A Comparison of BTA stat and NMP 22 as Non-Invasive Screening Methods for Bladder Cancer. A Systematic Review.

Abstract BackgroundThe purpose of this study was to systematically review the effects of bladder tumor antigen (BTA) stat and nuclear matrix protein (NMP) 22 as a screening method in an asymptomatic population. Methods We evaluated 381 international studies by selecting randomized controlled trials (RCTs). We descriptively evaluated and summarized all of the 381 studies to identify their strengths and weaknesses in terms of the use of BTA stat and NMP 22. ResultsWe did not identify any RCTs that used BTA stat or NMP 22 as a pure screening tools. We also did not identify any studies that used an asymptomatic population. Different cut-off values and individualized methods were discussed for NMP 22 based on age, sex, risk factors, and history of bladder cancer, introducing significant heterogeneity and bias. Interestingly, the use of NMP 22 demonstrated only in men younger than 65 years positive results. ConclusionsRCTs are needed to show a reliable sensitivity and specificity of using BTA stat or NMP 22 as a screening test. It may be worth investigating in future studies whether it would be useful to offer NMP 22 to only a certain profile of patients. Based on our findings and in consent with national and international guidelines, a screening recommendation using NMP 22 and/or BTA stat can not be given for bladder cancer in an asymptomatic population.

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Perioperative Nutritional Screening Tools Are Not Associated with Poor Outcomes After Musculoskeletal Trauma

Current Developments in Nutrition ◽

10.1093/cdn/nzaa055_021 ◽

2020 ◽

Vol 4 (Supplement_2) ◽

pp. 1136-1136

Author(s):

Aspen Miller ◽

John Davison ◽

Nathan Hendrickson ◽

Erin Wilson ◽

Natalie Glass ◽

...

Keyword(s):

Screening Tool ◽

Screening Method ◽

Screening Tools ◽

Nutritional Deficiencies ◽

Screening Methods ◽

Complication Rates ◽

Nutritional Screening ◽

Patient Reported ◽

Poor Outcomes ◽

Musculoskeletal Trauma

Abstract Objectives Malnutrition is predictive of poor outcomes after trauma. Side effects of both pain and narcotics often limit postoperative dietary intake increasing nutritional deficiencies and limiting wound healing. The purpose of this study was to compare the predictive ability of a dietician nutritional evaluation and a patient reported nutritional screening tool for post-operative complications after musculoskeletal trauma. Methods Adults with operative pelvis or long bone fractures were prospectively enrolled in a single-blinded RCT and included in this analysis. Subjects were evaluated with the Patient Generated Subjective Global Assessment (PG-SGA) survey at baseline. Dietician Nutritional Assessment Screening (NAS) was performed for patients ≥65 years with low Albumin or Vitamin D, or admitted to the ICU. Complication analysis included subjects having minimum 6-month follow-up and/or ≥1 complication within six months. Spearman's Correlation was used to evaluate agreement between screening methods. Comparison using X analysis was done of complications between pre-operative assignment of malnutrition for each screening tool. Results Agreement of NAS and self-reported PG-SGA for 265 subjects demonstrated a weak correlation of rho = 0.23, P = 0.0002. Neither screening method had significant correlation for rates of non-union, mortality, medical, or surgical complications between designations of malnutrition (all P > .05). Among study subjects, incidence of those having a medical or surgical complication not screened by a dietician was 31.3% and 37.7% respectively. Conclusions Results indicate inconsistency in methods for assigning malnutrition in trauma population. Additionally, designation of malnutrition by either method was not associated with post-operative complication rates. The high incidence of those with a complication who were not evaluated by a dietician during initial hospitalization (1/3rd) support the need to develop better methods for screening malnutrition after trauma. Funding Sources American Academy of Orthopaedic Surgeons, Board of Specialty Societies Quality and Patient Safety Action Fund.

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Exploring the Use of Two Brief Fatigue Screening Tools in Cancer Outpatient Clinics

Integrative Cancer Therapies ◽

10.1177/1534735420983443 ◽

2021 ◽

Vol 20 ◽

pp. 153473542098344

Author(s):

Elizabeth J. Pearson ◽

Allison Drosdowsky ◽

Lara Edbrooke ◽

Linda Denehy

Keyword(s):

