scholarly journals Clinicopathological characteristics and outcomes of 23 patients with secretory carcinoma of major salivary glands

2021 ◽  
Author(s):  
Jingjing Sun ◽  
Sirui Liu ◽  
Kun Fu ◽  
Ning Gao ◽  
Rui Li ◽  
...  
Keyword(s):  
Salivary Glands ◽  
Clinical Characteristics ◽  
Clinical Stage ◽  
Distant Metastases ◽  
Clinicopathological Characteristics ◽  
Low Grade ◽  
Secretory Carcinoma ◽  
Ki 67 ◽  
Major Salivary Glands ◽  
Salivary Gland Carcinomas

Abstract Background Secretory carcinoma of salivary glands (SCSGs) are generally low-grade salivary gland carcinomas, and are characterized by morphological resemblance to mammary analogue secretory carcinoma and ETV6–NTRK3 gene fusion. Several reports on histopathological features of SCSG have recently been published; however, little is known about the clinical characteristics of this new tumor, including its outcomes. The research is to investigate the clinicopathological characteristics of secretory carcinoma of major salivary glands and to analyze outcomes of these carcinomas as a reference for standardizing their diagnosis and treatment. Methods The cohort of this retrospective study comprised 23 patients treated for histopathologically-confirmed SCSG between January 2010 and December 2020. Their clinical characteristics and outcomes were retrieved from patient files. Results The 23 patients comprised 13 male and 10 female patients (male:female ratio 1.3:1). They were aged 10–69 years (median 45 years) and the average duration of disease was 2.44 years (0.25–20 years). Twenty-one patients (91.3%) had SCSGs in the parotid gland and two (8.7%) in the submandibular gland. All 23 patients had single nodules with diameters of 0.8–4.8 cm (average 2.6 cm). Five patients had lymph node metastases and two had distant metastases. All tumors were pathologically diagnosed as SCSGs. Immunohistochemical staining was strongly positive for S-100, mammaglobin, CK7, and Gata3, and negative for Dog1, P63 and calponin. Ki-67 positivity ranged from 1–50%. Fluorescence in situ hybridization data were available for 15 patients, in all of whom ETV6 gene rearrangement was confirmed. All patients had undergone oncological resections. Four had radioactive particles implanted postoperatively, one received chemotherapy, and seven underwent chemoradiotherapy. Six patients had regional recurrences, two distant metastases, and one had died at the time of last follow-up. Conclusions SCSGs are typically indolent with a low rate of locoregional recurrence and excellent survival. Their prognosis is correlated with clinical stage, pathological grade, and surgical procedures performed.

scholarly journals Clinicopathological Characteristics and Outcomes of 23 Patients with Secretory Carcinoma of Major Salivary Glands

2021 ◽  
Author(s):  
Jingjing Sun ◽  
Sirui Liu ◽  
Kun Fu ◽  
Ning Gao ◽  
Rui Li ◽  
...  
Keyword(s):  
Salivary Glands ◽  
Clinical Stage ◽  
Distant Metastases ◽  
Clinicopathological Characteristics ◽  
Secretory Carcinoma ◽  
Survival Prognosis ◽  
Ki 67 ◽  
S 100 ◽  
Locoregional Recurrence Rate ◽  
Node Metastases

Abstract This retrospective study investigated the clinicopathological characteristics of secretory carcinoma of salivary glands (SCSG) in 23 patients with histopathologically confirmed SCSG between January 2010 and December 2020. In total, 13 males and 10 females were enrolled (ratio, 1.3:1) from 10 to 69 years of age (median 45 y); the average disease duration was 2.44 y (0.25–20 y). Twenty-one patients (91.3%) had SCSG in the parotid gland, and two (8.7%) in the submandibular gland. All patients had single nodules with diameters of 0.8–4.8 cm (average 2.6 cm); five with lymph node metastases, and two with distant metastases. Immunohistochemically, tumors stained positive for S-100, mammaglobin, CK7, and GATA3, and negative for DOG1, P63, and calponin, with Ki-67 positivity from 1–50%. ETV6 gene rearrangement was confirmed in 15 patients. All patients underwent oncological resection, four had radioactive particles implanted postoperatively, one received chemotherapy, and seven underwent chemoradiotherapy. Six patients had regional recurrences, two distant metastases, and one died before the last follow-up. SCSGs are typically indolent, with a low locoregional recurrence rate and excellent survival. Prognosis is correlated to clinical stage, pathological grade, and surgical procedures.

