scholarly journals Leukopenia of Asymptomatic COVID-19 Infections under 18 Years Old in Recovery Stage

2020 ◽  
Author(s):  
Wei Zhang ◽  
Youshu Yuan ◽  
Zhengqiao Yang ◽  
Jinxia Fu ◽  
Yun Zhang ◽  
...  
Keyword(s):  
Treatment Period ◽  
Clinical Characteristics ◽  
Clinical Laboratory ◽  
World Health ◽  
Recovery Stage ◽  
Familial Cluster ◽  
Asymptomatic Infections ◽  
The Difference ◽  
Novel Coronavirus ◽  
Health Organization

Abstract Background In December, 2019, a type of novel coronavirus which was designated novel coronavirus 2019 (2019-nCoV) by World Health Organization (WHO) occurred in Wuhan, Hubei, China. The epidemiological and clinical characteristics of those patients under 18 years old in the recovery stage are limited. To compare the difference of epidemiological and clinical characteristics of COVID-19 involving 25 patients under 18 years old in recovery stage between confirmed and asymptomatic infections.Methods Retrospective, single-center cohort study of COVID-19 involving 25 patients under 18 years old in the recovery stage at Guizhou Provincial Staff Hospital in Guiyang, China, from January 29, to March 31, 2020; final date of follow-up was April 22. Epidemiological, demographic, clinical, laboratory, radiological, and treatment data were collected and analyzed. Epidemiological and clinical characteristics of confirmed COVID-19 infections and asymptomatic infections were compared.Results Among the 25 COVID infections under 18 years old, 16 (64%) were mild or moderate confirmed cases, and 9 (36%) were asymptomatic. The shortest treatment period was 6 days, the longest 26 days, and the average treatment period 14 days. Four cases (44.4%) had visited Wuhan or had a living story in the city. There were 9 (100%) asymptomatic cases were familial cluster outbreak, with an average infection number was 6 cases among all families. The number of asymptomatic COVID-19 infections’ Leukopenia were significantly more than confirmed cases (p = 0.04).Conclusions Leukopenia mostly occurred in asymptomatic COVID-19 infections under 18 years old compared with the confirmed patients.

scholarly journals Leukopenia of Asymptomatic COVID-19 Infections under 18 Years Old in Recovery Stage

2020 ◽  
Author(s):  
Wei Zhang ◽  
Youshu Yuan ◽  
Zhengqiao Yang ◽  
Jinxia Fu ◽  
Yun Zhang ◽  
...  
Keyword(s):  
Treatment Period ◽  
Clinical Characteristics ◽  
Clinical Laboratory ◽  
Case Series ◽  
World Health ◽  
Single Center ◽  
Recovery Stage ◽  
Familial Cluster ◽  
Asymptomatic Infections ◽  
Novel Coronavirus

ABSTRACTObjectivesIn December, 2019, a type of novel coronavirus which was designated novel coronavirus 2019 (2019-nCoV) by World Health Organization (WHO) occurred in Wuhan, Hubei, China. The epidemiological and clinical characteristics of those patients under 18 years old in the recovery stage are limited. To compare the difference of epidemiological and clinical characteristics of COVID-19 involving 25 patients under 18 years old in recovery stage between confirmed and asymptomatic infections.MethodsRetrospective, single-center cohort study of COVID-19 involving 25 patients under 18 years old in the recovery stage at Guizhou Provincial Staff Hospital in Guiyang, China, from January 29, to March 31, 2020; final date of follow-up was April 22. Epidemiological, demographic, clinical, laboratory, radiological, and treatment data were collected and analyzed. Epidemiological and clinical characteristics of confirmed COVID-19 infections and asymptomatic infections were compared.ResultsAmong the 25 COVID infections under 18 years old, 16 (64%) were mild or moderate confirmed cases, and 9 (36%) were asymptomatic. The shortest treatment period was 6 days, the longest 26 days, and the average treatment period 14 days. Four cases (44.4%) had visited Wuhan or had a living story in the city. There were 9 (100%) asymptomatic cases were familial cluster outbreak, with an average infection number was 6 cases among all families. The number of asymptomatic COVID-19 infections with leukopenia were significantly more than confirmed cases (p=0.04).ConclusionsLeukopenia mostly occurred in asymptomatic COVID-19 infections under 18 years old compared with the confirmed patients.Key PointIn this single-center case series involving 25 cases under 18 years old with COVID-19 infections, leukopenia mostly occurred in asymptomatic infections.

