The Effect of the Educational Brochure Versus the Video on Disease Knowledge in Juvenile Idiopathic Arthritis Patients: A Randomized Controlled Trial

Abstract Background: Juvenile idiopathic arthritis (JIA) is the most common pediatric rheumatic disease. Patient education plays an important role in the management of such chronic disease. Although JIA educational materials are available, patients may not reach them due to limited health literacy or limited access. This study aimed to compare the effectiveness between a brochure and a video in JIA-related knowledge.Methods: This was a randomized controlled trial study. 100 JIA patients or their caregivers, whose JIA patients were not graduated at least 8thgrade were randomized into two groups with 50 subjects per arms. The intervention groups were reading the brochure (n=50) or watching the content matched video (n=50). Fifteen multiple-choice knowledge questionnaires about JIA were answered before, immediately after intervention and at follow-up 4 weeks later. Demographic data and disease activity were recorded.Results: In this study, age of patients in the brochure and video group were 13.2 ± 4.6 years and 14.3 ± 5.1 years, respectively. Most of them were female (57%), diagnosed systemic JIA (37%) and were in active disease status (48%). There was no difference in all baseline demographic data. About 70% of patients had low average monthly family income per household. More than 50% of JIA graduated below secondary school. The mean correct score rates prior to the intervention were 51% and 56% in the brochure group and video group, respectively (p-value 0.28). Post-test total knowledge scores showed that participants in the video group had better knowledge than participants in the brochure group (p-value 0.003). In four-week post-test, both groups had statistically significantly lower total knowledge scores (the brochure 73%, the video 78%) when compared to the immediate post-test score. Moreover, there was no significant difference in four-week post-test scores between two groups (p-value 0.141).Conclusion: The JIA educational video was more effective than the pictorial brochure in improving immediate JIA related knowledge. However, the long-term retention of JIA related knowledge did not show the significant difference between both educational tools. To maintain JIA disease knowledge, patients should be given the knowledge of JIA disease repeatedly.Trial registration: Thaiclinicaltrials.org 06/03/2020, TCTR20200310004, prospectively registered.

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Effects of Bupropion on Cognitive Function in Schizophrenia: A Double Blind Randomized Controlled Trial

Global Journal of Health Science ◽

10.5539/gjhs.v9n5p67 ◽

2016 ◽

Vol 9 (5) ◽

pp. 67

Author(s):

Mansoureh Mirzadeh ◽

Najmeh Shahini ◽

Masoud Kashani Lotf Abadi ◽

Maryam Tavakoli ◽

Arash Javanbakht ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Cognitive Function ◽

Rating Scale ◽

Controlled Trial ◽

Control Group ◽

P Value ◽

Double Blind ◽

Randomized Controlled ◽

Significant Difference ◽

Schizophrenic Patients

Smoking habits are common in schizophrenic patients. Nicotine can suppress negative symptoms and cognitive impairments. The aim of this study was to determine the efficacy of bupropion on cognitive function in schizophrenic patients. This study is a double blind randomized controlled trial in a large referral psychiatric university hospital in Iran. Ninety smoker schizophrenic patients were randomly allocated (based on DSM -IV TR criteria) in two groups (46 patients for case group and 44 patients in control group). They get risperidone up to 6 mg/d and bupropion up to 400 mg/d .clinical assessment (Positive and Negative Syndrome Scale (PANSS), Brief psychiatric rating scale (BPRS) were taken in beginning of study, 14th and 28th days of study. Cognitive assessment (Stroop, Digit Span, and Wechsler, Wisconsin) were taken in begging of study, the days 2nd, 7th, 14th, 28th. All data were analyzed by SPSS Ver. 17 with analytic and descriptive tests. Mean age of patients was 37.66±1.01. Mean duration of disorder was 11.63±.98 years. The scores were significantly lower at the day 28th compared to the beginning of the study in both groups in Wechsler, Stroop color word , Stroop word , Stroop color , BPRS, PANSS p value ≤0.05 .The difference between the two treatments was not significant as indicated by the effect of group, the between-subjects factor p value ≥0.05. In this study, the side effects were examined and there was no significant difference between the two groups p value ≥0.05. Augmentation of bupropion to routine treatment improves cognitive symptoms of schizophrenia in abstinence of tobacco.

