Concordance in Detecting Amyloid Positivity Between 18F-florbetaben and 18F-flutemetamol Amyloid PET Using Quantitative and Qualitative Assessments

Abstract Background In the present study, the discrepancy in detecting amyloid beta (Aβ) positivity between 18F-florbetaben (FBB) and 18F-flutemetamol (FMM) positron emission tomography (PET) was quantitatively and qualitatively assessed.Methods Paired FBB and FMM PET images were obtained on separate days from 107 participants. Three experts visually quantified the scans as positive or negative for Aβ deposition. Quantitative assessment was performed using global cortical standardized uptake value ratio (SUVR) with the whole cerebellum (WC) as a reference region.Results Inter-rater agreement was excellent for FBB (Fleiss k = 0.86) and FMM (Fleiss k = 0.78). The concordance rates between FBB and FMM were 94.4% (101/107) for visual assessment and 98.1% (105/107) for SUVR cut-off categorisation. Both FBB and FMM showed high agreement rates between visual assessment and SUVR positive or negative categorisation (93.5% in FBB and 91.2% in FMM). When the two ligands were compared based on SUVR cut-off categorisation as standard of truth, although not statistically significant, the false-positive rate (visual assessment-positive, SUVR-negative) was higher in FMM (9.1%) than in FBB (1.8%) (P = 0.13). In those cases, assessing uptakes in the lateral temporal cortex was often more problematic than in other regions in visual analysis, especially near the border with the occipital lobe.Conclusion Our findings suggested that both FBB and FMM had excellent agreement when used to quantitatively and qualitatively evaluate Aβ deposits, thus, combining amyloid PET data associated with the use of different ligands from multi-centers can be useful in future research.

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Concordance in detecting amyloid positivity between 18F-florbetaben and 18F-flutemetamol amyloid PET using quantitative and qualitative assessments

Scientific Reports ◽

10.1038/s41598-020-76102-5 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Soo Hyun Cho ◽

Yeong Sim Choe ◽

Young Ju Kim ◽

Byungju Lee ◽

Hee Jin Kim ◽

...

Keyword(s):

False Positive Rate ◽

Standardized Uptake Value ◽

Visual Assessment ◽

Emission Tomography ◽

Amyloid Pet ◽

Reference Region ◽

Rater Agreement ◽

High Agreement ◽

Positron Emission ◽

Positive Rate

Abstract We aimed to quantitatively and qualitatively assess whether there is a discrepancy in detecting amyloid beta (Aβ) positivity between 18F-florbetaben (FBB) and 18F-flutemetamol (FMM) positron emission tomography (PET). We obtained paired FBB and FMM PET images from 107 participants. Three experts visually quantified the Aβ deposition as positive or negative. Quantitative assessment was performed using global cortical standardized uptake value ratio (SUVR) with the whole cerebellum as the reference region. Inter-rater agreement was excellent for FBB and FMM. The concordance rates between FBB and FMM were 94.4% (101/107) for visual assessment and 98.1% (105/107) for SUVR cut-off categorization. Both FBB and FMM showed high agreement rates between visual assessment and SUVR positive or negative categorization (93.5% in FBB and 91.2% in FMM). When the two ligands were compared based on SUVR cut-off categorization as standard of truth, although not statistically significant, the false-positive rate was higher in FMM (9.1%) than in FBB (1.8%) (p = 0.13). Our findings suggested that both FBB and FMM had excellent agreement when used to quantitatively and qualitatively evaluate Aβ deposits, thus, combining amyloid PET data associated with the use of different ligands from multi-centers is feasible.

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Texture-Based Analysis of 18F-Labeled Amyloid PET Brain Images

Applied Sciences ◽

10.3390/app11051991 ◽

2021 ◽

Vol 11 (5) ◽

pp. 1991

Author(s):

Alexander P. Seiffert ◽

Adolfo Gómez-Grande ◽

Eva Milara ◽

Sara Llamas-Velasco ◽

Alberto Villarejo-Galende ◽

...

Keyword(s):

Area Under The Curve ◽

Standardized Uptake Value ◽

Texture Features ◽

Roc Curves ◽

Significant Feature ◽

Study Cohort ◽

Amyloid Pet ◽

Reference Region ◽

Brain Images ◽

Positron Emission

Amyloid positron emission tomography (PET) brain imaging with radiotracers like [18F]florbetapir (FBP) or [18F]flutemetamol (FMM) is frequently used for the diagnosis of Alzheimer’s disease. Quantitative analysis is usually performed with standardized uptake value ratios (SUVR), which are calculated by normalizing to a reference region. However, the reference region could present high variability in longitudinal studies. Texture features based on the grey-level co-occurrence matrix, also called Haralick features (HF), are evaluated in this study to discriminate between amyloid-positive and negative cases. A retrospective study cohort of 66 patients with amyloid PET images (30 [18F]FBP and 36 [18F]FMM) was selected and SUVRs and 6 HFs were extracted from 13 cortical volumes of interest. Mann–Whitney U-tests were performed to analyze differences of the features between amyloid positive and negative cases. Receiver operating characteristic (ROC) curves were computed and their area under the curve (AUC) was calculated to study the discriminatory capability of the features. SUVR proved to be the most significant feature among all tests with AUCs between 0.692 and 0.989. All HFs except correlation also showed good performance. AUCs of up to 0.949 were obtained with the HFs. These results suggest the potential use of texture features for the classification of amyloid PET images.

