The need of close monitor of the patients infected with the 2019 novel coronavirus (SARS-Cov-2) in one designated medical institutions in Chengdu: a single-center, retrospective, observational study

Abstract Objective: To study the clinical characteristics of COVID-19 patients in one designated medical institutions in Chengdu. Methods: 20 patients admitted to one hospital in designated medical institutions in Chengdu with laboratory confirmed SARS-Cov-2 infection. Data were collected from 26 January 2020 to 1 March 2020. Clinical data were collected using Self-constructed questionnaire refer to World health organization nCoV CASE RECORDFORM Version 1.2 28JAN2020. If information was not clear, The team will review the original data from the designated computer. Results: Of the 20 COVID-19 infected patients studied (median age 42.5 years), 4 patients became severe sick and one was critical deteriorated in the process of treatment, they were later transferred to the superior medical institutions for treatment. This patient died after admitted to the intensive care unit (ICU). The other two mild patients remained positive for pharyngeal swabs of SARS-Cov-2 more than 3 weeks, so they were quarantined in a medical facility without medication. All studied cases were infected by human to human transmission without taking protective measures. It requires further confirmation of transmission through contact within families. The most common symptoms at onset of illness were fever in 13 (65%) patients, cough in 9 (45%), headache in 3 (15%), fatigue in 6 (30%), diarrhoea in 3 (15%), and Abdominal pain in 2 (10%). Six patients (30%) developed shortness of breath on admission. The median time from exposure to onset of illness was 6.5 days (interquartile range 3.25-9 days), and from the onset of symptoms to first hospital admission was 3.5(1.25-7) days. Conclusion: Up to the end of February 2020, compared with patients initially infected with SARS-Cov-2 in Wuhan, the symptoms of patients in this study was relatively mild and the patients are easily cured and discharged from hospital. the patients with mild symptoms of COVID-19 is general type of patients infected with SARS-Cov-2 in China. However, The COVID-19 is a self-limiting disease with no effective drug to treat it, it is important to detect and identify severe cases from mild cases early.

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Analysis of Epidemiological and Clinical Characteristics of COVID-19 in Northwest Mexico and the Relationship Between the Influenza Vaccine and the Survival of Infected Patients

Frontiers in Public Health ◽

10.3389/fpubh.2021.570098 ◽

2021 ◽

Vol 9 ◽

Author(s):

Uriel A. Angulo-Zamudio ◽

Francisco M. Martínez-Villa ◽

Nidia Leon-Sicairos ◽

Hector Flores-Villaseñor ◽

Jorge Velazquez-Roman ◽

...

Keyword(s):

Influenza Vaccine ◽

Chronic Diseases ◽

Lower Risk ◽

Healthcare Workers ◽

Clinical Characteristics ◽

Respiratory Infections ◽

World Health ◽

Novel Coronavirus ◽

Health Organization ◽

The Relationship

The first cases of unexplained pneumonia were reported in Wuhan, China, in December of 2019. Later, a novel coronavirus (SARS-CoV-2) was identified as the causal agent of pneumonia. This virus has since spread to more than 180 countries and has been declared a pandemic by the World Health Organization. Herein, we aimed to determine the epidemiological and clinical characteristics of symptomatic patients with coronavirus disease 2019 (COVID-19) and the relationship between the influenza vaccine with a lower risk of severe COVID-19 infection in the state of Sinaloa. We collected demographic and clinical data of 4,040 patients with acute respiratory infections across Sinaloa state hospitals from February 28 to May 15, 2020. The prevalence of COVID-19 among hospitalized patients with respiratory symptoms in Sinaloa showed 45.2% of men were more affected than women (p < 0.001), and people aged 40–49 years were the most affected. The main symptoms of COVID-19 infection were cough and fever (p < 0.001), while hypertension, obesity, and type 2 diabetes were the chronic diseases associated with COVID-19 than non-COVID-19 (p < 0.003). Healthcare workers were most likely to be infected compared to other occupations (p < 0.001). The general lethality rate was 14.1%, and males >62 years were the ones who had a higher lethality rate (p < 0.001); the aforementioned chronic diseases were related to higher lethality of COVID-19 (p < 0.001). Likewise, higher lethality was seen in housewives and patient retirees/pensioners compared with other occupations (p < 0.001). Finally, we found there was a relationship between influenza vaccination and a lower risk of severe COVID-19 infection and mortality (p < 0.001). These findings showed that healthcare workers, men >62 years with chronic diseases, and retired people were most affected. Furthermore, the influenza vaccine could decrease the severeness of COVID-19 cases.