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EVALUASI INTERVENSI MEDIA BOOKLET TERHADAP TINGKAT PENGETAHUAN DAN KEPATUHAN PASIEN DIABETES MELITUS TIPE 2 DI PUSKESMAS BANJARBARU SELATAN

Jurnal Publikasi Kesehatan Masyarakat Indonesia ◽

10.20527/jpkmi.v6i1.6874 ◽

2019 ◽

Vol 6 (1) ◽

Author(s):

Valentina Meta Srikartika ◽

M. Rasyid Akbar ◽

Herningtyas Nautika Lingga

Keyword(s):

Diabetes Mellitus ◽

Randomized Controlled Trial ◽

Controlled Trial ◽

Intervention Group ◽

Control Group ◽

P Value ◽

Randomized Controlled ◽

Significant Difference ◽

Level Of Knowledge ◽

Diabetes Melitus

ABSTRAKKeberhasilan pengobatan diabetes melitus tidak hanya dipengaruhi oleh kualitas pelayanan kesehatan, keterampilan petugasnya, sikap, dan pola hidup pasien, tetapi dipengaruhi juga oleh kepatuhan pasien terhadap pengobatannya. Tingkat kepatuhan minum obat pasien diabetes mellitus di Indonesia mayoritas masih berada dibawah 50%. Tujuan dari penelitian ini adalah mengukur pengaruh edukasi melalui media booklet terhadap pengetahuan dan kepatuhan pasien diabetes melitus tipe 2. Jenis penelitian yang digunakan adalah Randomized Controlled Trial (RCT). Populasi yang didapat dari penelitian ini sebanyak 40 orang dengan kelompok kontrol 20 orang dan kelompok intervensi 20 orang. Kelompok kontrol merupakan kelompok yang tidak mendapatkan booklet, sedangkan kelompok intervensi adalah kelompok yang mendapatkan booklet sebagi media edukasi. Pengetahuan dan kepatuhan responden diukur melalui kuesioner yang diberikan sebelum (pretest) dan 2 minggu kemudian (posttest). Rata-rata skor pengetahuan dan kepatuhan pre-test dibandingkan dengan skor post-test dengan menggunakan uji Wilcoxon. Berdasarkan hasil analisis, terjadi perbedaan tingkat pengetahuan dan kepatuhan yang signifikan (p value < 0,001) antara sebelum dan sesudah pemberian booklet pada kelompok intervensi dan tidak ada perbedaan yang signifikan pada tingkat pengetahuan (p value = 0,83) dan kepatuhan (p value = 0,317) pada kelompok kontrol. Oleh karena itu, dapat disimpulkan bahwa media booklet dapat meningkatkan tingkat pengetahuan dan kepatuhan pada pasien diabetes melitus.Kata-kata kunci: Diabetes melitus, pengetahuan, kepatuhan, bookletABSTRACTThe success of a treatment of diabetes mellitus is not only influenced by the quality of health services, the skills of its officers, attitudes, and lifestyle of patients, but it is also influenced by patient adherence to treatment. The level of medication compliance among diabetes patients in Indonesia were still below 50%. The purpose of this study was to measure the effect of education through booklet media on the knowledge and compliance of patients with type 2 diabetes mellitus. The type of research used was Randomized Controlled Trial (RCT). The population obtained from this study were 40 people with a control group of 20 people and an intervention group of 20 people. The control group was the group that did not get the booklet, while the intervention group was the group that received the booklet as an educational medium. Knowledge and compliance of respondents was measured through questionnaires given before (pretest) and 2 weeks later (posttest). The average score of knowledge and adherence between pretest and posttest will be compared using Wilcoxon analysis. Based on the results of data analysis with the Wilcoxon test, there was a significant difference in the level of knowledge and compliance (p value < 0.001) between before and after booklet administration in the intervention group and no significant difference in knowledge level (p value = 0.83) and compliance (p value = 0.317) in the control group. It can be concluded that the booklet media can increase the level of knowledge and compliance in diabetes mellitus patients.Keywords: Diabetes mellitus, knowledge, compliance, booklet

