scholarly journals Clinical Values of two Novel Estrogen Receptor Signaling Targeted lncRNAs in Invasive ductal breast carcinoma

2020 ◽  
Author(s):  
shahrzad ilbeigi ◽  
Mostafa Davood Abadi Farahani ◽  
Mohammad Rafiee Monjezi ◽  
Farahnaz Farahani ◽  
Abdolreza Daraei ◽  
...  
Keyword(s):  
Ductal Carcinoma ◽  
Histological Grade ◽  
Age At Menarche ◽  
Molecular Heterogeneity ◽  
Invasive Ductal Breast Carcinoma ◽  
Estrogen Receptor Signaling ◽  
Elevated Expression ◽  
Mcf7 Cell Line ◽  
Her 2 ◽  
Molecular Patterns

Abstract Invasive ductal carcinoma (IDC) is the most frequent type of breast cancer (BC) in women, with a high clinical burden due to its high invasive properties. Despite of new data regarding the molecular heterogeneity of invasive cancers is quickly emerging; far less is known about the molecular patterns among cases of IDC. An expanding body of evidence has demonstrated that dysregulation of long noncoding RNAs (lncRNAs) is involved in heterogeneity feature of the BC. In this study, we analyzed the expression levels of two novel lncRNAs LOC100288637 and RP11-48B3 in 51 IDC tissues in comparison with adjacent non-cancerous tissues (ANCTs). And finally, bioinformatic evaluation has been done.The qPCR results showed that LOC100288637 and RP11-48B3 were significantly overexpressed in tumor tissues compared to normal samples (P= 0.0085 and P= 0.0002, respectively). Also, the two lncRNAs were overexpressed in both MDA-MB-231 and MCF-7 BC cell lines, nevertheless, with a higher expression pattern in MDA-MB-231 than MCF7 cell line. Furthermore, LOC100288637 had an elevated expression level in HER-2 positive tumors compared to HER-2 negative tumors (P= 0.031). Interestingly, the lncRNA RP11-48B3.4 was upregulated in IDC subjects with age at menarche <14 compared to patients with age at menarche ≥14 (P= 0.041). It was observed in another result that lncRNA RP11-48B3.4 is significantly upregulated in tumors with a lower histological grade compared to tumor samples with higher grades (P= 0.047). And finally, using bioinformatic evaluation, we found a predicted interaction between RP11-48B3.4 and mRNA Zinc Finger and BTB Domain Containing 10 (ZBTB10).Altogether, our findings suggest that these lncRNAs with potential oncogenic roles involved in pathogenesis of IDC with clinical significance, and thus, they may serve as novel markers for diagnosis and treatment of IDC.

scholarly journals Immunohistochemical analysis of angiogenesis in invasive ductal breast carcinoma with correlations to clinic pathological factor

2006 ◽  
Vol 63 (7) ◽  
pp. 635-642 ◽  
Author(s):  
Tatjana Ivkovic-Kapicl ◽  
Slavica Knezevic-Usaj ◽  
Milana Panjkovic ◽  
Katarina Mastilovic
Keyword(s):  
Hormone Receptors ◽  
Ductal Carcinoma ◽  
Histological Grade ◽  
P53 Protein ◽  
Immunohistochemical Analysis ◽  
Metastatic Potential ◽  
Biological Indicators ◽  
Invasive Ductal Breast Carcinoma ◽  
Large Tumor ◽  
Tumor Phenotype

Background/aim: Angiogenesis is the formation of new vessels from preexisting ones. The aim of our study was to determine the relevance of tumor-induced angiogenesis, its correlation with some of the commonly used clinical, pathological factors and the recent biological indicators, and metastatic potential of the tumor in a series of 120 patients with invasive ductal carcinoma of the breast. Methods. The identification of microvessels was performed immunohistochemically with factor VIII-related antigen. The microvessel count (MVC) was assessed at the invasive front of each carcinoma. The cases were divided into high-and low-microvessel density groups according to an average number of microvessels found in the multiple fields of the most vessel-dense part of each tumor. The nuclear immunohistochemical staining for hormone receptors, and the p53, and the membranous staining for cerbB-2 were evaluated. Results. There were significant correlations between a high MVC and a large tumor size, high histological grade, and c-erbB-2 protein over expression. There was no association between tumor angiogenesis, as assessed by the MVC, and the hormone receptors status, and the p53 protein expression. In the cases with a high MVC, there was a significant number of tumors with lymph node metastases. Conclusion. Our findings showed that a high MVC might point out an aggressive tumor phenotype. This might help to stratify patients for an appropriate therapy on an individual basis and, thus, offer the possibility of a more effectively tailored treatment program.

