scholarly journals Pyogenic liver abscess in non-liver cancer patients and liver cancer patients treated with TACE: etiological characteristics, treatment, and outcome analysis

2021 ◽  
Author(s):  
Yiming Liu ◽  
Yanqiao Ren ◽  
Jun Chen ◽  
Songlin Song ◽  
Chuansheng Zheng
Keyword(s):  
Mortality Rate ◽  
Liver Cancer ◽  
Cancer Patients ◽  
Liver Abscess ◽  
Pyogenic Liver Abscess ◽  
Comprehensive Treatment ◽  
Common Pathogen ◽  
Cure Time ◽  
Positive Rate ◽  
Tace Group

Abstract Background: The purpose of this study was to evaluate the clinical, laboratory and microbiological features, clinical outcomes, and prognosis of pyogenic liver abscess (PLA) in non-liver cancer (Non-LC) patients and liver cancer patients treated with transarterial chemoembolization (TACE, LC-TACE).Methods: Clinical data of 48 consecutive PLA patients from January 2016 to December 2020 were retrospectively analyzed. The mortality was compared between the two groups of PLA patients, and risk factors for mortality were evaluated.Results: A total of 48 PLA patients meeting the inclusion criteria were included in this study from January 2016 to December 2020, including 31 males and 17 females. Among them, there were 32 patients in the Non-LC group and 16 patients in the LC-TACE group. Fever and chills were the most common symptoms in both groups, followed by abdominal pain. Shock occurred in 2 patient in the Non-LC group and 3 patients in the LC-TACE group. The positive rate of pus culture in the Non-LC group was 87.5%, among which the most common pathogen was Klebsiella pneumoniae (50%, 14/28), and the positive rate of pus culture in the LC-TACE group was 81.3%, among which the most common pathogen was Escherichia coli (30.8%, 4/13). In the Non-LC group, 28 patients improved after treatment, 1 patient did not improve, and 3 patients died during hospitalization, with a mortality rate of 9.4%. In the LC-TACE group, 9 cases improved after treatment, 3 cases did not improve, and 4 cases died during hospitalization, with a mortality rate of 25%. Multivariate analysis revealed no independent prognostic factor associated with mortality. The cure time of the Non-LC group was 37.4±23.1 days (6-90 days), while that of the LC-TACE group was 91.5±49.7 days (19-180 days), with a statistically significant difference between the two groups (P < 0.001).Conclusions: PLA of the Non-LC group and the LC-TACE group were different in terms of pathogenic bacteria and cure time, etc. For PLA after TACE, a more aggressive and comprehensive treatment should be considered.

scholarly journals Liver Abscess Caused by Fusobacterium nucleatum: A Case Report

2021 ◽  
Vol 14 (4) ◽  
Author(s):  
Wenhao Wu ◽  
Wenjia Fan ◽  
Zhewen Zhou ◽  
Shouhao Wang ◽  
Chengan Xu ◽  
...  
Keyword(s):  
Liver Abscess ◽  
Pathogenic Bacteria ◽  
Anaerobic Bacteria ◽  
Fusobacterium Nucleatum ◽  
Pyogenic Liver Abscess ◽  
Microbial Detection ◽  
Specimen Collection ◽  
First Case ◽  
Positive Rate ◽  
Bacteria Culture

Introduction: Pyogenic liver abscess (PLA) is a serious infectious disease of the liver. PLA caused by Fusobacterium nucleatum is extremely rare. Here we report the first case of liver abscess caused by F. nucleatum in China. Case Presentation: The case was a 34-year-old female patient admitted to the hospital due to high fever. The diagnosis of liver abscess was confirmed by imaging studies and liver puncture. We finally confirmed the pathogen as F. nucleatum by next-generation sequencing (NGS). After the targeted anti-infective treatment, the patient recovered and discharged. Conclusions: As a new microbial detection method, NGS can still help in clinical practice. In addition, to improve the positive rate of anaerobic bacteria culture, we should pay attention to avoid contact with air in the process of specimen collection when the pathogenic bacteria are suspected to be anaerobic bacteria.