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Comparison with tube core and Magill forceps for nasotracheal intubation: a randomized controlled trial

10.22541/au.160638138.82358073/v1 ◽

2020 ◽

Author(s):

Rui Hu ◽

Jingyi Niu ◽

Lining Wu ◽

Hao Sun ◽

Peng Sun ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Nasal Cavity ◽

Controlled Trial ◽

Demographic Data ◽

Nasotracheal Intubation ◽

Magill Forceps ◽

Randomized Controlled ◽

Paraffin Oil ◽

Significant Difference ◽

Oral Tissue

Objective: Magill forceps are frequently used to complete the process of nasotracheal intubation (NTI). We aimed to identify a tube core that could facilitate the NTI process conveniently without Magill forceps. Methods: Sixty patients scheduled for oral and maxillofacial surgeries with no differences between the two groups (30 per group) with regard to demographic data were enrolled in our study. In Group M, the wire-reinforced endotracheal catheter was inserted into the trachea using Magill forceps. However, in Group T, a tube core bent to the physiological curve of the nasal cavity lubricated with aseptic paraffin oil was inserted into the endotracheal catheter, and it was then withdrawn after the endotracheal catheter was advanced through the glottis under direct vision. Results: All NTIs were completed successfully, and no Magill forceps were used in Group T. There was a significant difference in total NTI time between the two groups (Group M, 59.7 (5.1) sec vs Group T, 52.4 (3.1) sec). Mild epistaxis was observed in 6 patients in Group M and 5 patients in Group T (6/30 vs 5/30, respectively). There was no presence of damaged oral tissue or damage to the teeth in either group. Conclusion: We conclude that using the tube core, which is a disposable sterilised stylet, for NTI is a convenient choice.

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A Randomized Controlled Trial Assessing the Effect of a Continuous Subcutaneous Infusion of Local Anesthetic Following Elective Surgery to the Great Toe

Foot & Ankle Specialist ◽

10.1177/1938640016666923 ◽

2016 ◽

Vol 10 (2) ◽

pp. 116-124 ◽

Cited By ~ 2

Author(s):

Barry Rose ◽

Kumar Kunasingam ◽

Tristan Barton ◽

James Walsh ◽

Karen Fogarty ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Continuous Infusion ◽

Postoperative Analgesia ◽

Local Anesthetic ◽

Elective Surgery ◽

Controlled Trial ◽

Demographic Data ◽

Randomised Control Trial ◽

Randomized Controlled ◽

Significant Difference

Local anesthetic use for wound infusions, single injection, and continuous nerve blocks for postoperative analgesia is well established. No study has investigated the effect of a continuous block of the saphenous and superficial peroneal nerves at the level of the ankle joint following first ray surgery. A double blind randomized controlled trial was designed. One hundred patients with hallux valgus and rigidus requiring surgical correction were recruited and randomized to receive a postoperative continuous infusion at the ankle of normal saline or ropivacaine for 24 hours. Pain scores were recorded on postoperative days 1 and 7. There were more females than males. Follow-up was 100%. There were no significant differences in demographic data between the 2 randomized groups. There was no significant difference between the absolute visual analog scale scores on day 1 (P = .14) and day 7 (P = .16); nor was there a significant difference in reduction in scores between days 1 and 7 (P = .70). This study has shown no benefit to postoperative analgesia with the use of a continuous infusion of ropivacaine at the ankle. We, therefore, cannot currently recommend its use in the way described. Further studies may still identify a role for continuous local anesthetic infusions at the ankle to improve postoperative analgesia. Levels of Evidence: Level I : Prospective randomised control trial.

