scholarly journals Assessment of Quality of Life Related to Radiation Proctitis in Patients Who Received Pelvic Radiotherapy

2020 ◽  
Author(s):  
Marcela Krug Seabra ◽  
Rafaela Gomes de Jesus ◽  
Tiago Pereira de Leão ◽  
Gabriel Teitelbaum Friedman ◽  
Alice Scalzilli Becker ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Adverse Events ◽  
Radiation Proctitis ◽  
Pelvic Radiotherapy ◽  
Pelvic Neoplasms ◽  
Global Quality ◽  
Global Quality Of Life ◽  
Bowel Movements ◽  
Eortc Qlq

Abstract Background: Radiotherapy is widely used in the treatment of several pelvic neoplasms, Radiation-related adverse events may result in intestinal, urinary, sexual, bone and dermatological disorders, impacting quality of life. The prevalence of radiation proctitis is probably underestimated. The aim of this study is to assess the quality of life associated with radiation proctitis in patients undergoing pelvic radiotherapy.Methods: A cohort of 40 consecutive patients from an academic institution in Brazil who received pelvic radiotherapy was analyzed. Patients completed questionnaires EORTC QLQ-C30 and EORTC QLQ-PRT20 at the beginning and at the end of treatment. Clinico-pathological features were also collected using standard templates. Results: Thirty-seven patients were included in the analysis. Thirty-two patients (80%) were male and had prostate cancer. Pelvic radiotherapy was associated with worsening bowel control (p=0.0171) leakage (p=0.0542) and pain (p=0.0074) in EORTC QLQ-PRT20. Patients had increased number of bowel movements per day after treatment (p=0.0036). Fatigue (p=0.0176) and diarrhea (p=0.0103) increased after radiation therapy. There was no statistical difference in global quality of life in patients who received radiotherapy. Conclusion: EORTC QLQ-PRT20 questionnaire is suitable for assessing the quality of life related to radiation proctitis in patients undergoing pelvic radiotherapy. This tool may help clinicians in the management and monitoring of treatment-related adverse events of this treatment modality.

QUALITY OF LIFE FOR PATIENTS WITH METASTATIC BREAST CANCER TREATED BY DOXORUBICIN AND PACLITAXEL

2014 ◽  
pp. 246-252
Author(s):  
Van Cau Nguyen ◽  
Ngoc Thanh Cao
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Metastatic Breast Cancer ◽  
Side Effects ◽  
Metastatic Breast ◽  
Emotional Function ◽  
Global Quality ◽  
Global Quality Of Life ◽  
Eortc Qlq

Background: Metastatic breast cancer is still remains essentially incurable. Palliative chemotherapy with the combination of Doxorubicin and Paclitaxel is to reduce the burden of disease, prolong overall survival and maintain quality of life for patients. The objectives of this study to evaluate the clinical effectiveness of this regimen for patients with metastatic breast cancer and the impact on the quality of life of patients. Patients and methods: Included 26 patients with metastatic breast cancer treated by Doxorubicin and Paclitaxel at the Hue University Hospital from 2010 to 1014. Patient characteristics and response rates were recorded. Quality of life questionnaires was assessed with the EORTC QLQ-C30 for general cancer patients and EORTC QLQ-BR23 for breast cancer. Results: Clinical response was achieved in 14 patients (53.8%), including 11.5% complete response, 43.4% partial remission and stable disease is 34.6%. The number of patients with response and stable disease are for at least 4 months prior to progression. Quality of life changes significantly statistical including: physical function decreased slightly (mean change 7.6 points) after 4 cycles of chemotherapy, cognitive function decreased slightly after the 8th cycle (8.1 points). Emotional function improved partially (7.7 points). However, the global quality of life has not changed. Changes in body image can adversely affect patients with a decrease of 15.9 points. These symptoms have been reported in breast including pain, swelling and discomfort with little difference of 2.9 points. The side effects of chemotherapy in organs such as the reduction or loss of appetite, headache, menstrual disorders vary in significance with an increase of 18.8 points. Distress associated with hair loss also increased significantly with 75.5 points. Conclusion: Paclitaxel and doxorubicin for patients with metastatic breast cancer showed significant clinical improvement and well-tolerated toxicity. Emotional function have been improved. Some aspects slightly decreased such as physical, cognitive, and distress of body image changes, side effects of chemotherapy and hair loss. However, global quality of life of was maintained. Although sample in this study was still small but routinely assess the quality of life for patients with metastatic breast cancer receiving chemotherapy should be routinely recommended.

