Radiosurgery ◽  
Median Number ◽  
University Of Pennsylvania ◽  
Multiple Brain Metastases ◽  
The Us ◽  
Median Diameter ◽  
Similar Survival ◽  
The University

Abstract BACKGROUND: Brain metastases are the most common central nervous system (CNS) tumors, occurring in 300,000 people per year in the US. The benefit of surgical resection, over radiosurgery, for dominant lesions remains unclear. METHODS: The University of Pennsylvania Health System database was retrospectively reviewed for patients presenting with multiple brain metastases from 1/1/16 to 8/31/18 with one dominant lesion > 2 cm in diameter, who underwent initial treatment with either resection of the dominant lesion or Gamma Knife radiosurgery (GKS). Inclusion criteria were age > 18, >1 brain metastasis, and presence of a dominant lesion (>2 cm). We analyzed factors associated with mortality. RESULTS: 129 patients were identified (surgery=84, GKS=45). The median number of intracranial metastases was 3 (IQR: 2-5). The median diameter of the largest lesion was 31 mm (IQR: 25-38) in the surgery group vs 21 mm (IQR: 20-24) in the GKS group (p<0.001). Mortality did not differ between surgery and GKS patients (69.1% vs 77.8%, p = 0.292). In a multivariate survival analysis, there was no difference in mortality between the surgery and GKS cohorts (aHR: 1.35, 95% CI: 0.74-2.45 p=0.32). Pre-operative KPS (aHR: 0.97, 95% CI: 0.95-0.99, p=0.004), CNS radiotherapy (aHR: 0.33, 95% CI: 0.19-0.56 p<0.001), chemotherapy (aHR: 0.27, 95% CI: 0.15-0.47, p<0.001), and immunotherapy (aHR: 0.41, 95% CI: 0.25-0.68, p=0.001) were associated with decreased mortality. CONCLUSION: In our institution, patients with multiple brain metastases and one symptomatic dominant lesion demonstrated similar survival after GKS when compared with up-front surgical resection of the dominant lesion.

scholarly journals From International Shortwave to Digital Rebroadcast

2018 ◽  
Author(s):  
Paul Conway ◽  
Kelly Askew
Keyword(s):  
University Of Michigan ◽  
Voice Of America ◽  
Radio Stations ◽  
Radio Program ◽  
Research And Teaching ◽  
The Us ◽  
Us Government ◽  
Radio Broadcast ◽  
The University ◽  
Musical Heritage

In January 2015, the US government agency Voice of America loaned the Leo Sarkisian Music Library to the University of Michigan with the goal of digitizing and providing access to the materials for research and teaching. Transfer created an archive where once existed a longstanding music resource that supported all aspects of the production of the VOA’s Music Time in Africa radio program. The archive encompasses sound recordings and type-scripts of the radio program (1965-2004), along with extensive recordings of live musical performances made by Leo Sarkisian in his travels through Africa or by African staff trained by Leo Sarkisian to make professional quality recordings on his behalf—often at the radio stations he helped establish. This article describes the Music Time in Africa radio broadcast and then contextualizes efforts to provide access to the digitized recordings in terms of the nature of the post-modern archive, performance studies, and the repatriation of musical heritage resources found in archives. The article concludes with a reflection on the complexities of providing access to digital recordings of international radio and the author’s efforts to explore opportunities for digital repatriation through rebroadcast on social media, which in many ways shares the underlying characteristics of the radio broadcast medium itself.

scholarly journals Mindful Leadership in the University

2019 ◽  
Author(s):  
John Paul Minda
Keyword(s):  
Professional Education ◽  
Policy Research ◽  
Basic Research ◽  
Well Being ◽  
Faculty Members ◽  
Leadership Role ◽  
Mindfulness Practice ◽  
Funding Agencies ◽  
The Us ◽  
The University

Academia, like many other sectors, is a complex work environment. Although universities vary in terms of their size and objectives, the average university in Canada and the US must simultaneously serve the interests of undergraduate education, graduate education, professional education, basic research, applied research, public policy research, and basic scholarship. A university receives its operating funds from tuition payments, governments, research funding agencies, and from private donors. Faculty are at the center of this diverse institution, providing the engine of teaching, research, and service. As a result, faculty members may find themselves occasionally struggling to manage these different interests. This article looks at the challenges that faculty members face, paying particular attention to the leadership role that many faculty play. I then explore the possible ways in which mindfulness practice can have a benefit on faculty well-being and productivity.

scholarly journals Nancy Potok, PhD

2018 ◽  
Vol 25 ◽  
pp. 77-83
Author(s):  
Policy Perspectives Editors
Keyword(s):  
The United States ◽  
Census Bureau ◽  
State University ◽  
University Of Alabama ◽  
Non Profit ◽  
Chief Operating Officer ◽  
The Public ◽  
The Us ◽  
The University ◽  
Us Census