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Does Artificial Rupture of Membranes (ARM) Reduce Duration of Labor in Primigravidae: A Randomized Controlled Trial

Journal of SAFOG with DVD ◽

10.5005/jp-journals-10006-1057 ◽

2010 ◽

Vol 2 (1) ◽

pp. 37-39

Author(s):

MB Bellad ◽

Patil Kamal ◽

Patil Rajeshwari

Keyword(s):

Randomized Controlled Trial ◽

Controlled Trial ◽

Mode Of Delivery ◽

Control Group ◽

P Value ◽

Chi Square ◽

Randomized Controlled ◽

Third Stage Of Labor ◽

Significant Difference ◽

One Year

ABSTRACT Objective To study the effectiveness of artificial rupture of membranes(ARM) in reducing the duration of labor in primigravida. Methods A one year prospective randomized controlled trial was carried out on 200 primigravida (100 each to ARM and no ARM group) meeting the selection criteria. The outcomes were noted in both the groups. Data analysis was done using Chi Square and Z test. Results The mean duration of labor from enrolment to full dilation of the cervix or bearing down sensation was 4.76 ± 1.64 in ARM group compared to 5.66 ± 1.85 in the control group which was statistically significant (p value = 0.000; 95%). There was no difference in the duration of second and third stage of labor in both groups. There was no significant difference in the mode of delivery between ARM and control group. There was no significant difference in mean birth weight and Apgar score between the two groups. Conclusion ARM definitely reduced the duration of labor without any detrimental effects on fetus, mother and mode of delivery. Hence, there is no reason to strive to maintain the integrity of the fetal membranes in spontaneous labor in women where ARM is not contraindicated.

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Toleransi Minum Enteral Bayi Prematur Menggunakan Spuit 20 Ml dan Spuit 50 Ml

Jurnal Keperawatan Silampari ◽

10.31539/jks.v3i2.1119 ◽

2020 ◽

Vol 3 (2) ◽

pp. 544-555

Author(s):

Elfira Awalia Rahmawati ◽

Yeni Rustina ◽

Defi Efendi

Keyword(s):

Randomized Controlled Trial ◽

Preterm Infants ◽

Controlled Trial ◽

Intervention Group ◽

Crossover Design ◽

P Value ◽

The Third ◽

Randomized Controlled ◽

Premature Babies ◽

Significant Difference

This study aims to determine the comparison of enteral drinking by using syringes of 20 ml and 50 ml of drinking tolerance in preterm infants. The method used is a randomized controlled trial with a crossover design. The results of this study illustrate that there is a significant difference in the duration of the drinking intervention intervention group using 20 ml syringes and 50 syringes on the first and second day (p value respectively 0.036; 0.033), there is no significant difference in the intervention group giving drinking using 20 ml syringe and 50 ml syringe on the third day (p value 0.984). There were no significant differences in gastric residue on the first, second and third day in the two intervention groups. The incidence of vomiting on the first, second and third day there was no significant difference in the intervention group of drinking using a 20 ml syringe and 50 ml syringe (p value each was 1,000). Conclusion, Provision of enteral drinking by using a 20 ml syringe and 50 ml syringe have the same drinking tolerance in premature babies. Keywords: Premature Babies, Enteral Drinking, Tolerance to Drink

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Pre-class versus In-class Video Lectures for the Flipped Classroom in Medical Education: A Non-randomized Controlled Trial

Siriraj Medical Journal ◽

10.33192/smj.2020.64 ◽

2020 ◽

Vol 72 (6) ◽

pp. 476-482

Author(s):

Monton Wongwandee ◽

Panwara Paritakul

Keyword(s):

