scholarly journals Research output on systemic sclerosis and socio-economic factors: An analysis of country-level panel data

2021 ◽  
Author(s):  
Wei Guo ◽  
Zeyu Zhou ◽  
Yinhe Liang ◽  
Chuanhui Xu ◽  
Lin Zeng ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Rare Disease ◽  
Research Output ◽  
Scientific Output ◽  
Annual Growth Rate ◽  
Middle Income ◽  
Middle Income Countries ◽  
Country Level ◽  
Country Factors ◽  
Effect Heterogeneity

Abstract Background Systemic sclerosis (SSc) is a rare detrimental disease warranting mobilization of global research efforts. We aimed to evaluate impacts of country factors on research output over SSc to identify solutions promoting research. Methods Publication production on SSc during 1969–2018 and data for structural and policy factors were collected from public sources. Effects of country-level factors were investigated through panel regression in WHO member countries. Difference-in-differences analysis assessed the impacts of rare disease legislation. Effect heterogeneity across income levels was evaluated using group regression. Results SSc publications showed increasing annual growth rate (−0.3% during 1969–1983 vs. 6.9% during 2000–2018). Totally, ten countries published 12 261 (77.5%) SSc publications but another 87 countries produced none. High-income countries with higher GDP, larger population, and higher health expenditure tended to publish more (p<0.001). Whereas in middle-income countries (MICs) SSc scientific output was significantly associated with expenditure on research and development( p <0.001). Rare disease legislation increased annual publication production by 62.8% (95% CI 0.390–0.867; p <0.001) averagely. Notably, the effect of legislation was swift and lasting in MICs during the first five years. No significant impact was found with GDP per capita, female percentage, and political indicators. Conclusions SSc research output increased over time with substantial country disparities. Effective health policies facilitating research should be expanded especially among MICs to accelerate global advancement.

scholarly journals Effects of socio-economic factors on research over systemic sclerosis: an analysis based on long time series of bibliometric data

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Wei Guo ◽  
Zeyu Zhou ◽  
Yinhe Liang ◽  
Chuanhui Xu ◽  
Lin Zeng ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Rare Disease ◽  
Research Output ◽  
Economic Factors ◽  
Middle Income ◽  
Middle Income Countries ◽  
Country Level ◽  
Long Time ◽  
Domestic Products ◽  
Socio Economic Factors

Abstract Background Systemic sclerosis (SSc) is a rare detrimental disease warranting global research efforts. Evaluating how socio-economic factors impact country research output on SSc could help to identify solutions advancing research. Methods Publication production on SSc during 1969–2018 and data for structural and policy factors for WHO member countries were collected from public sources. Associations between SSc research output and country-level factors were investigated through panel regression. Difference-in-differences analysis further assessed the causal effects of rare disease legislation. Results SSc publications demonstrated exponential growth (r = 0.9410, as against an r = 0.8845 after linear adjustment), but were concentrated in high-income countries (HICs). Ten countries, nine of which were HICs, published 12,261 (77.5%) SSc publications but another 87 countries produced none. Gross domestic products (GDP), population and expenditure on research and development were positively associated with SSc publications (p < 0.001). Higher health expenditure was only found to be associated with increased SSc publications in HICs (p < 0.001). Rare disease legislation increased annual publication production by 62.8% (95% CI 0.390–0.867; p < 0.001) averagely. In middle-income countries (MICs), the effect was especially swift and lasting. No significant impact was found with GDP per capita, female percentage, and political indicators. Conclusions SSc research output increased over time with substantial country disparities. Effective health policies facilitating research should be expanded especially among MICs to accelerate research advancement.

scholarly journals Effects of Socio-economic Factors on Research Over Systemic Sclerosis: an Analysis Based on Long Time Series of Bibliometric Data

2021 ◽  
Author(s):  
Wei Guo ◽  
Zeyu Zhou ◽  
Yinhe Liang ◽  
Chuanhui Xu ◽  
Lin Zeng ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Rare Disease ◽  
Research Output ◽  
Causal Effects ◽  
Economic Factors ◽  
Annual Growth Rate ◽  
Difference In Differences ◽  
Country Level ◽  
Long Time ◽  
Socio Economic Factors

