scholarly journals Conditional quantiles estimation of the incubation period of COVID-19

2020 ◽  
Author(s):  
Xiaohui Liu ◽  
Lei Wang ◽  
Xiansi Ma ◽  
Jiewen Wang
Keyword(s):  
Incubation Period ◽  
World Health ◽  
Likelihood Method ◽  
Biased Sampling ◽  
Unknown Etiology ◽  
Age Group ◽  
Conditional Quantiles ◽  
Age Dependent ◽  
Health Organization ◽  
Right Truncation

Abstract Background : In December 2019, some cases of pneumonia with unknown etiology were identified in Wuhan, Hubei province in China. The World Health Organization (WHO) has named this disease as COVID-19, standing for ``2019 coronavirus disease", and announced the disease have become a public health incident on December 31, 2019. This study aimed to investigate the conditional distribution of the incubation period of COVID-19 on the age of infected cases, and estimate its corresponding conditional quantiles from information on 2172 confirmed cases from 29 provinces outside Hubei in China. Methods : We collected data including the infection dates, onset dates, and ages of the confirmed cases from the websites of the centres of disease control, or the daily public reports through February 16th, 2020. A new maximum likelihood method was developed to account for the biased sampling, or right truncation, issue of the data as the epidemic is still ongoing. The estimators can be shown to be consistent asymptotically under mild conditions. Results : Based on the collected data, we found that the conditional quantiles of the incubation period distribution of COVID-19 varies over ages. In detail, the high conditional quantiles of people in the middle age group are shorter than those of others. We estimated that the 0.95-th quantile related to people in the age group 23$\sim$55 is less than 15 days. Conclusions : Observing that the conditional quantiles vary over ages, we may take more precise measures for people of different ages. For example, we may consider carrying out an age-dependent quarantine duration, rather than a uniform 14-days quarantine, in practice. Remarkably, we may need to extend the current quarantine duration for people aged $0\sim22$ and over 55 because the related 0.95-th quantiles are much greater than 14 days.

scholarly journals Modeling the effect of age on quantiles of the incubation period distribution of COVID-19

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xiaohui Liu ◽  
Lei Wang ◽  
Xiansi Ma ◽  
Jiewen Wang ◽  
Liwen Wu
Keyword(s):  
Incubation Period ◽  
Social Life ◽  
Likelihood Method ◽  
Biased Sampling ◽  
Unknown Etiology ◽  
Age Group ◽  
Conditional Quantiles ◽  
Period Distribution ◽  
First Case ◽  
Effect Of Age

Abstract Background The novel coronavirus SARS-CoV-2 (coronavirus disease 2019, COVID-19) has caused serious consequences on many aspects of social life throughout the world since the first case of pneumonia with unknown etiology was identified in Wuhan, Hubei province in China in December 2019. Note that the incubation period distribution is key to the prevention and control efforts of COVID-19. This study aimed to investigate the conditional distribution of the incubation period of COVID-19 given the age of infected cases and estimate its corresponding quantiles from the information of 2172 confirmed cases from 29 provinces outside Hubei in China. Methods We collected data on the infection dates, onset dates, and ages of the confirmed cases through February 16th, 2020. All the data were downloaded from the official websites of the health commission. As the epidemic was still ongoing at the time we collected data, the observations subject to biased sampling. To address this issue, we developed a new maximum likelihood method, which enables us to comprehensively study the effect of age on the incubation period. Results Based on the collected data, we found that the conditional quantiles of the incubation period distribution of COVID-19 vary by age. In detail, the high conditional quantiles of people in the middle age group are shorter than those of others while the low quantiles did not show the same differences. We estimated that the 0.95-th quantile related to people in the age group 23 ∼55 is less than 15 days. Conclusions Observing that the conditional quantiles vary across age, we may take more precise measures for people of different ages. For example, we may consider carrying out an age-dependent quarantine duration in practice, rather than a uniform 14-days quarantine period. Remarkably, we may need to extend the current quarantine duration for people aged 0 ∼22 and over 55 because the related 0.95-th quantiles are much greater than 14 days.

scholarly journals Modeling the Effect of Age on Quantiles of the Incubation Period Distribution of COVID-19