scholarly journals Clinicopathological characteristics and outcomes of 23 patients with secretory carcinoma of major salivary glands

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jingjing Sun ◽  
Sirui Liu ◽  
Kun Fu ◽  
Ning Gao ◽  
Rui Li ◽  
...  
Keyword(s):  
Salivary Glands ◽  
Clinical Stage ◽  
Distant Metastases ◽  
Clinicopathological Characteristics ◽  
Secretory Carcinoma ◽  
Survival Prognosis ◽  
Ki 67 ◽  
S 100 ◽  
Locoregional Recurrence Rate ◽  
Node Metastases

AbstractThis retrospective study investigated the clinicopathological characteristics of secretory carcinoma of salivary glands (SCSG) in 23 patients with histopathologically confirmed SCSG between January 2010 and December 2020. In total, 13 males and 10 females (ratio, 1.3:1) aged 10 − 69 years (median, 45 years) were enrolled in this study; the average disease duration was 2.44 years (0.25–20 years). Twenty-one patients (91.3%) had SCSG in the parotid gland, and two (8.7%) in the submandibular gland. All patients had single nodules of diameters 0.8–4.8 cm (average 2.6 cm); five with lymph node metastases, and two with distant metastases. Immunohistochemically, tumors stained positive for S-100, mammaglobin, CK7, GATA3 and pan-Trk, and negative for DOG1, P63, and calponin, with Ki-67 positivity from 1 to 50%. ETV6 gene rearrangement was confirmed in 15 patients. All patients underwent oncological resection, four had radioactive particles implanted postoperatively, one received chemotherapy, and seven underwent chemoradiotherapy. Six patients had regional recurrences, two distant metastases, and one died before the last follow-up. SCSGs are typically indolent, with a low locoregional recurrence rate and excellent survival. Prognosis is correlated to clinical stage, pathological grade, and surgical procedures.

Polymorphous low-grade adenocarcinoma of the major salivary glands: report of three cases in an unusual location

2004 ◽  
Vol 44 (2) ◽  
pp. 164-171 ◽  
Author(s):  
T Nagao ◽  
T A Gaffey ◽  
P A Kay ◽  
H Minato ◽  
H Serizawa ◽  
...  
Keyword(s):  
Salivary Glands ◽  
Low Grade ◽  
Unusual Location ◽  
Major Salivary Glands

Pathology Consultation Low-Grade and High-Grade Adenocarcinomas of the Salivary Duct System

1989 ◽  
Vol 98 (2) ◽  
pp. 162-163 ◽  
Author(s):  
John G. Batsakis ◽  
Mario A. Luna
Keyword(s):  
Oral Cavity ◽  
Parotid Gland ◽  
Salivary Glands ◽  
Low Grade ◽  
High Grade ◽  
Duct System ◽  
Salivary Duct ◽  
Adenoid Cystic ◽  
Major Salivary Glands

Adenocarcinomas of salivary glands are encountered less frequently than adenoid cystic or mucoepidermoid carcinomas. They fall into two well-defined clinicopathologic groups: 1) those arising from intercalated ducts and 2) those from the excretory and interlobular ducts. The former, designated terminal duct adenocarcinomas, are low-grade malignancies found preponderantly in the oral cavity, especially the palate. The latter, designated salivary duct carcinomas, are high-grade neoplasms and arise almost exclusively in major salivary glands, especially the parotid gland.

