Ag2O/GO/TiO2 Composite Nanostructure: an efficient heterogeneous catalyst for one pot synthesis of Bis (dihydropyrimidinone) and tetrahydro-4H-chromenes derivatives

Abstract The simple and efficient synthesis reaction was used for preparing Bis (dihydropyrimidinone) derivatives through Biginelli condensation reaction of terephthalic aldehyde, 1, 3-dicarbonyl compounds and (thio) urea or guanidine and tetrahydro-4H-chromenes via one pot condensation of aromatic aldehydes, malononitrile and dimedone with Ag2O/GO/TiO2 composite nanostructures as a catalyst. The structural functionalities and morphological observations of catalyst were obtained using characterization techniques of field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), Fourier transfer infrared (FT-IR) spectroscopy and transmission electron microscope (TEM). The structures of Bis (dihydropyrimidinone) and tetrahydro-4H-chromenes confirmed by FT- IR, NMR and mass spectroscopy. Excellent yields of the products, simple reaction process and simple work-up are attractive features of these effective synthesis methods.

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H3PW12O40 Anchored on the Three-Dimensional and Networked SBA-15 as an Efficient and Recyclable Catalyst for Mannich Reaction

Journal of the Mexican Chemical Society ◽

10.29356/jmcs.v64i1.1034 ◽

2019 ◽

Vol 64 (1) ◽

Cited By ~ 1

Author(s):

Tengfei Zhang ◽

Wei Zhang ◽

Hao Dong ◽

Qing Liu

Keyword(s):

Mannich Reaction ◽

Three Dimensional ◽

Impregnation Method ◽

X Ray Diffraction ◽

Reaction Conditions ◽

One Pot ◽

Solvent Free Condition ◽

Transmission Electron ◽

Ft Ir ◽

The One

Abstract. The three-dimensional and networked SBA-15 (3D-SBA-15) supported phosphotungstic acid (PW) was used as heterogeneous catalyst for the one-pot three-components Mannich reaction at room temperature. The H3PW12O40/3D-SBA-15 catalyst was prepared using an impregnation method and confirmed by series of characterizations such as Fourier-transform infrared spectra (FT-IR), scanning electron microscope (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), N2 physisorption and thermogravimetric (TG) analysis. 50PW/3D-SBA-15 catalyst with H3PW12O40 loading of 50 wt% showed the highest yield of 93% in 1.8 h for the Mannich reaction of benzaldehyde, aniline and acetophenone under solvent-free condition. A series of β-aminoketone derivatives were synthesized successfully in the presence of this catalyst. In addition, H3PW12O40/3D-SBA-15 catalyst can be easily recovered and reused four times without significant decrease of the activity. This work provides an improved modification of the three-component Mannich reaction in terms of mild reaction conditions, clean reaction profiles, small quantity of catalyst and a simple workup procedure. Resumen. El ácido fosfotungstico (PW) se soportó en sílice SBA-15 (3D-SBA-15) y se usó como catalizador heterogéneo en la reacción de Mannich en un solo paso de tres componentes a temperatura ambiente. El catalizador H3PW12O40/3D-SBA-15 se preparó mediante impregnación y se caracterizó por espectroscopia de infrarrojo (FT-IR), microscopia electrónica de barrido (SEM), microscopía electrónica de transmisión (TEM), difracción de rayos-X (XRD), fisisorción de N2 y análisis termogravimétrico (TG). El catalizador 50PW/3D-SBA-15, con una carga de H3PW12O40 del 50% en peso, mostró el rendimiento más alto del 93% en 1.8 h para la reacción de Mannich entre benzaldehído, anilina y acetofenona, sin disolvente. Se sintetizó una serie de derivados de β-aminocetona en presencia de este catalizador. Además, el catalizador H3PW12O40/3D-SBA-15 puede recuperarse fácilmente y reutilizarse cuatro veces sin pérdida significativa de la actividad. Este trabajo reporta una modificación de la reacción de Mannich de tres componentes bajo condiciones de reacción suaves, perfiles de reacción limpios, pequeña cantidad de catalizador y un procedimiento de tratamiento simple.