2020 ◽  
Author(s):  
Xiaohui Liu ◽  
Lei Wang ◽  
Xiansi Ma ◽  
Jiewen Wang ◽  
Liwen Wu
Keyword(s):  
Incubation Period ◽  
Likelihood Method ◽  
Biased Sampling ◽  
Unknown Etiology ◽  
Age Group ◽  
Conditional Quantiles ◽  
Period Distribution ◽  
First Case ◽  
Novel Coronavirus ◽  
And Control

Abstract Background: Since the first case of pneumonia with unknown etiology was identified in Wuhan, Hubei province in China in December 2019, the novel coronavirus pneumonia has placed a serious impact on many aspects of the world. Note that the incubation period distribution plays important roles in prevention and control efforts of COVID-19. This study aimed to investigate the conditional distribution of the incubation period of COVID-19 on the age of infected cases, and estimate its corresponding quantiles from information of 2172 confirmed cases from 29 provinces outside Hubei in China.Methods: We collected data including the infection dates, onset dates, and ages of the confirmed cases from the websites of the centres of disease control, or the daily public reports through February 16th, 2020. A maximum likelihood method was developed to account for the biased sampling issue of the data as the epidemic was still ongoing at the time of collecting data. Results: Based on the collected data, we found that the conditional quantiles of the incubation period distribution of COVID-19 varies over ages. In detail, the high conditional quantiles of people in the middle age group are shorter than those of others. We estimated that the 0.95-th quantile related to people in the age group 23∼55 is less than 15 days. Conclusions: Observing that the conditional quantiles vary over ages, we may take more precise measures for people of different ages. For example, we may consider carrying out an age-dependent quarantine duration, rather than a uniform 14-days quarantine, in practice. Remarkably, we may need to extend the current quarantine duration for people aged 0 ∼ 22 and over 55 because the related 0.95-th quantiles are much greater than 14 days.

COVID 19: REALS AND CHALLENGES AGAINST DOCTORS

2020 ◽  
Vol 2 (1) ◽  
pp. 65-87
Author(s):  
Zen Ahmad
Keyword(s):  
Virus Disease ◽  
Clinical Manifestations ◽  
World Health ◽  
Unknown Etiology ◽  
Wuhan City ◽  
Traditional Markets ◽  
Pneumonia Case ◽  
The World ◽  
New Type ◽  
Health Organization

Corona Virus Disease (Covid-19) is a contagious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) which was discovered in December 2019 in China. This disease can cause clinical manifestations in the airway, lung and systemic. The World Health Organization (WHO) representative of China reported a pneumonia case with unknown etiology in Wuhan City, Hubei Province, China on December 31, 2019. The cause was identified as a new type of coronavirus on January 7, 2020 with an estimated source of the virus from traditional markets (seafood market). ) Wuhan city

Addressing the importance of Stem cell-based therapy: a Perspective in the treatment of COVID-19’

2020 ◽  
Vol 20 ◽  
Author(s):  
Christine Ibrahim ◽  
Hanna Semaan ◽  
Marwan El-Sabban ◽  
Fadia Najjar ◽  
Aline Hamade
Keyword(s):  
Stem Cell ◽  
Drug Repositioning ◽  
World Health ◽  
Unknown Etiology ◽  
Cell Based Therapy ◽  
Pathogenic Virus ◽  
Lung Injuries ◽  
Healthcare Crisis ◽  
Health Organization ◽  
Potential Use

: Severe acute respiratory syndrome-associated corona virus 2 (SARS-CoV-2), is an extremely pathogenic virus belonging to the family of Coronaviridae. First identified in Wuhan China in December 2019 after an epidemiological investigation of an emerging cluster of pneumonia of unknown etiology, SARS-CoV-2 was declared the cause of a pandemic on March 11 by the World Health Organization (WHO) pointing to the over 118000 cases of Coronavirus disease 2019 (COVID- 19) in over 110 countries. Despite the promising results of drug repositioning studies in the treatment of COVID-19, the evidence of their safety and efficacy remains inconclusive. Cell based therapy has been proven safe and possibly effective in treating multiple lung injuries and diseases but its potential use in the treatment of COVID-19 has not been yet elucidated. Our aim in this review is to provide an overview on the immunomodulatory effect and the regenerative capacity of stem cells and their secretome in the treatment of many diseases including lung injuries. Those findings may contribute to a better understanding of the potential of stem cell therapy in SARS-CoV-2 infection and its potential use in order to find a solution for this healthcare crisis.