scholarly journals Analysis of Epidemiological and Clinical Characteristics of COVID-19 in Northwest Mexico and the Relationship Between the Influenza Vaccine and the Survival of Infected Patients

2021 ◽  
Vol 9 ◽  
Author(s):  
Uriel A. Angulo-Zamudio ◽  
Francisco M. Martínez-Villa ◽  
Nidia Leon-Sicairos ◽  
Hector Flores-Villaseñor ◽  
Jorge Velazquez-Roman ◽  
...  
Keyword(s):  
Influenza Vaccine ◽  
Chronic Diseases ◽  
Lower Risk ◽  
Healthcare Workers ◽  
Clinical Characteristics ◽  
Respiratory Infections ◽  
World Health ◽  
Novel Coronavirus ◽  
Health Organization ◽  
The Relationship

The first cases of unexplained pneumonia were reported in Wuhan, China, in December of 2019. Later, a novel coronavirus (SARS-CoV-2) was identified as the causal agent of pneumonia. This virus has since spread to more than 180 countries and has been declared a pandemic by the World Health Organization. Herein, we aimed to determine the epidemiological and clinical characteristics of symptomatic patients with coronavirus disease 2019 (COVID-19) and the relationship between the influenza vaccine with a lower risk of severe COVID-19 infection in the state of Sinaloa. We collected demographic and clinical data of 4,040 patients with acute respiratory infections across Sinaloa state hospitals from February 28 to May 15, 2020. The prevalence of COVID-19 among hospitalized patients with respiratory symptoms in Sinaloa showed 45.2% of men were more affected than women (p < 0.001), and people aged 40–49 years were the most affected. The main symptoms of COVID-19 infection were cough and fever (p < 0.001), while hypertension, obesity, and type 2 diabetes were the chronic diseases associated with COVID-19 than non-COVID-19 (p < 0.003). Healthcare workers were most likely to be infected compared to other occupations (p < 0.001). The general lethality rate was 14.1%, and males >62 years were the ones who had a higher lethality rate (p < 0.001); the aforementioned chronic diseases were related to higher lethality of COVID-19 (p < 0.001). Likewise, higher lethality was seen in housewives and patient retirees/pensioners compared with other occupations (p < 0.001). Finally, we found there was a relationship between influenza vaccination and a lower risk of severe COVID-19 infection and mortality (p < 0.001). These findings showed that healthcare workers, men >62 years with chronic diseases, and retired people were most affected. Furthermore, the influenza vaccine could decrease the severeness of COVID-19 cases.

scholarly journals COVID-19 Diagnosis, Treatments and Prevention: A Review

2020 ◽  
pp. 17-34
Author(s):  
Soumik Chatterjee ◽  
Sabyasachi Chatterjee
Keyword(s):  
Immune System ◽  
Respiratory Tract ◽  
World Health Organization ◽  
Clinical Characteristics ◽  
Treatment Strategies ◽  
World Health ◽  
Upper Respiratory Tract ◽  
The World ◽  
Novel Coronavirus ◽  
Health Organization

