scholarly journals Genetic variants of TLR9 Gene and Chronic Kidney Disease Susceptibility

2021 ◽  
Author(s):  
Jin Ho Kwak ◽  
Gyeong Im Yu ◽  
Woo Yeong Park ◽  
Jin Hyuk Paek ◽  
Yaerim Kim ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Risk Factor ◽  
Kidney Disease ◽  
Disease Susceptibility ◽  
Signal Pathway ◽  
Public Health Issue ◽  
Common Condition ◽  
Genetic Studies ◽  
Genome Wide ◽  
Tlr9 Gene

Abstract Objectives Chronic kidney disease (CKD) is a common condition that can lead to renal dysfunction and is closely in relation to an increased cardiovascular risk and mortality risk. CKD is an important public health issue, and recent genetic studies have verified common CKD susceptibility variants. In this research, we examined the interrelationship between candidate genes polymorphisms of IFNL induction and signaling pathway and CKD. Methods 92 CKD patients and 330 healthy subjects as control were participated in this research. Replication set consisting 137 CKD with CGN patients and 446 controls was used for additional analysis. The genotype of SNPs was determined by the Axiom Genome-Wide Human Assay and SNaPshot assay. Results The SNPs of IFNL3 and IFNL2 were significantly associated with chronic kidney disease in the codominant (p = 0.015, p = 0.013, respectively). The SNP of IFNRA2 was significantly associated with chronic kidney disease in the codominant (p = 0.029). The SNP of TLR9 was significantly associated with chronic kidney disease in the codominant (p = 0.016), dominant (p = 0.047) and recessive (p = 0.049). The SNP of IL-22 was significantly associated with chronic kidney disease in the codominant (p = 0.049). No significant associations involving IFNL3, IFNL2 and IL22 were observed in the replication set whereas concerning the rs187084, in the TLR9 gene, a significant association was observed pooling the original and the replication sets. Conclusions This results shows a possibility that IFNL induction and signal pathway genes polymorphisms as a risk factor for CKD. Secondly, our results seem to TRL9 gene variant may be play a risk factor on CKD with CGN.

scholarly journals Medical records-based chronic kidney disease phenotype for clinical care and “big data” observational and genetic studies

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Ning Shang ◽  
Atlas Khan ◽  
Fernanda Polubriaginof ◽  
Francesca Zanoni ◽  
Karla Mehl ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Medical Records ◽  
Large Scale ◽  
Association Studies ◽  
Clinical Care ◽  
Medical Systems ◽  
Genetic Studies ◽  
Genome Wide ◽  
Independent Case

AbstractChronic Kidney Disease (CKD) represents a slowly progressive disorder that is typically silent until late stages, but early intervention can significantly delay its progression. We designed a portable and scalable electronic CKD phenotype to facilitate early disease recognition and empower large-scale observational and genetic studies of kidney traits. The algorithm uses a combination of rule-based and machine-learning methods to automatically place patients on the staging grid of albuminuria by glomerular filtration rate (“A-by-G” grid). We manually validated the algorithm by 451 chart reviews across three medical systems, demonstrating overall positive predictive value of 95% for CKD cases and 97% for healthy controls. Independent case-control validation using 2350 patient records demonstrated diagnostic specificity of 97% and sensitivity of 87%. Application of the phenotype to 1.3 million patients demonstrated that over 80% of CKD cases are undetected using ICD codes alone. We also demonstrated several large-scale applications of the phenotype, including identifying stage-specific kidney disease comorbidities, in silico estimation of kidney trait heritability in thousands of pedigrees reconstructed from medical records, and biobank-based multicenter genome-wide and phenome-wide association studies.

scholarly journals An Update on Hepatocellular Carcinoma in Chronic Kidney Disease

Cancers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 3617
Author(s):  
Fabrizio Fabrizi ◽  
Roberta Cerutti ◽  
Carlo M. Alfieri ◽  
Ezequiel Ridruejo
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Early Stage ◽  
Survival Rates ◽  
International Study ◽  
Public Health Issue ◽  
Advanced Chronic Kidney Disease ◽  
Ablative Techniques ◽  
Risk Of Cancer

Chronic kidney disease is a major public health issue globally and the risk of cancer (including HCC) is greater in patients on long-term dialysis and kidney transplant compared with the general population. According to an international study on 831,804 patients on long-term dialysis, the standardized incidence ratio for liver cancer was 1.2 (95% CI, 1.0–1.4) and 1.5 (95% CI, 1.3–1.7) in European and USA cohorts, respectively. It appears that important predictors of HCC in dialysis population are hepatotropic viruses (HBV and HCV) and cirrhosis. 1-, 3-, and 5-year survival rates are lower in HCC patients on long-term dialysis than those with HCC and intact kidneys. NAFLD is a metabolic disease with increasing prevalence worldwide and recent evidence shows that it is an important cause of liver-related and extra liver-related diseases (including HCC and CKD, respectively). Some longitudinal studies have shown that patients with chronic hepatitis B are aging and the frequency of comorbidities (such as HCC and CKD) is increasing over time in these patients; it has been suggested to connect these patients to an appropriate care earlier. Antiviral therapy of HBV and HCV plays a pivotal role in the management of HCC in CKD and some combinations of DAAs (elbasvir/grazoprevir, glecaprevir/pibrentasvir, sofosbuvir-based regimens) are now available for HCV positive patients and advanced chronic kidney disease. The interventional management of HCC includes liver resection. Some ablative techniques have been suggested for HCC in CKD patients who are not appropriate candidates to surgery. Transcatheter arterial chemoembolization has been proposed for HCC in patients who are not candidates to liver surgery due to comorbidities. The gold standard for early-stage HCC in patients with chronic liver disease and/or cirrhosis is still liver transplant.

