scholarly journals Paraganglioma Not Only Secrete Catecholamines but Also Inflammatory Cytokines: A Case Report 

2020 ◽  
Author(s):  
Keke Song ◽  
Tingting Yang ◽  
Qiang Wang ◽  
Jing Tan
Keyword(s):  
Case Report ◽  
Inflammatory Response ◽  
Blood Cell ◽  
Inflammatory Cytokines ◽  
Metabolic Disorders ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Case Presentation ◽  
Reactive Protein ◽  
Paroxysmal Hypertension

Abstract Background: Paraganglioma not only can secrete catecholamines with vasoconstriction activity resulting in hypertension and metabolic disorders,but also cytokines which can induce inflammatory response syndrome.Case presentation: We report a 19-year-old girl with a paraganglioma that presented with fever and thrombocytosis, leukocytosis, and elevated high sensitivity C-reactive protein. After paraganglioma’s resection, the little girl had no fever and the platelet, white blood cell and high sensitivity C-reactive protein recover to nomal level. Conclusion: We propose in the future we should check cytokine in patients with paroxysmal hypertension complicated with inflammatory response syndrome and thrombocytosis, and think of that it may be caused by pheochromocytoma or paraganglioma.

scholarly journals Disseminated Nocardia infection with a lesion occupying the intracranial space complicated with coma: a case report

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Mei-Hong Yu ◽  
Xiao-Xin Wu ◽  
Chun-Lei Chen ◽  
Song-Jia Tang ◽  
Jian-Di Jin ◽  
...  
Keyword(s):  
Case Report ◽  
Immunosuppressive Treatment ◽  
Lung Infection ◽  
C Reactive Protein ◽  
Altered Consciousness ◽  
Blood Cell Count ◽  
Case Presentation ◽  
Reactive Protein ◽  
Nocardia Cyriacigeorgica ◽  
The Right

Abstract Background Disseminated Nocardia infection is a disease that is easily overlooked in patients with lesions occupying the intracranial space complicated with coma. Early diagnosis and treatment are crucial. Case presentation A 65-year-old man was admitted to the First Affiliated Hospital of Zhejiang University in October 2018 with weakness in the right limbs for 3 days and altered consciousness for 1 day. Five months earlier, he had been diagnosed with membranous kidney disease and had received cyclophosphamide and prednisone. At admission, the white blood cell count was 1.37 × 1010/L (with 86.4% neutrophils), and C-reactive protein was 115.60 mg/L. Imaging examinations revealed a lesion occupying the intracranial space, lung infection, and multiple abscesses in the rhomboid muscle. The abscesses were drained. Pus culture confirmed Nocardia cyriacigeorgica infection. With antibiotics and vacuum-sealed drainage of the back wound, the patient improved and was discharged from the hospital. Conclusions This case report shows that infection should be considered during the differential diagnosis of lesions in the intracranial space, especially in patients receiving immunosuppressive treatment. In patients with disseminated N. cyriacigeorgica infection, combination antibiotic therapy and surgical drainage of localised abscesses can be effective.

scholarly journals High Sensitivity C-Reactive Protein sebagai Parameter Diagnostik dan Prediktor Luaran Sepsis pada Anak yang Menderita Systemic Inflammatory Response Syndrome

Sari Pediatri ◽  
2016 ◽  
Vol 16 (4) ◽  
pp. 278
Author(s):  
Sofni Sarmen ◽  
Mayetti Mayetti ◽  
Hafni Bachtiar
Keyword(s):  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Immunosorbent Assay ◽  
High Sensitivity ◽  
Systemic Inflammatory Response ◽  
Enzyme Linked Immunosorbent Assay ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Elisa Data

Latar belakang. Sepsis merupakan salah satu penyebab morbiditas dan mortalitas pada anak. Diagnosissepsis ditegakkan berdasarkan gejala Systemic Inflammatory Response Syndrome (SIRS) dan penemuan bakteripada kultur darah. Kultur bakteri darah memiliki sensitifitas yang rendah dan membutuhkan waktu yanglama sehingga sering menyebabkan terjadinya overdiagnosis dan overtreatment. C-reactive protein adalahreaktan fase akut yang kadarnya meningkat pada keadaan infeksi. High sensitivity C-reactive protein (hs-CRP) adalah metode yang lebih sensitif untuk mengukur kadar CRP dalam jumlah kecil.Tujuan. Mengetahui peran hs-CRP sebagai parameter diagnostik dan prediktor luaran sepsis pada anakyang menderita SIRS.Metode. Penelitian uji diagnostik dengan desain potong lintang terhadap 85 anak dengan gejala SIRS berusia1 bulan sampai dengan 15 tahun dan dirawat di bangsal anak RS.Dr.M.Djamil Padang sejak Juni sampaiNovember 2012. Pemeriksaan hs-CRP dilakukan dengan metode enzyme-linked immunosorbent assay (ELISA).Data dianalisis dengan SPSS serta dilakukan uji diagnostik. Baku emas sepsis adalah biakan darah.Hasil. Cut off point hs-CRP untuk menentukan sepsis adalah 15,55 ng/ml, (sensitivitas 90,9% dan spesivisitas53,8%). Kadar rata-rata hs-CRP meningkat sesuai dengan beratnya penyakit.Kesimpulan. High sensitivity C-reactive protein dapat dijadikan sebagai parameter diagnostik sepsis padapasien SIRS dengan cut off point 15,55 ng/ml, serta dapat dipakai sebagai prediktor luaran sepsis.

