scholarly journals Effect of Body Mass Index on the Association Between Alcohol Consumption and the Development of Chronic Kidney Disease

2021 ◽  
Author(s):  
Yusaku Hashimoto ◽  
Sawako Kato ◽  
Yoshinari Yasuda ◽  
Takuji Ishimoto ◽  
Hiroaki Kawashiri ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Chronic Kidney Disease ◽  
Alcohol Consumption ◽  
Kidney Disease ◽  
Body Mass ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
The Body ◽  
Cox Proportional Hazards Models ◽  
Increased Risk

Abstract Although previous studies demonstrated that alcohol consumption is associated with low chronic kidney disease (CKD) risk, they did not consider individual body mass and metabolic capacity. We examined whether the body mass index (BMI) affects the association between drinking and CKD. We defined CKD as an estimated glomerular filtration rate decline < 60 mL/min/1.73 m2 and/or dipstick proteinuria (≥ 1+). Participants were 11,175 Japanese individuals aged 40–74 years without baseline CKD who underwent annual health checkups. Daily alcohol consumption was estimated from a questionnaire, and the participants were categorized as "infrequent drinkers," "light drinkers (< 20 g/day)," "moderate drinkers (20–40 g/day)," and "heavy drinkers (≥ 40 g/day)." Over a median 5-year observation period, 936 participants developed CKD. Cox proportional hazards models revealed that light drinkers had a significantly reduced risk of CKD compared with infrequent drinkers (P = 0.01). Stratified by BMI, the low BMI (< 18.5 kg/m2) group had an increased risk of CKD even in light drinkers, while the high BMI (≥ 25.0 kg/m2) group had a decreased risk of CKD regardless of alcohol consumption. Taken together, alcohol consumption did not reduce the CKD risk in all populations; individual tolerance must be considered.

scholarly journals Effect of body mass index on the association between alcohol consumption and the development of chronic kidney disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yusaku Hashimoto ◽  
Takahiro Imaizumi ◽  
Sawako Kato ◽  
Yoshinari Yasuda ◽  
Takuji Ishimoto ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Chronic Kidney Disease ◽  
Alcohol Consumption ◽  
Kidney Disease ◽  
Confidence Intervals ◽  
Body Mass ◽  
The Body ◽  
Hazard Ratios ◽  
Glomerular Filtration Rate Decline ◽  
Observation Period

AbstractThe influence of body mass or metabolic capacity on the association between alcohol consumption and lower risks of developing chronic kidney disease (CKD) is not fully elucidated. We examined whether the body mass index (BMI) affects the association between drinking alcohol and CKD. We defined CKD as an estimated glomerular filtration rate decline < 60 mL/min/1.73 m2 and/or positive proteinuria (≥ 1+). Participants were 11,175 Japanese individuals aged 40–74 years without baseline CKD who underwent annual health checkups. Daily alcohol consumption at baseline was estimated using a questionnaire, and the participants were categorized as “infrequent (occasionally, rarely or never),” “light (< 20 g/day),” “moderate (20–39 g/day),” and “heavy (≥ 40 g/day).” Over a median 5-year observation period, 936 participants developed CKD. Compared with infrequent drinkers, light drinkers were associated with low CKD risks; adjusted hazard ratios (95% confidence intervals) were 0.81 (0.69–0.95). Stratified by BMI (kg/m2), moderate drinkers in the low (< 18.5), normal (18.5–24.9), and high (≥ 25.0) BMI groups had adjusted hazard ratios (95% confidence intervals) of 3.44 (1.60–7.42), 0.75 (0.58–0.98), and 0.63 (0.39–1.04), respectively. Taken together, the association between alcohol consumption and CKD incidence was not the same in all the individuals, and individual tolerance must be considered.

scholarly journals Childhood body mass index and multiple sclerosis risk: a long-term cohort study

2013 ◽  
Vol 19 (10) ◽  
pp. 1323-1329 ◽  
Author(s):  
Kassandra L Munger ◽  
Joan Bentzen ◽  
Bjarne Laursen ◽  
Egon Stenager ◽  
Nils Koch-Henriksen ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Body Mass Index ◽  
Body Mass ◽  
School Health ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Z Score ◽  
Cox Proportional Hazards Models ◽  
Increased Risk ◽  
Unit Increase