Novel Coronavirus are very harmful virus. This viruses have positive single stranded RNA genome and enveloped which is called nucleocapsid. The family of this virus is Coronaviridae. This virus originated from species of avian and mammalian. This virus effect on upper respiratory tract in humans. Many species of these novel coronaviruses (HCoVs) are named as HCoV-HKU1, HCoV-NL63. Predominant species of this virus is Middle East respiratory syndrome (MERS-CoV) across the world.  In both adults and childrens HCoV-HKU1 sp. is causes for chronic pulmonary disease and HCoV-NL63 species causes for upper and lower respiratory tract disease. Most recent species of this virus is MERS-CoV. This species caused for acute pneumonia and occasional renal failure. The new strain of novel Coronavirus is SARS-CoV-2. This strain causes for the Coronavirus Disease 2019 (COVID-19). This disease named by the World Health Organization. Now world fighting against COVID-19 and according to the recent statistics report of world about the COVID-19 cases approx 22.6M confirmed cases and 792K death cases appeared and recovered 14.5M. COVID-19 disease starts to spread from December 2019 from china. Covid-19 disease is emerged in Wuhan seafood market at Wuhan of South China and then rapidly spread throughout the world. The corona virus outbreak has been declared a public health emergency of International concern by World Health Organization (WHO). In this article we summarize the current clinical characteristics of coronavirus and diagnosis, treatments and prevention of COVID-19 disease. In this review article, we analyze data from various Research Reports like WHO guidelines and other articles. It is very important to the readers that new data of COVID-19 updating nearly every hour of day regarding clinical characteristics, diagnosis, treatment strategies, and outcomes COVID-19 disease. The degree of COVID-19 disease varying throughout the world. COVID-19 affected patient shows various symptoms like fever, cough, sore throat, breathlessness, fatigue, and malaise among others. The COVID-19 disease is being treated through general treatment like symptomatic treatment, by using antiviral drugs, oxygen therapy and by the immune system. There is no vaccine or therapeutic strategies for deal with this disease yet. In this critical situation preventive measures must be require.  A very important issue in preventing viral infection is hand hygiene. There are other entities that people can boosting the immune system and help in infection prevention.

scholarly journals Cavitary Covid Lesions - An Unusual Imaging Feature

2021 ◽  
Vol 10 (36) ◽  
pp. 3188-3191
Author(s):  
Rajasbala Pradeep Dhande ◽  
Suresh Vasant Phatak ◽  
Gaurav Ved Prakash Mishra ◽  
Vaishali Patil Dhawan ◽  
Soumya Jain
Keyword(s):  
Chest Ct ◽  
World Health ◽  
Rare Entity ◽  
Stable Patient ◽  
Recovery Stage ◽  
Late Recovery ◽  
Novel Coronavirus ◽  
Health Organization ◽  
Pulmonary Cavity ◽  
Chest Ct Scan

On January 30, 2020, the coronavirus disease 2019 (Covid-19), formerly known as the 2019 novel coronavirus (2019-nCoV), was declared as a global health emergency by the World Health Organization. Coronavirus disease 2019 (Covid-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Imaging plays an essential role in the evaluation of Covid-19, with chest computed tomography (CT) being the major modality in diagnosing and managing Covid-19 pneumonia. Common signs of Covid-19 pneumonia on chest CT scan are ground-glass opacities, consolidation, nodules, and linear opacities, halo and reverse halo signs. It can be accompanied by a “crazy-paving” pattern, air bronchograms, pleural hypertrophy, and pleural effusion. Cavitations are known to occur but are rare presentations. There are cases reported in the literature of the development of pulmonary cavity after bacterial infection in the late recovery stage in SARS patients. We present a case report of this rare entity in Covid-19 infection in a previously stable patient

scholarly journals Asymptomatic COVID-19 Have Longer Treatment Cycle Than Moderate Type of Confirmed Patients

2020 ◽  
Author(s):  
Wei Zhang ◽  
Qinying Long ◽  
Yanbiao Huang ◽  
Changju Chen ◽  
Jinhua Wu ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Treatment Cycle ◽  
Clinical Laboratory ◽  
Case Series ◽  
Interquartile Range ◽  
Control Group ◽  
Single Center ◽  
Clinical Trial Registry ◽  
The Difference ◽  
Novel Coronavirus

