scholarly journals Fish Oil Can Significantly Reshape Diet-Based Gut Microbiota in Mice

2020 ◽  
Author(s):  
Han Sun ◽  
Dan Chen ◽  
Yingyue Yang ◽  
Bei Tan ◽  
Changzhi Huang ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Fish Oil ◽  
Microbial Diversity ◽  
Beneficial Effects ◽  
Proinflammatory Effect ◽  
Anti Inflammatory ◽  
Microbiota Diversity

Abstract Background Studies have demonstrated the influence of diet on the gut microbiota, and recent evidence has revealed the beneficial effects of fish oil supplements on the gut microbiota. The goal of the present study was to investigate the influence of fish oil on diet-based gut microbiota changes in mice. Results AIN-93M significantly decreased the gut microbial diversity of mice, increasing the abundances of Bacteroides and Parabacteroides and decreasing the abundance of Odoribacter. In contrast, gut microbial diversity was maintained in mice fed a fish oil-intensive diet, where the Firmicutes: Bacteroidetes ratio was increased, the abundance of Parabacteroides was increased and that of Odoribacter was decreased. In contrast, the VSL#3 intervention had little influence on gut microbiota diversity, decreasing the abundance of Firmicutes. Conclusions AIN-93M can decrease gut microbiota diversity, which may be associated with a potential proinflammatory effect. Fish oil may have anti-inflammatory effects by restoring and maintaining microbial diversity.

scholarly journals A High-Fish Oil Diet Can Significantly Reshape The Gut Microbiota In Mice

2021 ◽  
Author(s):  
Han Sun ◽  
Dan Chen ◽  
Yingyun Yang ◽  
Bei Tan ◽  
Changzhi Huang ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Fish Oil ◽  
Microbial Diversity ◽  
Essential Role ◽  
Dextran Sulphate ◽  
Beneficial Effects ◽  
Proinflammatory Effect ◽  
Fish Oil Diet ◽  
High Fish ◽  
Microbiota Diversity

Abstract Background: Gut microbiota plays an essential role for human health and recent evidence has revealed the beneficial effects of fish oil supplements on the gut microbiota. The present study was to investigate the influence of fish oil on diet-based gut microbiota changes and colitis in mice and whether pyroptosis plays a role in this process.Results: A high-fish oil diet alleviated colitis, resulted in less weight loss and improved pathological scores. Caspase-1, activated in the dextran sulphate sodium (DSS) group, was suppressed by a high-fish oil diet. AIN-93M significantly decreased the gut microbial diversity of mice, increasing the abundances of Bacteroides and Parabacteroides and decreasing the abundance of Odoribacter. In contrast, gut microbial diversity was maintained in mice fed a high-fish oil diet; the Firmicutes: Bacteroidetes ratio was increased, the abundance of Parabacteroides was increased, and that the abundance of Odoribacter was decreased.Conclusion: AIN-93M can decrease gut microbiota diversity, which may be associated with a potential proinflammatory effect. Fish oil has anti-inflammatory effects. It can also restore and maintain microbial diversity and suppress pyroptosis activation.

scholarly journals The Potential Effects of Probiotics and ω-3 Fatty Acids on Chronic Low-Grade Inflammation

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2402 ◽  
Author(s):  
Ashley N. Hutchinson ◽  
Lina Tingö ◽  
Robert Jan Brummer
Keyword(s):  
Fatty Acids ◽  
Gut Microbiota ◽  
Cell Function ◽  
Immune Cell ◽  
Low Grade ◽  
Beneficial Effects ◽  
Positive Effects ◽  
Immune Mediators ◽  
Low Grade Inflammation ◽  
Microbiota Diversity