Nancy Potok, PhD, is currently the Chief Statistician of the United States and the Chief of Statistical and Science Policy at the US Office of Management and Budget. She previously served as the Deputy Director and Chief Operating Officer of the US Census Bureau from 2012 to 2017. Her career spans more than 30 years of leadership in the public, non-profit, and private sectors. Dr. Potok has also been an adjunct professor at the Trachtenberg School since 2011. She received her BA from Sonoma State University, her MPA from the University of Alabama, and her PhD in public policy and administration from the Trachtenberg School.

scholarly journals A veterinary and nursing collaboration to increase access to healthcare

2021 ◽  
Vol 12 (3) ◽  
pp. 84
Author(s):  
Shuzhen Chee ◽  
Sarah Rivera ◽  
Aaron Algren Huntley ◽  
Lauren Lundahl ◽  
Claire Bocage ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Interprofessional Collaboration ◽  
University Of Pennsylvania ◽  
Health Clinic ◽  
Black Communities ◽  
Marginalized Communities ◽  
Schools Of Nursing ◽  
The Us ◽  
The University

Hypertension is associated with almost 25% of US deaths. Philadelphia has the highest prevalence of hypertension of the 6 largest cities in the US, predominantly in non-Hispanic Black communities. Social determinants of health (SDOH) contribute to the development of hypertension and limit access to preventative resources and treatment. This case study describes an interprofessional collaboration between the University of Pennsylvania Schools of Nursing and Veterinary Medicine to offer blood pressure screenings at the annual MLK Day of Service Wellness and Vaccination Clinic. Clients were approached for blood pressure screenings and health education. Sixty-seven clients (48.2%), largely from zip codes with high levels of hypertension, agreed to blood pressure screening; 45 (67.2%) clients were hypertensive. Our One Health clinic could be a model to reach residents in marginalized communities.

scholarly journals Organizational Hiring Practices Of Persons With Disabilities: A Study And Review Of Corporations, Small Businesses, Non-Profit Organizations, Foundations, And The US Government

2012 ◽  
Vol 7 (2) ◽  
pp. 79-82
Author(s):  
Nancy A. Maier ◽  
Gregory W. Ulferts ◽  
Terry L. Howard
Keyword(s):  
Small Businesses ◽  
Minority Group ◽  
People With Disabilities ◽  
Hiring Practices ◽  
Federal State ◽  
Persons With Disabilities ◽  
Non Profit ◽  
The Us ◽  
Us Government ◽  
Employment Rates

This paper presents findings from research conducted to identify organizational hiring practices of people with disabilities. Despite the passage of the American with Disabilities Act in 1990, employment rates for people with disabilities remain far lower than for people of any other minority group. Further, this paper will offer best practices in hiring people with disabilities and resources available through federal, state and private sectors.

Abstract 434: The Majority of Outpatients With Severe Hypercholesterolemia at an Academic Tertiary Centre Have Not Been Screened for FH

2017 ◽  
Vol 37 (suppl_1) ◽  
Author(s):  
Ezim Ajufo ◽  
Masako Ueda ◽  
Erik Hossain ◽  
Tracey Sikora ◽  
Scott M Damrauer ◽  
...  
Keyword(s):  
Family History ◽  
Clinical Care ◽  
University Of Pennsylvania ◽  
Family History Information ◽  
Tertiary Centre ◽  
The Us ◽  
Statin Prescription ◽  
History Of ◽  
Ascvd Risk ◽  
The University

Background: National and International guidelines recommend, as a minimum, that individuals with LDL-C ≥190mg/dL are asked about a family history of ASCVD and hypercholesterolemia to screen for familial hypercholesterolemia (FH), a monogenic condition that carries considerable ASCVD risk. However, FH is grossly underdiagnosed and undertreated in the US. One reason for this may be failure to screen severely hypercholesterolemic individuals for FH. Hypothesis: We evaluated the hypothesis that poor identification of FH might be due to inadequate screening for FH among individuals with severe hypercholesterolemia. Methods: An EHR query was used to identify active adult patients in the University of Pennsylvania outpatient EHR database (N=310 802) with LDL-C≥220mg/dL, excluding secondary causes of hypercholesterolemia. The EHR was then systematically reviewed for structured notation of family history information. Result: The query identified 3,475 individuals with severely elevated LDL-C. Among them, only 47.9% (1666) had family history data relating to ASCVD (968), hypercholesterolemia (336) or both (362) in the EHR. The history was positive in 94.2% (1569) of these cases. Overall, patients with LDL-C ≥220mg/dL were more likely to be screened (OR 1.57; 95% CI 1.47-1.68) than those with LDL <220mg/dL. Within the former group, the odds of being screened were higher in Caucasians (OR 1.52; 95% CI 1.33-1.75), with more severe LDL-C elevation or a history of ASCVD (OR 1.36; 95% CI 1.10 - 1.67). Conversely, the presence of diabetes (OR 0.73; 95% CI 0.61-0.86) or hypertension (OR 0.82; 95% CI 0.72-0.94), made screening less likely to occur. Interestingly, the setting of clinical care was also important; individuals seen in secondary care (OR 1.68; 95% CI 1.41-2.26), general (OR 1.69, 95% CI 1.47-1.95) or preventative cardiology (OR 1.82; 95% CI 1.47-2.25) were more likely to be screened. Finally, statin prescription was more common in those screened (OR 1.39; 95% CI 1.16-1.88), but this did not affect LDL-C goal achievement. Conclusion: At a large academic centre, the majority of outpatients with severe hypercholesterolemia had no record of being screened for FH. This report sheds light on factors that might be relevant to the underdiagnosis of FH in the US.