Health-Related Quality of Life (HRQoL) Measurements in Multiple Myeloma Patients Obtained By EORTC QLQ-C30; A Critical Review of Interpreting HRQoL Data in Longitudinal Studies

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 540-540 ◽  
Author(s):  
Lene Kongsgaard Nielsen ◽  
Mary Jarden ◽  
Christen Lykkegaard Andersen ◽  
Henrik Frederiksen ◽  
Niels Abildgaard
Keyword(s):  
Quality Of Life ◽  
First Line ◽  
Global Quality ◽  
Hrqol Data ◽  
Global Quality Of Life ◽  
Related Quality ◽  
Eortc Qlq C30 ◽  
Health Related ◽  
Eortc Qlq

Abstract Introduction: Multiple myeloma (MM) patients report more symptoms and more severe symptoms than patients with other hematological malignancies, resulting in reduced health-related quality of life (HRQoL). Because survival is improving in MM patients there is an increased need for focus on HRQoL. The aim of this review was to interpret published longitudinal studies in MM patients according to a difference in HRQoL score, which is perceived as beneficial to the patient. Such criteria for minimal important differences (MID) in HRQoL score has been explored by Kvam et al (Eur J Haematol 2010, 84:345-53) and has been defined by a concensus expert panel (Cocks et al, Eur J Cancer 2012, 48:1713-21). Methods: A literature search was performed May 2016 in PubMed, Embase, PsycINFO and CINAHL. Publications with longitudinal follow-up using the EORTC QLQ-C30 instrument for HRQoL measurement of physical functioning, global quality of life, fatigue or pain were included, and evaluation of mean change from baseline was carried out according to MID as defined by Kvam, and according to minimal, medium and large changes as defined by Cocks. Results: 11 first-line, 3 consolidation, 2 maintenance, 7 relapse studies, and one population-based study were included. In general, large and medium improvements were reported during first-line treatments. During consolidation with autologous hematopoietic stem cell transplantation, temporary large deteriorations were reported, but equalization occurred with even large improvements compared to baseline reportings. Deterioration or no beneficial change in global quality of life or fatigue are reported by the MM patients during relapse treatment. HRQoL data during maintenance therapy are sparse. For summary of results, see Figure 1. Conclusions: Guidelines for interpreting HRQoL changes with definitions of MID have been developed, but consensus is missing. Improvements in HRQoL are far more likely during first-line compared to relapse treatment regimens. The background of these findings should be in focus in future studies and HRQoL measurements should be part of maintenance studies in the future. Disclosures No relevant conflicts of interest to declare.

scholarly journals Psychometric properties of the EORTC QLQ-C30 in Uganda

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Allen Naamala ◽  
Lars E. Eriksson ◽  
Jackson Orem ◽  
Gorrette K. Nalwadda ◽  
Zarina Nahar Kabir ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Psychometric Properties ◽  
Physical Function ◽  
Internal Consistency ◽  
Global Quality ◽  
Group Validity ◽  
Global Quality Of Life ◽  
Eortc Qlq C30 ◽  
Eortc Qlq

Abstract Background Self-reported measures play a crucial role in research, clinical practice and health assessment. Instruments used to assess self-reported health-related quality of life (HRQoL) need validation to ensure that they measure what they are intended to, detect true changes over time and differentiate between subjects. A generic instrument measuring HRQoL adapted for use among people living with cancer in Uganda is lacking; therefore, this study aimed to evaluate the psychometric properties of the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 in patients with cancer in Uganda. Methods Adult patients with various types of cancer (n = 385) cared for at the Uganda Cancer Institute answered the EORTC QLQ-C30 in Luganda or English language, the two most spoken languages in the country. The two language versions were evaluated with regard to data quality (floor and ceiling effects and missing responses), reliability (internal consistency) and validity (construct, known-group and criterion). Construct validity was examined through confirmatory factor analysis (CFA). Mean scores were compared between groups differing in disease stage to assess known-group validity. Criterion validity was examined according to associations between two QLQ-C30 subscales (Global quality of life and Physical function) and the Karnofsky Performance Scale (KPS). Results Floor and ceiling effects were observed for several scales in the Luganda and English versions. All EORTC scales with the exception of Cognitive function (Luganda α = 0.66, English α = 0.50) had acceptable Cronbach’s alpha values (0.79–0.96). The CFA yielded good fit indices for both versions (RMSEA = 0.08, SRMR = 0.05 and CFI = 0.93). Known-group validity was demonstrated with statistically significant better HRQoL reported by patients with disease stages I–II compared to those in stages III–IV. Criterion validity was supported by positive correlations between KPS and the subscales Physical function (Luganda r = 0.75, English r = 0.76) and Global quality of life (Luganda r = 0.59, English r = 0.72). Conclusion The Luganda and English versions of the EORTC QLQ-C30 appear to be valid and reliable measures and can be recommended for use in clinical research to assess HRQoL in adult Ugandans with cancer. However, the cognitive scale did not reach acceptable internal consistency and needs further evaluation.

scholarly journals Psychometric Properties of the EORTC QLQ-C30 in a Ugandan Context

