scholarly journals Prognostic role of sarcopenia and body composition with long-term outcomes in obstructive colorectal cancer: a retrospective cohort study

2020 ◽  
Author(s):  
Chul Seung Lee ◽  
Daeyoun David Won ◽  
Soon Nam Oh ◽  
Yoon Suk Lee ◽  
In Kyu Lee ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Body Composition ◽  
Visceral Obesity ◽  
Disease Free Survival ◽  
Lumbar Vertebra ◽  
Oncologic Outcomes ◽  
Short Term ◽  
Neutrophil Lymphocyte Ratio ◽  
Obstructive Colorectal Cancer

Abstract Background: The clinical significance of sarcopenia in colorectal cancer obstruction has not yet been described. The present study aimed to determine the short and long-term oncologic impacts of sarcopenia in obstructive colorectal cancer. Methods: We retrospectively analyzed 214 patients with obstructive colon cancer between January 2004 and December 2013. Initial staging computed tomography (CT) scans identified sarcopenia and visceral obesity by measuring the muscle and visceral fat areas at the third lumbar vertebra level. Both short-term postoperative and long-term oncologic outcomes were analyzed. Results: Among all 214 patients, 71 (33.2%) were diagnosed with sarcopenia. Sarcopenia had a negative oncologic impact in both disease-free survival (DFS) and overall survival (OS), (hazard ratio [HR] = 1.86, 95 % confidence interval [CI] 1.04 – 3.13, p = 0.037, and HR = 1.92, CI 1.02 – 3.60, p = 0.043, respectively). Visceral adiposity, body mass index (BMI) and neutrophil-lymphocyte ratio (NLR) did not significantly impact DFS and OS. Conclusion: Sarcopenia is a clinical factor significantly associated with OS and DFS but not with short-term complications in obstructive colorectal cancer. In future, prospective studies should incorporate body composition data in patient risk assessments and oncologic prediction tools.

scholarly journals Prognostic role of pre-sarcopenia and body composition with long-term outcomes in obstructive colorectal cancer: a retrospective cohort study

2020 ◽  
Author(s):  
Chul Seung Lee ◽  
Daeyoun David Won ◽  
Soon Nam Oh ◽  
Yoon Suk Lee ◽  
In Kyu Lee ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Body Composition ◽  
Visceral Obesity ◽  
Disease Free Survival ◽  
Lumbar Vertebra ◽  
Oncologic Outcomes ◽  
Short Term ◽  
Neutrophil Lymphocyte Ratio ◽  
Obstructive Colorectal Cancer

Abstract Background: The clinical significance of pre-sarcopenia in colorectal cancer obstruction has not yet been described. The present study aimed to determine the short and long-term oncologic impacts of pre-sarcopenia in obstructive colorectal cancer.Methods: We retrospectively analyzed 214 patients with obstructive colon cancer between January 2004 and December 2013. Initial staging computed tomography (CT) scans identified pre-sarcopenia and visceral obesity by measuring the muscle and visceral fat areas at the third lumbar vertebra level. Both short-term postoperative and long-term oncologic outcomes were analyzed.Results: Among all 214 patients, 71 (33.2%) were diagnosed with pre-sarcopenia. Pre-sarcopenia had a negative oncologic impact in both disease-free survival (DFS) and overall survival (OS), (hazard ratio [HR] = 1.86, 95 % confidence interval [CI] 1.04 – 3.13, p = 0.037, and HR = 1.92, CI 1.02 – 3.60, p = 0.043, respectively). Visceral adiposity, body mass index (BMI) and neutrophil-lymphocyte ratio (NLR) did not significantly impact DFS and OS.Conclusion: Pre-sarcopenia is a clinical factor significantly associated with OS and DFS but not with short-term complications in obstructive colorectal cancer. In future, prospective studies should incorporate body composition data in patient risk assessments and oncologic prediction tools.

scholarly journals Prognostic role of sarcopenia and body composition with long-term outcomes in obstructive colorectal cancer

2020 ◽  
Author(s):  
Chul Seung Lee ◽  
Daeyoun David Won ◽  
Soon Nam Oh ◽  
Yoon Suk Lee ◽  
In Kyu Lee ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Body Composition ◽  
Visceral Obesity ◽  
Disease Free Survival ◽  
Lumbar Vertebra ◽  
Oncologic Outcomes ◽  
Short Term ◽  
Neutrophil Lymphocyte Ratio ◽  
Obstructive Colorectal Cancer