Rating Scale ◽

Statistical Tests ◽

Screening Method ◽

Numeric Rating Scale ◽

Outpatient Setting ◽

Screening Tools ◽

Outpatient Clinics ◽

Screening Methods ◽

Clinically Significant ◽

The Impact

Purpose: Cancer fatigue guidelines recommend routine fatigue screening, with further assessment for people reporting moderate to severe fatigue. There is neither a gold-standard, nor a broadly accepted screening method, and knowledge about the impact of screening on care processes is limited. This study aimed to explore the feasibility of 2 fatigue screening methods and current clinical practice in cancer outpatient clinics. Methods: Hospital outpatients attending cancer clinics during 1 week completed a five-item survey: a numeric scale for current tiredness, 2 categorical pictorial scales rating tiredness last week and the impact of fatigue (Fatigue Pictogram), screening tool preference and help needed for survey completion. Participant demographics and fatigue documentation by clinical staff for that appointment were extracted from medical records. Analyses used descriptive statistics. Groups were compared using appropriate statistical tests. Results: Over 75% of participants rated their fatigue consistently as mild or significant on both screening tools. Of 1709 eligible outpatients, 533 (31%) completed the survey. Records were audited for 430 (81%) identifiable participants. Over half of the participants reported moderate or severe tiredness either “now” (237, 57%) and/or “last week” (226, 53%). Clinician documentation of fatigue seldom matched self-reports. Fatigue was rated as severe by 103 participants (24%), yet was noted in only 21 (20%) of these individuals’ clinical notes. Both screening tools were equally preferred. Conclusion: The numeric rating scale and Fatigue Pictogram are equally applicable for screening fatigue in cancer outpatient care. There is a high prevalence of clinically significant fatigue in a hospital outpatient setting that is not documented. Adequate care pathways for further management should be established alongside fatigue screening.

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Molecular Markers of Urothelial Cancer and Their Use in the Monitoring of Superficial Urothelial Cancer

Journal of Clinical Oncology ◽

10.1200/jco.2006.08.0895 ◽

2006 ◽

Vol 24 (35) ◽

pp. 5528-5535 ◽

Cited By ~ 58

Author(s):

Peter C. Black ◽

Gordon A. Brown ◽

Colin P. Dinney

Keyword(s):

Bladder Cancer ◽

Molecular Markers ◽

Cancer Patients ◽

Clinical Utility ◽

Matrix Protein ◽

Urothelial Cancer ◽

Disease Recurrence ◽

Urinary Cytology ◽

History Of ◽

Monitoring Treatment

Multiple molecular markers have been described for use in bladder cancer patients. Some of these have been studied more extensively than others, and it is difficult for the clinician to maintain a perspective over the myriad findings that have been made. We have reviewed a selection of markers used for surveillance with an emphasis on clinical utility. The best studied markers and those with the most promising preliminary results were selected. Only studies that included surveillance for recurrence in patients with a history of bladder cancer were considered. Each marker is briefly described and its performance in monitoring bladder cancer patients is summarized. Several promising markers are available, although only four have obtained US Food and Drug Administration approval. The clinical applications that have been studied include replacement or reduction in the number of cystoscopies performed in the surveillance of bladder cancer patients, substitution for or complementary use with urinary cytology in the same setting, predicting disease recurrence and progression, and predicting and monitoring treatment response. None of the markers have been proved sensitive and specific enough to replace cystoscopy. Others, such as nuclear matrix protein 22 (NMP22) and UroVysion, appear to have some utility when used to complement or replace cytology. The other applications have not been adequately studied for any given marker. While multiple molecular markers exist for bladder cancer, their full clinical utility will not be realized until more multicenter prospective trials are conducted to verify their efficacy and safety in the monitoring of patients with superficial bladder cancer.

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Assessment of Knowledge of Breast Cancer and Screening Methods among Nurses in University Hospitals in Addis Ababa, Ethiopia, 2011

ISRN Oncology ◽

10.1155/2013/470981 ◽

2013 ◽

Vol 2013 ◽

pp. 1-8 ◽

Cited By ~ 6

Author(s):

Semarya Berhe Lemlem ◽

Worknish Sinishaw ◽

Mignote Hailu ◽

Mesfin Abebe ◽

Alemseged Aregay

Keyword(s):

Breast Cancer ◽

Addis Ababa ◽

Screening Method ◽

Simple Random Sampling ◽

Bivariate Analysis ◽

Screening Methods ◽

University Hospitals ◽

Cancer Society ◽

Cross Sectional ◽

History Of

Background. According to the American Cancer Society, about 1.3 million women will be diagnosed with breast cancer annually worldwide and about 465,000 will die from the disease. In Ethiopia breast cancer is the second most often occurring cancer among women. Early diagnosis is especially important for breast cancer because the disease responds best to treatment before it has spread. Objective. To assess knowledge of breast cancer and screening methods among nurses in university hospitals. Method. This cross-sectional descriptive study used simple random sampling on sample of 281 nurses. Structured questionnaires draw out responses about knowledge and screening method of nurses in regard to breast cancer. Bivariate analysis was used principally and variables were then entered to multiple logistic regressions model for controlling the possible effect of confounders and the variables which have significant association were identified on the basis of OR, with 95% CI and P value. Results. The findings of this study revealed that only 156 (57.8%) of them were knowledgeable about breast cancer and its screening and 114 (42.2%) were not. Knowledge of breast cancer was found to be significantly associated with regular course in nursing, family history of respondents, and unit of work. Conclusion and Recommendation. The results of this study indicate that the knowledge of nurses is not satisfying and highlight the need to improve the content in the nursing curriculum and to undergo more workplace training in the area of breast cancer and screening methods.