scholarly journals Bleeding risks are higher in children versus adults given prophylactic platelet transfusions for treatment-induced hypoproliferative thrombocytopenia

Blood ◽  
2012 ◽  
Vol 120 (4) ◽  
pp. 748-760 ◽  
Author(s):  
Cassandra D. Josephson ◽  
Suzanne Granger ◽  
Susan F. Assmann ◽  
Marta-Inés Castillejo ◽  
Ronald G. Strauss ◽  
...  
Keyword(s):  
Bleeding Risk ◽  
World Health ◽  
Age Group ◽  
Transplant Recipients ◽  
Disease Treatment ◽  
Platelet Counts ◽  
Wide Range ◽  
Treatment Category ◽  
Dose Trial ◽  
Health Organization

Age-group analyses were conducted of patients in the prophylactic platelet dose trial (PLADO), which evaluated the relation between platelet dose per transfusion and bleeding. Hospitalized patients with treatment-induced hypoproliferative thrombocytopenia were randomly assigned to 1 of 3 platelet doses: 1.1 × 1011, 2.2 × 1011, or 4.4 × 1011 platelets/m2 per transfusion, given for morning counts of ≤ 10 000 platelets/μL. Daily hemostatic assessments were performed. The primary end point (percentage of patients who developed grade 2 or higher World Health Organization bleeding) was evaluated in 198 children (0-18 years) and 1044 adults. Although platelet dose did not predict bleeding for any age group, children overall had a significantly higher risk of grade 2 or higher bleeding than adults (86%, 88%, 77% vs 67% of patients aged 0-5 years, 6-12 years, 13-18 years, vs adults, respectively) and more days with grade 2 or higher bleeding (median, 3 days in each pediatric group vs 1 day in adults; P < .001). The effect of age on bleeding differed by disease treatment category and was most pronounced among autologous transplant recipients. Pediatric subjects were at higher risk of bleeding over a wide range of platelet counts, indicating that their excess bleeding risk may be because of factors other than platelet counts. This trial was registered at www.clinicaltrials.gov as #NCT00128713.

Health Problems of Adolescence: Report of a WHO Expert Committee. World Health Organization:

PEDIATRICS ◽  
1966 ◽  
Vol 37 (2) ◽  
pp. 392-392
Author(s):  
THOMAS E. CONE
Keyword(s):  
World Health Organization ◽  
Health Problems ◽  
World Health ◽  
Expert Committee ◽  
Age Group ◽  
Committee Meeting ◽  
Adolescent Population ◽  
The World ◽  
Group 15 ◽  
Health Organization

This is a timely, concise, eminently practical, thoughtfully, even tenderly, written 28 page report of a recent WHO Expert Committee meeting on the health problems of adolescence. The members and the consultants to the Committee deftly summarize the major worldwide trends affecting our adolescent population. The size of this population is staggering; in the age group 15-19 years alone there are already 300 million adolescents in the world, and there seems every likelihood that these numbers will increase rapidly during the next decade.

Mental Health

2021 ◽  
pp. 143-152
Author(s):  
Shazia Ali ◽  
Amat Us Samie ◽  
Asma Ali ◽  
Aashiq Hussain Bhat ◽  
Tariq Mir ◽  
...  
Keyword(s):  
Mental Health ◽  
Political Conflict ◽  
World Health ◽  
Global Burden ◽  
Age Group ◽  
Health Issues ◽  
The People ◽  
Working Age ◽  
War And Conflict ◽  
Health Organization

Global health issues are a global burden and are relatively common in industrialized societies. The World Health Organization and researchers have developed and rebuilt tools to report the burden of disease affecting mortality and health of the people. Apart from America and Europe, which are at an average of global burden for mental health disease, in some regions it is a major priority to be addressed globally. In South East Asia, one of the affected regions is Kashmir, Northern Indian. Disasters have manifested in various forms encompassing the natural calamities of earthquake, flood, landslides and manmade calamities of violence. Trauma due to manmade calamities has taken over as a leading cause of morbidity and mortality among the most productive working age group of 12-35 years. The chapter aims to understand the patterns of resilience in people surviving war and conflict in Kashmir over last 60 years. The focus is on the young population of society. Generations in Kashmir have faced the psychosocial impact of ongoing political conflict since the 1980's.

