Prevalence and screening of precancerous lesions in the upper gastrointestinal tract: A cross-sectional study in North of Iran

Abstract Purpose: Precancerous lesions of the UGI tract are the second major cancer-related deaths and responsible for more than ten percent of cancer-related deaths worldwide. The aim of this study was to evaluate the frequency of precancerous lesions in the upper gastrointestinal tract of patients under patronage of Imam Khomeini Relief Foundation in Guilan province as vulnerable population. Methods: In a cross-sectional study from March 2017 to March 2018, three hundred patients under patronage of Guilan branch of Imam Khomeini Relief Foundation aged more than 40 years were enrolled. All patients were underwent endoscopy and checked for Helicobacter pylori infection. Results: The most frequent lesions in the esophagus, stomach and bulb were grade A mucosal breaking (58.7%), erosions (57.0%), and ulcers (6.3%), respectively. Esophageal lesions were higher in the age more than 60 years (P=0.036). Smokers and patients with familial history of cancers in the 2ndand 3rd grade of relatives had more lesions in the bulb (P=0.005 and P=0.010, respectively). Female patients, those with age lower than 50 years and no-smoker had lower frequency of intestinal metaplasia (IM) (P=0.024, P=0.030, and P=0.003, respectively). Also, there was positive association between gastric atrophy and age (P=0.009). Furthermore, chronic active gastritis were seen more frequently in male patients (P=0.003) and smokers (P=0.010). Significant positive association between consumption of fish meat and occurrence of IM was detected (P=0.010). Conclusions: Male gender, higher age and smoking for IM and male gender, higher BMI and smoking for H. pylori infection were the predictive risk factors. It seems early diagnosis of precancerous lesions help to prevent cancers and to increase the survival rate.

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Successful Endoscopic Management of Suspected Foreign Bodies in Upper Gastrointestinal Tract among Patients Undergoing Upper Gastrointestinal Endoscopy in a Tertiary Care Hospital: A Descriptive Cross-sectional Study

Journal of Nepal Medical Association ◽

10.31729/jnma.6714 ◽

2021 ◽

Vol 59 (239) ◽

Author(s):

Ramila Shrestha ◽

Shankhar Baral ◽

Mukesh Sharma ◽

Jiwan Thapa ◽

Dibas Khadka

Keyword(s):

Gastrointestinal Tract ◽

Foreign Body ◽

Foreign Bodies ◽

Cross Sectional Study ◽

Upper Gastrointestinal Tract ◽

Care Hospital ◽

Endoscopic Removal ◽

Sectional Study ◽

Cross Sectional ◽

Upper Gastrointestinal

Introduction: Most ingested foreign bodies pass through the gastrointestinal tract spontaneously. However, some foreign bodies may get impacted in the upper gastrointestinal tract. A variety of endoscopic techniques and instruments are indicated for the removal of such impacted foreign bodies. This study was conducted to find out the prevalence of successful endoscopic removal of foreign bodies. Methods: This descriptive cross-sectional study was conducted among patients who presented at the Department of Gastroenterology with complaints of upper gastrointestinal foreign body ingestion from 2/11/2008 to 23/07/2020 after taking ethical approval of the research proposal was taken from Institutional Review Board (Reference no 13). Convenient sampling was done. The data were entered into Microsoft Excel and analyzed in Statistical Package of Social Sciences version 22. Results: A total of 119 cases were identified with foreign bodies ingestion. In hundred patients, foreign bodies 100 (84 %) (77.41-90.58 at 95% Confidence Interval) were extracted completely. Complete extraction failed in 19 (16%) patients. Six (5%) patients were treated by push technique and 10 (8.4%) patients with failed retrieval, received surgical intervention for foreign body removal. Conclusions: Endoscopic removal technique of foreign bodies in the upper gastrointestinal tract was successful in most of the cases and is associated with few complications.

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Prevalence of tobacco dependence and associated factors among patients with schizophrenia attending their treatments at southwest Ethiopia; hospital-based cross-sectional study

PLoS ONE ◽

10.1371/journal.pone.0261154 ◽

2021 ◽

Vol 16 (12) ◽

pp. e0261154

Author(s):

Defaru Desalegn ◽

Zakir Abdu ◽

Mohammedamin Hajure

Keyword(s):