A PROSPECTIVE STUDY ON RELATION OF HISTOLOGICAL GRADE AS WELLAS HORMONE RECEPTOR PROFILE IN LOCALLY ADVANCED BREAST CARCINOMA PATIENTS IN RESPONSE TO NEOADJUVANT CHEMOTHERAPY

2021 ◽  
pp. 59-61
Author(s):  
Samir Ranjan ◽  
Arun Gupta
Keyword(s):  
Breast Carcinoma ◽  
Neoadjuvant Chemotherapy ◽  
Prospective Study ◽  
Ductal Carcinoma ◽  
Histological Grade ◽  
Lobular Carcinoma ◽  
Locally Advanced ◽  
Receptor Status ◽  
Her 2 ◽  
A Prospective Study

Introduction: Inltrating ductal carcinoma being the most common type of carcinoma (70%), lobular carcinoma is the 2nd most common followed by smaller groups such as medullary, mucinous,comedo, paget's disease, papillary, tubular and inammatory carcinoma. Aims and objectives:To establish incidence and correlation between ER, PR, HER 2 neu receptor status, histology with different patient proles. Assessment of therapeutic effectivity and its relation with receptor status and histology after neoadjuvant chemotherapy. Material and methods: This will be an institution-based observational and prospective study. Lab studies- hemoglobin, total count, fasting and postprandial blood sugar, urea, creatinine, albumin and total protein Pretested and predesigned perform Conclusion: This study shows that age group is an important factor for developing breast carcinoma, which was more prevalent in premenstrual population.

scholarly journals The influence of aging on pathologic and immunobiologic parameters of invasive ductal breast carcinoma

2006 ◽  
Vol 63 (11) ◽  
pp. 921-927
Author(s):  
Tatjana Ivkovic-Kapicl ◽  
Slavica Knezevic-Usaj ◽  
Milana Panjkovic ◽  
Dejan Nincic ◽  
Katarina Mastilovic
Keyword(s):  
Breast Cancer ◽  
Cancer Biology ◽  
Hormone Receptors ◽  
Ductal Carcinoma ◽  
Histological Grade ◽  
Steroid Hormone Receptors ◽  
Axillary Lymph ◽  
Invasive Ductal Breast Carcinoma ◽  
Ki 67 ◽  
Axillary Lymph Node Metastases

Background/Aim. Most human cancers, including breast one, increase in frequency with aging. The aim of this study was to explore the hypothesis that aging also alters breast cancer biology. Methods. The study included 120 women with primary invasive ductal carcinoma of the breast. We correlated the patients age and diagnosis with the commonly used clinical, pathological factors and newer tumor biomarkers. Immunohistochemical staining was conducted for p53, c-erbB-2, Ki-67, estrogen (ER), progesterone (PR) receptors, and angiogenesis. Results. In our study, the patients with axillary lymph node metastases and negative steroid hormone receptors (ER and PR) were significantly younger than the patients with nodal involvement and positive hormone receptors. There was also a significant association between the patients age, diagnosis and angiogenesis. No association was found between the patients age and tumor size, histological grade, p53, c-erbB-2, and Ki-67. Conclusion. The results of our study supported only partially the hypothesis that the breast cancer biology is significantly affected by a patient's age.

scholarly journals Acute appendicitis as an unusual cause of invasive ductal breast carcinoma metastasis

