Randomized Controlled Trial of DDS for Covid-19 ARDS

Abstract Background Clinicians considered DDS administration to treat SARS-CoV-2 inflammasome. DDS is helpful in the molecular regulation of Nod-like receptor family pyrin domain-containing 3 (NLRP3).Objective To study the targeting of NLRP3 itself or up-/downstream factors of the NLRP3 inflammasome by DDS must be responsible for its observed preventive effects, functioning as a competitor.Methods This is a randomized controlled trial (RCT). We set out to use objective criteria of improvement. We treated the patients with standard Covid-19 acute respiratory distress syndrome (ARDS) treatment with DDS. The RCT results were analyzed.Results ARDS progression was blocked in 17 of 19 total patients at the first period. The 44 subjects were analyzed during the second period. It is significant at the ARDS onset stage. The mortality of ARDS-onset patients was 0% with DDS and 40% without DDS among the total of 65 cases. The t-value of RCT is -1.5, and the p-value is .075475. The result is significant at p < 0.10. ARDS onset with DDS prescribed group survived more 90% than ARDS onset without DDS group. The chi-square is 5.8108. The p-value is .015928. (Significant at p < .05) (RR 0.15, OR 0.09)Conclusion There was a significant difference in DDS treatment results in the ARDS-onset group. We confirmed that DDS clinically treated the onset of ARDS by targeting SARS-CoV-2-activated inflammasomes. Like chemically reacting substances, inflammasome and DDS compete, proving that it is effective in early ARDS.ClinicalTrials.gov Identifier: NCT04918914

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The Method and Results of a Treatment Targeting SARS-CoV-2-Activated Inflammasomes

10.21203/rs.3.rs-509122/v4 ◽

2021 ◽

Author(s):

Jong Hoon Lee ◽

Badar Kanwar ◽

Chul Joong Lee ◽

Jenny Balentine ◽

Asif Khattak ◽

...

Keyword(s):

Controlled Trial ◽

P Value ◽

Test Statistic ◽

Chi Square ◽

Exact Test ◽

Pyrin Domain ◽

Significant Difference ◽

Chemically Reacting ◽

Second Period ◽

Receptor Family

Abstract Background Clinicians considered dapsone administration to treat SARS-CoV-2 inflammasome. Dapsone is helpful in the molecular regulation of Nod-like receptor family pyrin domain-containing 3 (NLRP3).Objective To study the targeting of NLRP3 itself or up-/downstream factors of the NLRP3 inflammasome by dapsone must be responsible for its observed preventive effects, functioning as a competitor.Methods This is a randomized controlled trial (RCT). We set out to use objective criteria of improvement, such as A. a reduction in the FIO2 requirement and B. a decrease in the progression of hypoxia. We treated the patients with standard COVID-19 acute respiratory distress syndrome (ARDS) treatment with dapsone. The RCT results were analyzed.Results ARDS progression was blocked in 17 of 19 total patients at the first period. The 44 (trial 22/ control 22) subjects were analyzed during the second period. The chi-square statistic is 5.1836. The p-value is .02280. (RR 0.21, OR 0.1) Fisher's exact test statistic value is 0.0433. (The result is significant at p < .05) (RR 0.15, OR 0) It is significant at the ARDS onset stage.Conclusion There was a significant difference in dapsone treatment results in the ARDS-onset group. We confirmed that dapsone clinically treated the onset of ARDS by targeting SARS-CoV-2-activated inflammasomes. Like chemically reacting substances, inflammasome and dapsone compete, proving that it is effective in early ARDS. ClinicalTrials.gov Identifier NCT04918914

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Does Artificial Rupture of Membranes (ARM) Reduce Duration of Labor in Primigravidae: A Randomized Controlled Trial

Journal of SAFOG with DVD ◽

10.5005/jp-journals-10006-1057 ◽

2010 ◽

Vol 2 (1) ◽

pp. 37-39

Author(s):

MB Bellad ◽

Patil Kamal ◽

Patil Rajeshwari

Keyword(s):