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COVID-19 Diagnosis, Treatments and Prevention: A Review

Journal of Advances in Medicine and Medical Research ◽

10.9734/jammr/2020/v32i1730637 ◽

2020 ◽

pp. 17-34

Author(s):

Soumik Chatterjee ◽

Sabyasachi Chatterjee

Keyword(s):

Immune System ◽

Respiratory Tract ◽

World Health Organization ◽

Clinical Characteristics ◽

Treatment Strategies ◽

World Health ◽

Upper Respiratory Tract ◽

The World ◽

Novel Coronavirus ◽

Health Organization

Novel Coronavirus are very harmful virus. This viruses have positive single stranded RNA genome and enveloped which is called nucleocapsid. The family of this virus is Coronaviridae. This virus originated from species of avian and mammalian. This virus effect on upper respiratory tract in humans. Many species of these novel coronaviruses (HCoVs) are named as HCoV-HKU1, HCoV-NL63. Predominant species of this virus is Middle East respiratory syndrome (MERS-CoV) across the world. In both adults and childrens HCoV-HKU1 sp. is causes for chronic pulmonary disease and HCoV-NL63 species causes for upper and lower respiratory tract disease. Most recent species of this virus is MERS-CoV. This species caused for acute pneumonia and occasional renal failure. The new strain of novel Coronavirus is SARS-CoV-2. This strain causes for the Coronavirus Disease 2019 (COVID-19). This disease named by the World Health Organization. Now world fighting against COVID-19 and according to the recent statistics report of world about the COVID-19 cases approx 22.6M confirmed cases and 792K death cases appeared and recovered 14.5M. COVID-19 disease starts to spread from December 2019 from china. Covid-19 disease is emerged in Wuhan seafood market at Wuhan of South China and then rapidly spread throughout the world. The corona virus outbreak has been declared a public health emergency of International concern by World Health Organization (WHO). In this article we summarize the current clinical characteristics of coronavirus and diagnosis, treatments and prevention of COVID-19 disease. In this review article, we analyze data from various Research Reports like WHO guidelines and other articles. It is very important to the readers that new data of COVID-19 updating nearly every hour of day regarding clinical characteristics, diagnosis, treatment strategies, and outcomes COVID-19 disease. The degree of COVID-19 disease varying throughout the world. COVID-19 affected patient shows various symptoms like fever, cough, sore throat, breathlessness, fatigue, and malaise among others. The COVID-19 disease is being treated through general treatment like symptomatic treatment, by using antiviral drugs, oxygen therapy and by the immune system. There is no vaccine or therapeutic strategies for deal with this disease yet. In this critical situation preventive measures must be require. A very important issue in preventing viral infection is hand hygiene. There are other entities that people can boosting the immune system and help in infection prevention.

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Leukopenia of Asymptomatic COVID-19 Infections under 18 Years Old in Recovery Stage

10.21203/rs.3.rs-29855/v1 ◽

2020 ◽

Author(s):

Wei Zhang ◽

Youshu Yuan ◽

Zhengqiao Yang ◽

Jinxia Fu ◽

Yun Zhang ◽

...

Keyword(s):

Treatment Period ◽

Clinical Characteristics ◽

Clinical Laboratory ◽

World Health ◽

Recovery Stage ◽

Familial Cluster ◽

Asymptomatic Infections ◽

The Difference ◽

Novel Coronavirus ◽

Health Organization

Abstract Background In December, 2019, a type of novel coronavirus which was designated novel coronavirus 2019 (2019-nCoV) by World Health Organization (WHO) occurred in Wuhan, Hubei, China. The epidemiological and clinical characteristics of those patients under 18 years old in the recovery stage are limited. To compare the difference of epidemiological and clinical characteristics of COVID-19 involving 25 patients under 18 years old in recovery stage between confirmed and asymptomatic infections.Methods Retrospective, single-center cohort study of COVID-19 involving 25 patients under 18 years old in the recovery stage at Guizhou Provincial Staff Hospital in Guiyang, China, from January 29, to March 31, 2020; final date of follow-up was April 22. Epidemiological, demographic, clinical, laboratory, radiological, and treatment data were collected and analyzed. Epidemiological and clinical characteristics of confirmed COVID-19 infections and asymptomatic infections were compared.Results Among the 25 COVID infections under 18 years old, 16 (64%) were mild or moderate confirmed cases, and 9 (36%) were asymptomatic. The shortest treatment period was 6 days, the longest 26 days, and the average treatment period 14 days. Four cases (44.4%) had visited Wuhan or had a living story in the city. There were 9 (100%) asymptomatic cases were familial cluster outbreak, with an average infection number was 6 cases among all families. The number of asymptomatic COVID-19 infections’ Leukopenia were significantly more than confirmed cases (p = 0.04).Conclusions Leukopenia mostly occurred in asymptomatic COVID-19 infections under 18 years old compared with the confirmed patients.