scholarly journals The Expressions of Wnt/β-catenin Pathway-Related Components in Brainstem Gliomas

2013 ◽  
Vol 40 (3) ◽  
pp. 355-360 ◽  
Author(s):  
Wenhao Wu ◽  
Yongji Tian ◽  
Hong Wan ◽  
Yongmei Song ◽  
Junhua Li ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Clinicopathological Characteristics ◽  
Current Treatment ◽  
Brainstem Glioma ◽  
Low Grade ◽  
Normal Brain ◽  
Ki 67 ◽  
Significant Difference ◽  
The Relationship ◽  
Brain Tissues

Background:The overall prognosis of brainstem gliomas is very poor, and the current treatment cannot significantly prolong the overall survival of these patients; therefore, studying the molecular biological mechanisms of the occurrence and development of brainstem gliomas has important significance for their treatment. The Wnt/β-catenin signaling pathway is closely associated with the occurrence and development of tumors, but its relationship with brainstem gliomas remains unclear.Methods:This study used Western blot and immunohistochemistry methods to detect the expressions of Wnt/β-catenin signaling pathway-related components such as Wnt-1, Wnt-2, β-catenin and C-myc in six cases of normal brain tissues and 24 cases of brainstem gliomas and analyzed the relationship between their expressions and clinicopathological characteristics.Results:Wnt-1 had no obvious expression in normal brain tissues and did not show any significant difference between high- and low-grade brainstem gliomas; the expressions of Wnt-2, β-catenin and C-myc in high-grade brainstem gliomas were significantly higher than that in low-grade brainstem gliomas and normal brain tissues and were positively correlated with the expression of Ki-67. Moreover, the expressions of Wnt-2 and C-myc were significantly associated with the prognosis of brainstem glioma patients; additionally, there was a trend toward increased β-catenin expression with shorter survival, but there was no statistical difference.Conclusions:Wnt/β-catenin signaling pathway might be abnormally activated and plays an important role in the occurrence and development of brainstem gliomas. Wnt-2, β-catenin and C-myc may be potential targets for brainstem glioma treatment.

scholarly journals Secretory Carcinoma of the Breast With Multiple Distant Metastases in Brain and Unfavorable Prognosis: a Case Report and Literature Review

2021 ◽  
Author(s):  
Hongping Tang ◽  
Lihua Zhong ◽  
Hongbing Jiang ◽  
Gui’e Xie
Keyword(s):  
Case Report ◽  
Neoadjuvant Chemotherapy ◽  
Distant Metastases ◽  
Left Breast ◽  
Low Grade ◽  
Secretory Carcinoma ◽  
Mri Scan ◽  
Carcinoma Of The Breast ◽  
Favorable Prognosis ◽  
Axillary Lymphadenectomy

Abstract Background: Secretory carcinoma of the breast is one of the rarest entities accounting for less than 0.15% of all infiltrating breast carcinomas. It has characteristic histopathological and molecular features and more favorable prognosis. In this case report, we describe a local advanced secretory carcinoma of the breast with chemo-resisted for neoadjuvant chemotherapy and unfavorable prognosis.Case Presentation: A hard, painless and palpably bossed mass about 12 cm in diameter occupied most of the left breast of a 39-year-old woman and fixation to the overlying skin. Breast ultrasonography and magnetic resonance imaging (MRI) scan gave the same grading as BI-RADS IV. A needle biopsy was performed and pathological diagnosis was secretory carcinoma. Neoadjuvant chemotherapy (NAC) was then performed, after which ultrasonography and MRI scan revealed the tumor was partial response for EC therapy while progressive disease after the DC therapy. The tumor showed chemo-resisted for neoadjuvant chemotherapy. Left breast mastectomy and axillary lymphadenectomy were subsequently performed. Tumor cells were triple-negative and positive for S-100 and periodic acid-Schiff (PAS) staining. Fluorescence in-situ hybridization (FISH) analysis indicated the fusion arrangement of ETV6-NTRK3 gene. The patient underwent multiple distant metastases in brain, and died of these metastases 19 months after initial diagnosis.Conclusion: Secretory carcinomas of breast have been described as a low-grade histologic subtype with a favorable prognosis. This case showed chemo-resisted for neoadjuvant chemotherapy, multiple distant metastases, and final an unfavorable prognosis. Further research is needed to better understanding of its behavior and treatment of this rare tumor.