Randomized Controlled Trial ◽

Controlled Trial ◽

Mode Of Delivery ◽

Control Group ◽

P Value ◽

Chi Square ◽

Randomized Controlled ◽

Third Stage Of Labor ◽

Significant Difference ◽

One Year

ABSTRACT Objective To study the effectiveness of artificial rupture of membranes(ARM) in reducing the duration of labor in primigravida. Methods A one year prospective randomized controlled trial was carried out on 200 primigravida (100 each to ARM and no ARM group) meeting the selection criteria. The outcomes were noted in both the groups. Data analysis was done using Chi Square and Z test. Results The mean duration of labor from enrolment to full dilation of the cervix or bearing down sensation was 4.76 ± 1.64 in ARM group compared to 5.66 ± 1.85 in the control group which was statistically significant (p value = 0.000; 95%). There was no difference in the duration of second and third stage of labor in both groups. There was no significant difference in the mode of delivery between ARM and control group. There was no significant difference in mean birth weight and Apgar score between the two groups. Conclusion ARM definitely reduced the duration of labor without any detrimental effects on fetus, mother and mode of delivery. Hence, there is no reason to strive to maintain the integrity of the fetal membranes in spontaneous labor in women where ARM is not contraindicated.

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Randomized controlled trial of erdosteine for acute cough in children with colds

Paediatrica Indonesiana ◽

10.14238/pi51.2.2011.111-5 ◽

2011 ◽

Vol 51 (2) ◽

pp. 111

Author(s):

Yenny Yenny ◽

Roni Naning ◽

Amalia Setyati

Keyword(s):

Randomized Controlled Trial ◽

Clinical Improvement ◽

Common Cold ◽

Controlled Trial ◽

Research Subjects ◽

Acute Cough ◽

Chi Square ◽

Double Blind ◽

Randomized Controlled ◽

Significant Difference

Background T h e prevalence of the common cold in children is high, v.ith 30% of cases exhibiting an acute cough, the most common complaint by parents. Erdosteine, a recently developed cough medicine, is available for children. Erdosteine has been reported to increase mucodliary clearance, act as an antioxidant and prevent bacterial adhesion.Objective To assess the clinical improvement in acute cough in children \\lith a common cold taking erdosteine vs. a placebo.Methods We conducted a double􀀾blind, randomized, controlled trial at the Public Health Center of Gedongtengen, Yogyakarta with 140 children selected by a consecutive sampling method. Research subjects were randomized by computer program into two treatment groups, those receiving erdosteine therapy and those receiving a placebo. Both groups were monitored for 6 days. A scoring system was used to assess the improvement of acute cough symptoms and analyzed by Chi-square test.Results No significant differences in basic characteristics, cough severity, or environment were found among the 140 children with common cold in the two groups. After 6 days of treatment, no significant difference in clinical improvement of acute cough was found between the erdosteine (65 subjects improved out of 70) and placebo groups (62/70),92.5% and 88.6%, respectively (P=0.382).Conclusion Erdosteine was not more effective than the placebo for treatment of acute cough in children with common cold.

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Effects of Bupropion on Cognitive Function in Schizophrenia: A Double Blind Randomized Controlled Trial

Global Journal of Health Science ◽

10.5539/gjhs.v9n5p67 ◽

2016 ◽

Vol 9 (5) ◽

pp. 67

Author(s):

Mansoureh Mirzadeh ◽

Najmeh Shahini ◽

Masoud Kashani Lotf Abadi ◽

Maryam Tavakoli ◽

Arash Javanbakht ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Cognitive Function ◽

Rating Scale ◽

Controlled Trial ◽

Control Group ◽

P Value ◽

Double Blind ◽

Randomized Controlled ◽

Significant Difference ◽

Schizophrenic Patients

Smoking habits are common in schizophrenic patients. Nicotine can suppress negative symptoms and cognitive impairments. The aim of this study was to determine the efficacy of bupropion on cognitive function in schizophrenic patients. This study is a double blind randomized controlled trial in a large referral psychiatric university hospital in Iran. Ninety smoker schizophrenic patients were randomly allocated (based on DSM -IV TR criteria) in two groups (46 patients for case group and 44 patients in control group). They get risperidone up to 6 mg/d and bupropion up to 400 mg/d .clinical assessment (Positive and Negative Syndrome Scale (PANSS), Brief psychiatric rating scale (BPRS) were taken in beginning of study, 14th and 28th days of study. Cognitive assessment (Stroop, Digit Span, and Wechsler, Wisconsin) were taken in begging of study, the days 2nd, 7th, 14th, 28th. All data were analyzed by SPSS Ver. 17 with analytic and descriptive tests. Mean age of patients was 37.66±1.01. Mean duration of disorder was 11.63±.98 years. The scores were significantly lower at the day 28th compared to the beginning of the study in both groups in Wechsler, Stroop color word , Stroop word , Stroop color , BPRS, PANSS p value ≤0.05 .The difference between the two treatments was not significant as indicated by the effect of group, the between-subjects factor p value ≥0.05. In this study, the side effects were examined and there was no significant difference between the two groups p value ≥0.05. Augmentation of bupropion to routine treatment improves cognitive symptoms of schizophrenia in abstinence of tobacco.