Clinical Outcomes and Prognostic Factors of Cancer Patients with Pyogenic Liver Abscess

2011 ◽  
Vol 15 (11) ◽  
pp. 2036-2043 ◽  
Author(s):  
Shiuan-Chih Chen ◽  
Yuan-Ti Lee ◽  
Shih-Jei Tsai ◽  
Kuang-Chi Lai ◽  
Chi-Chou Huang ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Cancer Patients ◽  
Clinical Outcomes ◽  
Liver Abscess ◽  
Pyogenic Liver Abscess

Primary liver cancer presenting as pyogenic liver abscess: Characteristics, diagnosis, and management

2011 ◽  
Vol 105 (7) ◽  
pp. 687-691 ◽  
Author(s):  
Cong Li ◽  
Guangbing Li ◽  
Ruoyu Miao ◽  
Xin Lu ◽  
Shouxian Zhong ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Liver Abscess ◽  
Primary Liver Cancer ◽  
Pyogenic Liver Abscess ◽  
Diagnosis And Management

scholarly journals Pyogenic Liver Abscess as a Warning Sign for Primary Liver Cancer: A Nationwide Population-based Study

2013 ◽  
Vol 14 (8) ◽  
pp. 4727-4731 ◽  
Author(s):  
Wen-Kuan Huang ◽  
Yung-Chang Lin ◽  
Meng-Jiun Chiou ◽  
Tsai-Sheng Yang ◽  
John Wen-Cheng Chang ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Liver Abscess ◽  
Primary Liver Cancer ◽  
Pyogenic Liver Abscess ◽  
Population Based ◽  
Warning Sign ◽  
Population Based Study

scholarly journals Clinical Significance of Serum Albumin/Globulin Ratio in Patients With Pyogenic Liver Abscess

2021 ◽  
Vol 8 ◽  
Author(s):  
Jia Zhang ◽  
Tao Wang ◽  
Yi Fang ◽  
Mengzhou Wang ◽  
Wuming Liu ◽  
...  
Keyword(s):  
Serum Albumin ◽  
Clinical Significance ◽  
Liver Abscess ◽  
Clinical Manifestations ◽  
Pyogenic Liver Abscess ◽  
Peritoneal Effusion ◽  
Positive Rate ◽  
Treatment Plans ◽  
The Mean ◽  
Clinical Characteristic

Pyogenic liver abscess (PLA) remains a significant challenge for modern clinicians. Serum albumin/globulin ratio (AGR) can reflect the progress of many diseases. However, the clinical significance of AGR in PLA has not been evaluated. The aim of this study was to explore the effect of AGR on the clinical characteristic and prognosis in PLA patients. This retrospective study included 392 PLA patients who admitted to the First Affiliated Hospital of Xi'an Jiaotong University from January, 2007 to December, 2016. The medical records on admission were collected. Compared with the healthy controls and the patients with extraperitoneal infection or non-infectious liver disease, PLA patients had lower levels of AGR. The mean level of AGR in PLA patients was 1.02 ± 0.25. There were 179 (45.4%) patients with AGR &gt; 1.02 and 213 (54.6%) patients with AGR ≤ 1.02. The baseline data and treatment plans of PLA patients with high or low AGR were comparative. However, PLA patients with a low AGR had higher body temperature, leukocytes and neutrophils, lower hemoglobin, poorer liver and coagulation function, larger abscess diameter, higher positive rate of pus culture and proportion of Escherichia coli, and were more susceptible to multiple bacteria. Moreover, PLA patients with a low AGR had more complications, including systemic inflammatory response syndrome (SIRS), peritoneal effusion and pleural effusion. And it also needs longer time for temperature normalization and hospital stay. In conclusion, PLA patients have lower AGR and lower AGR is associated with worse clinical manifestations, more complications and poorer prognosis. Thus, monitoring of AGR is of great clinical significance for evaluating the progress of PLA patients.

scholarly journals Clinical research of primary liver cancer mimicking liver abscess

2017 ◽  
Vol 4 (3) ◽  
pp. 1033
Author(s):  
Kong Jun ◽  
Leng Tongmin ◽  
Gong Jianping ◽  
Tang Maoming
Keyword(s):  
Liver Cancer ◽  
Liver Abscess ◽  
Early Stage ◽  
Primary Liver Cancer ◽  
Clinical Manifestations ◽  
Pyogenic Liver Abscess ◽  
Diagnosis And Treatment ◽  
Hepatic Arteriography ◽  
Laboratory Findings ◽  
Post Operation

