Long-term nutritional deficiencies following sleeve gastrectomy: a 6-year single-center retrospective study

Abstract Sleeve gastrectomy (SG) is associated with short-term nutritional deficiencies postoperatively. This study evaluates the long-term percent excess weight loss (%EWL), and nutritional deficiencies in a single-center cohort undergoing SG as a primary procedure, with a 6-year follow-up. From January 2005 to December 2010, records of 209 patients who underwent laparoscopic SG were retrieved from a computer database for analysis. 60 out of 209 completed follow-ups of 6 years. Median %EWL at 1, 2, 3, 4, 5 and 6 year postoperatively was 80.9%, 79.1%, 73.8%, 71.8%, 71.5%, and 64.9%, respectively. Prior to surgery, 17.2% had anemia. Deficiencies of iron, ferritin, folic acid, vitamin B12, magnesium, and phosphorus were 22%, 5.3%, 1.4%, 3.8%, 29.7%, 5.3%, respectively. Six years post-surgery, deficiencies of hemoglobin, ferritin, and B12 worsened (36.7%, 43.3%, and 11.7%, p = 0.001, p < 0.001, p = 0.019, respectively), whereas there was no significant difference in deficiencies of iron, folic acid, magnesium, and phosphorus (25%, 1.7%, 20%, and 3%, p = 0.625, p = 0.896, p = 0.139, p = 0.539, respectively). There was elevated PTH before and six years post-surgery (2.9% and 1.7%, p = 0.606). This retrospective study shows that LSG had a considerable effect on specific nutritional deficiencies in our patients at six-year post-surgery.

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Long-Term Outcomes of Laparoscopic Sleeve Gastrectomy—a Single-Center, Retrospective Study

Obesity Surgery ◽

10.1007/s11695-017-2795-2 ◽

2017 ◽

Vol 28 (1) ◽

pp. 130-134 ◽

Cited By ~ 29

Author(s):

Piotr K. Kowalewski ◽

Robert Olszewski ◽

Maciej S. Walędziak ◽

Michał R. Janik ◽

Andrzej Kwiatkowski ◽

...

Keyword(s):

Sleeve Gastrectomy ◽

Retrospective Study ◽

Laparoscopic Sleeve Gastrectomy ◽

Single Center ◽

Long Term Outcomes

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Long-term nutritional deficiencies following sleeve gastrectomy: a 6-year single-centre retrospective study

Menopausal Review ◽

10.5114/pm.2021.110954 ◽

2021 ◽

Author(s):

Francesk Mulita ◽

Charalampos Lampropoulos ◽

Dimitrios Kehagias ◽

Georgios-Ioannis Verras ◽

Levan Tchabashvili ◽

...

Keyword(s):

Sleeve Gastrectomy ◽

Retrospective Study ◽

Nutritional Deficiencies ◽

Single Centre

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Five-Year Outcome of Laparoscopic Sleeve Gastrectomy, Resolution of Comorbidities, and Risk for Cumulative Nutritional Deficiencies

Scandinavian Journal of Surgery ◽

10.1177/1457496918783723 ◽

2018 ◽

Vol 108 (1) ◽

pp. 10-16 ◽

Cited By ~ 10

Author(s):

E. M. Kikkas ◽

T. Sillakivi ◽

J. Suumann ◽

Ü. Kirsimägi ◽

T. Tikk ◽

...

Keyword(s):