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EVALUASI INTERVENSI MEDIA BOOKLET TERHADAP TINGKAT PENGETAHUAN DAN KEPATUHAN PASIEN DIABETES MELITUS TIPE 2 DI PUSKESMAS BANJARBARU SELATAN

Jurnal Publikasi Kesehatan Masyarakat Indonesia ◽

10.20527/jpkmi.v6i1.6874 ◽

2019 ◽

Vol 6 (1) ◽

Author(s):

Valentina Meta Srikartika ◽

M. Rasyid Akbar ◽

Herningtyas Nautika Lingga

Keyword(s):

Diabetes Mellitus ◽

Randomized Controlled Trial ◽

Controlled Trial ◽

Intervention Group ◽

Control Group ◽

P Value ◽

Randomized Controlled ◽

Significant Difference ◽

Level Of Knowledge ◽

Diabetes Melitus

ABSTRAKKeberhasilan pengobatan diabetes melitus tidak hanya dipengaruhi oleh kualitas pelayanan kesehatan, keterampilan petugasnya, sikap, dan pola hidup pasien, tetapi dipengaruhi juga oleh kepatuhan pasien terhadap pengobatannya. Tingkat kepatuhan minum obat pasien diabetes mellitus di Indonesia mayoritas masih berada dibawah 50%. Tujuan dari penelitian ini adalah mengukur pengaruh edukasi melalui media booklet terhadap pengetahuan dan kepatuhan pasien diabetes melitus tipe 2. Jenis penelitian yang digunakan adalah Randomized Controlled Trial (RCT). Populasi yang didapat dari penelitian ini sebanyak 40 orang dengan kelompok kontrol 20 orang dan kelompok intervensi 20 orang. Kelompok kontrol merupakan kelompok yang tidak mendapatkan booklet, sedangkan kelompok intervensi adalah kelompok yang mendapatkan booklet sebagi media edukasi. Pengetahuan dan kepatuhan responden diukur melalui kuesioner yang diberikan sebelum (pretest) dan 2 minggu kemudian (posttest). Rata-rata skor pengetahuan dan kepatuhan pre-test dibandingkan dengan skor post-test dengan menggunakan uji Wilcoxon. Berdasarkan hasil analisis, terjadi perbedaan tingkat pengetahuan dan kepatuhan yang signifikan (p value < 0,001) antara sebelum dan sesudah pemberian booklet pada kelompok intervensi dan tidak ada perbedaan yang signifikan pada tingkat pengetahuan (p value = 0,83) dan kepatuhan (p value = 0,317) pada kelompok kontrol. Oleh karena itu, dapat disimpulkan bahwa media booklet dapat meningkatkan tingkat pengetahuan dan kepatuhan pada pasien diabetes melitus.Kata-kata kunci: Diabetes melitus, pengetahuan, kepatuhan, bookletABSTRACTThe success of a treatment of diabetes mellitus is not only influenced by the quality of health services, the skills of its officers, attitudes, and lifestyle of patients, but it is also influenced by patient adherence to treatment. The level of medication compliance among diabetes patients in Indonesia were still below 50%. The purpose of this study was to measure the effect of education through booklet media on the knowledge and compliance of patients with type 2 diabetes mellitus. The type of research used was Randomized Controlled Trial (RCT). The population obtained from this study were 40 people with a control group of 20 people and an intervention group of 20 people. The control group was the group that did not get the booklet, while the intervention group was the group that received the booklet as an educational medium. Knowledge and compliance of respondents was measured through questionnaires given before (pretest) and 2 weeks later (posttest). The average score of knowledge and adherence between pretest and posttest will be compared using Wilcoxon analysis. Based on the results of data analysis with the Wilcoxon test, there was a significant difference in the level of knowledge and compliance (p value < 0.001) between before and after booklet administration in the intervention group and no significant difference in knowledge level (p value = 0.83) and compliance (p value = 0.317) in the control group. It can be concluded that the booklet media can increase the level of knowledge and compliance in diabetes mellitus patients.Keywords: Diabetes mellitus, knowledge, compliance, booklet