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405: Previous History of Bladder Cancer is an Independent Prognostic Factor for Upper Tract Transitional Cell Carcinoma

The Journal of Urology ◽

10.1016/s0022-5347(18)30658-x ◽

2007 ◽

Vol 177 (4S) ◽

pp. 135-135

Author(s):

Eiji Kikuchi ◽

Akira Miyajima ◽

Ken Nakagawa ◽

Mototsugu Oya ◽

Takashi Ohigashi ◽

...

Keyword(s):

Bladder Cancer ◽

Prognostic Factor ◽

Transitional Cell Carcinoma ◽

Cell Carcinoma ◽

Transitional Cell ◽

Previous History ◽

Independent Prognostic Factor ◽

Upper Tract ◽

History Of

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984: Variability in the Performance of Nuclear Matrix Protein 22 in the Detection of Bladder Cancer

The Journal of Urology ◽

10.1016/s0022-5347(18)33209-9 ◽

2006 ◽

Vol 175 (4S) ◽

pp. 317-317

Author(s):

Shahrokh F. Shariat ◽

Michael Marberger ◽

Yair Lotan ◽

Marta Sanchez-Carbayo ◽

Craig D. Zippe ◽

...

Keyword(s):

Bladder Cancer ◽

Nuclear Matrix ◽

Matrix Protein ◽

Nuclear Matrix Protein

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1233: Natural History of Bladder Cancer in Patients with P0 Disease at Radical Cystectomy

The Journal of Urology ◽

10.1016/s0022-5347(18)33446-3 ◽

2006 ◽

Vol 175 (4S) ◽

pp. 397-397 ◽

Cited By ~ 2

Author(s):

Wassim Kassouf ◽

Philippe E. Spiess ◽

Gordon A. Brown ◽

Mark F. Munsell ◽

H. Barton Grossman ◽

...

Keyword(s):

Bladder Cancer ◽

Natural History ◽

Radical Cystectomy ◽

History Of

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Clinical Characteristics of Patients Diagnosed with Strongyloidiasis in a United States Urban Outpatient Dermatology Department: A Case Series

SKIN The Journal of Cutaneous Medicine ◽

10.25251/skin.1.3.8 ◽

2017 ◽

Vol 1 (3) ◽

pp. 156-160

Author(s):

Jacqueline Watchmaker ◽

Sean Legler ◽

Dianne De Leon ◽

Vanessa Pascoe ◽

Robert Stavert

Keyword(s):

United States ◽

Case Series ◽

The United States ◽

Screening Tools ◽

Dermatology Department ◽

Cutaneous Manifestations ◽

Serologic Testing ◽

Patient Reported ◽

History Of ◽

Endemic Areas

Background: Although considered a tropical disease, strongyloidiasis may be encountered in non-endemic regions, primarily amongst immigrants and travelers from endemic areas. Chronic strongyloides infection may be under-detected owing to its non-specific cutaneous presentation and the low sensitivity of commonly used screening tools. Methods: 18 consecutive patients with serologic evidence of strongyloides infestation who presented to a single urban, academic dermatology clinic between September 2013 and October 2016 were retrospectively included. Patient age, sex, country of origin, strongyloides serology titer, absolute eosinophil count, presenting cutaneous manifestations, and patient reported subjective outcome of pruritus after treatment were obtained via chart review. Results: Of the 18 patients, all had non-specific pruritic dermatoses, 36% had documented eosinophila and none were originally from the United States. A majority reported subjective improvement in their symptoms after treatment. Conclusion: Strongyloides infection and serologic testing should be considered in patients living in non-endemic regions presenting with pruritic dermatoses and with a history of exposure to an endemic area.Key Points:Chronic strongyloidiasis can be encountered in non-endemic areas and clinical manifestations are variableEosinophilia was not a reliable indicator of chronic infection in this case series Dermatologists should consider serologic testing for strongyloidiasis in patients with a history of exposure and unexplained pruritus

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Genetic Analysis of a Cohort of 275 Patients with Hyper-IgE Syndromes and/or Chronic Mucocutaneous Candidiasis

Journal of Clinical Immunology ◽

10.1007/s10875-021-01086-4 ◽

2021 ◽

Author(s):

Natalie Frede ◽

Jessica Rojas-Restrepo ◽

Andrés Caballero Garcia de Oteyza ◽

Mary Buchta ◽

Katrin Hübscher ◽

...