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Changes in synaptic density in the subacute phase after ischemic stroke: A 11C-UCB-J PET/MR study

Journal of Cerebral Blood Flow & Metabolism ◽

10.1177/0271678x211047759 ◽

2021 ◽

pp. 0271678X2110477

Author(s):

Laura Michiels ◽

Nathalie Mertens ◽

Liselot Thijs ◽

Ahmed Radwan ◽

Stefan Sunaert ◽

...

Keyword(s):

Ischemic Stroke ◽

Standardized Uptake Value ◽

Brain Regions ◽

Asymmetry Index ◽

Cerebellar Hemisphere ◽

Future Research ◽

Stroke Patients ◽

Synaptic Density ◽

Positron Emission

Functional alterations after ischemic stroke have been described with Magnetic Resonance Imaging (MRI) and perfusion Positron Emission Tomography (PET), but no data on in vivo synaptic changes exist. Recently, imaging of synaptic density became available by targeting synaptic vesicle protein 2 A, a protein ubiquitously expressed in all presynaptic nerve terminals. We hypothesized that in subacute ischemic stroke loss of synaptic density can be evaluated with 11C-UCB-J PET in the ischemic tissue and that alterations in synaptic density can be present in brain regions beyond the ischemic core. We recruited ischemic stroke patients to undergo 11C-UCB-J PET/MR imaging 21 ± 8 days after stroke onset to investigate regional 11C-UCB-J SUVR (standardized uptake value ratio). There was a decrease (but residual signal) of 11C-UCB-J SUVR within the lesion of 16 stroke patients compared to 40 healthy controls (ratiolesion/controls = 0.67 ± 0.28, p = 0.00023). Moreover, 11C-UCB-J SUVR was lower in the non-lesioned tissue of the affected hemisphere compared to the unaffected hemisphere (ΔSUVR = −0.17, p = 0.0035). The contralesional cerebellar hemisphere showed a lower 11C-UCB-J SUVR compared to the ipsilesional cerebellar hemisphere (ΔSUVR = −0.14, p = 0.0048). In 8 out of 16 patients, the asymmetry index suggested crossed cerebellar diaschisis. Future research is required to longitudinally study these changes in synaptic density and their association with outcome.

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DYNAMIC MRI FOR TUMOR ENHANCEMENT: AN EXPERIMENTAL BREAST CANCER MODEL

Biomedical Engineering Applications Basis and Communications ◽

10.4015/s1016237213500117 ◽

2013 ◽

Vol 25 (01) ◽

pp. 1350011 ◽

Cited By ~ 2

Author(s):

Ting-Kai Leung ◽

Pai-Jung Huang ◽

Chi-Ming Lee ◽

Chih-Hsiung Wu ◽

Yi-Fan Chen ◽

...

Keyword(s):

False Positive Rate ◽

Maximum Intensity Projection ◽

Breast Mri ◽

Dynamic Mri ◽

Future Research ◽

Post Processing ◽

Contrast Enhanced ◽

Novel Drugs ◽

Positive Rate ◽

Magnetic Resonance Imaging Mri

Dynamic contrast-enhanced magnetic resonance imaging (MRI) with post-processing is routinely used for the analysis of tumors. However, although breast MRI has gained broad clinical recognition, the relationship between imaging findings and tumor pathogenesis has yet to be fully elucidated. We grafted tumors on rats, to examine dynamic MRI images of the tumors, using post-processing subtraction with 3D maximum intensity projection (sMIP). We established a preliminary platform for analysis to compare hemodynamic-based images with histopathological findings and to further biomolecular research. This platform could facilitate future research on the mechanisms of breast tumor enhancement using MRI, improvements to MRI analysis and reduction of the false positive rate, and the development of novel drugs and contrast media.

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Diagnostic utility of fluorodeoxyglucose positron emission tomography in prosthetic joint infection based on MSIS criteria

The Bone & Joint Journal ◽

10.1302/0301-620x.101b8.bjj-2018-0929.r2 ◽

2019 ◽

Vol 101-B (8) ◽

pp. 910-914 ◽

Cited By ~ 5

Author(s):

M. Kiran ◽

T D. Donnelly ◽

C. Armstrong ◽

B. Kapoor ◽

G. Kumar ◽

...

