Two Opposing Roles of SARS-CoV-2 RBD-Reactive Antibodies in Pre-Pandemic Plasma Samples From Elderly People in ACE2-Mediated Pseudovirus Infection

A novel coronavirus designated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged and caused an outbreak of unusual viral pneumonia. Several reports have shown that cross-reactive antibodies against SARS-CoV-2 also exist in people unexposed to this virus. However, the neutralizing activity of cross-reactive antibodies is controversial. Here, we subjected plasma samples from SARS-CoV-2-unexposed elderly Korean people (n = 119) to bead-based IgG antibody analysis. SARS-CoV-2 S1 subunit-reactive IgG antibody analysis detected positive signals in some samples (59 of 119, 49.6%). SARS-CoV-2 receptor-binding domain (RBD)-reactive antibody levels were most significantly correlated with human coronavirus-HKU1 S1 subunit-reactive antibody levels. To check the neutralizing activity of plasma samples, the SARS-CoV-2 spike pseudotype neutralizing assay was used. However, the levels of cross-reactive antibodies did not correlate with neutralizing activity. Instead, SARS-CoV-2 pseudovirus infection was neutralized by some RBD-reactive plasma samples (n = 9, neutralization ≥ 25%, P ≤ 0.05), but enhanced by other RBD-reactive plasma samples (n = 4, neutralization ≤ -25%, P ≤ 0.05). Interestingly, the blood plasma groups with enhancing and neutralizing effects had high levels of SARS-CoV-2 RBD-reactive antibodies than the plasma group that had no effect. These results suggest that some SARS-CoV-2 RBD-reactive antibodies from pre-pandemic elderly people exert two opposing functions during SARS-CoV-2 pseudovirus infection. In conclusion, preformed RBD-reactive antibodies may have two opposing functions, namely, protecting against and enhancing viral infection. Analysis of the epitopes of preformed antibodies will be useful to elucidate the underlying mechanism.

The influence of multidimensional deprivation on problem drinking developmental trajectory among young adults: a longitudinal study using latent class growth analysis

Background Many young people in Korea today experience deprivation in various areas of life. The social determinants of health approach maintains that social factors play an important role in an individual’s physical and mental health. This study aimed to investigate the problem drinking trajectory of young Korean people and identify the effects of multidimensional deprivation on problem drinking. Methods The study used data from 2012 to 2018 found in the Korea Welfare Panel Study. Latent class growth analysis was performed to determine the number of trajectories of problem drinking. After identifying latent classes, a multinomial logistic regression analysis was utilized to examine multidimensional deprivation as a predictor of class membership. Results Latent class analysis yielded three groups: (1) a low-level maintenance group (low level of alcohol use maintained at the low level), (2) a moderate-level increasing group (moderate level of problem drinking with a moderate increase in problem drinking), and (3) a risky drinking increasing group (high level of problem drinking with a rapid increase in problem drinking). Results from multinomial logistic regression showed that deprivation in housing and social deprivation increased the probability of belonging to the risky drinking increasing group compared to other reference groups. Conclusion The study speaks to the need to establish appropriate intervention strategies according to the level and changes in the pattern of alcohol use. The implications of housing and social deprivation concerning problem drinking among young Korean people are also discussed.

Helminth Eggs Detected in Soil Samples of a Possible Toilet Structure Found at the Capital Area of Ancient Baekje Kingdom of Korea

Although research conducted in East Asia has uncovered parasite eggs from ancient toilets or cesspits, data accumulated to date needs to be supplemented by more archaeoparasitological studies. We examined a total of 21 soil samples from a toilet-like structure at the Hwajisan site, a Baekje-period royal villa, in present-day Korea. At least 4 species of helminth eggs, i.e., Trichuris trichiura, Ascaris lumbricoides, Clonorchis sinensis, and Trichuris sp. (or Trichuris vulpis) were detected in 3 sediment samples of the structure that was likely a toilet used by Baekje nobles. The eggs of T. trichiura were found in all 3 samples (no. 1, 4, and 5); and A. lumbricoides eggs were detected in 2 samples (no. 4 and 5). C. sinensis and T. vulpis-like eggs were found in no. 5 sample. From the findings of this study, we can suppose that the soil-transmitted helminths were prevalent in ancient Korean people, including the nobles of Baekje Kingdom during the 5th to 7th century.

Mask Wearing Behavior and COVID-19: Synthetic Effects of Individualism and Collectivism in Korea

The behavior of the general public has largely been critical to the effective COVID-19 response. Republic of Korea has shown a better response performance than many other countries around the world. Based on the theories of individualism-collectivism, this study analyzes how the Korean culture influences the mask-wearing behavior of people in Korea. Two online surveys were conducted after the first wave and in the middle of third wave of COVID-19 pandemic in Korea. The results of regression analysis demonstrate that, when demographic variables are controlled, concerns around infecting others and respondents’ horizontal individualistic tendency have significant positive effects on mask wearing behavior. Meanwhile, horizontal collectivism also positively affects the respondents’ mask-wearing behavior as expected in collectivistic culture of Korean people. We conclude that the general collectivism of Korean people is mutually synergetic with the horizontal individualism in responding to the COVID-19 pandemic in Korea.