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Synthesis, Characterization, Crystallographic Studies of 5-Acetyl-8-hydroxyquinoline and Their Chalcone Derivatives

Asian Journal of Chemistry ◽

10.14233/ajchem.2020.22628 ◽

2020 ◽

Vol 32 (7) ◽

pp. 1609-1613

Author(s):

C.B. Vagish ◽

Karthik Kumara ◽

N.K. Lokanath ◽

K. Ajay Kumar ◽

P.G. Chandrasherkar

Keyword(s):

Single Crystal ◽

Benzoyl Chloride ◽

Condensation Reaction ◽

Aromatic Aldehydes ◽

Spectral Studies ◽

Monoclinic Crystal System ◽

X Ray Diffraction ◽

Monoclinic Crystal ◽

One Pot ◽

X Ray

An efficient, easy and one pot synthesis for the Friedel-Craft acetylation reaction of quinolines was developed. The reaction between 8-hydroxyquinoline and acetyl/benzoyl chloride in nitrobenzene immediately flocculates as yellow precipitate. On further addition of Lewis acid causes the Friedel-Craft acetylation leads to formation of acetylated quionlines in good yields. The structure of compound 5-acetyl-8-hydroxyquinoline (3) was confirmed by single crystal X-ray diffraction studies. The compound crystallizes in the monoclinic crystal system with the space group P21/c. The synthesized acetylated quionlines undergoes condensation reaction with aromatic aldehydes leads to 8-hydroxyquinoline chalcones derivatives. The products were characterized by spectral studies, elemental analysis and single crystal X-ray diffraction studies.

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The Construction of the Heterostructural Bi2O3/g-C3N4 Composites with an Enhanced Photocatalytic Activity

NANO ◽

10.1142/s1793292018500637 ◽

2018 ◽

Vol 13 (06) ◽

pp. 1850063 ◽

Cited By ~ 4

Author(s):

Jinhua Zhang ◽

Huiyue Qian ◽

Wencheng Liu ◽

Hao Chen ◽

Yang Qu ◽

...

Keyword(s):

Photocatalytic Activity ◽

Photoelectron Spectroscopy ◽

Photogenerated Electron ◽

X Ray Diffraction ◽

One Pot ◽

X Ray ◽

Air Atmosphere ◽

Transmission Electron ◽

Ft Ir ◽

The One

A heterostructural composite composed of g-C3N4 and Bi2O3 was achieved by the one-pot and thermal-induced polycondensation method using melamine and Bi(NO[Formula: see text] as precursor at 550[Formula: see text]C under air atmosphere. The crystalline phase, components and morphologies of the as-prepared composites were investigated by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS) and transmission electron microscopy (TEM). Besides, the photocatalytic activity of composites was evaluated by degrading RhB aqueous solution at room temperature under visible light irradiation. Compared with bulk g-C3N4, the photocatalytic efficiency of the 0.5% Bi2O3/g-C3N4 (Bi–CN) was increased by up to four times. The introduction of Bi2O3 enhances not only the light absorption ability, but also the separation of photogenerated electron–hole pairs.

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Green Synthesis of New Category of Pyrano[3,2-c]Chromene-Diones Catalyzed by Nanocomposite as Fe3O4@SiO2-Propyl Covalented Dapsone-Copper Complex

Frontiers in Chemistry ◽

10.3389/fchem.2021.720555 ◽

2021 ◽

Vol 9 ◽

Author(s):

Leila Zare Fekri

Keyword(s):

Reaction Times ◽

Aromatic Aldehydes ◽

Green Solvent ◽

X Ray Diffraction ◽

Multicomponent Synthesis ◽

X Ray ◽

High Productivity ◽

Transmission Electron ◽

Ft Ir ◽

Derivatives Of

Nanomagnetic dapsone-Cu supported on the silica-coated Fe3O4 (Fe3O4@SiO2-pr@dapsone-Cu) nanocomposite was synthesized and characterized by Fourier transform infrared (FT-IR), energy-dispersive X-ray (EDX), X-ray diffraction (XRD), field emission scanning electron microscope (FE-SEM), transmission electron microscopy (TEM), zeta potential, vibrating sample magnetometer (VSM), and thermogravimetric analysis (TGA). This newly synthesized nanocomposite was chosen to act as a green, efficient, and recyclable Lewis acid for the multicomponent synthesis of new derivatives of pyrano[3,2-c]chromene-diones through the reaction of aromatic aldehydes, indandione, and 4-hydroxycoumarin in water. All of the synthesized compounds are new and are recognized by FT-IR, NMR, and elemental analysis; this avenue is new and has advantages such as short reaction times, high productivity, economical synthesis, and use of green solvent, H2O, as a medium. The catalyst is magnetically recoverable and can be used after six runs without a decrease in the efficiency.