Associated Factors ◽

Positive Association ◽

Tobacco Dependence ◽

Cross Sectional Study ◽

Male Gender ◽

Sectional Study ◽

Significant Positive Association ◽

Cross Sectional ◽

Southwest Ethiopia ◽

History Of

Background Tobacco smoking is the most typically employed in patients with mental disorders; among them, patients with schizophrenia are the very best users. The rate of smoking among patients with schizophrenia is between two and three times greater than the general population in western countries. However, there is a scarcity of studies on the magnitude and associated factors of tobacco dependence among patients with schizophrenia in Ethiopia. Therefore, we assessed the prevalence of tobacco dependence and associated factors among patients with schizophrenia at Mettu Karl referral, Bedelle, and Agaro hospitals, Southwest, Ethiopia. Method Hospital-based the multistage stratified cross-sectional study design was conducted among 524 patients with schizophrenia who are on treatment. Fagerstrom Test for Nicotine Dependence (FTND) was used to screen the prevalence of tobacco dependence. Analysis of data was done using SPSS version 24. Result The prevalence of tobacco dependence among study participants was 22.3% (95% CI) (18.6, 26). Concerning the severity of tobacco dependence, 3.5%, 13.8%, and 5% of the respondents report moderate, high, and very high levels of tobacco dependence respectively. The proportions of tobacco dependence among male schizophrenic patients 88 (25.8%) were higher compared to their counterparts 27 (15.5%). After controlling the effects of cofounders in the final regression analysis, male gender (AOR 2.19, 95% CI = 1.25, 3.83), being on treatment for more than 5years (AOR 4.37, 95% CI = 2.11, 9.02), having a history of admission (AOR 4.01, 95% CI = 1.99, 8.11), and family history of mental illness (AOR 1.90, 95% CI = 1.04, 3.48) were shown to have a significant positive association with tobacco dependence. Conclusion and recommendation A study show a significant proportion of tobacco dependence among people living with schizophrenia. Factors like, being male gender, being on treatment for more than 5 years, having a history of admission, and family history of mental illness was found to have a significant positive association with tobacco dependence. Hence, there is a need for coordinated and comprehensive management clinically to manage tobacco dependence along with identified risk factors in patients with schizophrenia. Also the finding call for the clinicians, managers, ministry of health and other stakeholders on the substance use prevention strategies that target personal and environmental control.

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Removable denture is a risk indicator for peri-implantitis and facilitates expansion of specific periodontopathogens: a cross-sectional study

BMC Oral Health ◽

10.1186/s12903-021-01529-9 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Jasmin Grischke ◽

Szymon P. Szafrański ◽

Uthayakumar Muthukumarasamy ◽

Susanne Haeussler ◽

Meike Stiesch

Keyword(s):

Bacterial Species ◽

Positive Association ◽

Cross Sectional Study ◽

Risk Indicators ◽

Risk Indicator ◽

Sectional Study ◽

Significant Positive Association ◽

Cross Sectional ◽

Linear Discriminant ◽

Removable Denture

Abstract Background The prevalence of peri-implantitis ranges between 7 and 38.4% depending on risk indicators such as smoking, diabetes mellitus, lack of periodontal maintenance program, and history or presence of periodontitis. Currently, the possible effect of the type of superstructure on peri-implant health is unclear. This cross-sectional study aims to investigate the influence of the superstructure on the prevalence of peri-implant mucositis, peri-implantitis and peri-implant dysbiosis. Methods During a 32-month recruitment period dental implants were assessed to diagnose healthy peri-implant tissues, mucositis or peri-implantitis. The study included 1097 implants in 196 patients. Out of all peri-implantitis cases 20 randomly chosen submucosal biofilms from implants with fixed denture (FD) originating from 13 patients and 11 biofilms from implants with removable dentures (RD) originating from 3 patients were studied for microbiome analysis. Composition of transcriptionally active biofilms was revealed by RNAseq. Metatranscriptomic profiles were created for thirty-one peri-implant biofilms suffering from peri-implantitis and microbiome changes associated with superstructure types were identified. Results 16.41% of the implants were diagnosed with peri-implantitis, 25.00% of implants with RD and 12.68% of implants with FD, respectively. Multivariate analysis showed a significant positive association on patient (p = < 0.001) and implant level (p = 0.03) between the prevalence of peri-implantitis and RD. Eight bacterial species were associated either with FD or RD by linear discriminant analysis effect size method. However, significant intergroup confounders (e.g. smoking) were present. Conclusions Within the limitations of the present work, RDs appear to be a risk indicator for peri-implantitis and seem to facilitate expansion of specific periodontopathogens. Potential ecological and pathological consequences of shift in microbiome from RDs towards higher activity of Fusobacterium nucleatum subspecies animalis and Prevotella intermedia require further investigation.