2020 ◽  
Vol 2020 (12) ◽  
Author(s):  
Vincent De Pauw ◽  
Julie Navez ◽  
Stephane Holbrechts ◽  
Jean Lemaitre
Keyword(s):  
Abdominal Pain ◽  
Breast Carcinoma ◽  
Acute Appendicitis ◽  
Ductal Carcinoma ◽  
Hormonal Treatment ◽  
Locoregional Therapy ◽  
Invasive Ductal Breast Carcinoma ◽  
Ductal Breast Carcinoma ◽  
History Of ◽  
Anticancer Treatment

Abstract Acute appendicitis is one of the most common causes of abdominal pain at the emergency room. In rare cases, it can be caused by malignancy, even metastatic lesions from extra-abdominal neoplasia. Herein, we report a case of a 64-year-old female with a history of invasive ductal carcinoma of the breast treated by chemotherapy, surgery, radiotherapy and hormonotherapy, relapsing several years later as a bone and a pleura metastasis successfully cured by locoregional therapy and hormonal treatment. She presented with acute abdominal pain without signs of peritonitis. Abdominal computed tomodensitometry showed sign of appendicitis. Therefore, laparoscopic exploration and appendicectomy was performed. During surgery, multiple peritoneal nodules were found and harvested. Pathology showed metastatic nodules of invasive ductal breast carcinoma, including in the appendicular wall, concluding to peritoneal carcinomatosis. The postoperative course was uneventful, but the patient died 1 year later after refusing anticancer treatment.

scholarly journals Unusual Occurrence of Rare Lipid-Rich Carcinoma and Conventional Invasive Ductal Carcinoma in the One Breast: Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Katarina Machalekova ◽  
Karol Kajo ◽  
Marian Bencat
Keyword(s):  
Lymph Nodes ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Frozen Section ◽  
Histological Grade ◽  
Resection Margins ◽  
Axillary Lymph Nodes ◽  
Positive Staining ◽  
Axillary Lymph ◽  
Palpable Mass

A 56-year-old woman noticed a palpable mass in her left breast during self-examination. Patient was admitted to our hospital and malignant bifocal tumour was diagnosed by ultrasonography, digital mammography, magnetic resonance, and core-cut biopsy. The patient underwent planned conservative surgery (biquadrantectomy) with a sentinel node examination, but after results of the frozen section with positive resection margins and positive sentinel lymph nodes subsequent mastectomy with axillary lymph node dissection were realized. Histology in the resection specimen revealed two isolated and distinct tumours. One of the lesions represented conventional invasive ductal carcinoma of histological grade 3, and the second tumour was evaluated as invasive lipid-rich carcinoma, containing tumour cells with clear and foamy cytoplasm. Lipids in neoplastic cells were detected by Oil Red O staining and ultrastructural examination. Immunohistochemical analysis of both carcinomas was almost identical with negative steroid receptors, positive staining of HER-2, and p53 and with high proliferation activity (Ki-67). Mastectomy specimen contained residual foci of invasive ductal carcinoma and dissected axillary lymph nodes were free of metastasis. Patient underwent first cycles of chemotherapy with paclitaxel and Herceptin together with local radiotherapy and two month after surgery is without any evidence of the disease.

scholarly journals Analysis of EGFR and HER-2 expressions in ductal carcinomas in situ in canine mammary glands

2014 ◽  
Vol 66 (3) ◽  
pp. 763-768 ◽  
Author(s):  
I.L.D. Silva ◽  
A.P.M. Dias ◽  
A.C. Bertagnolli ◽  
G.D. Cassali ◽  
E. Ferreira
Keyword(s):  
Ductal Carcinoma ◽  
Mammary Glands ◽  
Statistical Correlation ◽  
Low Grade ◽  
Neoplastic Progression ◽  
Her 2 ◽  
Epidermal Growth ◽  
Ductal Carcinomas

Biomolecular evidence has shown that ductal carcinoma in situ(DCIS) may develop into invasive carcinoma of the canine mammary gland, and mutations in proto-oncogenes HER2 and EGFR; two members of the family of epidermal growth factor receptors, may be involved in this process. The purpose of this study was the characterization of the immunohistochemical expression of the EGFR and HER2 proteins in the process of neoplastic transformation, supposedly present in ductal carcinomas in situin canine mammary glands. Fifteen cases of DCIS were evaluated, with a higher expression of HER2 and EGFR being observed in low-grade carcinomas when compared with high-grade neoplasms, and with a high positive statistical correlation in the latter. Results suggest that aggressive tumors tend to lose the expression of EGFR and HER2 simultaneously. The loss of the expression of these markers may be related to the process of neoplastic progression in canine mammary tumors.

scholarly journals Isolated right adrenal metastasis from an invasive ductal breast carcinoma.