2020 ◽  
Author(s):  
Allen Naamala Mayanja ◽  
Lars E. Eriksson ◽  
Jackson Orem ◽  
Gorrette Kayondo Nalwadda ◽  
Zarina Nahar Kabir ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Psychometric Properties ◽  
Physical Function ◽  
Internal Consistency ◽  
Global Quality ◽  
Group Validity ◽  
Global Quality Of Life ◽  
Eortc Qlq C30 ◽  
Eortc Qlq

Abstract Background Self-reported measures play a crucial role in research, clinical practice and health assessment. Instruments used to assess self-reported health-related quality of life (HRQoL) need validation to ensure that they measure what they are intended to, detect true changes over time and differentiate between subjects. A generic instrument measuring HRQoL adapted for use among people living with cancer in Uganda is lacking; therefore, this study aimed to evaluate the psychometric properties of the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 when used in a Ugandan context. Methods Adult patients with various types of cancer (N=385) cared for at the Uganda Cancer Institute answered the Luganda or English version of the EORTC QLQ-C30. The two language versions were evaluated with regard to data quality (floor and ceiling effects and missing responses), reliability (internal consistency) and validity (construct, known-group and criterion). Construct validity was examined through confirmatory factor analysis (CFA). Mean scores were compared between groups differing in disease stage to assess known-group validity. Criterion validity was examined according to associations between two QLQ-C30 subscales (Global quality of life and Physical function) and the Karnofsky Performance Scale (KPS).Results Floor and ceiling effects were observed for several scales in the Luganda and English versions. All EORTC scales with the exception of Cognitive function (Luganda α=0.66, English α=0.50) had acceptable Cronbach’s alpha values (0.79–0.96). The CFA yielded good fit indices for both versions (RMSEA=0.076–0.081, SRMR=0.048 and CFI=0.928–0.932). Known-group validity was demonstrated with statistically significant better HRQoL reported by patients with disease stages I–II compared to those in stages III–IV. The Global quality of life and the Physical function scales correlated positively to KPS (r=0.65 and r=0.75), indicating criterion validity. Conclusion The Luganda and English versions of the EORTC QLQ-C30 appear to be valid and reliable measures and can be recommended for use in clinical research to assess HRQoL in adult Ugandans with cancer. However, the cognitive scale did not reach acceptable internal consistency and needs further evaluation.

scholarly journals Measurement of Quality of Life VII. Statistical Covariation and Global Quality of Life Data: The Method of Weight-Modified Linear Regression

2003 ◽  
Vol 3 ◽  
pp. 1020-1029 ◽  
Author(s):  
Soren Ventegodt ◽  
Joav Merrick
Keyword(s):  
Quality Of Life ◽  
Linear Regression ◽  
Scientific Community ◽  
Population Studies ◽  
Life Data ◽  
Global Quality ◽  
Global Quality Of Life ◽  
Psychometric Measures ◽  
Exact Size

Existing standard statistical procedures do not seem to fulfill the needs of the researcher in global quality-of-life (QOL) research, because the most interesting question seems to be the exact size of statistical covariations. A method is necessary if we are to isolate the most important factors connected to quality of life among the thousands of possible factors in life. We have developed a new procedure we call �weight-modified linear regression�. Unfortunately as demonstrated in the discussion, the procedure is not totally without problems and weaknesses. In spite of the critique, we believe the procedure to be valid for the purpose of estimating the size of the covariation in population studies including psychometric measures of global quality of life. As we need to be certain that the procedure is valid, we hereby invite the scientific community to give us further critique of the method and suggestions for its improvement.

scholarly journals Fertility Related Quality of Life in Primary Infertile Couples: A Comparative Study from Eastern India

2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Swarnali Bose ◽  
Bharati Roy
Keyword(s):  
Quality Of Life ◽  
Infertile Couple ◽  
Psychological Burden ◽  
Primary Infertility ◽  
Global Quality ◽  
Global Quality Of Life ◽  
The Family ◽  
Related Quality ◽  
Written Informed Consent

Fertility is considered as a marital responsibility in most the communities and a kind of social respectability for couples. The societal and parental pressures for propagation of the family name can also place a psychological burden on the infertile couple and may significantly affect quality of life. The present study aimed to investigate the gender differences in fertility related quality of life in primary infertility. 30 couples with primary infertility were recruited for the study after a written informed consent. Hindi version of FertiQoL was applied to all participants. Males had significantly better emotional, relational, social and global quality of life (QoL) as compared to females. Tolerability to infertility related problems was significantly better in females compared to males. This study found that primary infertility has extensive negative repercussions on the QOL of women as compared to males.

scholarly journals Painful and non-painful chemotherapy-induced peripheral neuropathy and quality of life in colorectal cancer survivors: results from the population-based PROFILES registry