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Fast and Efficient One-Pot Three-Component Synthesis of Some 1,2,3,4- Tetrahydro-6-methyl-N-phenyl-5-pyrimidinecarboxamide Derivatives via Biginelli Condensation Reaction

Letters in Organic Chemistry ◽

10.2174/1570178616666190819142221 ◽

2020 ◽

Vol 17 (5) ◽

pp. 366-371 ◽

Cited By ~ 1

Author(s):

Şirin Gülten ◽

Ufuk Gezer ◽

Elmas Aksanli Gündoğan

Keyword(s):

Medicinal Chemistry ◽

Condensation Reaction ◽

Aromatic Aldehydes ◽

Catalytic Amount ◽

Heterocyclic Ring ◽

Biological Properties ◽

Spectroscopic Techniques ◽

One Pot ◽

Efficient Catalyst ◽

Biginelli Condensation

Tetrahydropyrimidine (THPM) synthesis has an enormous importance in organic chemistry and especially in pharmaceutical applications. Pyrimidines are the most active class of N-containing heterocyclic compounds and have different biological properties. The heterocyclic ring system with a thio group occupy a unique position in medicinal chemistry. This type of compounds play an important role in synthetic drugs and in biological processes. Dihydropyrimidinethione derivatives occur widely in nature. Several modifications of THPM-5-carboxamides have attracted considerable interest of medicinal chemists due to their pharmacological and therapeutic properties. A series of 1,2,3,4-tetrahydro- 2-pyrimidinone/thione derivatives bearing a phenylcarbamoyl group at C-5 position were synthesized by one-pot three-component Biginelli condensation reaction. The reaction of acetoacetanilide as the 1,3-dicarbonyl component with various aromatic aldehydes and urea/thiourea in the presence of a catalytic amount of p-toluenesulfonic acid monohydrate (PTSA·H2O) or concentrated HCl as an efficient catalyst leads to Biginelli compounds. We have prepared eight THPM 5-carboxamide derivatives, four of them are new compounds. Their structures were confirmed by spectroscopic techniques and elemental analysis. These compounds have potential applications in organic synthesis and medicinal chemistry. We have synthesized a series of THPM-5-carboxamides by simple and efficient threecomponent Biginelli condensation reaction. Significant benefits of the present procedure include: a) application of inexpensive, non-toxic, environmentally friendly and easily available catalysts, b) the reactions are easy to carry out without high temperature and the workup is very simple, c) the required reaction times are relatively short (30-80 min with HCl and 8-24 h with PTSA·H2O), d) compatibility with various functional groups, e) the products are isolated in good to excellent yields (50-95%).

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One pot three component synthesis of substituted 3,4,6,7-tetrahydro-3,3,6,6-tetramethyl-9,10-diphenylacridine-1,8(2H,5H,9H,10H)-diones catalyzed by efficient In2O3-SiO2

10.21203/rs.3.rs-899408/v1 ◽

2021 ◽

Author(s):

Deepak Totaram Tayde ◽

Madhukar E. Navgire ◽

Machhindra K. Lande

Keyword(s):

High Yield ◽

Reusable Catalyst ◽

X Ray Diffraction ◽

One Pot ◽

Synthetic Strategy ◽

Transmission Electron ◽

Catalytic Material ◽

Ir Transmission ◽

Ft Ir ◽

Temperature Programmed

Abstract A convenient, One pot synthesis of heterocyclic nucleous acridine derivative compound has been achieved those are having very much attention in medicinal chemistry because of their extensive application in biology. The mixture of dimedone, substituted benzaldehyde and aniline were catalyzed by efficient In2O3-SiO2 heterogeneous reusable catalyst in ethanol to obtain the desired acridine derivatives with good yield. Hydrothermal method used to synthesize In2O3-SiO2 catalytic material. This catalytic material were characterized by using X-ray diffraction spectroscopy (XRD), scanning electron microscopy (SEM), Energy dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy (FT-IR), Transmission electron microscope (TEM), Temperature-programmed desorption (NH3-TPD) and Brunauer-Emmett-Teller (BET). Our synthetic strategy features high yield, simple work up procedure, non-toxic, clean, and easy recovery and reusability of the catalytic system.