ABSTRACTObjectivesA kind of pneumonia caused by unknown causes that occurred in Wuhan, Hubei, China in December 2019, was reported as a result of novel coronavirus infection on January 7, 2020, and then WHO named it COVID-19. To compare the difference of epidemiology and clinical characteristics between asymptomatic COVID-19 infections and moderate type of confirmed cases.MethodsRetrospective, single-center cohort study of COVID-19 involving 52 infections of both 26 asymptomatic and 26 moderate type of confirmed cases in the recovery stage at Guizhou Provincial Staff Hospital in Guiyang, China, from January 29, to March 31, 2020; final date of follow-up was April 22. This study was registered in Chinese Clinical Trial Registry Center. Documented the asymptomatic COVID-19 infections and moderate type of confirmed cases. Epidemiological, demographic, clinical, laboratory, radiological, and treatment data were collected and analyzed. Epidemiological and clinical characteristics of asymptomatic COVID-19 infections and moderate type of confirmed cases were compared.ResultsThe median treatment cycle of asymptomatic COVID-19 infections was 16 days (interquartile range, 11-20 days) and longer than 13 days (interquartile range, 10-15 days) of moderate type of confirmed cases (p=0.049). The median incubation period of asymptomatic COVID-19 infections was 10 days (interquartile range, 0-21 days), while the control group was 7 days (interquartile range, 1-15 days) (p=0.27). On the initial chest computerized tomography (CT) check, 18 (69.2%, 18/26) asymptomatic COVID-19 infections were no imaging changes, which was of no significance compared with 12 (46.2%, 12/26) patients with moderate type of confirmed patients (p=0.092).ConclusionsIn this single-center study, we found that asymptomatic COVID-19 infections have longer treatment cycle than those moderate type of confirmed cases.Key PointsIn this single-center case series involving 52 infections with asymptomatic and moderate type of COVID-19 cases, asymptomatic COVID-19 infections have longer treatment cycle than those moderate type of confirmed patients.

scholarly journals Clinical characteristics, management, maternal and neonatal outcome among seven severe and critically ill pregnant women with COVID-19 pneumonia

2020 ◽  
Vol 3 (2) ◽  
pp. 158-166
Author(s):  
Hazari Komal Sundeep ◽  
Paulose Litty ◽  
Kurien Nimmi ◽  
Mohammad Hozaifah ◽  
A Elgergawi Taghrid Faek ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Clinical Characteristics ◽  
Case Series ◽  
Fetal Outcome ◽  
World Health ◽  
Investigational Therapies ◽  
Serious Disease ◽  
Novel Coronavirus ◽  
Health Organization ◽  
In Pregnancy

Pneumonia caused by the Novel coronavirus disease 2019 (COVID-19) is a highly infectious disease and the ongoing outbreak has been declared as a Pandemic by the World health organization. Pneumonia is a serious disease in pregnancy and requires prompt attention. Viral pneumonia has higher morbidity and mortality compared to bacterial pneumonia in pregnancy. All efforts are well exerted to understand the newly emerged disease features but still some areas are gray. The treatment is primarily supportive with antivirals, steroids, anticoagulation and antibiotics for secondary bacterial infection. Severe cases require intensive care monitoring with oxygen support, mechanical ventilation. Investigational therapies include convalescent plasma, cytokine release inhibitors and other immunomodulatory agents like interferons. The mortality appears driven by the presence of severe Adult Respiratory Syndrome (ARDS) and organs failure. COVID pandemic is a challenging and stressful socio-economic situation with widespread fear of infection, disease and death. In the specialty of obstetrics and gynecology, studies are being conducted to ascertain the manifestation of disease in pregnant women and the fetal outcome. The aim of our case series is to describe the demographics, clinical characteristics, laboratory and radiological findings, feto- maternal outcome of severe and critical COVID pneumonia in pregnant women in Latifa Hospital.