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Clinical features of COVID-19 patients in one designated medical institutions in Chengdu, China

10.21203/rs.3.rs-30405/v1 ◽

2020 ◽

Author(s):

Gui Zhou ◽

Yun-Hui Tan ◽

Jiang-Cuo Luo ◽

Yi-Xiao Lu ◽

Jing Feng ◽

...

Keyword(s):

Medical Center ◽

Fasting Blood Glucose ◽

Disease Status ◽

Original Data ◽

World Health ◽

State Of Emergency ◽

Medical Institutions ◽

History Of ◽

Health Organization ◽

Epidemiological Characteristics

Abstract OBJECTIVE: To study the clinical characteristics of patients infected with the 2019 severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) responsible for coronavirus disease (COVID-2019).METHODS: Data were collected from 20 patients admitted to the Pidu District People’s Hospital in Chengdu from January 26, 2020 to March 1, 2020 with laboratory-confirmed SARS-Cov-2 infection. Clinical data were collected using the World Health Organization (WHO) nCoV CASE RECORDFORM Version 1.2 28JAN2020, which includes parameters such as: temperature, epidemiological characteristics, social network, history of exposure, and incubation period. If information was unclear, the team reviewed the original data and contacted patients directly if necessary.RESULTS: The median age of the 20 COVID-19 infected patients studied was 42.5 years. In this cohort, four patients became severely ill and one deteriorated rapidly during treatment. This patient was transferred to another medical center with an intensive care unit (ICU) for treatment. This patient died after admission to the ICU. Two of the twenty patients remained positive SARS-Cov-2 more than three weeks, and they were quarantined in a medical facility without medication. According to our analysis, all of the studied cases were infected by human-to-human transmission due to the lack of protective measures; transmission through contact within families requires confirmation. The most common symptoms at onset of illness were fever in 13 (65%) patients, cough in 9 (45%), headache in 3 (15%), fatigue in 6 (30%), diarrhea in 3 (15%), and abdominal pain in 2 (10%). Six patients (30%) developed shortness of breath upon admission. The median time from exposure to onset of illness was6.5 days (interquartile range 3.25–9 days), and from the onset of symptoms to first hospital admission was 3.5 (1.25–7) days.CONCLUSION: Compared with patients infected with SARS-Cov-2 in Wuhan (up to the end of February 2020), the symptoms of patients in one hospital in Chengdu, Sichuan Province, were relatively mild and patients were discharged from the hospital after only a short stay. However, the fasting blood glucose of the infected individuals was found to be slightly elevated because of the state of emergency. The dynamic changes in lymphocyte levels can predict disease status of COVID-19. They are also suggestive of changes in mean platelet volume during disease progression. This suggests that the patients had mild cases of COVID-19. However, because there is no effective drug treatment for COVID-19, it is important to detect and identify severe cases from mild cases early.

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Clinical features of COVID-19 patients in one designated medical institutions in Chengdu, China

10.21203/rs.3.rs-23967/v1 ◽

2020 ◽

Author(s):

Gui Zhou ◽

Yun-Hui Tan ◽

Jiang-Cuo Luo ◽

Yi-Xiao Lu ◽

Jing Feng ◽

...

Keyword(s):