Chronic low-grade inflammation negatively impacts health and is associated with aging and obesity, among other health outcomes. A large number of immune mediators are present in the digestive tract and interact with gut bacteria to impact immune function. The gut microbiota itself is also an important initiator of inflammation, for example by releasing compounds such as lipopolysaccharides (LPS) that may influence cytokine production and immune cell function. Certain nutrients (e.g., probiotics, ω-3 fatty acids [FA]) may increase gut microbiota diversity and reduce inflammation. Lactobacilli and Bifidobacteria, among others, prevent gut hyperpermeability and lower LPS-dependent chronic low-grade inflammation. Furthermore, ω-3 FA generate positive effects on inflammation-related conditions (e.g., hypertriglyceridemia, diabetes) by interacting with immune, metabolic, and inflammatory pathways. Ω-3 FA also increase LPS-suppressing bacteria (i.e., Bifidobacteria) and decrease LPS-producing bacteria (i.e., Enterobacteria). Additionally, ω-3 FA appear to promote short-chain FA production. Therefore, combining probiotics with ω-3 FA presents a promising strategy to promote beneficial immune regulation via the gut microbiota, with potential beneficial effects on conditions of inflammatory origin, as commonly experienced by aged and obese individuals, as well as improvements in gut-brain-axis communication.

Anti-inflammatory effects of purple sweet potato anthocyanin extract in DSS-induced colitis: modulation of commensal bacteria and attenuated bacterial intestinal infection

2021 ◽  
Author(s):  
jingjing Mu ◽  
jingwen xu ◽  
linlin wang ◽  
Caifa Chen ◽  
Ping Chen
Keyword(s):  
Gut Microbiota ◽  
Sweet Potato ◽  
Inflammatory Bowel Diseases ◽  
Commensal Bacteria ◽  
Intestinal Infection ◽  
Beneficial Effects ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Anti Inflammatory ◽  
Purple Sweet Potato

The purple sweet potato anthocyanin has been acknowledged for its beneficial effects on human inflammatory bowel diseases (IBD). Although the ability of anthocyanin in modulating gut microbiota has been reported,...

scholarly journals D-mannose attenuates bone loss in mice via Treg cell proliferation and gut microbiota-dependent anti-inflammatory effects

2020 ◽  
Vol 11 ◽  
pp. 204062232091266 ◽  
Author(s):  
Hao Liu ◽  
Ranli Gu ◽  
Yuan Zhu ◽  
Xiaomin Lian ◽  
Siyi Wang ◽  
...  
Keyword(s):  
T Cells ◽  
Bone Loss ◽  
Regulatory T Cells ◽  
Gut Microbiota ◽  
Bone Microarchitecture ◽  
Enzyme Linked Immunosorbent Assay ◽  
Tartrate Resistant Acid Phosphatase ◽  
Beneficial Effects ◽  
Anti Inflammatory ◽  
Underlying Mechanisms

Background: D-mannose exhibits strong anti-inflammatory properties, but whether it has beneficial effects on preventing and treating osteoporosis remains unknown. Methods: Female, 12-month-old senile C57BL6/J mice (s-Man group) and 8-week-old ovariectomized C57BL6/J mice (OVX-Man group) were treated with D-mannose in drinking water for 2 months (six mice/group). Microcomputed tomography analysis and hematoxylin and eosin staining were performed to investigate the effect of D-mannose on attenuation of bone loss. Tartrate-resistant acid phosphatase staining of tissue sections, flow cytometry, enzyme-linked immunosorbent assay, quantitative real-time polymerase chain reaction, and gut microbiome biodiversity tests were used to explore the underlying mechanisms. Results: D-mannose-induced marked increases in cortical bone volume and trabecular bone microarchitecture in the s-Man and OVX-Man group compared with that in the s-CTRL (senile control) and OVX group, respectively. Moreover, D-mannose downregulated osteoclastogenesis-related cytokines in the bone marrow and expanded regulatory T cells in the spleen of mice. Furthermore, D-mannose reconstructed the gut microbiota and changed the metabolite composition. Conclusion: D-mannose attenuated bone loss induced by senility and estrogen deficiency in mice, and this effect may be mediated by D-mannose-induced proliferation of regulatory T cells and gut microbiota-dependent anti-inflammatory effects.