Novel Coronavirus (COVID-19)-A Critical Review

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 43-47
Author(s):  
Puneet Sudan ◽  
Manish Goswami ◽  
Arockia Babu M
Keyword(s):  
Clinical Characteristics ◽  
World Health ◽  
Research Articles ◽  
Treatment And Prevention ◽  
Lack Of Information ◽  
The World ◽  
Novel Coronavirus ◽  
Health Organization ◽  
And Control ◽  
Young Researchers

No one has even imagined that infection in the respiratory system in the form of pneumonia because of novel coronavirus (SARS-CoV2) in small town of China, Wuhan during end of December in the year 2019 will come out as an extremely communicable infection. The World Health Organization (WHO) has acknowledged the current epidemic as a threat to whole population worldwide. At present, still we have not reached the advanced levels of research to treat and control this contagious disease. Due to lack of information about the pathogenesis and proliferation pathways of this novel corona virus, whole world is looking forward for its exact prophylaxis. On the basis of recent proofs provided by review and research articles from various genuine sources, we tried thoroughly to summarize the various factors regarding COVID-19 like its epidemiology, clinical characteristics, diagnosis, treatment and prevention. Through this review we have made an effort to present a common conceptual literature on coronavirus to help community to fight against this dangerous virus, and will hope that this review will be a source of reference to young researchers for advanced studies.

scholarly journals Clinical Characteristics and Laboratory Findings in Coronavirus Disease 2019 (COVID-2019) Infected Cancer Patients and Chemotherapeutic Medicines against COVID-19

2020 ◽  
Vol 2 (4) ◽  
pp. 367-373
Author(s):  
Nikolaos Chrysanthakopoulos ◽  
Keyword(s):  
Cancer Patients ◽  
Clinical Characteristics ◽  
Underlying Disease ◽  
High Risk Group ◽  
World Health ◽  
Laboratory Findings ◽  
Oncological Patients ◽  
Increased Risk ◽  
Novel Coronavirus ◽  
Health Organization

In December 2019 in Wuhan, China, the World Health Organization (WHO) declares that a severe pandemic of Coronavirus disease 2019 (COVID-19) was emerged and was spread rapidly resulted in dramatic global economic and health implications. The novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is responsible for a severe inflammatory reaction and clinically severe complications, although the majority of the infected individuals had mild symptoms and favorable prognosis after recovery. However, cancer patients are a high-risk group as are already susceptible to COVID-19 infection due to their underlying disease and their immunosuppression. Moreover, cancer patients are at increased risk of developing clinically severe complications in case of COVID-19 infection such as, Intensive Care Unit admission, required mechanical ventilation or even death. Another aggravating factor for oncological patients, during that pandemic crisis is the risk of postponing cancer treatment. The present review presents the clinical characteristics accompanied by the corresponding laboratory findings in COVID-19 infected cancer patients and the possible therapeutic role of some known chemo-therapeutic agents based on the recent observations of the International literature.

RT-PCR Status and Antibody Response in Patients with Coronavirus Disease 2019

2020 ◽  
Author(s):  
Lan Chen ◽  
Xiao-Bin Zhang ◽  
Zhen-Yu Zhang ◽  
Su-Zhen Zhang ◽  
Qiu-Ying Han ◽  
...  
Keyword(s):  
Clinical Laboratory ◽  
Peak Level ◽  
World Health ◽  
Rt Pcr ◽  
Igg Antibody ◽  
Open Label ◽  
Potential Biomarker ◽  
Novel Coronavirus ◽  
Health Organization ◽  
High Level