Mental Health

2020 ◽  
pp. 18-29
Author(s):  
Shazia Ali ◽  
Amat Us Samie ◽  
Asma Ali ◽  
Aashiq Hussain Bhat ◽  
Tariq Mir ◽  
...  
Keyword(s):  
Mental Health ◽  
Political Conflict ◽  
World Health ◽  
Global Burden ◽  
Age Group ◽  
Health Issues ◽  
The People ◽  
Working Age ◽  
War And Conflict ◽  
Health Organization

Global health issues are a global burden and are relatively common in industrialized societies. The World Health Organization and researchers have developed and rebuilt tools to report the burden of disease affecting mortality and health of the people. Apart from America and Europe, which are at an average of global burden for mental health disease, in some regions it is a major priority to be addressed globally. In South East Asia, one of the affected regions is Kashmir, Northern Indian. Disasters have manifested in various forms encompassing the natural calamities of earthquake, flood, landslides and manmade calamities of violence. Trauma due to manmade calamities has taken over as a leading cause of morbidity and mortality among the most productive working age group of 12-35 years. The chapter aims to understand the patterns of resilience in people surviving war and conflict in Kashmir over last 60 years. The focus is on the young population of society. Generations in Kashmir have faced the psychosocial impact of ongoing political conflict since the 1980's.

scholarly journals A super-spreader of SARS-CoV-2 in incubation period among health-care workers

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Chaojie Wei ◽  
Yufeng Yuan ◽  
Zhenshun Cheng
Keyword(s):  
Health Care ◽  
Severe Acute Respiratory Syndrome ◽  
World Health Organization ◽  
Incubation Period ◽  
Health Care Workers ◽  
World Health ◽  
Doctor Who ◽  
Care Workers ◽  
Potential Sources ◽  
Health Organization

AbstractSince the coronavirus disease 2019 (COVID-19) identified in Wuhan, Hubei, China in December 2019, it has been characterized as a pandemic by World Health Organization (WHO). It was reported that asymptomatic persons are potential sources of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We present an outbreak among health-care workers incited by a doctor who cared a patient with COVID-19 in a Hospital in Wuhan, Hubei, China, which indicates existence of super-spreader even during incubation period.

Predicting the community prevalence of schistosomiasis mansoni from the prevalence among 7- to 14-year-olds

Parasitology ◽  
2000 ◽  
Vol 121 (5) ◽  
pp. 507-512 ◽  
Author(s):  
L. C. RODRIGUES ◽  
J. G. WHEELER ◽  
R. SHIER ◽  
H. L. GUERRA ◽  
F. PIMENTA ◽  
...  
Keyword(s):  
Treatment Strategies ◽  
Strong Relationship ◽  
Community Treatment ◽  
World Health ◽  
Age Group ◽  
Predictive Values ◽  
Schistosomiasis Mansoni ◽  
Indicator Group ◽  
The World ◽  
Health Organization

The World Health Organization suggested that the prevalence of Schistosoma mansoni among 7- to 14-year-olds be used to guide treatment strategies in endemic areas. This study explores how well the prevalence in that age group predicted the overall prevalence in the community in data from stool examinations (Kato–Katz method) from 180000 people in 3 municipalities in Brazil in 1984 and 1985. The median prevalence was higher in 1984, before community treatment was introduced. There was a strong relationship between the prevalence among 7- to 14-year-olds and the overall prevalence in the community. We present sensitivities and positive predictive values for the use of prevalence in the indicator group to select communities for mass treatment as recommended by WHO. For a range of assumptions sensitivity and positive predictive value were never both above 80%. We suggest that the estimates of validity presented in this paper inform future evaluations of strategies for S. mansoni control.

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