Keyword(s):

Prosthetic Joint Infection ◽

False Positive ◽

Fdg Pet ◽

Preoperative Evaluation ◽

Joint Infection ◽

False Positive Rate ◽

Prosthetic Joint ◽

Positron Emission ◽

Positive Rate ◽

The Mean

Aims Prosthetic joint infection (PJI) and aseptic loosening in total hip arthroplasty (THA) can present with pain and osteolysis. The Musculoskeletal Infection Society (MSIS) has provided criteria for the diagnosis of PJI. The aim of our study was to analyze the utility of F18-fluorodeoxyglucose (FDG) positron emission tomography (PET) CT scan in the preoperative diagnosis of septic loosening in THA, based on the current MSIS definition of prosthetic joint infection. Patients and Methods A total of 130 painful unilateral cemented THAs with a mean follow-up of 5.17 years (sd 1.12) were included in this prospective study. The mean patient age was 67.5 years (sd 4.85). Preoperative evaluation with inflammatory markers, aspiration, and an F18 FDG PET scan were performed. Diagnostic utility tests were also performed, based on the MSIS criteria for PJI and three samples positive on culture alone. Results The mean erythrocyte sedimentation rate, C-reactive protein, and white cell count were 47.83 mm/hr, 25.21 mg/l, and 11.05 × 109/l, respectively. The sensitivity, specificity, accuracy, negative predictive value, and false-positive rate of FDG PET compared with MSIS criteria were 94.87%, 38.46 %, 56.38%, 94.59 %, and 60.21%, respectively. The false-positive rate of FDG PET compared with culture alone was 77.4%. Conclusion FDG PET has a definitive role in the preoperative evaluation of suspected PJI. This the first study to evaluate its utility based on MSIS criteria and compare it with microbiology results alone. However, FDG PET has a high false-positive rate. Therefore, we suggest that F18 FDG PET is useful in confirming the absence of infection, but if positive, may not be confirmatory of PJI. Cite this article: Bone Joint J 2019;101-B:910–914.

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Metabolic Tumor Volume for Patients with Lymphomas

Journal of oncology: diagnostic radiology and radiotherapy ◽

10.37174/2587-7593-2021-4-4-40-45 ◽

2021 ◽

Vol 4 (4) ◽

pp. 40-45

Author(s):

Yu. N. Vinogradova ◽

N. V. Ilyin ◽

M. S. Tlostanova ◽

A. A. Ivanova

Keyword(s):

Tumor Volume ◽

Visual Analysis ◽

International Prognostic Index ◽

Prognostic Index ◽

Clinical Importance ◽

Standardized Uptake Value ◽

Metabolic Tumor Volume ◽

Total Lesion Glycolysis ◽

Positron Emission ◽

Pet Ct

Visual analysis of positron emission tomography/computed tomography (PET/CT) scans and semiquantitative parameter of glucose’s standardized uptake value are used in PET/CT with 18F-fluorodeoxyglucose (18F-FDG). Recently some volumetric parameters, which can evaluate metabolic tumor volume for patients with lymphomas and total lesion glycolysis in the tumor sites are established. In our study this problem was analyzed for different types of lymphomas considering clinical importance of these rates and their bond to known factors of international prognostic index.

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False-Positive Rate of Posttherapy Positron Emission Tomography in Cervical Cancer—Reply

JAMA ◽

10.1001/jama.299.8.898-b ◽

2008 ◽

Vol 299 (8) ◽

pp. 898

Author(s):

Julie K. Schwarz

Keyword(s):

Cervical Cancer ◽

Positron Emission Tomography ◽

False Positive ◽

False Positive Rate ◽

Emission Tomography ◽

Positron Emission ◽

Positive Rate

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Medial temporal tau can be a predictor for amyloid-ß positivity in mild cognitive impairment

10.21203/rs.3.rs-16213/v1 ◽

2020 ◽

Author(s):

Hanna Cho ◽

Min Seok Baek ◽

Hye Sun Lee ◽

Jae Yong Choi ◽

Jae Hoon Lee ◽

...

Keyword(s):

Area Under The Curve ◽

Standardized Uptake Value ◽

Visual Assessment ◽

Parahippocampal Cortex ◽

Positron Emission ◽

Auc Value ◽

Tau Pet ◽

Sensitivity Specificity ◽

Post Hoc ◽

Pet Scans

Abstract Introduction Although both amyloid-ß (Aß) and tau positron emission tomography (PET) are important for the assessment of Alzheimer’s disease pathology, obtaining two PET scans can be challenging in clinical practice. We sought to determine whether Aß-positivity in MCI patients can be predicted with only a single tau PET scan. Methods We prospectively recruited 105 MCI patients and performed two PET scans with 18 F-florbetaben and 18 F-flortaucipir with all patients. Regional 18 F-flortaucipir standardized uptake value ratios (SUVR) were measured using FreeSurfer-generated volumes-of-interest and with the cerebellar crus median as a reference. Results We classified 49 (46.7%) MCI patients as Aß-positive using visual assessment. In 12 regions showing greater tau uptake in the MCI-Aβ+ patients compared to the MCI-Aβ- patients, tau uptake in the entorhinal cortex showed the greatest area under the curve (AUC) value (AUC = 0.835, sensitivity/specificity = 73.5% /85.7%) for discriminating Aß-positivity. The second and third largest AUCs were obtained with tau uptake in the amygdala (AUC = 0.814, sensitivity/specificity = 65.3%/94.6%) and the parahippocampal cortex (AUC = 0.802, sensitivity/specificity = 67.4%/91.1%). However, post-hoc analyses revealed no statistical differences between the three regions. Conclusions Single tau PET scans may be helpful in the evaluation of disease state and stage at the same time in MCI patients.

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