Weight Loss ◽

Sleeve Gastrectomy ◽

Total Cholesterol ◽

Laparoscopic Sleeve Gastrectomy ◽

Excess Weight Loss ◽

Density Lipoprotein ◽

Nutritional Deficiencies ◽

Low Density

Background and Aims: The aim of this study was to evaluate the long-term (5-year follow-up) results of laparoscopic sleeve gastrectomy in terms of weight loss and obesity-related comorbidities, as well as the risk factors associated with postoperative nutritional deficiencies. Material and Methods: The first 99 consecutive patients who underwent laparoscopic sleeve gastrectomy for the treatment of morbid obesity between October 2008 and August 2011 at Tartu University Hospital were followed prospectively in cohort study. The outpatient hospital follow-up visits were conducted at 3 months, 1 year, and 5 years postoperatively. At 5 years, the follow-up rate was 90.9%; 86 laparoscopic sleeve gastrectomy patients were included in final analysis. Results: The mean excess weight loss (%EWL) was 44.3% ± 13.0%, 75.8% ± 23.1%, and 61.0% ± 24.3% at 3 months, 1 year, and 5 years, respectively. A linear association between preoperative weight and weight at 5 years was found. Remission rates at 5-year follow-up for type 2 diabetes, hypertension, dyslipidemia, and obstructive sleep apnea were 68.8%, 32.7%, 27.4%, and 61.5%, respectively (all p < 0.05). There was a statistical difference (p < 0.05) in the dynamics of triglyceride, low-density lipoprotein, and high-density lipoprotein level at 5-year follow-up but the level of total cholesterol did not show significant improvement. The risk for cumulative iron, vitamin B12 deficiency, and anemia was 20%, 48%, and 28%, respectively. Conclusion: In conclusion, laparoscopic sleeve gastrectomy ensured long-term excess weight loss 61.0% at 5 years. Laparoscopic sleeve gastrectomy has a long-term effect on significant improvement in the median values of triglycerides, low-density lipoproteins, and high-density lipoproteins, but not on total cholesterol levels. There is a risk of postoperative vitamin B12 and iron deficiency.

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Does meloxicam provide adequate pain management as a post-operative analgesic in canine ovariohysterectomy patients?

The Veterinary Nurse ◽

10.12968/vetn.2020.11.4.192 ◽

2020 ◽

Vol 11 (4) ◽

pp. 192-197

Author(s):

Gavin Goldsbrough ◽

Helen Reynolds

Keyword(s):

Pain Management ◽

Pain Score ◽

Pain Scale ◽

Short Term ◽

Post Surgery ◽

Pain Scores ◽

Significant Difference ◽

Time Frames ◽

Adequate Pain Management

Background: Meloxicam is an analgesic agent with anti-inflammatory properties, commonly used in veterinary practices to treat a variety of different long-term medical conditions and is also used as a short-term pain relief following particularly traumatic surgeries. Aims: An observational study was conducted to determine whether meloxicam provides adequate pain management as a post-operative analgesic for canine ovariohysterectomies. Methods: 13 canines were admitted for ovariohysterectomy. Each patient was assessed using the Glasgow composite pain scale (CMPS) prior to surgery during the admission procedure, 15 minutes post-operatively, at discharge and at their post-operative check (POC) 3–5 days after surgery. Results: Data were statistically analysed to determine the overall effectiveness of meloxicam in reducing pain following canine ovariohysterectomy. The results showed a statistically significant difference (Kruskal-Wallis test: H3 =12.98, p=0.005) in pain scores between admission, 15 minutes post operatively, discharge and 3–5 days POC. The greatest decrease in pain score was between 15 minutes post-operatively and POC (Mann-Whitney U test: W=236, n=13, 13, p=0.0014) and between discharge and POC (Mann-Whitney U test: W=227, n=13, 13, p=0.0060). Overall, this demonstrated that there was an improvement in pain suggesting meloxicam is effective between these time frames. In addition, 69.2% (n=9) of patients in the study showed a pain score of 0, indicating an absence of pain, on their final POC. Statistical analysis was also used to determine if there was any difference in pain score between the 3, 4 or 5 day POC pain score. The results show there was no significant difference (Kruskal-Wallis test: H2 =0.090, p=0.638) suggesting that meloxicam's effectiveness was similar across this range of time post surgery. Conclusion: The results from the study indicate that meloxicam is an effective post-operative analgesic for canine patients undergoing an ovariohysterectomy.

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Long-term functional outcomes of different subtypes of primary congenital glaucoma

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2019-315131 ◽

2019 ◽

pp. bjophthalmol-2019-315131 ◽

Cited By ~ 2

Author(s):

Richard Sher Chaudhary ◽

Amisha Gupta ◽

Ajay Sharma ◽

Shikha Gupta ◽

Rayees Ahmad Sofi ◽

...