scholarly journals Polymorphous low grade adenocarcinoma of the parotid gland: A case report with cytohistological correlation and its immunohistochemical study

2012 ◽  
Vol 2 (4) ◽  
pp. 331-334
Author(s):  
S Shrestha ◽  
CB Pun ◽  
R Basyal ◽  
T Pathak ◽  
S Bastola ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Case Report ◽  
Parotid Gland ◽  
Salivary Glands ◽  
Malignant Tumor ◽  
Immunohistochemical Study ◽  
Low Grade ◽  
Minor Salivary Glands ◽  
Major Salivary Glands

Polymorphous low-grade adenocarcinoma is a rare salivary gland malignant tumor of low aggressiveness, commonly occurring in minor salivary glands. Its origin in major salivary glands is considered exceedingly rare. We report a case of polymorphous low grade adenocarcinoma arising from left parotid in a 21-yearold female patient.Journal of Pathology of Nepal (2012) Vol. 2, 331-334DOI: http://dx.doi.org/10.3126/jpn.v2i4.6890

scholarly journals Pulmonary mucoepidermoid carcinoma: Clinicopathological characteristics of 20 cases and a literature review

2020 ◽  
Author(s):  
Jing Zhang ◽  
Yan Xiao Chen ◽  
Jun Zi Qian ◽  
Ping Yue ◽  
Jialei Wang ◽  
...  
Keyword(s):  
Tumor Markers ◽  
Medical Records ◽  
Mucoepidermoid Carcinoma ◽  
Clinicopathological Characteristics ◽  
Smoking History ◽  
Categorical Variables ◽  
Low Grade ◽  
High Grade ◽  
Alk Rearrangement ◽  
Ki 67

Abstract Background: Pulmonary mucoepidermoid carcinoma is a rare tumor of the lung. The clinicopathological characteristics of pulmonary mucoepidermoid carcinoma are not well defined due to the low incidence. This study was performed to provide more supplementary clues for the identification and understanding of pulmonary mucoepidermoid carcinoma. Methods: We reviewed the medical records since January 1, 2000 to December 31, 2018. The patients’ medical records，including age at the time of diagnosis , gender, smoking history, preoperative evaluations, operative procedures, tumor location, tumor size, tumor stage, lymph node metastasis, pathological markers, prognosis and survival information were extracted and reviewed. Categorical variables were presented as parameters and percentages. A comparison was performed between patients with high and low grade of pulmonary mucoepidermoid carcinoma. Results: 20 patients were identified and the age span is from 18 to 67 year-old with the average age is 45. Mucoepidermoid carcinomas were commonly found in men（60%）. 80% patients had clinical presentations and the positive rate of tumor markers was 78%, although no specific tumor markers were found. TTF-1 were negative in all cases. ALK rearrangement was identified in a non-smoking woman with high grade pulmonary mucoepidermoid carcinoma. Surgery is the main procedure. 3-year survival rate is 72% and 80% patients achieved disease-free alive. High-grade patients tend to harbor older age (p=0.035), larger tumor volume (p=0.026) and higher index of ki-67(p=0.0005). Conclusions: Pulmonary mucoepidermoid carcinoma could occur in a wide age span. Early diagnosis and complete surgical resection may promise a good prognosis. Grading is a key factor to predict the overall survival time. Combined TTF-1 and MAML2 will benefit the identification of pulmonary mucoepidermoid carcinoma from other lung tumors. Future prospective randomized controlled trials and larger, multi-centric series are needed.

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