‘In the climate of continuing financial restraint’: Finding a sustainable future in the neo-liberal university

2019 ◽  
pp. 188-204
Author(s):  
Alice Garner ◽  
Diane Kirkby
Keyword(s):  
Private Sector ◽  
Academic Research ◽  
Australian Government ◽  
Sustainable Future ◽  
Financial Restraint ◽  
The Us ◽  
Us Government ◽  
Corporate Funding ◽  
The University ◽  
The Impact

The impact of neo-liberalism on the university sector had profound consequences for the Fulbright program’s ability to support academic research. Binationalism had meant the Australian Fulbright program was well-funded by the Australian government even as the US government reduced its contribution in the late 1960s-70s. From the 1980s further cutbacks meant the program had to turn towards private sector and corporate funding for support, involve the alumni and to introduce targeted scholarships. This raised dilemmas about autonomy and freedom from interference that had plagued the Fulbright program throughout its history.

scholarly journals Perspectives on the draft ICH-M10 guidance: an interview with Mark Arnold

Bioanalysis ◽  
2019 ◽  
Vol 11 (15) ◽  
pp. 1379-1382 ◽  
Author(s):  
Mark E Arnold
Keyword(s):  
Immune Cell ◽  
Quantitative Polymerase Chain Reaction ◽  
University Of Pennsylvania ◽  
Clinical Samples ◽  
Indiana University ◽  
Bioanalytical Method Validation ◽  
University Of Pittsburgh ◽  
The Us ◽  
Us Fda ◽  
The University

Biography Mark E Arnold, PhD, is Director of Science for Covance Laboratories. In that role, he develops the bioanalytical strategy for immune-, cell-based, quantitative polymerase chain reaction (qPCR) and LC–MS/MS assays to quantify drugs and metabolites, antidrug antibodies and biomarkers in animal and clinical samples for pharmacokinetic and pharmacodynamic assessments. Mark was previously Executive Director of Bioanalytical Sciences at Bristol–Myers Squibb. He received a BS (biology) from Indiana University of Pennsylvania and PhD (pharmacology) from the University of Pittsburgh. For more than 30 years, Mark has been involved in the evolving field of bioanalysis, including the science and the review and interpretation of regulations and guidance. He co-chaired the AAPS Crystal City V and VI Workshops on the US ‘FDA Draft Revised Guidance on Bioanalytical Method Validation’ and ‘Biomarkers’. He is actively involved in the Land O’Lakes Bioanalytical Conference and American Association of Pharmaceutical Scientists (AAPS, named Fellow in 2014). Mark has over 100 peer-reviewed publications, and numerous invited podium presentations. This interview was conducted by Sankeetha Nadarajah, Managing Commissioning Editor of Bioanalysis.

Pakistan Papers

2020 ◽  
Vol 40 (3) ◽  
pp. 507-525
Author(s):  
Farhan Karim
Keyword(s):  
Capital City ◽  
University Of Pennsylvania ◽  
The Political ◽  
Architectural Drawings ◽  
Spatial Practices ◽  
The Past ◽  
The Us ◽  
Political Idea ◽  
The University ◽  
Vital Resource

Abstract As political questions behind Pakistan's emergence distilled themselves into aesthetic questions of how to represent a country without a past, the debate erupted through the spatial practices determining the form and architectural character of the nation's two capitols. President Ayub Khan's two ambitious urban projects—Islamabad, the new capital city of Pakistan and Ayub-Nagar (renamed Sher-e-Bangla Nagar), and a second capitol complex in East Pakistan—brought together local and foreign stakeholders with differing interpretations of the idea of “Pakistan.” A significant part of each project's documentation lies far from its site—with the University of Pennsylvania, in the personal papers of Louis Kahn, the US-based architect whose firm designed each. This collection—a vital resource to consider the expanded meaning of architecture, not as an end product, but as a process—emerges as a crucial body of evidence for the evolution of multiple narratives of the political idea of Pakistan. The design process, as documented in sketches, architectural drawings, reports, and correspondence, reflects the frictions created from unfulfilled expectations and the subsequent disillusionment of vested interest groups, shedding new light on constructions of the past and future in postindependence Pakistan.

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