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The Effect of the Educational Brochure Versus the Video on Disease Knowledge in Juvenile Idiopathic Arthritis Patients: A Randomized Controlled Trial

10.21203/rs.3.rs-330802/v1 ◽

2021 ◽

Author(s):

Waraporn Sunthornsup ◽

Sirisucha Soponkanaporn ◽

Soamarat Vilaiyuk

Keyword(s):

Randomized Controlled Trial ◽

Juvenile Idiopathic Arthritis ◽

Controlled Trial ◽

Demographic Data ◽

P Value ◽

Disease Knowledge ◽

Randomized Controlled ◽

Significant Difference ◽

Post Test ◽

Video Group

Abstract Background: Juvenile idiopathic arthritis (JIA) is the most common pediatric rheumatic disease. Patient education plays an important role in the management of such chronic disease. Although JIA educational materials are available, patients may not reach them due to limited health literacy or limited access. This study aimed to compare the effectiveness between a brochure and a video in JIA-related knowledge.Methods: This was a randomized controlled trial study. 100 JIA patients or their caregivers, whose JIA patients were not graduated at least 8thgrade were randomized into two groups with 50 subjects per arms. The intervention groups were reading the brochure (n=50) or watching the content matched video (n=50). Fifteen multiple-choice knowledge questionnaires about JIA were answered before, immediately after intervention and at follow-up 4 weeks later. Demographic data and disease activity were recorded.Results: In this study, age of patients in the brochure and video group were 13.2 ± 4.6 years and 14.3 ± 5.1 years, respectively. Most of them were female (57%), diagnosed systemic JIA (37%) and were in active disease status (48%). There was no difference in all baseline demographic data. About 70% of patients had low average monthly family income per household. More than 50% of JIA graduated below secondary school. The mean correct score rates prior to the intervention were 51% and 56% in the brochure group and video group, respectively (p-value 0.28). Post-test total knowledge scores showed that participants in the video group had better knowledge than participants in the brochure group (p-value 0.003). In four-week post-test, both groups had statistically significantly lower total knowledge scores (the brochure 73%, the video 78%) when compared to the immediate post-test score. Moreover, there was no significant difference in four-week post-test scores between two groups (p-value 0.141).Conclusion: The JIA educational video was more effective than the pictorial brochure in improving immediate JIA related knowledge. However, the long-term retention of JIA related knowledge did not show the significant difference between both educational tools. To maintain JIA disease knowledge, patients should be given the knowledge of JIA disease repeatedly.Trial registration: Thaiclinicaltrials.org 06/03/2020, TCTR20200310004, prospectively registered.

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Toleransi Minum Enteral Bayi Prematur Menggunakan Spuit 20 Ml dan Spuit 50 Ml

Jurnal Keperawatan Silampari ◽

10.31539/jks.v3i2.1119 ◽

2020 ◽

Vol 3 (2) ◽

pp. 544-555

Author(s):

Elfira Awalia Rahmawati ◽

Yeni Rustina ◽

Defi Efendi

Keyword(s):

Randomized Controlled Trial ◽

Preterm Infants ◽

Controlled Trial ◽

Intervention Group ◽

Crossover Design ◽

P Value ◽

The Third ◽

Randomized Controlled ◽

Premature Babies ◽

Significant Difference

This study aims to determine the comparison of enteral drinking by using syringes of 20 ml and 50 ml of drinking tolerance in preterm infants. The method used is a randomized controlled trial with a crossover design. The results of this study illustrate that there is a significant difference in the duration of the drinking intervention intervention group using 20 ml syringes and 50 syringes on the first and second day (p value respectively 0.036; 0.033), there is no significant difference in the intervention group giving drinking using 20 ml syringe and 50 ml syringe on the third day (p value 0.984). There were no significant differences in gastric residue on the first, second and third day in the two intervention groups. The incidence of vomiting on the first, second and third day there was no significant difference in the intervention group of drinking using a 20 ml syringe and 50 ml syringe (p value each was 1,000). Conclusion, Provision of enteral drinking by using a 20 ml syringe and 50 ml syringe have the same drinking tolerance in premature babies. Keywords: Premature Babies, Enteral Drinking, Tolerance to Drink

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Perbandingan Aromaterapi Pepermin dengan Ondansetron Intravena sebagai Terapi Rescue Mual Muntah Pascaoperasi Mastektomi