scholarly journals Association of Elevated Levels of Inflammatory Marker High-Sensitivity C-Reactive Protein and Hypertension

2020 ◽  
Vol 11 ◽  
pp. 215013272098442
Author(s):  
Sharmila Bisaria ◽  
Vittorio Terrigno ◽  
Krystal Hunter ◽  
Satyajeet Roy
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Blood Cell ◽  
High Sensitivity ◽  
Continuous Variables ◽  
C Reactive Protein ◽  
Blood Cell Count ◽  
Reactive Protein ◽  
Hs Crp ◽  
Artery Disease

Introduction The correlation between inflammation and vascular disease is widely accepted. High levels of C-reactive protein (CRP) have been shown to play a role in the process of endothelial dysfunction. Hypertension is described as an inflammatory vascular disease, and is 1 of the most commonly encountered diseases in the outpatient setting. We studied the association between the elevated high sensitivity-CRP (hs-CRP) level and hypertension, as well as other comorbid conditions. Methods Electronic medical records of 169 adult patients in our internal medicine office were reviewed for hs-CRP levels, and divided into 2 groups: elevated hs-CRP (≥2 mg/L; n = 110) and normal hs-CRP (<2 mg/L; n = 59). Independent T-Test was used to compare the means of continuous variables between the groups if they were normally distributed. Mann Whitney U-Test was used to compare the continuous variables that were non-parametric. Logistic regression was used to compare the dependent and independent variables. Results Among subjects with elevated hs-CRP, 58.2% had hypertension while 47.5% of subjects with normal hs-CRP levels had hypertension ( P = .182). There were higher frequencies of association of coronary artery disease (CAD), cerebrovascular disease and hypothyroidism in elevated hs-CRP group but the differences were not statistically significant. Mean white blood cell count was statistically higher in elevated hs-CRP group ( P < .05), while alcohol use was significantly higher ( P < .05) and statin use was higher in the normal hs-CRP group. There was an inverse relationship between HDL-C and hs-CRP. Conclusions There was no statistically significant correlation between hs-CRP level and hypertension. Hs-CRP has statistically significant associations between alcohol use, dementia, white blood cell count, and HDL levels. Promising but not statistically significant correlations were observed between hs-CRP and statin therapy, hypothyroidism, coronary artery disease, and cerebrovascular disease.

scholarly journals Elevated levels of inflammatory cytokines and high-sensitivity C-reactive protein in periodontitis patients in Kosovo: A pilot study

2013 ◽  
Vol 03 (01) ◽  
pp. 32-38
Author(s):  
Zana Sllamniku-Dalipi ◽  
Hasan Mehmeti ◽  
Fatmir Dragidella ◽  
Ferit Koçani ◽  
Metush Disha ◽  
...  
Keyword(s):  
Pilot Study ◽  
Inflammatory Cytokines ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Novel Systemic Inflammation Markers to Predict COVID-19 Prognosis

2021 ◽  
Vol 12 ◽  
Author(s):  
Amirali Karimi ◽  
Parnian Shobeiri ◽  
Arutha Kulasinghe ◽  
Nima Rezaei
Keyword(s):  
Inflammatory Response ◽  
Patient Outcomes ◽  
Severe Disease ◽  
Prognostic Nutritional Index ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Albumin Ratio ◽  
Reactive Protein ◽  
Nutritional Index ◽  
Global Pandemic

Coronavirus disease 2019 (COVID-19) has resulted in a global pandemic, challenging both the medical and scientific community for the development of novel vaccines and a greater understanding of the effects of the SARS-CoV-2 virus. COVID-19 has been associated with a pronounced and out-of-control inflammatory response. Studies have sought to understand the effects of inflammatory response markers to prognosticate the disease. Herein, we aimed to review the evidence of 11 groups of systemic inflammatory markers for risk-stratifying patients and prognosticating outcomes related to COVID-19. Numerous studies have demonstrated the effectiveness of neutrophil to lymphocyte ratio (NLR) in prognosticating patient outcomes, including but not limited to severe disease, hospitalization, intensive care unit (ICU) admission, intubation, and death. A few markers outperformed NLR in predicting outcomes, including 1) systemic immune-inflammation index (SII), 2) prognostic nutritional index (PNI), 3) C-reactive protein (CRP) to albumin ratio (CAR) and high-sensitivity CAR (hsCAR), and 4) CRP to prealbumin ratio (CPAR) and high-sensitivity CPAR (hsCPAR). However, there are a limited number of studies comparing NLR with these markers, and such conclusions require larger validation studies. Overall, the evidence suggests that most of the studied markers are able to predict COVID-19 prognosis, however NLR seems to be the most robust marker.

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