Randomized Controlled Trial ◽

Test Score ◽

Flipped Classroom ◽

Controlled Trial ◽

Randomized Controlled ◽

Video Viewing ◽

Total Satisfaction ◽

Significant Difference ◽

Post Test ◽

Fourth Year Medical Students

Objective: The objective was to test the effectiveness of the two different teaching models focusing on pre-class preparation.Methods: This study was a single-center, post-test only, non-randomized, controlled trial. The fourth-year medical students were assigned to attend either flipped classroom (FC) or in-class video classroom (IVC). The FC students watched a pre-class video lecture individually. In contrast, IVC students viewed the video together during class time. Both groups had the same in-class activities, including case quizzes and discussion. The primary outcomes were a post-test score and student satisfaction.Results: Of 105 students, 53 were assigned to the FC group and 52 to the IVC group. 77% of the FC students reported video viewing. There was no significant difference in the post-test score between the FC and the IVC groups (p = 0.107). However, the subgroup analysis showed that the post-test score of the IVC group was significantly higher than the FC subgroup who did not view the video (p = 0.024). The total satisfaction score was not significantly different between the FC and the IVC groups (p = 0.945). 83% of the FC who did not view the video claimed they had too many out-of-class workloads.Conclusion: There were no differences in the effectiveness between the FC and IVC approach. However, the IVC students showed better knowledge acquisition over the FC subgroup, who did not watch the video. Hence our study emphasized an essential role of the knowledge preparation on the successful flipped classroom.

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Randomized Controlled Trial of DDS for Covid-19 ARDS

10.21203/rs.3.rs-509122/v5 ◽

2021 ◽

Author(s):

Jong Hoon Lee ◽

Badar Kanwar ◽

Chul Joong Lee ◽

Jenny Balentine ◽

Asif Khattak ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Controlled Trial ◽

P Value ◽

Chi Square ◽

Randomized Controlled ◽

Pyrin Domain ◽

Significant Difference ◽

Chemically Reacting ◽

Second Period ◽

Receptor Family

Abstract Background Clinicians considered DDS administration to treat SARS-CoV-2 inflammasome. DDS is helpful in the molecular regulation of Nod-like receptor family pyrin domain-containing 3 (NLRP3).Objective To study the targeting of NLRP3 itself or up-/downstream factors of the NLRP3 inflammasome by DDS must be responsible for its observed preventive effects, functioning as a competitor.Methods This is a randomized controlled trial (RCT). We set out to use objective criteria of improvement. We treated the patients with standard Covid-19 acute respiratory distress syndrome (ARDS) treatment with DDS. The RCT results were analyzed.Results ARDS progression was blocked in 17 of 19 total patients at the first period. The 44 subjects were analyzed during the second period. It is significant at the ARDS onset stage. The mortality of ARDS-onset patients was 0% with DDS and 40% without DDS among the total of 65 cases. The t-value of RCT is -1.5, and the p-value is .075475. The result is significant at p < 0.10. ARDS onset with DDS prescribed group survived more 90% than ARDS onset without DDS group. The chi-square is 5.8108. The p-value is .015928. (Significant at p < .05) (RR 0.15, OR 0.09)Conclusion There was a significant difference in DDS treatment results in the ARDS-onset group. We confirmed that DDS clinically treated the onset of ARDS by targeting SARS-CoV-2-activated inflammasomes. Like chemically reacting substances, inflammasome and DDS compete, proving that it is effective in early ARDS.ClinicalTrials.gov Identifier: NCT04918914

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Comparison of Intravenous Paracetamol Prophylaxis versus Placebo for Prevention of Pain with Injection Rocuronium

10.53350/pjmhs211581852 ◽

2021 ◽

Vol 15 (8) ◽

pp. 1852-1854

Author(s):