Jurnal Anestesi Perioperatif ◽

10.15851/jap.v7n1.1587 ◽

2019 ◽

Vol 7 (1) ◽

pp. 25-32

Author(s):

Arna Fransisca ◽

Iwan Fuadi ◽

Dewi Yulianti Bisri

Keyword(s):

Randomized Controlled Trial ◽

Postoperative Nausea ◽

Controlled Trial ◽

Postoperative Nausea And Vomiting ◽

Nausea And Vomiting ◽

Chi Square ◽

Double Blind ◽

Consecutive Sampling ◽

Randomized Controlled ◽

Significant Difference

Mual muntah pascaoperasi merupakan salah satu komplikasi anestesi dan operasi yang menjadi perhatian khusus karena memengaruhi kualitas pelayanan kesehatan, memperpanjang lama perawatan, dan meningkatkan angka morbiditas perioperatif. Pascaoperasi payudara berkaitan dengan angka kejadian mual muntah pascaoperasi yang tinggi. Beberapa konsensus penatalaksanaan mual muntah pascaoperasi merekomendasikan pemberian terapi nonfarmakologi dengan aromaterapi sebagai terapi rescue untuk mengatasi mual muntah pascaoperasi. Tujuan penelitian ini adalah membandingkan aromaterapi pepermin dengan ondansetron sebagai terapi rescue dalam menurunkan kejadian mual muntah pascaoperasi mastektomi. Penelitian ini merupakan penelitian eksperimental yang dilakukan secara prospektif dengan desain penelitian double blind randomized controlled trial dan consecutive sampling terhadap 32 subjek penelitian yang menjalani operasi mastektomi elektif dan memenuhi kriteria inklusi di RSUP Dr. Hasan Sadikin Bandung pada bulan Juli–September 2018. Pada penelitian ini, data ordinal diuji dengan Uji Mann Whitney dan untuk data kategorik diuji dengan uji chi-square. Hasil penelitian ini didapatkan penurunan kejadian mual muntah pascaoperasi yang signifikan pada kelompok pepermin dibanding dengan kelompok ondansetron dengan perbedaan yang bermakna (p<0,05) pada penilaian menit kedua dan menit kelima setelah perlakuan. Simpulan, aromaterapi pepermin efektif menurunkan kejadian mual muntah pascaoperasi mastektomi dan dapat digunakan sebagai alternatif terapi atau terapi tambahan untuk penatalaksanaan mual muntah pascaoperasi.Comparison of Peppermint Aromatherapy with Ondansetron Intravenous as a Rescue for Postoperative Nausea Vomiting after Mastectomy SurgeryPostoperative nausea and vomiting are among anesthesia and surgery complications that receive special considerations as it affects the quality of healthcare services, prolongs care, and increases perioperative morbidities. The incidence of postoperative nausea and vomiting is high in patients that have undergone breast surgery. The consensus for postoperative nausea and vomiting management recommends non-pharmacological treatments, one of which is through the use of aromatherapy as a rescue to resolve postoperative nausea and vomiting. This study aimed to compare the effects of peppermint aromatherapy and ondansetron as a rescue in reducing the incidence of postoperative nausea and vomiting after elective mastectomies. This was a prospective experimental double blind randomized controlled trial study with consecutive sampling on 32 research subjects underwent elective mastectomies and met the inclusion criteria in Dr. Hasan Sadikin General Hospital in July–September 2018. The ordinal data were tested using the Mann Whitney statistics test and the categorical data using the chi square test. The results show a significant decrease in nausea and vomiting incidence in the peppermint group compared to the ondansetron group with significant difference (p<0.05) in two minutes and five minutes after treatment. In conclusion, peppermint aromatherapy is effective in reducing the incidence of postoperative nausea and vomiting after mastectomies and can be used as an alternative or additional treatment in managing postoperative nausea and vomiting.