Is autism stigma higher in South Korea than the United States? Examining cultural tightness, intergroup bias, and concerns about heredity as contributors to heightened autism stigma

South Korea, a relatively collectivistic and homogeneous country with heightened cultural tightness, is believed to have particularly high levels of stigma toward autistic individuals, who sometimes engage in behaviors that diverge from social norms. This study investigated cross-cultural differences in autism stigma (assessed with a Social Distance Scale) in the United States and South Korea. Two-hundred and seventy-six American and 494 Korean participants who completed an online survey were included in the analysis. We conducted a multiple regression predicting autism stigma with variables that were correlated with stigma. Koreans reported greater autism stigma than Americans. Greater vertical individualism, lesser horizontal collectivism, less accurate autism knowledge, less pleasant and frequent previous contact with autism, concerns about the marriageability of family members, and higher cultural tightness predicted greater stigma. Cultural tightness, or an emphasis on social norms, which was heightened among Korean participants, contributed to greater autism stigma in South Korea. Findings highlight the need to increase autism knowledge and foster pleasant and frequent contact with autistic individuals, especially for those who accept inequality as a part of human interactions in both South Korea and the United States. Moreover, interventions that help Koreans understand the relativeness of social appropriateness may reduce autism stigma in South Korea. Lay abstract Misunderstandings about autism may be more common in South Korea than the United States. Koreans often have clear ideas about how people should act. Another way of saying this is that Korea has a tight culture. Americans are looser, meaning people are freer to act as they like. Autistic people often do not act as people expect them to. This makes autistic people stand out. Autistic people may stand out more in tight cultures like South Korea. We studied how people in South Korea and the United States feel about autism. We wanted to see why Korean people might reject autistic people more than people in the United States do. American and Korean people did online surveys. Koreans said they did not want to get close to autistic people more than Americans did. People who understood autism and had met and liked autistic people wanted to get closer to autistic people. We were surprised to learn that Americans said having an autistic brother or sister makes it harder to find a romantic partner more than Korean people did. People who believed that autism makes it harder for family members to find love did not want to get very close to autistic people. Koreans said people should act as expected more than Americans did. People who believed that acting as expected was important did not want to get very close to autistic people. Teaching people that there are many ways of being a good person may help them understand and appreciate autistic people.

No Tendencies of Personality Traits in Blood Groups: a cross-sectional study conducted on Bangladeshi people.

No studies to date came up with fruitful consequences regarding if or not there is a relationship between blood groups and personality traits rather providing most conflicting, floundering, discrete, equivocal outcomes. Traditionally, Japanese and Korean people support the conception that there are natural inclinations of personality traits in blood groups. Our study aims to explore the rationality of this conception that personality traits and blood groups are interrelated. However, responses of the participants were collected using 50 items big-five factor personality inventory developed by Goldberg: Extraversion, Agreeableness, Neuroticism, Conscientiousness, Intellect (Openness to experience). A two way multivariate analysis (MANOVA) was performed on total 148 participants including 85 males and 65 females using IBM SPSS Statistics version 26. MANOVA results revealed that neither the significant main effect of blood groups [F (15,414) = 1.102, p > 0.05] nor had the significant interaction effect of blood groups and gender [F (15,414) = 1.111, p > 0.05] on the combined dependent variables. But this study found significant main effect of gender on the combined dependent variables [F (5,136) = 4.520, p = 0.001, (1-β) = 0.967, η2 = 0.143].This present study does not support the idea that there is significant relationship between blood groups and personality traits. But the idea that male personality significantly differs from female personality is well-supported by this study.

Association between chronic low back pain and degree of stress: a nationwide cross-sectional study

Low back pain (LBP) is a very common health problem worldwide, and has a major impact on quality of life. This is a cross-sectional study using data obtained from the Korea National Health and Nutrition Examination Survey (KNHANES) to investigate the health and nutritional status of Korean people, conducted in 2013, 2014, and 2015. The total of 8,473 patients included in the analysis. A 357 (19.34%) subjects in the chronic LBP group and 1,697 (25.61%) subjects in the no chronic LBP group reported no stress (P < 0.001). The numbers of subjects reporting mild, moderate, and severe stress in the two groups were 934 (50.6%) vs. 3,785 (57.11%), 432 (23.4%) vs. 910 (13.73%), and 123 (6.66%) and 235 (3.55%), respectively (all P < 0.001). Multiple logistic regression analysis with full adjustment for other variables indicated higher OR for severe stress (OR 2.82, P < 0.001) than moderate (OR 2.54, P < 0.001) and mild (OR 1.55, P < 0.001) stress. We confirmed that there was a significant association between chronic LBP and degree of stress. Therefore, the degree of stress should be assessed in clinical treatment of chronic LBP patients.

Human Rights Activism Among North Korean Refugees in the UK: Hope for a Democratic Future?

Social work plays a crucial role in defending the human rights of migrants, asylum seekers and refugees from systems of oppression. This paper explores the meanings and challenges of human rights activism and its driving forces among North Korean refugees in the UK. The data are drawn from life history interviews with 10 participants, together with two activists’ public speeches. The findings suggest that gaining awareness of human rights after their escape had significant implications for the activists, giving meaning to their life and sparking on their activism. Simultaneously, they expressed misconceptions and criticisms from other fellow North Korean refugees as one of the greatest difficulties they encountered in their work. I argue that to overcome such challenges human rights activism requires altruism and a creative imagination that envisions better future lives for other North Korean people. Based on this, I propose altruistic political imagination (API) as a concept that captures North Korean activists’ experiences, built on Passy’s (2001) notion of political altruism, to put emphasis on the visionary aspect of their activism. I maintain that the concept of API potentially has a wider appeal to those activists who face similar situations to North Korean activists, as well as social work practitioners who work with forced migrants and/or marginalised communities.