Abstract Background Systemic sclerosis (SSc) is a rare detrimental disease warranting mobilization of global research efforts. Evaluating how socio-economic factors impact country research output on SSc could help to identify solutions advancing SSc research.Methods Publication production on SSc during 1969–2018 and data for structural and policy factors for WHO member countries were collected from public sources. Associations between SSc research output and country-level factors were investigated through panel regression. Difference-in-differences analysis further assessed the causal effects of rare disease legislation. Results SSc publications showed an increasing annual growth rate (−0.3% during 1969–1983 vs. 6.9% during 2000–2018), but were concentrated in high-income countries (HICs). Ten countries, nine of which were HICs, published 12 261 (77.5%) SSc publications but another 87 countries produced none. GDP, population and expenditure on research and development were positively associated with SSc publications (p<0.001). Higher health expenditure was only found to be associated with increased SSc publications in HICs (p<0.001). Rare disease legislation increased annual publication production by 62.8% (95% CI 0.390–0.867; p<0.001) averagely. In MICs, the effect was especially swift and lasting. No significant impact was found with GDP per capita, female percentage, and political indicators.Conclusions SSc research output increased over time with substantial country disparities. Effective health policies facilitating research should be expanded especially among MICs to accelerate research advancement.

scholarly journals Predictors of Contemporary under-5 Child Mortality in Low- and Middle-Income Countries: A Machine Learning Approach

2021 ◽  
Vol 18 (3) ◽  
pp. 1315
Author(s):  
Andrea Bizzego ◽  
Giulio Gabrieli ◽  
Marc H. Bornstein ◽  
Kirby Deater-Deckard ◽  
Jennifer E. Lansford ◽  
...  
Keyword(s):  
Machine Learning ◽  
Child Mortality ◽  
Learning Approach ◽  
Unique Contribution ◽  
Middle Income ◽  
Middle Income Countries ◽  
Country Level ◽  
Machine Learning Approach ◽  
Operational Information ◽  
Low And Middle Income

Child Mortality (CM) is a worldwide concern, annually affecting as many as 6.81% children in low- and middle-income countries (LMIC). We used data of the Multiple Indicators Cluster Survey (MICS) (N = 275,160) from 27 LMIC and a machine-learning approach to rank 37 distal causes of CM and identify the top 10 causes in terms of predictive potency. Based on the top 10 causes, we identified households with improved conditions. We retrospectively validated the results by investigating the association between variations of CM and variations of the percentage of households with improved conditions at country-level, between the 2005–2007 and the 2013–2017 administrations of the MICS. A unique contribution of our approach is to identify lesser-known distal causes which likely account for better-known proximal causes: notably, the identified distal causes and preventable and treatable through social, educational, and physical interventions. We demonstrate how machine learning can be used to obtain operational information from big dataset to guide interventions and policy makers.

scholarly journals Tobacco intervention research in low- and middle-income countries: lessons learned and future directions

2016 ◽  
Vol 11 (2) ◽  
pp. 61-64 ◽  
Author(s):  
Kenneth D. Ward
Keyword(s):  
Tobacco Control ◽  
Tobacco Use ◽  
Tobacco Cessation ◽  
Tobacco Dependence ◽  
Lessons Learned ◽  
Future Directions ◽  
Middle Income ◽  
Middle Income Countries ◽  
Country Level ◽  
Tobacco Intervention

Treating tobacco dependence is paramount for global tobacco control efforts, but is often overshadowed by other policy priorities. As stated by Jha (2009), “cessation by current smokers is the only practical way to avoid a substantial proportion of tobacco deaths worldwide before 2050.” Its importance is codified in Article 14 of the Framework Convention on Tobacco Control (FCTC), and in the WHO's MPOWER package of effective country-level policies. Unfortunately, only 15% of the world's population have access to appropriate cessation support (WHO, 2015). Moreover, parties to the FCTC have implemented only 51% of the indicators within Article 14, on average, which is far lower than many other articles (WHO, 2014). Further, commenting on the use of “O” measures (Offer help to quit tobacco use) in the MPOWER acronym, WHO recently concluded, “while there has been improvement in implementing comprehensive tobacco cessation services, this is nonetheless a most under-implemented MPOWER measure in terms of the number of countries that have fully implemented it” (WHO, 2015). To the detriment of global tobacco control efforts, only one in eight countries provides comprehensive cost-covered services, only one in four provide some cost coverage for nicotine replacement therapy, and fewer than one third provide a toll-free quit line (WHO, 2015).

