scholarly journals Lack of Association Between Patients Characteristics and the Carriage of Extended-spectrum β-Lactamase Producing Enterobacteriaceae in Community Settings in Blantyre, Malawi

Author(s):  
Onduru Gervas Onduru ◽  
Susan Fred Rumisha ◽  
Rajhab Sawasawa Mkakosya ◽  
Gabriel Kambale Bunduki ◽  
Said Aboud

Abstract Objective: This study examined factors associated with the carriage of extended-spectrum β-lactamase (ESBL) producing Enterobacteriaceae in community patients in Blantyre, Malawi. ResultsA total of 50 community patients with ESBL producing Enterobacteriaceae (ESBL-E) carriage were identified from 300 adults recruited in the study, which gave a prevalence of 16.67% (50/300, 95% CI=12.43-20.91%). The mean age ±SD was 32.41±12.07 years; range, 18-75 years and 54.33% (163/300) were women. The results of unadjusted logistic regression model fitted to identify factors associated with ESBL-E carriage in community patients showed that there was no any degree of association between carriage of extended-spectrum β-lactamase producing Enterobacteriaceae in community patients with either their demographic or clinical characteristics.

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Jean-Philippe Rozon ◽  
Guillaume Lavertu ◽  
Mélanie Hébert ◽  
Eunice You ◽  
Serge Bourgault ◽  
...  

Purpose. To identify predictive factors for visual outcomes of patients presenting with a posterior segment intraocular foreign body (IOFB). Methods. A retrospective chart review was performed for all consecutive patients operated for posterior segment IOFB removal between January 2009 and December 2018. Data were collected for patient demographics, clinical characteristics at presentation, IOFB characteristics, surgical procedures, and postoperative outcomes. A multiple logistic regression model was built for poor final visual acuity (VA) as an outcome (defined as final VA 50 letters or worse [Snellen equivalent: 20/100]). Results. Fifty-four patients were included in our study. Ninety-three percent of patients were men, with a mean age of 40.4 ± 12.6 years. Metallic IOFB comprised 88% of cases with a mean ± standard deviation (SD) size of 5.31 ± 4.62 mm. VA improved in 70% of patients after IOFB removal. Predictive factors for poor VA outcome included poor baseline VA, larger IOFB size, high number of additional diagnoses, an anterior chamber extraction, a second intervention, the use of C3F8 or silicone tamponade, and the presence of vitreous hemorrhage, hyphema, and iris damage. Predictive factors for a better visual outcome included first intention intraocular lens (IOL) implantation and the use of air tamponade. In the multiple logistic regression model, both baseline VA ( p  = 0.009) and number of additional complications ( p  = 0.01) were independent risk factors for a poor final VA. Conclusions. A high number of concomitant complications and poor baseline VA following posterior segment IOFB were significant predictive factors of poor visual outcome.


2021 ◽  
Vol 31 (2) ◽  
pp. 85-92
Author(s):  
Somayeh Moaddaby ◽  
◽  
Masoomeh Adib ◽  
Sadra Ashrafi ◽  
Ehsan Kazemnezhad Leili ◽  
...  

Introduction: The development of science and technology has provided more opportunities for patients to live and even receiving futile medical care or treatment with no hope of recovery. This process leads to awkward experiences and moral distress in nurses who frequently deliver with such care. Objective: This study aimed to determine the perception of futile care and its relationship with moral distress in nurses working in intensive care units Materials and Methods: This is a cross-sectional study conducted on 155 nurses working in Intensive Care Units (ICUs) employed in educational-therapeutic centers and hospitals of Guilan Province, Iran. They were selected by convenience sampling method. The study data were collected using the researcher-made questionnaire and Corley moral distress questionnaire. The obtained data were analyzed using descriptive statistics and inferential statistics the Kolmogorov-Smirnov test, nonparametric Mann-Whitney U, Kruskal-Wallis, Fisher exact and Backward logistic regression model. Results: The mean±SD age of the samples was 34.71±6.68 years; their mean±SD work experience was 10.24±5.63 years, and the mean±SD work experience in the ICU was 6.76±4.64 years. The results indicated that their mean±SD perception of futile care was 63±7, and their mean±SD moral distress was 92±54. The score of moral distress showed a low but significant and positive correlation with the legal and organizational aspects of futile care (r=0. 279, P=0.001) and the total score of perception futile care (r=0.2, P=0.012). In the multivariate analysis based on the logistic regression model of futile care, only the relationship between the legal and organizational score in care had a significant relationship with moral distress. So that by increasing one unit in the legal and organizational aspect of care, the chances of scoring above the mean of moral distress increases 1.2 times (P=0.0001, 95% CI; 1.077-1.324). Conclusion: Perhaps by familiarizing nurses with the legal and organizational nature of patient’s care, the moral distress of caring can be reduced.