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Exploring the relationship of human–nature interaction and mindfulness: a cross-sectional study

10.31231/osf.io/9dx72 ◽

2021 ◽

Author(s):

Pooja Sahni ◽

Jyoti Kumar

Keyword(s):

Mental Health Problems ◽

Positive Association ◽

Cross Sectional Study ◽

Sectional Study ◽

Significant Positive Association ◽

Cross Sectional ◽

Nature Relatedness ◽

Relationship Of ◽

The Relationship ◽

Nature Experience

History is replete with examples where humans have sought refuge in nature for psychological restoration. In this cross-sectional study we explore the relationship of nature experience and mindfulness. Nature experience is assessed through “nature in the neighbourhood”, “frequency of visit” to nature-rich spaces, as well as one's inherent connection with nature described as “nature relatedness”. The study sample consisted of 334 Indian adults. The findings from this study show that frequency of visit to nature-rich spaces has a significant positive association with mindfulness. The hierarchical regression analysis suggests an interaction effect of “nature relatedness” in the association of the presence of nature rich spaces in the neighbourhood, frequency of visit as well as mindfulness. Interestingly, when childhood experiences were explored they had a significant association with “nature relatedness” and mindfulness. The evidence from this research suggests that nature experience may find its application as one of the mindfulness techniques prescribed for self-management of mental health problems.

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The visceral fat area to leg muscle mass ratio is significantly associated with the risk of hyperuricemia among women: a cross-sectional study

Biology of Sex Differences ◽

10.1186/s13293-021-00360-9 ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Xiao-He Wang ◽

Wei-Ran Jiang ◽

Min-Ying Zhang ◽

Ying-Xin Shi ◽

Yun-Ping Ji ◽

...

Keyword(s):

Visceral Fat ◽

Density Lipoprotein ◽

Positive Association ◽

Cross Sectional Study ◽

Sectional Study ◽

Significant Positive Association ◽

Visceral Fat Area ◽

Cross Sectional ◽

Menopausal Women ◽

Leg Muscle

Abstract Background A significant positive association was found in previous studies among obesity, visceral fat accumulation, and hyperuricemia. The purpose of this study was to explore the association between the ratio of visceral fat area to leg muscle mass (VFA-to-LMM) and hyperuricemia, and verify the role of gender differences in the association. Methods A total of 3393 (43.3% are men) participants from Tianjin Union Medical Center-Health Management Center were recruited for this cross-sectional study. The VFA-to-LMM ratio was used as the independent variable. Hyperuricemia, a serum uric acid level ≥ 416 μmol/L in men and in menopausal women and ≥ 357 μmol/L in premenopausal women, was used as the dependent variable. Multiple logistic regression analysis was used to estimate the odds ratio and the 95% confidence interval between the VFA-to-LMM ratio and hyperuricemia. Results The overall prevalence of hyperuricemia was 14.8% (8.9% in women, and 22.5% in men). After adjustment by age, smoking status (for males), menopause status (for females), drinking status, exercise frequency, blood pressure, alanine aminotransferase, fasting plasma glucose, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, creatinine, and history of diseases, a strong positive association was found between the VFA-to-LMM ratio and hyperuricemia in both men (4th vs. 1st quartile 1.60, 95%CI: 1.03–2.49) and women (4th vs. 1st quartile 5.22, 95%CI: 2.44–12.56). After additional adjustment by BMI, there was still a significant positive association in women (4th vs. 1st quartile 2.57, 95%CI: 1.06–6.77). The results of subgroup analysis showed that pre-menopausal women (4th vs. 1st quartile OR: 3.61) have a higher risk of hyperuricemia than postmenopausal women (4th vs. 1st quartile OR: 1.94) with the increase of the VFA-to-LMM ratio. Besides, the interaction analysis results showed the highest risk of hyperuricemia when VFA and LMM were both in the highest quantile (OR: 11.50; 95% CI: 4.86–31.98). Conclusion The VFA-to-LMM ratio was positively associated with the risk of hyperuricemia in women after adjustment by confounders. Pre-menopausal women have a higher risk of hyperuricemia than postmenopausal women with the increase of the VFA-to-LMM ratio. In addition, the highest risk of hyperuricemia was demonstrated when both VFA and LMM were at the highest quartile.

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Visceral Fat Area to Leg Muscle Mass Ratio Are Significantly Associated With the Risk of Hyperuricemia Among Women: A Cross-sectional Study

10.21203/rs.3.rs-28417/v1 ◽

2020 ◽

Author(s):

Xiao-He WANG ◽

Wei-Ran JIANG ◽

Min-Ying ZHANG ◽

Ying-Xin SHI ◽

Yun-Ping JI ◽

...