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Comparison of mean pain score using topical and oral metronidazole in post milligan morgan hemorrhoidectomy patient; A randomized controlled trial

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.36.5.1796 ◽

2020 ◽

Vol 36 (5) ◽

Author(s):

Syed Tatheer Abbas ◽

Ahmad Raza ◽

Ihtasham Chaudhry ◽

Tahira Hameed ◽

Nausheen Hasham ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Pain Score ◽

Controlled Trial ◽

Pain Scale ◽

Chi Square ◽

Creative Commons ◽

Randomized Controlled ◽

Significant Difference ◽

Topical Metronidazole ◽

Oral Metronidazole

Background and Objectives: Milligan Morgan Hemorrhoidectomy is one of the most commonly performed surgeries. Post-operative pain is the major cause of morbidity in post hemorrhoidectomy patients. Metronidazole has an established role in relieving post hemorrhoidectomy pain. The objective was to evaluate the pain score by using topical and oral metronidazole in post Milligan Morgan hemorrhoidectomy patients. Methods: A prospective randomized controlled trail was done in surgical departments of Akbar Niazi Teaching Hospital, Islamabad. A total of 166 consecutive patients with 3rd and 4th degree hemorrhoids were presenting in surgical OPD and who underwent Milligan Morgan hemorrhoidectomy between July 2018 and December 2018 were included in the study. Patients allocated in two groups, Group-A received topical metronidazole 10% post hemorrhoidectomy for seven days and Group-B were given oral metronidazole 400mg for 07 days. Analgesics were given on patient’s requirement. Patients post hemorrhoidectomy pain was recorded by using VSA scale at baseline (1st day) and on 7th post-operative day. Data analysis was done by using SPSS 21. Pain calculated by compared in terms of mean, standard deviation between groups and independent sample T test was used. Association between demographic details like gender and ages of the patients with pain scale on 7th day was measured and chi-square distribution was used. Results: Total 166 patients were included in this study. The mean ages of the patients were 44.07±10.62 years with minimum 20 and maximum 60 years. Out of 166 patients, female were 55 (33.1%) and male were 111 (66.9%). Results showed significantly lower pain in patients using topical metronidazole as compared to oral metronidazole (p=0.001). Association of pain with respect to ages was insignificant (p=0.202) whereas between genders inside the groups showed significant difference (p=0.028). Conclusion: These results showed that topical metronidazole significantly reduces pain in post hemorrhoidectomy patients as compared to oral metronidazole overall and even when data stratified among age, gender and type of hemorrhoids. doi: https://doi.org/10.12669/pjms.36.5.1796 How to cite this:Abbas ST, Raza A, Chaudhry I, Hameed T, Hasham N, Arshad N. Comparison of mean pain score using topical and oral metronidazole in post milligan morgan hemorrhoidectomy patient; A randomized controlled trial. Pak J Med Sci. 2020;36(5):---------. doi: https://doi.org/10.12669/pjms.36.5.1796 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comparison of Intravenous Paracetamol Prophylaxis versus Placebo for Prevention of Pain with Injection Rocuronium

10.53350/pjmhs211581852 ◽

2021 ◽

Vol 15 (8) ◽

pp. 1852-1854

Author(s):

Aneeque Alam Khan ◽

Kiran Mehwish ◽

Ravi Kumar ◽

Pavan Kumar ◽

Tahir Ali ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Placebo Group ◽

Pain Score ◽

Elective Surgery ◽

Controlled Trial ◽

P Value ◽

Randomized Controlled ◽

Intravenous Paracetamol ◽

Significant Difference ◽

The Mean

Aim: To compare the frequency of absence of pain with injection paracetamol versus placebo given before injection rocuronium in patients undergoing elective procedures Study design: Randomized Controlled Trial Place and duration of study: Dept of Anaesthesia, Civil Hospital, Karachi from 15th January to 14th July 2017. Methodology: One hundred and two patients aged 25-75 years of either gender undergoing elective surgery were enrolled. The lottery method was used to divide the patients into two equal groups. Paracetamol (5 mL, 10 mg/mL) or normal saline (5 mL) were used as pretreatment solutions. When the tourniquet was removed after 2 minutes, the rocuronium at 1% concentration was injected throughout the 10 second’s period. Patients were then advised and asked to rate their pain on the hand's dorsum using VAS. Results: Mean age of the patients was 44.11±7.75 years. Mean pain score was 1.49±1.38. Significant difference was observed in the mean pain score in between paracetamol and placebo group (p-value <0.001). Overall absence of pain was found in 49 (40.8%). Absence of pain was found to be higher 34 (69.4%) in paracetamol group as compared to placebo group (p-value <0.001). Conclusion: Frequency of absence of pain found lower in patients undergoing elective procedures with injection paracetamol versus placebo given before injection rocuronium. Keywords: Injection rocuronium, Elective procedures, Injection paracetamol, Absence of pain

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