Abstract Background The clinical significance of sarcopenia in colorectal cancer obstruction has not yet been described. The present study aimed to determine the short and long-term oncologic impacts of sarcopenia in obstructive colorectal cancer. MethodsA total of 214 patients with obstructive colon cancer were included in this study, between January 2004 and December 2013. Initial staging computed tomography (CT) scans identified sarcopenia and visceral obesity by measuring the muscle and visceral fat areas at the third lumbar vertebra level. Both short-term postoperative and long-term oncologic outcomes were analyzed. Results Among all 214 patients, 71 (33.2%) were diagnosed with sarcopenia. Sarcopenia had a negative oncologic impact in both disease-free survival (DFS) and overall survival (OS), (hazard ratio [HR] = 1.860, 95% confidence interval [CI] 1.035 – 3.128, p = 0.037, and HR = 1.917, CI 1.021 – 3.602, p = 0.043, respectively). Visceral adiposity, body mass index (BMI) and neutrophil-lymphocyte ratio (NLR) did not significantly impact DFS and OS. Conclusion Sarcopenia is a clinical factor significantly associated with OS and DFS but not with short-term complications in obstructive colorectal cancer. In future, prospective studies should incorporate body composition data in patient risk assessments and oncologic prediction tools.

scholarly journals Prognostic Impact of Tumor-Associated Macrophages on Long-Term Oncologic Outcomes in Colorectal Cancer

Life ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1240
Author(s):  
Hyeong Chan Shin ◽  
Incheol Seo ◽  
Hasong Jeong ◽  
Sang Jun Byun ◽  
Shin Kim ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Disease Free Survival ◽  
Oncologic Outcomes ◽  
Prognostic Impact ◽  
Tumor Associated Macrophages ◽  
Free Survival ◽  
Disease Free ◽  
Term Data

This study evaluated the correlation between tumor-associated macrophages (TAMs) and long-term oncologic outcomes in colorectal cancer (CRC). We evaluated TAMs based on the expression of CD68, CD11c, and CD163 as optimal markers via immunohistochemistry in 148 patients with CRC who underwent surgical resection between September 1999 and August 2004. A high proportion of CD68-positive macrophages were associated with the occurrence of distant metastasis. A low proportion of CD11c-positive macrophages were associated with unfavorable overall survival (OS) and disease-free survival. CD11c-positive macrophages were found to act as independent prognostic factors for OS. An analysis of our long-term data indicated that TAMs are significantly associated with OS and prognosis in CRC.

scholarly journals One-Stage Total Laparoscopic Treatment for Colorectal Cancer With Synchronous Metastasis. Is It Safe and Feasible?

2021 ◽  
Vol 8 ◽  
Author(s):  
Giuseppe Sena ◽  
Arcangelo Picciariello ◽  
Fabio Marino ◽  
Marta Goglia ◽  
Aldo Rocca ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Laparoscopic Surgery ◽  
Blood Loss ◽  
Hospital Stay ◽  
Open Surgery ◽  
Disease Free Survival ◽  
Long Term Outcomes ◽  
Short Term ◽  
One Stage

Liver is the main target organ for colorectal cancer (CRC) metastases. It is estimated that ~25% of CRC patients have synchronous metastases at diagnosis, and about 60% of CRC patients will develop metastases during the follow up. Although several teams have performed simultaneous laparoscopic resections (SLR) of liver and colorectal lesions, the feasibility and safety of this approach is still widely debated and few studies on this topic are present in the literature. The purpose of this literature review is to understand the state of the art of SLR and to clarify the potential benefits and limitations of this approach. Several studies have shown that SLR can be performed safely and with short-term outcomes similarly to the separated procedures. Simultaneous laparoscopic colorectal and hepatic resections combine the advantages of one stage surgery with those of laparoscopic surgery. Several reports compared the short-term outcomes of one stage laparoscopic resection with open resections and showed a similar or inferior amount of blood loss, a similar or lower complication rate, and a significant reduction of hospital stay for laparoscopic surgery respect to open surgery but much longer operating times for the laparoscopic technique. Few retrospective studies compared long term outcomes of laparoscopic one stage surgery with the outcomes of open one stage surgery and did not identify any differences about disease free survival and the overall survival. In conclusion, hepatic and colorectal SLR are a safe and effective approach characterized by less intraoperative blood loss, faster recovery of intestinal function, and shorter length of postoperative hospital stay. Moreover, laparoscopic approach is associated to lower rates of surgical complications without significant differences in the long-term outcomes compared to the open surgery.

scholarly journals Laparoscopic vs open colorectal cancer surgery in elderly patients: short- and long-term outcomes and predictors for overall and disease-free survival

BMC Surgery ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Sicheng Zhou ◽  
Xuewei Wang ◽  
Chuanduo Zhao ◽  
Qian Liu ◽  
Haitao Zhou ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Elderly Patients ◽  
Open Surgery ◽  
Perineural Invasion ◽  
Disease Free Survival ◽  
Short Term ◽  
Free Survival ◽  
Disease Free ◽  
Surgery In Elderly