Keyword(s):

Muscle Mass ◽

Visceral Fat ◽

Density Lipoprotein ◽

Positive Association ◽

Cross Sectional Study ◽

Sectional Study ◽

Significant Positive Association ◽

Visceral Fat Area ◽

Cross Sectional ◽

Leg Muscle

Abstract Background: Previous studies have found a significant positive association between obesity, visceral fat accumulation and hyperuricemia. The purpose of the study was to explore the association between the ratio of visceral fat area to leg muscle mass(VFA-to-LMM) and hyperuricemia, and verify the role of sex differences in the association.Methods:In this cross-sectional study, a total of 3393 (43.3% for men) participants from Tianjin Union Medical Center-Health Management Center were recruited. Body composition were measured by multielectrode bioelectrical impedance analyzer. The VFA-to-LMM ratio was used as independent variable. Hyperuricemia, defined as a serum uric acid level ≥ 416 μmol/L in men and menopausal women, and ≥ 357 μmol/L in premenopausal women, was used as the dependent variable. Multiple logistic regression analysis was used to estimate the odds ratio and 95% confidence interval between VFA-to-LMM ratio and hyperuricemia.Results:The overall prevalence of hyperuricemia was 14.8%, and the prevalence of hyperuricemia in women (8.9%) was significantly lower than that in men (22.5%). After adjustment for age, smoking status (for males), menopause status (for females), drinking status, exercise frequency, blood pressure, alanine aminotransferase, fasting plasma glucose, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, creatinine, and history of diseases, a strong positive association was observed between VFA-to-LMM ratio and hyperuricemiain bothmen (4th vs. 1st quartile 1.60, 95%CI: 1.03-2.49) and women (4th vs. 1st quartile 5.22, 95%CI: 2.44-12.56).After additionally adjustment for BMI, there was still a significant positive association in women (4th vs. 1st quartile 2.57, 95%CI: 1.06-6.77), while the association disappeared in men(4th vs. 1st quartile 0.97, 95%CI: 0.55-1.70).Conclusions:The VFA-to-LMM ratio was positively associated with the risk of hyperuricemia in women after adjustments for confounders. In addition, the highest risk of hyperuricemia was observed when both VFA and LMM were at the highest quartile. However, well-controlled prospective studies are needed to further confirm the causality between VFA-to-LMM ratio and hyperuricemia.

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Associations between thyroid-stimulating hormone and hypertension according to thyroid cyst status in the general population: a cross-sectional study

Environmental Health and Preventive Medicine ◽

10.1186/s12199-020-00910-4 ◽

2020 ◽

Vol 25 (1) ◽

Author(s):

Yuji Shimizu ◽

Yuko Nabeshima-Kimura ◽

Shin-Ya Kawashiri ◽

Yuko Noguchi ◽

Yasuhiro Nagata ◽

...

Keyword(s):

Thyroid Hormone ◽

Positive Association ◽

Cross Sectional Study ◽

Thyroid Stimulating Hormone ◽

Sectional Study ◽

Free Triiodothyronine ◽

Significant Positive Association ◽

Cross Sectional ◽

Thyroid Cyst ◽

Stimulating Hormone

Abstract Background The absence of thyroid cysts may indicate latent thyroid damage, as demonstrated in our previous study. However, the association between the absence of thyroid cysts and latent functional damage of the thyroid is unknown. At low thyroid hormone productivity, which may be associated with latent functional damage of the thyroid, the association between thyroid-stimulating hormone (TSH) and hypertension might be enhanced. Therefore, we evaluated the association between TSH level and hypertension stratified by thyroid cyst status. Methods We conducted a cross-sectional study of 1724 euthyroid Japanese individuals aged 40–74 years who participated in an annual health checkup in 2014. Results In the study population, 564 and 686 participants had thyroid cysts and hypertension, respectively. A significant positive association was observed between TSH and hypertension in subjects without a thyroid cyst but not in subjects with thyroid cysts. There was a significant positive association between hypertension and TSH in subjects without a thyroid cyst (odds ratio [OR] 1.27; 95% confidence intervals [CI] 1.01, 1.61) but not in subjects with thyroid cysts (OR 0.79; CI 0.57, 1.09) in the model fully adjusted for known confounding factors. The correlation between the TSH and free triiodothyronine (fee T3) levels (simple correlation coefficient [r] = − 0.13, p < 0.01) was stronger in the subjects without thyroid cysts than in those with thyroid cysts (r = − 0.03, p = 0.525). Conclusions TSH is positively associated with hypertension only in individuals without thyroid cysts. The correlation between the TSH and free T3 levels was stronger in the subjects without thyroid cysts than in those with thyroid cysts. Therefore, the absence of thyroid cysts could be related to the association between TSH level and hypertension, possibly by indicating that the subjects without thyroid cysts had limited thyroid hormone reserves. Therefore, the absence of thyroid cysts could indicate the latent functional damage of the thyroid.