Keyword(s):

Visual Acuity ◽

Congenital Glaucoma ◽

Cumulative Probability ◽

Primary Congenital Glaucoma ◽

Visual Outcomes ◽

Post Surgery ◽

Kaplan Meier ◽

Significant Difference

AimTo analyse long-term visual outcomes across different subtypes of primary congenital glaucoma (PCG).MethodsPatients with PCG with a minimum of 5-year follow-up post surgery were included in the study. Snellen visual acuity recordings taken at their last follow-up were analysed. We evaluated the results using Kaplan-Meier curves to predict the probability of maintaining good vision (as defined by a visual acuity of 6/18 or better) in our patients after 30-year follow-up. The results were also analysed to determine whether there were any differences in the long-term visual acuities with time between the neonatal and infantile PCG. We also analysed the reasons for poor visual outcomes.ResultsWe assessed a cohort of 140 patients with PCG (235 eyes) with an average follow-up of 127±62.8 months (range 60–400 months). Overall, the proportion of eyes with good visual acuity was 89 (37.9%), those with fair visual acuity between 6/60 and 6/18 was 41 (17.4%), and those with poor visual acuity (≤6/60) was 105 (44.7%). We found a significant difference (p=0.047) between neonatal and infantile patients with PCG whereby the neonatal cohort fared worse off in terms of visual morbidity. On Kaplan-Meier analysis, the cumulative probability of survival of a visual acuity of 6/18 or better was more among the infantile PCG in comparison to the neonatal PCG (p=0.039) eyes, and more among the bilateral than the unilateral affected eyes (p=0.029). Amblyopia was the most important cause for poor visual acuity as shown on a Cox proportional-hazards regression model .ConclusionsLong-term visual outcomes of infantile are better than neonatal PCG. Eyes with unilateral have worse visual outcomes compared with those with bilateral PCG because of the development of dense amblyopia.

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Clinical features and long-term outcomes of moyamoya disease: a single-center experience with 528 cases in China

Journal of Neurosurgery ◽

10.3171/2014.10.jns132369 ◽

2015 ◽

Vol 122 (2) ◽

pp. 392-399 ◽

Cited By ~ 56

Author(s):

Xing-ju Liu ◽

Dong Zhang ◽

Shuo Wang ◽

Yuan-li Zhao ◽

Mario Teo ◽

...

Keyword(s):

Clinical Features ◽

Moyamoya Disease ◽

Positive Impact ◽

Chinese Patients ◽

Single Center ◽

Long Term Outcomes ◽

Kaplan Meier ◽

Significant Difference ◽

Revascularization Procedures

OBJECT The aim of this study was to describe the baseline clinical features and long-term outcomes of patients with moyamoya disease (MMD) based on a 25-year period at a single center in China. METHODS Data obtained in 528 consecutive patients with MMD treated at the authors' hospital from 1984 to 2010 were reviewed retrospectively. Events of transient ischemic attack, new infarction, and hemorrhage were included. The Kaplan-Meier risk of stroke was calculated. RESULTS The mean (± SD) patient age was 26 ± 13 years (range 2–67 years), and the female/male ratio was 0.9:1. There were 332 cases of ischemia and 196 hemorrhages. Adults had a higher rate of bleeding than children (50.7% vs 14.0%, respectively; p < 0.001). One hundred twenty-two patients were treated conservatively, and 406 patients underwent revascularization procedures. Of 528 patients, 331 (62.7%) had at least 1 year of follow-up (median 39.5 months) and data from these patients were analyzed. Rebleeding and mortality rates in patients with hemorrhagic MMD (n = 104) were higher than in those with ischemic MMD (n = 227) (26.9% vs 2.2% [p < 0.001] and 4.8% vs 0.4% [p < 0.05], respectively). Twenty-five of 60 (41.7%) conservatively treated patients and 8 of 271 (2.9%) surgically treated patients experienced rebleeding events, a difference that was significant in the Kaplan-Meier curve of rebleeding (p < 0.01). An improvement in perfusion was found in 164 of 224 (73.2%) surgically treated patients 1 month after discharge. However, there was no significant difference in the rate of ischemic events in the surgical and conservative groups (18.8% and 28.3%, respectively; p = 0.09). Among the 104 hemorrhagic cases, rebleeding attacks were observed in 25 patients in the nonsurgical group (n = 60) and 3 patients in the surgical group (n = 44) (41.7% and 6.8%, respectively; OR 9.7 [95% CI 2.7–35.0]; p < 0.01). CONCLUSIONS There was no difference in the sex distribution of Chinese patients with MMD. Patients with hemorrhagic MMD had a much higher rate of rebleeding and poorer prognosis than those with the ischemic type. Surgical revascularization procedures can improve cerebral perfusion and have a positive impact in preventing rebleeding in patients with hemorrhagic MMD.