Medical Center ◽

Fasting Blood Glucose ◽

Disease Status ◽

Original Data ◽

World Health ◽

State Of Emergency ◽

Medical Institutions ◽

History Of ◽

Health Organization ◽

Epidemiological Characteristics

Abstract OBJECTIVE: To study the clinical characteristics of patients infected with the 2019 severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) responsible for coronavirus disease (COVID-2019).METHODS: Data were collected from 20 patients admitted to the Pidu District People’s Hospital in Chengdu from January 26, 2020 to March 1, 2020 with laboratory-confirmed SARS-Cov-2 infection. Clinical data were collected using the World Health Organization (WHO) nCoV CASE RECORDFORM Version 1.2 28JAN2020, which includes parameters such as: temperature, epidemiological characteristics, social network, history of exposure, and incubation period. If information was unclear, the team reviewed the original data and contacted patients directly if necessary.RESULTS: The median age of the 20 COVID-19 infected patients studied was 42.5 years. In this cohort, four patients became severely ill and one deteriorated rapidly during treatment. This patient was transferred to another medical center with an intensive care unit (ICU) for treatment. This patient died after admission to the ICU. Two of the twenty patients remained positive SARS-Cov-2 more than three weeks, and they were quarantined in a medical facility without medication. According to our analysis, all of the studied cases were infected by human-to-human transmission due to the lack of protective measures; transmission through contact within families requires confirmation. The most common symptoms at onset of illness were fever in 13 (65%) patients, cough in 9 (45%), headache in 3 (15%), fatigue in 6 (30%), diarrhea in 3 (15%), and abdominal pain in 2 (10%). Six patients (30%) developed shortness of breath upon admission. The median time from exposure to onset of illness was 6.5 days (interquartile range 3.25–9 days), and from the onset of symptoms to first hospital admission was 3.5 (1.25–7) days.CONCLUSION: Compared with patients infected with SARS-Cov-2 in Wuhan (up to the end of February 2020), the symptoms of patients in one hospital in Chengdu, Sichuan Province, were relatively mild and patients were discharged from the hospital after only a short stay. However, the fasting blood glucose of the infected individuals was found to be slightly elevated because of the state of emergency. The dynamic changes in lymphocyte levels can predict disease status of COVID-19. They are also suggestive of changes in mean platelet volume during disease progression. This suggests that the patients had mild cases of COVID-19. However, because there is no effective drug treatment for COVID-19, it is important to detect and identify severe cases from mild cases early.

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Novel Coronavirus in India Outbreaks around World: A Statistical Analysis of Odisha, India & World

Coronaviruses ◽

10.2174/2666796701999200901184905 ◽

2020 ◽

Vol 01 ◽

Author(s):

Debabrata Singh ◽

Suman Sekhar Sarangi ◽

Milu Acharya ◽

Surjeet Sahoo ◽

Shakti Ketan Prusty ◽

...

Keyword(s):

Research Work ◽

World Health ◽

Swine Flu ◽

Protective Measures ◽

The Public ◽

The World ◽

Rate Of Recovery ◽

The Government ◽

Novel Coronavirus ◽

Health Organization

Background: The Public Health Emergency of International Concern by the World Health Organization (WHO) declared novel Coronavirus (nCoV-2019) outbreaks in 2019 and is pandemic. Methods: This research work made an analysis of the nCoV-2019 outbreak in India solely based on a mathematical model. Results: The historical epidemics in the world are plague, AIDS, Swine flu, ebola, zika virus, Black Death and SARS. Considering the model used for SARS 2003, the present research on Covid-2019 estimates characteristics of rate of infectious (I) and rate of recovery(R) which leads to estimation the I and R leads to predict the number of infectious and recovery. Through ruling out the unpredictable, unreasonable data, the model predicts that the number of the cumulative 2019-nCoV cases may reach from 3398458(mid of May) to 15165863, with a peak of the unrecovered infective (2461434-15165863) occurring in late April to late July. In this paper we predicate how the confirmed infected cases would rapidly decrease until late March to July in India. We also focus how the Government of Odisha (a state of India) creates a history in the protective measures of Covid-19. Conclusion: The growing infected cases may get reduced by 70-79% by strong anti-epidemic measures. The enforcement of shutdown, lockdown, awareness, and improvement of medical and health care could also lead to about one-half transmission decrease and constructively abridge the duration of the 2019 n-CoV.

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Clinical characteristics, management, maternal and neonatal outcome among seven severe and critically ill pregnant women with COVID-19 pneumonia

Clinical Journal of Obstetrics and Gynecology ◽

10.29328/journal.cjog.1001071 ◽

2020 ◽

Vol 3 (2) ◽

pp. 158-166

Author(s):

Hazari Komal Sundeep ◽

Paulose Litty ◽

Kurien Nimmi ◽

Mohammad Hozaifah ◽

A Elgergawi Taghrid Faek ◽

...

Keyword(s):