Background: Aiming at diagnosing at an early stage, minimizing the misdiagnosis rate and improving the prognosis, the author has investigated the clinical characteristics, diagnosis and treatment of primary liver cancer mimicking liver abscess with a summary and discussion.Methods: All of the 11 cases of primary liver cancer mimicking liver abscess, diagnosed during January 2009 to December 2015, were retrospectively viewed in terms of clinical manifestations, laboratory tests, radiological feature, diagnosis and treatment. And statistic analysis was made in all aspects mentioned above with that of pyogenic liver abscess and other types of liver cancer diagnosed in the corresponding period.  Results: The clinical manifestations of the 11 cases were mostly characterized by fever, abdominal pain and weight loss. There was no significantly statistic difference between the study group and any of the three matched groups in underlying disease and lab results. All of the 11 patients were treated with enhanced antibiotics as basic therapy. Furthermore, eight cases accepted surgical operation, among them, one object underwent puncture and drainage of the liver abscess by ultrasound (PDLA) twice pre-operation, one object underwent PDLA and hepatic arteriography pre-operation and death in hospital post-operation, one object suffered myocardial infarction post-operation. In addition, three cases received conservative treatment only, in which, one object died in hospital.Conclusions: It is difficult to distinguish primary liver cancer mimicking liver abscess from pyogenic liver abscess as there are no specific clinical manifestations and laboratory findings which is prone to leading to misdiagnosis. What’s worse, the prognosis is so poor that high alert and close follow-up are required as well as early diagnosis and treatment. 

scholarly journals Does pyogenic liver abscess increase the risk of delayed-onset primary liver cancer?

Medicine ◽  
2017 ◽  
Vol 96 (34) ◽  
pp. e7785 ◽  
Author(s):  
Chia-Sheng Chu ◽  
Che-Chen Lin ◽  
Cheng-Yuan Peng ◽  
Po-Heng Chuang ◽  
Wen-Pang Su ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Liver Abscess ◽  
Primary Liver Cancer ◽  
Pyogenic Liver Abscess ◽  
Delayed Onset

scholarly journals Analysis of Mortality and Survival Rate of Liver Cancer in Zhejiang Province in China: A General Population-Based Study

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Fang-Rong Fei ◽  
Ru-Ying Hu ◽  
Wei-Wei Gong ◽  
Jin Pan ◽  
Meng Wang
Keyword(s):  
Survival Rate ◽  
Mortality Rate ◽  
Liver Cancer ◽  
Cancer Patients ◽  
Rural Areas ◽  
Urban Areas ◽  
Survival Rates ◽  
Relative Survival ◽  
Zhejiang Province ◽  
World Population

Background. Few accurate up-to-date studies provide liver cancer mortality and survival information in Zhejiang province. This research aimed to depict the mortality and survival of liver cancer in Zhejiang province in China during 2005-2010. Methods. The data were collected from the Zhejiang Chronic Disease Surveillance Information and Management System, and the mortality rates of liver cancer were calculated by gender, age, and areas. Chinese population census in 2000 and Segi’s world population were used for age-standardized mortality rate. The observed and relative survival rates of liver cancer patients were analyzed. Results. The crude mortality rate of liver cancer was 32.11/105. The age-standardized mortality rate was 17.39/105 and 23.07/105 by Chinese population (ASIRC) and Segi’s world population (ASIRW), respectively. The crude liver cancer mortality rate and age-standardized rate in urban areas were lower than those of rural areas. The overall 1-, 3-, and 5-year observed survival (OS) rates of liver cancer patients were 38.61%, 21.65%, and 16.83%, respectively. The 1-, 3-, and 5-year relative survival (RS) rates of liver cancer patients were 39.49%, 23.27%, and 19.09%, respectively. Survival rate decreased obviously within 1 to 5 years and then leveled off. It was shown that the male overall survival rate was higher than the female one and the difference was statistically significant (P<0.05). Conclusions. Both lower mortality and better survival rates were observed in urban areas, compared to rural areas. Relevant parties including government, public resource, and propaganda department should devote enough attention to rural areas.

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