Abstract Background: Novel coronavirus (COVID-19) is a new viral species that causes pneumonia. Currently, RT-PCR and IgM/IgG antibody assays have been recommended for the diagnosis of COVID-19 infection. However, the correlation between RT-PCR status and antibody (IgG, IgM) response remains unknown. Methods: Consecutive COVID-19 patients admitted to our department between February 10, 2020 and March 10, 2020, were diagnosed by guidelines issued by the World Health Organization (WHO) and included in this study. RT-PCR and antibody (IgM/IgG) assays for COVID-19 infection were performed for all patients according to the manufactures’ protocols. Other data, such as demographic, clinical, laboratory, as well as treatment and outcome, were collected using data collection tables from electronic medical records.Results: During the study period, a total of 103 patients were diagnosed as having a moderate type of COVID-19 at our department, including 55 males and 48 females, with an average age of 57.53 ± 1.65 years old (range 23 to 90 years old). The peak level of SARS-CoV-2 IgM antibody (243.10 ± 89.84 AU/ml) was reported 4 days after the negative RT-PCR (-) (all P < 0.05). Subsequently, the IgM decreased to 42.69 ± 22.39 AU/ml 21 days after RT-PCR (-). However, the IgG was maintained at a high level 4 days before RT-PCR (-) and later. The lymphocyte count was at the lowest level on day7 before the RT-PCR(-) result (P<0.05), and then elevated after RT-PCR conversion (viral clearance).Conclusions: SARS-CoV-2 IgM/IgG levels did not correlate with RT-PCR status in our study sample. We found that SARS-CoV-2 IgM/IgG could be a potential biomarker to monitor clinical course, determine discharge, and assess recovery of those infected patients with the novel coronavirus. Trial registration: A prospective, open label, randomized, control trial for chloroquine or hydroxychloroquine in patients with mild and common novel coronavirus pulmonary (COVIP-19). ChiCTR2000030054. Registered 18 Feb,2020. http://www.chictr.org.cn/edit.aspx?pid=49869&htm=4

scholarly journals The need of close monitor of the patients infected with the 2019 novel coronavirus (SARS-Cov-2) in one designated medical institutions in Chengdu: a single-center, retrospective, observational study

2020 ◽  
Author(s):  
Gui Zhou ◽  
Yun-Hui Tan ◽  
Yi-Xiao Lu ◽  
Jiang-Cuo Luo ◽  
Jing Feng ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
General Type ◽  
Original Data ◽  
World Health ◽  
Medical Facility ◽  
Shortness Of Breath ◽  
Protective Measures ◽  
Medical Institutions ◽  
Novel Coronavirus ◽  
Health Organization

Abstract Objective: To study the clinical characteristics of COVID-19 patients in one designated medical institutions in Chengdu. Methods: 20 patients admitted to one hospital in designated medical institutions in Chengdu with laboratory confirmed SARS-Cov-2 infection. Data were collected from 26 January 2020 to 1 March 2020. Clinical data were collected using Self-constructed questionnaire refer to World health organization nCoV CASE RECORDFORM Version 1.2 28JAN2020. If information was not clear, The team will review the original data from the designated computer. Results: Of the 20 COVID-19 infected patients studied (median age 42.5 years), 4 patients became severe sick and one was critical deteriorated in the process of treatment, they were later transferred to the superior medical institutions for treatment. This patient died after admitted to the intensive care unit (ICU). The other two mild patients remained positive for pharyngeal swabs of SARS-Cov-2 more than 3 weeks, so they were quarantined in a medical facility without medication. All studied cases were infected by human to human transmission without taking protective measures. It requires further confirmation of transmission through contact within families. The most common symptoms at onset of illness were fever in 13 (65%) patients, cough in 9 (45%), headache in 3 (15%), fatigue in 6 (30%), diarrhoea in 3 (15%), and Abdominal pain in 2 (10%). Six patients (30%) developed shortness of breath on admission. The median time from exposure to onset of illness was 6.5 days (interquartile range 3.25-9 days), and from the onset of symptoms to first hospital admission was 3.5(1.25-7) days. Conclusion: Up to the end of February 2020, compared with patients initially infected with SARS-Cov-2 in Wuhan, the symptoms of patients in this study was relatively mild and the patients are easily cured and discharged from hospital. the patients with mild symptoms of COVID-19 is general type of patients infected with SARS-Cov-2 in China. However, The COVID-19 is a self-limiting disease with no effective drug to treat it, it is important to detect and identify severe cases from mild cases early.

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