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The Relationships Between Serum DHEA-S and AMH Levels in Infertile Women: A Retrospective Cross-Sectional Study

Journal of Clinical Medicine ◽

10.3390/jcm10061211 ◽

2021 ◽

Vol 10 (6) ◽

pp. 1211

Author(s):

Li-Te Lin ◽

Kuan-Hao Tsui

Keyword(s):

Generalized Linear Models ◽

Large Scale ◽

Linear Models ◽

Positive Association ◽

Cross Sectional Study ◽

Dehydroepiandrosterone Sulphate ◽

Sectional Study ◽

Cross Sectional ◽

Infertile Women ◽

The Relationship

The relationship between serum dehydroepiandrosterone sulphate (DHEA-S) and anti-Mullerian hormone (AMH) levels has not been fully established. Therefore, we performed a large-scale cross-sectional study to investigate the association between serum DHEA-S and AMH levels. The study included a total of 2155 infertile women aged 20 to 46 years who were divided into four quartile groups (Q1 to Q4) based on serum DHEA-S levels. We found that there was a weak positive association between serum DHEA-S and AMH levels in infertile women (r = 0.190, p < 0.001). After adjusting for potential confounders, serum DHEA-S levels positively correlated with serum AMH levels in infertile women (β = 0.103, p < 0.001). Infertile women in the highest DHEA-S quartile category (Q4) showed significantly higher serum AMH levels (p < 0.001) compared with women in the lowest DHEA-S quartile category (Q1). The serum AMH levels significantly increased across increasing DHEA-S quartile categories in infertile women (p = 0.014) using generalized linear models after adjustment for potential confounders. Our data show that serum DHEA-S levels are positively associated with serum AMH levels.

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A cross-sectional study of glucose regulation in young adults with very low birth weight: impact of male gender on hyperglycaemia

BMJ Open ◽

10.1136/bmjopen-2011-000327 ◽

2012 ◽

Vol 2 (1) ◽

pp. e000327 ◽

Cited By ~ 9

Author(s):

Ryosuke Sato ◽

Hiroshi Watanabe ◽

Kenji Shirai ◽

Shigeru Ohki ◽

Rieko Genma ◽

...

Keyword(s):

Young Adults ◽

Birth Weight ◽

Low Birth Weight ◽

Very Low Birth Weight ◽

Cross Sectional Study ◽

Male Gender ◽

Glucose Regulation ◽

Sectional Study ◽

Cross Sectional ◽

Weight Impact

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Determinants of corporate voluntary disclosure in a transition economy

Problems and Perspectives in Management ◽

10.21511/ppm.18(4).2020.12 ◽

2020 ◽

Vol 18 (4) ◽

pp. 130-141

Author(s):

Mofijul Hoq Masum ◽

Ahmed Razman Abdul Latiff ◽

Mohammad Noor Hisham Osman

Keyword(s):

Voluntary Disclosure ◽

Transition Economy ◽

Stock Exchange ◽

Positive Association ◽

Cross Sectional Study ◽

Significant Positive Association ◽

Cross Sectional ◽

Regulatory Bodies ◽

International University ◽

Chemical Companies

Corporate voluntary disclosure becomes a burning issue in the literature of accounting throughout the last two decades. The study aims to explore the most crucial determinants that influence corporate voluntary disclosure in a transition economy. A cross-sectional study based on the pharmaceutical and chemical companies listed in the Dhaka Stock Exchange is conducted to reconnoiter the crucial determinants affecting the voluntary disclosure. Based on the agency theory, stakeholder theory, and previous literature, the determinants are selected. An unweighted disclosure index is used to measure the extent of voluntary disclosure; after that, a multivariate analysis is steered to reconnoiter the key determinants of voluntary disclosure. It is found that firm leverage and firm liquidity are the key determinants that significantly influence the corporate voluntary disclosure in a transition economy. In contrast, no significant positive association is found between voluntary disclosure and board size. In additon, it is also found that market category significantly influences voluntary disclosure with an inverse direction. This study has important implications for both the corporate people and the regulatory bodies of the transition economy. The study also helps various stakeholders of the transition economy – Bangladesh, in designing their strategies regarding the most significant determinants of voluntary disclosure. Acknowledgment We are very thankful to the Institute of Advanced Research (IAR), United International University, Bangladesh, to grant us the fund by mobilizing which we generate our required data for the study and complete this empirical study.

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