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A simple and facile synthesis of amidoalkyl naphthols catalyzed by Yb(OTf)3 in ionic liquids

Canadian Journal of Chemistry ◽

10.1139/v09-049 ◽

2009 ◽

Vol 87 (6) ◽

pp. 714-719 ◽

Cited By ~ 37

Author(s):

Anil Kumar ◽

M. Sudershan Rao ◽

Israr Ahmad ◽

Bharti Khungar

Keyword(s):

Ionic Liquids ◽

Condensation Reaction ◽

Acid Catalyst ◽

Aromatic Aldehydes ◽

High Yield ◽

Facile Synthesis ◽

One Pot ◽

Ytterbium Triflate ◽

Amidoalkyl Naphthols ◽

One Pot Condensation

An improved, simple, and facile synthesis of amidoalkyl naphthols by employing three-component one-pot condensation reaction of β-naphthol, aromatic aldehydes, and amides in ionic liquids using ytterbium triflate as a mild Lewis acid catalyst is described. Advantageously, amidoalkyl naphthols were obtained in high yield under eco-friendly, economical, and non-corrosive conditions, and the catalyst was recycled.

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Efficient synthesis of biscoumarins using zinc acetate as a catalyst in aqueous media

10.31221/osf.io/fy9ps ◽

2019 ◽

Author(s):

Chem Int

Keyword(s):

Aromatic Aldehyde ◽

Zinc Acetate ◽

Condensation Reaction ◽

Aqueous Media ◽

Aromatic Aldehydes ◽

Efficient Synthesis ◽

One Pot ◽

One Pot Condensation ◽

Operational Simplicity

Bis-(4-hydroxycoumarin)methanes derivatives (1-9) were synthesized via one pot condensation reaction of various aromatic aldehyde and 4-hydroxycoumarin using zinc acetate as a catalyst in presence of water as a solvent. This mediated reaction of various aromatic and hetero-aromatic aldehydes using catalytic amounts of zinc acetate avoids the use of expensive, corrosive reagents, toxic solvents and provides operational simplicity.

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Synthesis of 3-(Cyclohexylamino)-2-arylimidazo[1,2-a]pyridine-8- carboxylic Acids Via an Efficient Three-component Condensation Reaction between Cyclohexylisocyanide and 2-Aminopyridine-3-carboxylic Acid in the Presence of Aromatic Aldehyde

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207321666180416153112 ◽

2018 ◽

Vol 21 (4) ◽

pp. 298-301 ◽

Cited By ~ 3

Author(s):

Ghasem Marandi

Keyword(s):

Biological Sciences ◽

Carboxylic Acid ◽

Carboxylic Acids ◽

High Performance ◽

Condensation Reaction ◽

Aromatic Aldehydes ◽

New Materials ◽

One Pot ◽

High Yields ◽

Benzaldehyde Derivatives

Aim and Objective: The reaction of cyclohexylisocyanide and 2-aminopyridine-3- carboxylic acid in the presence of benzaldehyde derivatives in ethanol led to 3-(cyclohexylamino)-2- arylimidazo[1,2-a]pyridine-8-carboxylic acids in high yields. In a three component condensation reaction, isocyanide reacts with 2-aminopyridine-3-carboxylic acid and aromatic aldehydes without any prior activation. Material and Methods: The synthesized products have stable structures which have been characterized by IR, 1H, 13C and Mass spectroscopy as well as CHN-O analysis. Results: In continuation of our attempts to develop simple one-pot routes for the synthesis of 3- (cyclohexylamino)-2-arylimidazo[1,2-a]pyridine-8-carboxylic acids, aromatic aldehydes with divers substituted show a high performance. Conclusion: In conclusion, this study introduces the art of combinatorial chemistry using a simple one-pot procedure for the synthesis of new materials which are interesting compounds in medicinal and biological sciences.

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