Background: Obesity in late adolescence has been associated with an increased risk of multiple sclerosis (MS); however, it is not known if body size in childhood is associated with MS risk. Methods: Using a prospective design we examined whether body mass index (BMI) at ages 7–13 years was associated with MS risk among 302,043 individuals in the Copenhagen School Health Records Register (CSHRR). Linking the CSHRR with the Danish MS registry yielded 774 MS cases (501 girls, 273 boys). We used Cox proportional hazards models to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs). Results: Among girls, at each age 7–13 years, a one-unit increase in BMI z-score was associated with an increased risk of MS (HRage 7=1.20, 95% CI: 1.10–1.30; HRage 13=1.18, 95% CI: 1.08–1.28). Girls who were ≥95th percentile for BMI had a 1.61–1.95-fold increased risk of MS as compared to girls <85th percentile. The associations were attenuated in boys. The pooled HR for a one-unit increase in BMI z-score at age 7 years was 1.17 (95% CI: 1.09–1.26) and at age 13 years was 1.15 (95% CI: 1.07–1.24). Conclusion: Having a high BMI in early life is a risk factor for MS, but the mechanisms underlying the association remain to be elucidated.

scholarly journals Low lung function and the risk of incident chronic kidney disease in the Malmö Preventive Project cohort

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Suneela Zaigham ◽  
Anders Christensson ◽  
Per Wollmer ◽  
Gunnar Engström
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Lung Function ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Main Diagnosis ◽  
Men And Women ◽  
Increased Risk ◽  
Incident Chronic Kidney Disease ◽  
Future Risk

Abstract Background Although the prevalence of kidney disease is higher in those with reduced lung function, the longitudinal relationship between low lung function and future risk of chronic kidney disease (CKD) has not been widely explored. Methods Baseline lung function was assessed in 20,700 men and 7325 women from 1974 to 1992. Mean age was 43.4 (±6.6) and 47.5 (±7.9) for men and women respectively. Sex-specific quartiles of FEV1 and FVC (L) were created (Q4: highest, reference) and the cohort was also divided by the FEV1/FVC ratio (≥ or < 0.70). Cox proportional hazards regression was used to determine the risk of incident CKD events (inpatient or outpatient hospital diagnosis of CKD) in relation to baseline lung function after adjustment for various confounding factors. Results Over 41 years of follow-up there were 710 and 165 incident CKD events (main diagnosis) in men and women respectively. Low FEV1 was strongly associated with future risk of CKD in men (Q1 vs Q4 adjusted HR: 1.46 (CI:1.14–1.89), p-trend 0.002). Similar findings were observed for FVC in men (1.51 (CI:1.16–1.95), p-trend 0.001). The adjusted risks were not found to be significant in women, for either FEV1 or FVC. FEV1/FVC < 0.70 was not associated with increased incidence of CKD in men or women. Conclusion Low FEV1 and FVC levels at baseline are a risk factor for the development of future incident CKD in men. Monitoring kidney function in those with reduced vital capacity in early life could help with identifying those at increased risk of future CKD.

scholarly journals Association of Arterial Stiffness With Kidney Function Among Adults Without Chronic Kidney Disease

2020 ◽  
Vol 33 (11) ◽  
pp. 1003-1010
Author(s):  
Seiji Itano ◽  
Yuichiro Yano ◽  
Hajime Nagasu ◽  
Hirofumi Tomiyama ◽  
Hiroshi Kanegae ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Arterial Stiffness ◽  
Kidney Function ◽  
Proportional Hazards ◽  
Multivariable Analysis ◽  
Cox Proportional Hazards ◽  
Kidney Dysfunction ◽  
Cox Proportional Hazards Models ◽  
Egfr Decline

Abstract BACKGROUND Our aims were to assess whether arterial stiffness is associated with a higher risk for kidney dysfunction among persons without chronic kidney disease (CKD). METHODS We analyzed data from the national health checkup system in Japan; for our analyses, we selected records of individuals who completed assessments of cardio-ankle vascular index (CAVI) and kidney function from 2005 to 2016. We excluded participants who had CKD at baseline, defined as the presence of proteinuria or estimated glomerular filtration rate (eGFR) &lt;60 ml/min/1.73 m2. We compared 2 groups of CAVI measurements—the highest quartile (≧8.1) and the combined lower 3 quartiles (&lt;8.1). We used Cox proportional hazards models to assess associations between these 2 groups and subsequent CKD events, proteinuria, eGFR &lt;60 ml/min/1.73 m2, and rapid eGFR decline (greater than or equal to −3 ml/min/1.73 m2 per year). RESULTS The mean age of the 24,297 included participants was 46.2 years, and 60% were female. Over a mean follow-up of 3.1 years, 1,435 CKD events occurred. In a multivariable analysis, the hazard ratios with 95% confidence intervals (CIs) for the highest vs. combined lower quartiles of CAVI measurements were 1.3 (1.1, 1.5) for CKD events, 1.3 (0.96, 1.62) for proteinuria, 1.4 (1.1, 1.7) for eGFR &lt;60 ml/min/1.73 m2, and the odds ratio with 95% CI was 1.3 (1.1, 1.4) for rapid eGFR decline. CONCLUSIONS Persons with CAVI measurements ≧8.1 had a higher risk for CKD events compared with their counterparts with CAVI measurements &lt;8.1. Greater arterial stiffness among adults without CKD may be associated with kidney dysfunction.