Abstract Background Colorectal cancer is common in elderly patients. Laparoscopy is widely used to approach this kind of disease. This study was to examine short-term outcomes and long-term survival for laparoscopic and open surgery in elderly patients with colorectal cancer. Methods From January 2007 to December 2018, patients with colorectal cancer older than 80 operated at China National Cancer Center were included in the study. Propensity score matching (PSM) was used to minimize the adverse effects. The clinical data between open and laparoscopic surgery was compared, and the effect of factors on overall survival (OS) and disease-free survival (DFS) was analyzed by Cox proportional hazard model. Results Ninety-three pairs were selected after PSM. Patients in laparoscopic group had less intraoperative blood loss, postoperative complications, time to first flatus, time to oral feeding, postoperative hospital stay, and higher retrieved lymph node (P < 0.05). The OS and DFS rates were similar (P > 0.05), besides the CEA level, III/IV stage, and perineural invasion were independent predictors of survival (P < 0.05). Conclusion In elderly patients with colorectal cancer, laparoscopic surgery had better short-term outcomes than open surgery. CEA level, III/IV stage, and perineural invasion were reliable predictors for OS and DFS.

scholarly journals Long-term oncologic outcomes of transanal TME compared with transabdominal TME for rectal cancer: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Jae Young Moon ◽  
Min Ro Lee ◽  
Gi Won Ha
Keyword(s):  
Rectal Cancer ◽  
Meta Analysis ◽  
Disease Free Survival ◽  
Distant Recurrence ◽  
Oncologic Outcomes ◽  
Cochrane Library ◽  
Transanal Total Mesorectal Excision ◽  
Random Effects Models ◽  
The Cochrane Library

Abstract Background Transanal total mesorectal excision (TaTME) appears to have favorable surgical and pathological outcomes. However, the evidence on survival outcomes remains unclear. We performed a meta-analysis to compare long-term oncologic outcomes of TaTME with transabdominal TME for rectal cancer. Methods PubMed, EMBASE, and the Cochrane Library were searched. Data were pooled, and overall effect size was calculated using random-effects models. Outcome measures were overall survival (OS), disease-free survival (DFS), and local and distant recurrence. Results We included 11 nonrandomized studies that examined 2,143 patients for the meta-analysis. There were no significant differences between the two groups in OS, DFS, and local and distant recurrence with a RR of 0.65 (95% CI 0.39–1.09, I2 = 0%), 0.79 (95% CI 0.57–1.10, I2 = 0%), 1.14 (95% CI 0.44–2.91, I2 = 66%), and 0.75 (95% CI 0.40–1.41, I2 = 0%), respectively. Conclusion In terms of long-term oncologic outcomes, TaTME may be an alternative to transabdominal TME in patients with rectal cancer. Well-designed randomized trials are warranted to further verify these results.

scholarly journals Erratum to: A Review of the Long-Term Oncologic Outcomes of Robotic Surgery Versus Laparoscopic Surgery for Colorectal Cancer

2016 ◽  
Vol 78 (3) ◽  
pp. 220-220
Author(s):  
Fatima G. Wilder ◽  
Atuhani Burnett ◽  
Joseph Oliver ◽  
Michael F. Demyen ◽  
Ravi J. Chokshi
Keyword(s):  
Colorectal Cancer ◽  
Laparoscopic Surgery ◽  
Robotic Surgery ◽  
Oncologic Outcomes

scholarly journals More Favorable Short and Long-Term Outcomes for Screen-Detected Colorectal Cancer Patients

2021 ◽  
Vol 11 ◽  
Author(s):  
Gaya Spolverato ◽  
Giulia Capelli ◽  
Jessica Battagello ◽  
Andrea Barina ◽  
Susi Nordio ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Disease Free Survival ◽  
Target Population ◽  
Proximal Colon ◽  
Long Term Outcomes ◽  
Curative Intent ◽  
Diagnostic Modality ◽  
Screening Programs ◽  
Short And Long Term

BackgroundScreening significantly reduces mortality from colorectal cancer (CRC). Screen detected (SD) tumors associate with better prognosis, even at later stage, compared to non-screen detected (NSD) tumors. We aimed to evaluate the association between diagnostic modality (SD vs. NSD) and short- and long-term outcomes of patients undergoing surgery for CRC.Materials and MethodsThis retrospective cohort study involved patients aged 50–69 years, residing in Veneto, Italy, who underwent curative-intent surgery for CRC between 2006 and 2018. The clinical multi-institutional dataset was linked with the screening dataset in order to define diagnostic modality (SD vs. NSD). Short- and long-term outcomes were compared between the two groups.ResultsOf 1,360 patients included, 464 were SD (34.1%) and 896 NSD (65.9%). Patients with a SD CRC were more likely to have less comorbidities (p = 0.013), lower ASA score (p = 0.001), tumors located in the proximal colon (p = 0.0018) and earlier stage at diagnosis (p &lt; 0.0001). NSD patients were found to have more aggressive disease at diagnosis, higher complication rate and higher readmission rate due to surgical complications (all p &lt; 0.05). NSD patients had a significantly lower Disease Free Survival and Overall Survival (all p &lt; 0.0001), even after adjusting by demographic, clinic-pathological, tumor, and treatment characteristics.ConclusionsSD tumors were associated with better long-term outcomes, even after multiple adjustments. Our results confirm the advantages for the target population to participate in the screening programs and comply with their therapeutic pathways.

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