Aneeque Alam Khan ◽

Kiran Mehwish ◽

Ravi Kumar ◽

Pavan Kumar ◽

Tahir Ali ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Placebo Group ◽

Pain Score ◽

Elective Surgery ◽

Controlled Trial ◽

P Value ◽

Randomized Controlled ◽

Intravenous Paracetamol ◽

Significant Difference ◽

The Mean

Aim: To compare the frequency of absence of pain with injection paracetamol versus placebo given before injection rocuronium in patients undergoing elective procedures Study design: Randomized Controlled Trial Place and duration of study: Dept of Anaesthesia, Civil Hospital, Karachi from 15th January to 14th July 2017. Methodology: One hundred and two patients aged 25-75 years of either gender undergoing elective surgery were enrolled. The lottery method was used to divide the patients into two equal groups. Paracetamol (5 mL, 10 mg/mL) or normal saline (5 mL) were used as pretreatment solutions. When the tourniquet was removed after 2 minutes, the rocuronium at 1% concentration was injected throughout the 10 second’s period. Patients were then advised and asked to rate their pain on the hand's dorsum using VAS. Results: Mean age of the patients was 44.11±7.75 years. Mean pain score was 1.49±1.38. Significant difference was observed in the mean pain score in between paracetamol and placebo group (p-value <0.001). Overall absence of pain was found in 49 (40.8%). Absence of pain was found to be higher 34 (69.4%) in paracetamol group as compared to placebo group (p-value <0.001). Conclusion: Frequency of absence of pain found lower in patients undergoing elective procedures with injection paracetamol versus placebo given before injection rocuronium. Keywords: Injection rocuronium, Elective procedures, Injection paracetamol, Absence of pain

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Efficacy Comparison of Hyaluronic Acid and Corticosteroid Injection in Treatment of Trigger Digits: A Randomized Controlled Trial

The Journal of Hand Surgery (Asian-Pacific Volume) ◽

10.1142/s2424835520500101 ◽

2020 ◽

Vol 25 (01) ◽

pp. 76-81 ◽

Cited By ~ 1

Author(s):

Thepparat Kanchanathepsak ◽

Picharn Pichyangkul ◽

Sorasak Suppaphol ◽

Ittirat Watcharananan ◽

Panithan Tuntiyatorn ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Hyaluronic Acid ◽

Controlled Trial ◽

P Value ◽

Dash Score ◽

Ultrasound Guided ◽

Randomized Controlled ◽

Significant Difference ◽

Group 1

Background: Although the current nonsurgical treatment for trigger digits is corticosteroid (CS) injection, it often comes with adverse effects that may cause some limitations. Currently, Hyaluronic acid (HA) has been successfully used in tendinopathy and may be used in stenosing tenosynovitis. The aim of this study is to compare the efficacy of ultrasound-guided injection between the HA and CS in trigger digits treatment. Methods: Double-blind randomized controlled trial was conducted. Fifty patients with 66 trigger digits were randomly assigned into an intervention group (1 ml of low-molecular weight HA) and a control group (1 ml of 10mg/ml triamcinolone acetate). The ultrasound-guided injection and local anesthesia (0.5 ml of 1% lidocaine without adrenaline) were used. The Quinnell grading, Visual Analog Scale (VAS) score of pain, Disabilities of the Arm, Shoulder and Hand (DASH) score and complications were collected at 1-, 3-and 6-month follow-up. Results: The mean age of HA group (33 digits) and CS group (33 digits) were 58.3 years and 54.7 years respectively. Nine patients were loss of follow-up (7 in HA group and 2 in CS group). The Quinnell grades have shown an improvement in both group. The CS group had a significant better improvement at 1-month (p-value < 0.001) and there was no significant difference at 3-and 6-month follow-up between the two groups. The median of VAS and DASH score were significantly improved by time in both groups (p-value < 0.01). The CS group showed a better significant improvement in early period of follow-up (p-value < 0.05). However, there was no significant difference between the two groups in the last follow-up. Conclusions: HA and CS injection has a comparable therapeutic effect in treatment of trigger digits. However, CS injection has higher efficacy of pain and inflammation reduction in the early phase of the disease.

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