Dementia is a major risk factor for hip fractures in patients with chronic kidney disease

2015 ◽  
Vol 27 (4) ◽  
pp. 1665-1669 ◽  
Author(s):  
M. Maravic ◽  
A. Ostertag ◽  
P. Urena ◽  
M. Cohen-Solal
Keyword(s):  
Chronic Kidney Disease ◽  
Risk Factor ◽  
Kidney Disease ◽  
Hip Fractures ◽  
Major Risk Factor

HIV-associated kidney disease in the context of an aging population

Sexual Health ◽  
2011 ◽  
Vol 8 (4) ◽  
pp. 485 ◽  
Author(s):  
Claire Naftalin ◽  
Bavithra Nathan ◽  
Lisa Hamzah ◽  
Frank A. Post
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Risk Factor ◽  
Antiretroviral Therapy ◽  
Kidney Disease ◽  
General Population ◽  
Life Expectancy ◽  
Hiv Care ◽  
Developed World

Acute renal failure and chronic kidney disease are more common in HIV-infected patients compared with the general population. Several studies have shown age to be a risk factor for HIV-associated kidney disease. The improved life expectancy of HIV-infected patients as a result of widespread use of antiretroviral therapy has resulted in progressive aging of HIV cohorts in the developed world, and an increased burden of cardiovascular and kidney disease. Consequently, HIV care increasingly needs to incorporate strategies to detect and manage these non-infectious co-morbidities.

Chronic kidney disease as a risk factor for acute coronary syndromes in patients presenting to the emergency room with chest pain

2012 ◽  
Vol 159 (5) ◽  
pp. 391-396 ◽  
Author(s):  
Sherezade Khambatta ◽  
Michael E. Farkouh ◽  
R. Scott Wright ◽  
Guy S. Reeder ◽  
Peter A. McCullough ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Risk Factor ◽  
Chest Pain ◽  
Kidney Disease ◽  
Emergency Room ◽  
Acute Coronary Syndromes ◽  
Coronary Syndromes

Sa1389 - Baseline Chronic Kidney Disease is a Risk Factor for Severity and Mortality in Acute Pancreatitis: A Multicenter Study

2018 ◽  
Vol 154 (6) ◽  
pp. S-288 ◽  
Author(s):  
Vijit Chouhan ◽  
Marc Monachese ◽  
Mohannad Abou Saleh ◽  
Allyson Richardson ◽  
Peter Lee ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Acute Pancreatitis ◽  
Risk Factor ◽  
Kidney Disease ◽  
Multicenter Study

Abstract MP74: Long Term Risk-Factor Profiles for Chronic Kidney Disease in the Framingham Heart Study

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Gearoid M McMahon ◽  
Sarah R Preis ◽  
Shih-Jen Hwang ◽  
Caroline S Fox
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Risk Factor ◽  
Kidney Disease ◽  
Framingham Heart Study ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Standard Deviation Increase ◽  
Heart Study ◽  
Increased Risk

Background: Chronic Kidney Disease (CKD) is an important public health issue and is associated with an increased risk of cardiovascular disease. Risk factors for CKD are well established, but most are typically assessed at or near the time of CKD diagnosis. Our hypothesis was that risk factors for CKD are present earlier in the course of the disease. We compared the prevalence of risk factors between CKD cases and controls at time points up to 30 years prior to CKD diagnosis. Methods: Participants were drawn from the Framingham Heart Study Offspring cohort. CKD was defined as an estimated glomerular filtration rate of ≤60ml/min/1.73m2. Incident CKD cases occurring at examination cycles 6, 7, and 8 were age- and sex-matched 1:2 to controls. Risk factors including systolic blood pressure (SBP), hypertension, lipids, diabetes, smoking status, body mass index (BMI) and dipstick proteinuria were measured at the time of CKD diagnosis and 10, 20 and 30 years prior. Logistic regression models, adjusted for age, sex, and time period, were constructed to compare risk factor profiles at each time point between cases and controls Results: During follow-up, 441 new cases of CKD were identified and these were matched to 882 controls (mean age 69.2 years, 52.4% women). Up to 30 years prior to CKD diagnosis, those who ultimately developed CKD were more likely to have hypertension (OR 1.74, CI 1.21-2.49), be obese (OR 1.74, CI 1.15-2.63) and have higher triglycerides (OR 1.43, CI 1.12-1.84, p=0.005 per 1 standard deviation increase). Each 10mmHg increase in SBP was associated with an OR of 1.22 for future CKD (95% CI 1.10-1.35) Additionally, cases were more likely to have diabetes (OR 2.90, CI 1.59-5.29) and be on antihypertensive therapy (OR 1.65, CI 1.14-2.40, p=0.009) up to 20 years prior to diagnosis. Increasing HDLc was associated with a lower risk of CKD (OR 0.84, CI 0.81-0.97 per 10mg/dl). Conclusions: As many as 30 years prior to diagnosis, risk factors for CKD are identifiable. In particular, modifiable risk factors such as obesity, hypertension and dyslipidemia are present early in the course of the disease. These findings demonstrate the importance of early identification of risk factors in patients at risk of CKD through a life-course approach.

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