2020 ◽  
Vol 28 (12) ◽  
pp. 5933-5941 ◽  
Author(s):  
C. S. Bonhof ◽  
H. R. Trompetter ◽  
G. Vreugdenhil ◽  
L. V. van de Poll-Franse ◽  
F. Mols
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Peripheral Neuropathy ◽  
Population Based ◽  
Disease Stage ◽  
Netherlands Cancer Registry ◽  
Global Quality Of Life ◽  
Eortc Qlq ◽  
Time Since Diagnosis

Abstract Purpose This study aims to (1) examine the prevalence of painful versus non-painful chemotherapy-induced peripheral neuropathy (CIPN) among long-term colorectal cancer (CRC) survivors, (2) identify sociodemographic, clinical, and psychological factors associated with painful and non-painful CIPN, and (3) examine the associations of painful CIPN with health-related quality of life (HRQoL) in comparison with non-painful CIPN, i.e., numbness/tingling. Methods All CRC survivors diagnosed between 2000 and 2009 as registered by the population-based Netherlands Cancer Registry (Eindhoven region) were eligible for participation. Chemotherapy-treated survivors (n = 477) completed questions on CIPN (EORTC QLQ-CIPN20) and HRQoL (EORTC QLQ-C30). Results Painful CIPN was reported by 9% (n = 45) of survivors and non-painful CIPN was reported by 22% (n = 103). Time since diagnosis was related to painful CIPN, and time since diagnosis, a higher disease stage, osteoarthritis, and more anxiety symptoms were related to non-painful CIPN. Finally, survivors with painful CIPN reported a worse global quality of life and worse physical, role, cognitive, and social functioning compared to survivors with non-painful CIPN and those without any sensory CIPN. No differences were found between survivors with non-painful CIPN and those without sensory CIPN. Conclusions It seems that painful CIPN must be distinguished from non-painful CIPN, as only painful CIPN was related to a worse HRQoL. Future research is needed to examine whether painful CIPN must be distinguished from non-painful CIPN regarding predictors, mechanisms, and treatment.

scholarly journals Trend of global quality of life in localized or metastatic prostate cancer patients after treatment

2016 ◽  
Vol 27 (2) ◽  
pp. S53-S54
Author(s):  
Yao-Lin Kao ◽  
Yuh-Shyan Tsai ◽  
Zong-Ying Lin ◽  
Chien-Hui Ou ◽  
Wen-Horng Yang ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Cancer Patients ◽  
Metastatic Prostate Cancer ◽  
Global Quality ◽  
Global Quality Of Life

scholarly journals Quality of life in persons living with HIV–AIDS in three healthcare institutions of Cali, Colombia

2010 ◽  
pp. 206-214 ◽  
Author(s):  
Claudia Patricia Valencia ◽  
Gladys Eugenia Canaval ◽  
Diana Marín ◽  
Carmen J. Portillo
Keyword(s):  
Quality Of Life ◽  
Health Insurance ◽  
Antiretroviral Therapy ◽  
Satisfaction With Life ◽  
Pearson Correlation ◽  
Global Quality ◽  
Persons Living With Hiv ◽  
Global Quality Of Life ◽  
Hiv Aids

Antecedents: The Human Immunodeficiency Virus is currently considered a chronic disease; hence, quality of life is an important goal for those suffering the disease or living with someone afflicted by the virus. Objectives: We sought to measure the quality of life in individuals living with acquired immunodeficiency syndrome virus and establish its relationship with socio-demographic and clinical variables. Methods: This is a cross-sectional, descriptive study with a sample of 137 HIV-infected individuals attending three healthcare institutions in the city of Cali, Colombia. Quality of life was measured via the HIV/AIDS-Targeted Quality of Life (HAT-QoL) instrument. The descriptive analyses included mean and standard deviation calculations. To determine the candidate variables, we used the student t test and the Pearson correlation. The response variable in the multiple linear regression was the score for quality of life. Results: Some 27% of the sample were women and 3% were transgender; the mean age of the sample was 35 + 10.2 years; 88% had some type of health insurance; 27% had been diagnosed with AIDS, and 64% were taking antiretroviral medications at the time of the study. Quality of life was measured through a standard scale with scores from 0 to 100. Participants’ global quality of life mean was 59 + 17.8. The quality-of-life dimensions with the highest scores were sexual function, satisfaction with the healthcare provider, and satisfaction with life. The highest quality-of-life scores were obtained by participants who received antiretroviral therapy, had health insurance, lower symptoms of depression, low frequency and intensity of symptoms, and no prior reports of sexual abuse. Eight variables explained 53% of the variability of the global quality of life. Conclusions: Those receiving antiretroviral therapy and who report fewer symptoms best perceived their quality of life. Implications for practice: Healthcare providers, especially nursing professional face a challenge in caring to alleviate symptoms and contribute to improving the quality of life of their patients.

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