Keyword(s):

Screening Method ◽

Cost Effective ◽

Illumina Miseq ◽

Clinical Findings ◽

Genetic Defects ◽

Chronic Mucocutaneous Candidiasis ◽

Mucocutaneous Candidiasis ◽

Serious Infections ◽

History Of ◽

Panel Sequencing

AbstractHyper-IgE syndromes and chronic mucocutaneous candidiasis constitute rare primary immunodeficiency syndromes with an overlapping clinical phenotype. In recent years, a growing number of underlying genetic defects have been identified. To characterize the underlying genetic defects in a large international cohort of 275 patients, of whom 211 had been clinically diagnosed with hyper-IgE syndrome and 64 with chronic mucocutaneous candidiasis, targeted panel sequencing was performed, relying on Agilent HaloPlex and Illumina MiSeq technologies. The targeted panel sequencing approach allowed us to identify 87 (32 novel and 55 previously described) mutations in 78 patients, which generated a diagnostic success rate of 28.4%. Specifically, mutations in DOCK8 (26 patients), STAT3 (21), STAT1 (15), CARD9 (6), AIRE (3), IL17RA (2), SPINK5 (3), ZNF341 (2), CARMIL2/RLTPR (1), IL12RB1 (1), and WAS (1) have been detected. The most common clinical findings in this cohort were elevated IgE (81.5%), eczema (71.7%), and eosinophilia (62.9%). Regarding infections, 54.7% of patients had a history of radiologically proven pneumonia, and 28.3% have had other serious infections. History of fungal infection was noted in 53% of cases and skin abscesses in 52.9%. Skeletal or dental abnormalities were observed in 46.2% of patients with a characteristic face being the most commonly reported feature (23.1%), followed by retained primary teeth in 18.9% of patients. Targeted panel sequencing provides a cost-effective first-line genetic screening method which allows for the identification of mutations also in patients with atypical clinical presentations and should be routinely implemented in referral centers.

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419 STOP-Bang Score and History of Radiation Predicts Risk of Obstructive Sleep Apnea in Cancer Patients: A Machine Learning Study

SLEEP ◽

10.1093/sleep/zsab072.418 ◽

2021 ◽

Vol 44 (Supplement_2) ◽

pp. A166-A166

Author(s):

Ankita Paul ◽

Karen Wong ◽

Anup Das ◽

Diane Lim ◽

Miranda Tan

Keyword(s):

Machine Learning ◽

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Cancer Patients ◽

Prediction Accuracy ◽

Screening Tools ◽

Cancer Type ◽

Sleep Study ◽

Obstructive Sleep ◽

History Of

Abstract Introduction Cancer patients are at an increased risk of moderate-to-severe obstructive sleep apnea (OSA). The STOP-Bang score is a commonly used screening questionnaire to assess risk of OSA in the general population. We hypothesize that cancer-relevant features, like radiation therapy (RT), may be used to determine the risk of OSA in cancer patients. Machine learning (ML) with non-parametric regression is applied to increase the prediction accuracy of OSA risk. Methods Ten features namely STOP-Bang score, history of RT to the head/neck/thorax, cancer type, cancer stage, metastasis, hypertension, diabetes, asthma, COPD, and chronic kidney disease were extracted from a database of cancer patients with a sleep study. The ML technique, K-Nearest-Neighbor (KNN), with a range of k values (5 to 20), was chosen because, unlike Logistic Regression (LR), KNN is not presumptive of data distribution and mapping function, and supports non-linear relationships among features. A correlation heatmap was computed to identify features having high correlation with OSA. Principal Component Analysis (PCA) was performed on the correlated features and then KNN was applied on the components to predict the risk of OSA. Receiver Operating Characteristic (ROC) - Area Under Curve (AUC) and Precision-Recall curves were computed to compare and validate performance for different test sets and majority class scenarios. Results In our cohort of 174 cancer patients, the accuracy in determining OSA among cancer patients using STOP-Bang score was 82.3% (LR) and 90.69% (KNN) but reduced to 89.9% in KNN using all 10 features mentioned above. PCA + KNN application using STOP-Bang score and RT as features, increased prediction accuracy to 94.1%. We validated our ML approach using a separate cohort of 20 cancer patients; the accuracies in OSA prediction were 85.57% (LR), 91.1% (KNN), and 92.8% (PCA + KNN). Conclusion STOP-Bang score and history of RT can be useful to predict risk of OSA in cancer patients with the PCA + KNN approach. This ML technique can refine screening tools to improve prediction accuracy of OSA in cancer patients. Larger studies investigating additional features using ML may improve OSA screening accuracy in various populations Support (if any):

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