2019 ◽  
pp. 10-13
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Invasive Ductal Carcinoma ◽  
Adrenal Glands ◽  
Ductal Carcinoma ◽  
Adrenal Metastasis ◽  
Breast Carcinomas ◽  
Invasive Ductal Breast Carcinoma ◽  
Invasive Breast Carcinomas ◽  
Histopathological Type

Invasive ductal carcinoma (IDC) is the most common histopathological type of breast cancer, accounting for up to 85% of all invasive breast carcinomas [1]. It spreads usually to the bone first. Solitary metastasis is commonly located in the lung, liver or brain [2]. Adrenal glands locations are extremely rare [3]. We report a case of isolated metachronous right adrenal metastasis, diagnosed four years after breast IDC management. The aim is to highlight clinical, diagnostic and therapeutic characteristics of this entity.

scholarly journals Uterine Metastases in a Diagnosed Case of Invasive Ductal Breast Carcinoma: A Rare Presentation

2021 ◽  
pp. 29-33
Author(s):  
Musa Azhar ◽  
Syed Abdul Mannan Hamdani ◽  
Jhanzeb Iftikhar ◽  
Waqas Ahmad ◽  
Sajid Mushtaq ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Endometrial Hyperplasia ◽  
Ductal Carcinoma ◽  
Carcinoma Of The Breast ◽  
Invasive Ductal Breast Carcinoma ◽  
Rare Presentation ◽  
Curative Intent ◽  
Initial Management ◽  
High Propensity

Breast cancer is the commonest cancer among females and has a high propensity to metastasize, but gynaecological organs are rarely affected. We report a case where invasive ductal carcinoma of the breast metastasized to the uterus after initial management with curative intent. Our patient was on tamoxifen, which can cause endometrial hyperplasia and lead to a challenge in eventual diagnosis.

scholarly journals Functional capacity of women with breast neoplasm undergoing palliative chemotherapy

2021 ◽  
Vol 55 ◽  
Author(s):  
Suzy Ramos Rocha ◽  
Carla Andreia Vilanova Marques
Keyword(s):  
Breast Neoplasm ◽  
Functional Capacity ◽  
Palliative Chemotherapy ◽  
Ductal Carcinoma ◽  
Histological Grade ◽  
Performance Status ◽  
Cross Sectional Study ◽  
Moderate Activity ◽  
Cross Sectional ◽  
Activity Restriction

ABSTRACT Objective: To evaluate the functional capacity of women with breast neoplasm undergoing palliative chemotherapy. Method: Cross-sectional study with an analysis of medical records of women with breast cancer undergoing palliative chemotherapy. Results: Out of one hundred evaluated records, most registered 50 years or older (66%), primary education (53%), an income of 1 to 2 minimum wages (87%), invasive ductal carcinoma (95%), positive hormone receptor (64%), and histological grade 1 and 2 (57%). Performance status 0 (49%), 1 (39%), and 2 (12%) were prevalent; these imply, respectively, active patients, with mild and moderate activity restriction. One to four chemotherapy schemes were associated with the inappetence (p =0.00) and weight loss (p =0.001) symptoms. The main complications were neuropathy (31%), medullary compression syndrome (21%), neutropenia (9%), and death (28%). Conclusion: Out of the analyzed women, 88% presented functional capacity 0 and 1, had no or mild restriction of daily activities, were multiply treated, and manifested manageable symptoms. Others, however, presented moderate to severe clinical complications during the treatment, progressing to exclusive palliative care or death.

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