Pregnant Women ◽

Clinical Characteristics ◽

Case Series ◽

Fetal Outcome ◽

World Health ◽

Investigational Therapies ◽

Serious Disease ◽

Novel Coronavirus ◽

Health Organization ◽

In Pregnancy

Pneumonia caused by the Novel coronavirus disease 2019 (COVID-19) is a highly infectious disease and the ongoing outbreak has been declared as a Pandemic by the World health organization. Pneumonia is a serious disease in pregnancy and requires prompt attention. Viral pneumonia has higher morbidity and mortality compared to bacterial pneumonia in pregnancy. All efforts are well exerted to understand the newly emerged disease features but still some areas are gray. The treatment is primarily supportive with antivirals, steroids, anticoagulation and antibiotics for secondary bacterial infection. Severe cases require intensive care monitoring with oxygen support, mechanical ventilation. Investigational therapies include convalescent plasma, cytokine release inhibitors and other immunomodulatory agents like interferons. The mortality appears driven by the presence of severe Adult Respiratory Syndrome (ARDS) and organs failure. COVID pandemic is a challenging and stressful socio-economic situation with widespread fear of infection, disease and death. In the specialty of obstetrics and gynecology, studies are being conducted to ascertain the manifestation of disease in pregnant women and the fetal outcome. The aim of our case series is to describe the demographics, clinical characteristics, laboratory and radiological findings, feto- maternal outcome of severe and critical COVID pneumonia in pregnant women in Latifa Hospital.

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The review of COVID-19 and the current progress in intervention and diagnostics

E3S Web of Conferences ◽

10.1051/e3sconf/202129203075 ◽

2021 ◽

Vol 292 ◽

pp. 03075

Author(s):

Chunyun Chen ◽

Xi Chen ◽

Liwei Guo ◽

Kanghui Zou

Keyword(s):

Genome Structure ◽

World Health ◽

The Novel ◽

Control Methods ◽

Wuhan City ◽

The Public ◽

Medical Institutions ◽

Important Challenge ◽

Novel Coronavirus ◽

Health Organization

COVID-19 was first reported in Wuhan city of Hubei Province of China in December 2019, becoming a pandemic declared by the world health organization. This article is a review of the novel coronavirus disease (COVID-19). It typically informs the genome structure of the SARS-CoV-2 and its pathogenic mechanisms, concludes a series of non-pharmaceutical control methods, and focuses on several testing measures. The inventions of the disease treatments remain an important challenge to all medical institutions while a series of medications have been brought to the public.

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Novel Coronavirus (COVID-19)-A Critical Review

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11ispl1.2112 ◽

2020 ◽

Vol 11 (SPL1) ◽

pp. 43-47

Author(s):

Puneet Sudan ◽

Manish Goswami ◽

Arockia Babu M

Keyword(s):

Clinical Characteristics ◽

World Health ◽

Research Articles ◽

Treatment And Prevention ◽

Lack Of Information ◽

The World ◽

Novel Coronavirus ◽

Health Organization ◽

And Control ◽

Young Researchers

No one has even imagined that infection in the respiratory system in the form of pneumonia because of novel coronavirus (SARS-CoV2) in small town of China, Wuhan during end of December in the year 2019 will come out as an extremely communicable infection. The World Health Organization (WHO) has acknowledged the current epidemic as a threat to whole population worldwide. At present, still we have not reached the advanced levels of research to treat and control this contagious disease. Due to lack of information about the pathogenesis and proliferation pathways of this novel corona virus, whole world is looking forward for its exact prophylaxis. On the basis of recent proofs provided by review and research articles from various genuine sources, we tried thoroughly to summarize the various factors regarding COVID-19 like its epidemiology, clinical characteristics, diagnosis, treatment and prevention. Through this review we have made an effort to present a common conceptual literature on coronavirus to help community to fight against this dangerous virus, and will hope that this review will be a source of reference to young researchers for advanced studies.

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Know the unknown fact of novel COVID -19 corona virus

Letters in Applied NanoBioScience ◽

10.33263/lianbs92.10831088 ◽

2020 ◽

Vol 9 (2) ◽

pp. 1083-1088

Keyword(s):

Severe Acute Respiratory Syndrome ◽

World Health ◽

The Novel ◽

Shortness Of Breath ◽

Corona Virus ◽

First Case ◽

Kerala State ◽

Novel Coronavirus ◽

Health Organization ◽

Learning Points

Coronavirus disease (COVID-19) is a contagious disease triggered by the novel coronavirus. A novel coronavirus was observed as the causative agent and was subsequently termed COVID-19 by the World Health Organization (WHO). In December 2019, a disruption of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections appeared in Wuhan, Hubei Province, China and spread across China and beyond. In India, the first case of CORONA virus was reported in Kerala state on 30 January 2020. The most common symptoms of COVID-19 are fever, cough, shortness of breath, and breathing difficulties. In more severe cases infection can give rise to pneumonia, severe acute respiratory syndrome, and even death. The period within which the symptoms would appear is 1-14 days i.e. the incubation period of COVID-19. The present review highlights the types, etiology, transmission stages, manifestations, prevention, therapeutic options, learning points from outbreak, and initiative taken by Government of India (GOI) to control the spread of literary deathly disease.

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