2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S159-S160
Author(s):  
Adeel A Butt ◽  
Peng Yan ◽  
Samia Aslam ◽  
Kenneth Sherman ◽  
Dawd Siraj ◽  
...  

Abstract Background There are scant data regarding hepatitis C (HCV) virologic response to directly acting antiviral agents (DAAs) in chronic hepatitis B (HBV) and HCV coinfected persons. HCV treatment response in those with spontaneously cleared HBV infection is unknown. Methods All HCV-infected persons treated with a DAA regimen in ERCHIVES were identified and categorized into HBV/HCV-coinfected (HBsAg, HBV DNA or both positive), HCV-monoinfected, and resolved HBV (isolated HBcAb+). SVR rates were determined and compared for all groups. A logistic regression model was used to determine factors associated with SVR. Results Among 115 HCV/HBV-coinfected, 38,570 HCV-monoinfected persons, and 13,096 persons with resolved HBV, 31.6% of HCV/HBV-coinfected, 24.6% of HCV-monoinfected and 26.4% with resolved HBV had cirrhosis at baseline. SVR was achieved in 90.4% of HCV/HBV-coinfected, 83.4% of HCV-monoinfected and 84.5% of those with resolved HBV infection (P = 0.04 HCV/HBV vs. HCV monoinfected). In a logistic regression model, those with HCV/HBV were more likely to achieve SVR compared with HCV monoinfected (OR 2.25, 95% CI 1.17, 4.31). For HCV/HBV coinfected, the SVR rates dropped numerically with increasing severity of liver fibrosis (P-value non-significant). Factors associated with a lower likelihood of attaining SVR included cirrhosis at baseline (OR 0.85, 95% CI 0.80, 0.92), diabetes (OR 0.93, 95% CI 0.87, 0.99) and higher pretreatment HCV RNA (OR 0.86, 95% CI 0.84, 0.87). Conclusion HBV/HCV-coinfected persons have higher overall SVR rates with newer DAA regimens. The virologic response is graded, with decreasing SVR rates with increasing degree of liver fibrosis as determined by the FIB-4 scores. Disclosures All authors: No reported disclosures.


2017 ◽  
Vol 30 (2) ◽  
pp. 199-202 ◽  
Author(s):  
María I. Tomás-Rodríguez ◽  
Antonio Palazón-Bru ◽  
Damian R.J. Martínez-St John ◽  
Felipe Navarro-Cremades ◽  
José V. Toledo-Marhuenda ◽  
...  

2020 ◽  
Vol 4 ◽  
pp. 43-56
Author(s):  
Ravi Kiran Poudel ◽  
Shankar Prasad Khanal

Background: Chepang Community in Nepal has often been characterized as the poorest among Nepal’s poor, and has faced food insecurity at a household level each year. Health status of their children is poor compared to other community children and more so for the age group under the age of five years. Objective: To find the proportion of stunting, wasting and underweight, and to assess the most promising factors associated with the nutritional status of children under five years of Chepang community in Siddi, Chitwan, Nepal. Materials and Methods: A cross-sectional research design was used with 170 samples. To find the association of different factors with the nutritional status of children under 5 years of age (stunting, wasting and underweight, each) binary multiple logistic regression model was used and the goodness of fit of the model was assessed through Hosmer and Lemeshow test. Results: The overall proportion of children under five years of the Chepang community is 60.6%, 30.6% and 44.7% for underweight, stunting and wasting respectively. Among many factors, the mother’s illiteracy (OR: 5.30, 95 % CI: 1.37 to 21.57), external monthly family income (≤ NRs. 2000) (OR: 9.65, 95 % CI: 3.23 to 30.78) and food availability for six months from own land (OR: 4.17, 95 % CI: 1.90 to 17.98) have a significant association with underweight. Similarly, for stunting, female child (OR: 2.19, 95 % CI: 1.02 to 4.70), number of children (more than one) below 14 years at home (OR: 4.15, 95 % CI : 1.77 to 11.04) and external family income (≤ NRs. 2000) (OR: 4.42, 95% CI: 1.01 to 17.06) are significantly associated, and for wasting, a number of children (more than one) below 14 years at home (OR: 4.64, 95 % of CI: 1.71 to 12.60) and external family income (≤ NRs. 2000) (OR: 5.17, 95 % CI: 2.27 to 11.79) are significantly associated. Conclusion: Substantial numbers of children from Chepang community are having the problem of underweight, stunting and wasting. Different demographic and socio-economic variables have been found associated for odds of having low level of nutritional status of children.