scholarly journals THU0201 ANALYSIS OF GUT MICROBIOTA DIVERSITY IN PATIENTS WITH RHEUMATOID ARTHRITIS AND BENEFICIAL EFFECTS OF PROBIOTICS ON INTESTINAL FLORA

2019 ◽  
Author(s):  
Ming Yan ◽  
Sheng-Xiao Zhang ◽  
Chong Gao ◽  
Xiao-Bin Zheng ◽  
Lili Shang ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Gut Microbiota ◽  
Intestinal Flora ◽  
Beneficial Effects ◽  
Microbiota Diversity

scholarly journals A probiotic has differential effects on allergic airway inflammation in A/J and C57BL/6 mice and is correlated with the gut microbiome

Microbiome ◽  
2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Mateus B. Casaro ◽  
Andrew M. Thomas ◽  
Eduardo Mendes ◽  
Claudio Fukumori ◽  
Willian R. Ribeiro ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Airway Inflammation ◽  
Allergic Inflammation ◽  
Allergic Airway Inflammation ◽  
Allergic Diseases ◽  
Mouse Strains ◽  
Microbial Composition ◽  
Beneficial Effects ◽  
Probiotic Treatment ◽  
Microbiota Diversity

AbstractThe phenotypes of allergic airway diseases are influenced by the interplay between host genetics and the gut microbiota, which may be modulated by probiotics. We investigated the probiotic effects on allergic inflammation in A/J and C57BL/6 mice. C57BL/6 mice had increased gut microbiota diversity compared to A/J mice at baseline. Acetate producer probiotics differentially modulated and altered the genus abundance of specific bacteria, such as Akkermansia and Allistipes, in mouse strains. We induced airway inflammation followed by probiotic treatment and found that only A/J mice exhibited decreased inflammation, and the beneficial effects of probiotics in A/J mice were partially due to acetate production. To understand the relevance of microbial composition colonization in the development of allergic diseases, we implanted female C57BL/6 mice with A/J embryos to naturally modulate the microbial composition of A/J mice, which increased gut microbiota diversity and reduced eosinophilic inflammation in A/J. These data demonstrate the central importance of microbiota to allergic phenotype severity.

Evaluation of anti-pyretic activity of Dracaena sanderiana by Brewer’s yeast method

2020 ◽  
Vol 9 (2) ◽  
pp. 32-34
Author(s):  
Pavani C H
Keyword(s):  
Herbal Remedies ◽  
Standard Drug ◽  
Chemical Substances ◽  
Beneficial Effects ◽  
Potential Value ◽  
Plant Effects ◽  
Therapeutic Properties ◽  
Dracaena Sanderiana ◽  
Anti Inflammatory ◽  
Inflammatory Action

These medicinal plants are used to develop a therapy for the disease. To improve the science, investigate the scientific proof and activities validation, therefore the use of various herbal remedies for their pain-relieving and anti-inflammatory action in these current days. includes influence, anti-inflammatory, anti effect, analgesia, effects and some beneficial effects on the GI system. show the potential value of pain relief, cancer prevention and weight loss. According to these plant effects, consider that this present study was mainly based on to investigate and likely to reduce the fever caused by the outdoor and indoor. potential of is evidenced in leave studies. The medicinal plant produces a variety of chemical substances which shows significant therapeutic properties with the standard drug paracetamol.

scholarly journals Effect of nanocurcumin and fish oil as natural anti-inflammatory compounds vs. glucocorticoids in a lipopolysaccharide inflammation model on Holstein calves’ health status

Heliyon ◽  
2021 ◽  
Vol 7 (1) ◽  
pp. e05894 ◽  
Author(s):  
S. Kamel Oroumieh ◽  
L. Vanhaecke ◽  
R. Valizadeh ◽  
L. Van Meulebroek ◽  
A.A. Naserian
Keyword(s):  
Health Status ◽  
Fish Oil ◽  
Inflammation Model ◽  
Holstein Calves ◽  
Anti Inflammatory
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