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Abstract 3864: A single-center retrospective study of the immune landscape in patients with untreated liposarcoma (LS) with long-term follow-up

10.1158/1538-7445.am2020-3864 ◽

2020 ◽

Author(s):

Brett A. Schroeder ◽

Natalie A. LaFranzo ◽

Bonnie J. LaFleur ◽

Kevin C. Flanagan ◽

Rachel M. Gittelman ◽

...

Keyword(s):

Retrospective Study ◽

Single Center ◽

Long Term Follow Up

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Combination therapy with beraprost sodium and aspirin for acute ischemic stroke: a single-center retrospective study

Journal of International Medical Research ◽

10.1177/0300060519850401 ◽

2019 ◽

Vol 47 (7) ◽

pp. 3014-3024 ◽

Cited By ~ 1

Author(s):

De Cai ◽

Xiao-Pu Chen ◽

Dun-Can Wei ◽

Qian Zhang ◽

Si-Qia Chen ◽

...

Keyword(s):

Ischemic Stroke ◽

Retrospective Study ◽

Combination Therapy ◽

Adverse Events ◽

Acute Ischemic Stroke ◽

Blood Coagulation ◽

Control Group ◽

Single Center ◽

Beraprost Sodium ◽

Significant Difference

Objectives To evaluate the effectiveness and safety of the combination of beraprost sodium (BPS) and aspirin in patients with acute ischemic stroke (AIS). Methods There were 384 patients with AIS enrolled in this single-center, retrospective study. The BPS group comprised patients who received combination therapy with BPS and aspirin, and the control group comprised those who received only aspirin. Primary measurements were glomerular filtration rate (GFR), cystatin-c (Cys-C), National Institute of Health Stroke Scale (NIHSS) score, modified activities of daily living index (MBI), modified Rankin scale (mRS), and blood coagulation indexes. Recurrence and adverse events were recorded. Results There were no significant differences in patient characteristics at baseline between the two groups. GFR and Cys-C levels increased in the BPS group compared with the control group. After treatment, the NIHSS and mRS score were significantly lower in the BPS group compared with the control group, whereas the MBI scores were significantly higher in the BPS group compared with the control group. There was no significant difference in blood coagulation between the two groups. There were no serious adverse events in either group. Conclusions Combination therapy with BPS and aspirin may be a safe and effective treatment for AIS.

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P1417Short and long term efficiency of different therapeutic approaches to perimitral atrial flutter

EP Europace ◽

10.1093/europace/euaa162.114 ◽

2020 ◽

Vol 22 (Supplement_1) ◽

Author(s):

P Kupo ◽

R Pap ◽

G Bencsik ◽

L Saghy

Keyword(s):

Retrospective Study ◽

Atrial Flutter ◽

Pulmonary Vein ◽

Success Rates ◽

Therapeutic Approaches ◽

Significant Difference ◽

Mitral Isthmus ◽

Short And Long Term ◽

Left Pulmonary Vein

Abstract Introduction Catheter ablation of perimitral flutter can be challenging, owing to difficult anatomy. The most commonly applied procedure is the creation of a mitral isthmus line (between the lower left pulmonary vein and the mitral anulus) or an anteroseptal line (between the upper right pulmonary vein and the anterior mitral anulus). Purpose Our study aimed to compare the short and long term efficacy of two different ablation methods. Methods In our retrospective study 45 consecutive patients diagnosed with perimitral flutter were included between 2009 and 2018. Results Radiofrequency ablation was performed in 48 cases in 31 patients (mitral isthmus line (n = 25, 52.1%); anteroseptal line (n = 23, 47.9%)). Arrhythmia-termination and sinus rhythm restoration could be achieved in 64.6% of the cases (mitral isthmus line: 16/25 (64.0%), anteroseptal line: 15/23 (65.2%). Comparing two different techniques, there was no significant difference (p = 0.85) in acute success rates. During 24.3 months of follow-up period, in 60.0% of the patients no recurrence occurred. The arrhythmia recurred in 6 cases (40.0%) after anteroseptal line ablation, and in 8 cases (53.3%) after mitral isthmus line ablation. No difference was found in the long term efficiency of two different ablation techniques (p = 0.211). Conclusion In our retrospective study we found no significant difference in the short and long term efficiency of two different therapeutic approaches to perimitral atrial flutter.

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