scholarly journals Estimating the Impact and Cost of the WHO 2010 Recommendations for Antiretroviral Therapy

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
John Stover ◽  
Lori Bollinger ◽  
Carlos Avila
Keyword(s):  
Antiretroviral Therapy ◽  
Cd4 Count ◽  
Eligibility Criterion ◽  
Eligibility Criteria ◽  
Art Programs ◽  
Middle Income ◽  
Middle Income Countries ◽  
Country Level ◽  
Potential Impact ◽  
The Impact

In July 2010, WHO published new recommendations on providing antiretroviral therapy to adults and adolescents, including starting ART earlier, usually at a CD4 count of 350 or lower, specific regimens for first- and second-line therapies, and other recommendations. This paper estimates the potential impact and cost of the revised guidelines by first, calculating the number of people that would be in need of antiretroviral therapy (ART) with different eligibility criteria, and second, calculating the costs associated with the potential impact. Results indicate that switching the eligibility criterion from CD4 count <200 to <350 increases the need for ART in low- and middle-income countries (country-level) by 50% (range 34% to 70%). The costs of ART programs only to increase coverage to 80% by 2015 would be 44% more (range 29% to 63%) when switching the eligibility criterion to CD4 count <350. When testing and outreach costs are included, total costs increase by 62%, from US$26.3 billion under the previous eligibility criterion of treating those with CD4 <200 to US$42.5 billion using the revised eligibility criterion of treating those with CD4 <350.

scholarly journals Consumption of breast milk, formula and other non-human milk by children aged under 2 years: analysis of eighty-six low- and middle-income countries

2020 ◽  
pp. 1-9
Author(s):  
Paulo AR Neves ◽  
Aluísio JD Barros ◽  
Phillip Baker ◽  
Ellen Piwoz ◽  
Thiago M Santos ◽  
...  
Keyword(s):  
Breast Milk ◽  
Human Milk ◽  
Breast Feeding ◽  
Milk Formula ◽  
Milk Consumption ◽  
Middle Income ◽  
Middle Income Countries ◽  
Country Level ◽  
Low And Middle Income ◽  
Economic Inequalities

Abstract Objective: To investigate the prevalence and socio-economic inequalities in breast milk, breast milk substitutes (BMS) and other non-human milk consumption, by children under 2 years in low- and middle-income countries (LMIC). Design: We analysed the prevalence of continued breast-feeding at 1 and 2 years and frequency of formula and other non-human milk consumption by age in months. Indicators were estimated through 24-h dietary recall. Absolute and relative wealth indicators were used to describe within- and between-country socio-economic inequalities. Setting: Nationally representative surveys from 2010 onwards from eighty-six LMIC. Participants: 394 977 children aged under 2 years. Results: Breast-feeding declined sharply as children became older in all LMIC, especially in upper-middle-income countries. BMS consumption peaked at 6 months of age in low/lower-middle-income countries and at around 12 months in upper-middle-income countries. Irrespective of country, BMS consumption was higher in children from wealthier families, and breast-feeding in children from poorer families. Multilevel linear regression analysis showed that BMS consumption was positively associated with absolute income, and breast-feeding negatively associated. Findings for other non-human milk consumption were less straightforward. Unmeasured factors at country level explained a substantial proportion of overall variability in BMS consumption and breast-feeding. Conclusions: Breast-feeding falls sharply as children become older, especially in wealthier families in upper-middle-income countries; this same group also consumes more BMS at any age. Country-level factors play an important role in explaining BMS consumption by all family wealth groups, suggesting that BMS marketing at national level might be partly responsible for the observed differences.

scholarly journals Inequality in physical activity, global trends by income inequality and gender in adults

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Chastin SFM ◽  
J. Van Cauwenberg ◽  
L. Maenhout ◽  
G. Cardon ◽  
E. V. Lambert ◽  
...  
Keyword(s):  
Physical Activity ◽  
Health Care ◽  
Income Inequality ◽  
Physical Inactivity ◽  
World Health ◽  
Middle Income ◽  
Physical Activity Guidelines ◽  
Middle Income Countries ◽  
Country Level ◽  
The World