2021 ◽  
Author(s):  
Onduru Gervas Onduru ◽  
Susan Fred Rumisha ◽  
Rajhab Sawasawa Mkakosya ◽  
Gabriel Kambale Bunduki ◽  
Said Aboud

Abstract Background: Infections caused by extended-spectrum β-lactamase (ESBL) producing bacteria are global health threat contributing to increased morbidity and mortality in resource-constrained countries. This cross sectional study examined factors associated with the carriage of ESBL-producing Enterobacteriaceae (ESBL-E) in community patients in Blantyre, Malawi. Methods: We collected rectal swabs and urine samples from randomly recruited participants and screened for ESBL-E on CHROMagarTM ESBL medium (CHROMagar, Paris, France). The ESBL-E isolates were identified using commercially acquired biochemical strips (Microbact™ GNB, Oxoid, UK) and production of ESBL was confirmed by the combination disk test using cefotaxime and ceftazidime disks with and without clavulanic acid. Antibiotic susceptibility test was done by the disc diffusion method and interpreted according to the recommendations of the Clinical and Laboratory Standards Institute (CLSI) 2019. Univariate logistic regression was used to evaluate association between ESBL-E carriage and the assosiated factors. To quantify relationships, dichotomous variables were compared using Pearson’s chi-square test or Fisher exact test as appropriate and continuous variables were compared using the Student’s t-test. Results were expressed as odds ratio (OR) with a 95% confidence intervalResults A total of 50 community patients with ESBL-E phenotypes were identified from 300 adults recruited in the study, which gave a ESBL-E prevalence of 16.67% (50/300, 95% CI=12.43-20.91%). The mean age ±SD of participants was 32.41±12.07 years; range, 18-75 years and 54.33% (163/300) were women. on unadjusted logistic regression, no association between carriage of ESBL-E and community patient characteristics was observed.Conclussions The carriage of ESBL-E is prevalent in the community in Blantyre-Malawi. Nevertheless, factors associated with this carriage remain unidentified. Further investigations including large case-control and molecular studies using one health approach are required to confirm community-based transmission of ESBLs and to determine the factors, reservoirs and vehicles associated with the dissemination of ESBL within the community in Blantyre, Malawi.


2020 ◽  
Author(s):  
Abdalla Hussein ◽  
Jackline Mbishi

Abstract Background This study gives the finding of the assessment made on the quality of antenatal care (ANC) services received by women in Tanzania during pregnancy and the associated risk factors. Methods We used the data from the 2015-16Tanzania Demographic and Health Survey and Malaria Indicator Survey (TDHS-MIS). The sample included 6,924 women who gave birth in the five years before the survey and having at least one ANC visit in the most current pregnancy. The quality of ANC services provided was assessed using six questions on receipt of recommended components of ANC services. The responses of the individual components were summed up to generate the ANC service provision score. In so doing, the women who received all six components were considered to receive good quality ANC services. A weighted logistic regression model was employed in the examination of the factors associated with the quality of ANC services. Results The average service provision score was 4.4 out of a total of 6. Approximately, 31% of the women received good quality ANC services. The most provided ANC components were blood sample measurement (87%) and iron tablets/syrup (82.1%). The urine sample (60%) was the least offered ANC service. The results of the adjusted logistic regression model revealed that age, place of residence, education level, the time of the first ANC visit, number of ANC visits, and family wealth index were significant factors associated with the quality of ANC services. Conclusions In terms of service provision, the quality of ANC service in Tanzania is suboptimal. With differences by observed risk factors, there must be more efforts to strengthen the quality of ANC services and to remove the differences.


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