Abstract Background Physical inactivity is a global pandemic associated with a high burden of disease and premature mortality. There is also a trend in growing economic inequalities which impacts population health. There is no global analysis of the relationship between income inequality and population levels of physical inactivity. Methods Two thousand sixteen World Health Organisation’s country level data about compliance with the 2010 global physical activity guidelines were analysed against country level income interquantile ratio data obtained from the World Bank, OECD and World Income Inequality Database. The analysis was stratified by country income (Low, Middle and High) according to the World Bank classification and gender. Multiple regression was used to quantify the association between physical activity and income inequality. Models were adjusted for GDP and percentage of GDP spent on health care for each country and out of pocket health care spent. Results Significantly higher levels of inactivity and a wider gap between the percentage of women and men meeting global physical activity guidelines were found in countries with higher income inequality in high and middle income countries irrespective of a country wealth and spend on health care. For example, in higher income countries, for each point increase in the interquantile ratio data, levels of inactivity in women were 3.73% (CI 0.89 6.57) higher, levels of inactivity in men were 2.04% (CI 0.08 4.15) higher and the gap in inactivity levels between women and men was 1.50% larger (CI 0.16 2.83). Similar relationships were found in middle income countries with lower effect sizes. These relationships were, however, not demonstrated in the low-income countries. Conclusions Economic inequalities, particularly in high- and middle- income countries might contribute to physical inactivity and might be an important factor to consider and address in order to combat the global inactivity pandemic and to achieve the World Health Organisation target for inactivity reduction.

scholarly journals Technological Learning, Industrial Policy, and Catch-up

2019 ◽  
pp. 1-12
Author(s):  
Arkebe Oqubay ◽  
Kenichi Ohno
Keyword(s):  
Industrial Policy ◽  
First Century ◽  
Dynamic Learning ◽  
Middle Income ◽  
Technological Learning ◽  
Middle Income Countries ◽  
Early Stages ◽  
Country Level ◽  
The Future ◽  
Catch Up

Why is catch-up rare? And why have some nations succeeded while others failed? What are the prospects for successful learning and catch-up in the twenty-first century? This chapter introduces the aims, themes, and analytical perspectives of How Nations Learn, outlining the focus of each chapter, and considering pathways to the future. The volume examines how nations learn by reviewing key structural and contingent factors that contribute to dynamic learning and catch-up. It uses historical as well as firm-, industry-, and country-level evidence and experiences to identify sources and drivers of successful learning and catch-up and the lessons for late-latecomer countries. It aims to generate interest and debate among policymakers, practitioners, and researchers on the complexity of learning and catch-up, not only for late late developers but also for middle-income countries in the early stages of industrialization.

scholarly journals Protocol for a Multi-Level Policy Analysis of Non-Communicable Disease Determinants of Diet and Physical Activity: Implications for Low- and Middle-Income Countries in Africa and the Caribbean

2021 ◽  
Vol 18 (24) ◽  
pp. 13061
Author(s):  
Maylene Shung-King ◽  
Amy Weimann ◽  
Nicole McCreedy ◽  
Lambed Tatah ◽  
Clarisse Mapa-Tassou ◽  
...  
Keyword(s):  
Physical Activity ◽  
South Africa ◽  
Policy Development ◽  
Salt Intake ◽  
Communicable Disease ◽  
Middle Income ◽  
Middle Income Countries ◽  
Country Level ◽  
Promotion Of Physical Activity ◽  
Low And Middle Income

Non-communicable diseases (NCDs) are the leading cause of death globally. Despite significant global policy development for addressing NCDs, the extent to which global policies find expression in low-and-middle income countries’ (LMIC) policies, designed to mitigate against NCDs, is unclear. This protocol is part of a portfolio of projects within the Global Diet and Activity Research (GDAR) Network, which aims to support the prevention of NCDs in LMICs, with a specific focus on Kenya, Cameroon, South Africa and Jamaica. This paper outlines the protocol for a study that seeks to explore the current policy environment in relation to the reduction of key factors influencing the growing epidemic of NCDs. The study proposes to examine policies at the global, regional and country level, related to the reduction of sugar and salt intake, and the promotion of physical activity (as one dimension of healthy placemaking). The overall study will comprise several sub-studies conducted at a global, regional and country level in Cameroon, Kenya and South Africa. In combination with evidence generated from other GDAR workstreams, results from the policy analyses will contribute to identifying opportunities for action in the reduction of NCDs in LMICs.

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