scholarly journals Association between the body mass index and chronic kidney disease in men and women. A population-based study from Israel

2013 ◽  
Vol 28 (suppl 4) ◽  
pp. iv130-iv135 ◽  
Author(s):  
E. Cohen ◽  
A. Fraser ◽  
E. Goldberg ◽  
G. Milo ◽  
M. Garty ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Body Mass ◽  
Population Based ◽  
The Body ◽  
Population Based Study ◽  
Men And Women

Large Body Mass Index does not Predict Short-Term Survival in Peritoneal Dialysis Patients

2002 ◽  
Vol 22 (2) ◽  
pp. 191-196 ◽  
Author(s):  
Nabeel Aslam ◽  
Judith Bernardini ◽  
Linda Fried ◽  
Beth Piraino
Keyword(s):  
Body Mass Index ◽  
Peritoneal Dialysis ◽  
Body Mass ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Dialysis Patients ◽  
Term Survival ◽  
Technique Survival ◽  
Risk Of Death ◽  
Increased Risk

♦ Objective Higher than normal body mass index (BMI) is associated with an increased risk of death in the general population. We examined the effect of higher than normal BMI on patient and technique survival in peritoneal dialysis patients (PD), controlling for comorbidity, initial albumin, dialysate-to-plasma ratio of creatinine (D/PCr), and initial urea clearance (Kt/V). ♦ Design Registry database. ♦ Settings Four dialysis centers. ♦ Patients Incident PD patients. ♦ Methods All data were collected prospectively. Demographics, BMI, serum albumin, D/PCr, and comorbidity using the Charlson Comorbidity Index (CCI) were determined at the start of PD. 104 patients with a high BMI (> 27) were matched to a control group of 104 patients with normal BMI (20 – 27) for age, gender, presence of diabetes, and CCI. Patient and technique survival were compared using Cox proportional hazards model. ♦ Main Outcome Measures Patient and technique survival. ♦ Results The groups were of similar age (56.1 vs 56.7 years), sex (60% males in both groups), race (Caucasian 80% vs 86%), presence of diabetes (40% vs 37%), CCI score (5.4 in both groups), initial albumin (3.6 vs 3.5 g/dL), and D/PCr (0.65 in both groups). Kaplan–Meier survival analysis showed similar 2-year patient survival between large BMI (> 27) and control (20 – 27) groups (76.6% vs 76.1%). Two-year technique survival was also similar between the two groups (59.7% vs 66.8%). With Cox proportional hazards analysis, BMI was not a predictor of patient mortality or technique survival when controlling for initial albumin, D/PCr, and initial Kt/V. ♦ Conclusions We conclude that a BMI above normal is not associated with any increased or decreased risk of death in patients on PD for 2 years.

scholarly journals Sarcopenia is an independent predictor of hospitalization in chronic kidney disease outpatients

2019 ◽  
Author(s):  
Hye Yun Jeong ◽  
Wooyeol Ahn ◽  
Jun Chul Kim ◽  
Yu Bum Choi ◽  
Jinkwon Kim ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Muscle Strength ◽  
Proportional Hazards ◽  
Handgrip Strength ◽  
Cox Proportional Hazards ◽  
Chronic Illnesses ◽  
Free Survival ◽  
Cox Proportional Hazards Models ◽  
Appendicular Skeletal Muscle

AbstractBackgroundPatients with chronic kidney disease (CKD) experience much more marked and earlier muscle wasting than subjects who do not have chronic illnesses. However, a few studies that have examined sarcopenia have been reported in CKD patients. We investigated the prevalence of sarcopenia in predialysis and dialysis outpatients with CKD and explored its relationship with the clinical outcomes.MeasurementsSarcopenia was defined as reduced muscle strength accompanied by decreased adjusted appendicular skeletal muscle (ASM), while those patients who exhibited only one of these characteristics were categorized as presarcopenic patients. ASM was measured by bioimpedence analysis, and muscle strength was evaluated by handgrips. ASM was adjusted by weight (ASM/wt). Patients were prospectively followed for up to 2 years.ResultsOne hundred seventy-nine patients were recruited (114 male and 65 female patients who were classified into 103 predialysis patients and 76 dialysis patients, with 44.7% having diabetes). Their mean age was 60.6 ± 13.5 years old. The prevalence of sarcopenia was 9.5%, while 55.9% of the patients were categorized as presarcopenic. The ASM/wt index showed significant correlations with age, handgrip strength, HOMA-IR and frailty scores. Multivariate Cox proportional hazards models demonstrated that the risk of hospitalization was significantly higher for patients with presarcopenia [hazard ratio (HR), 2.48; 95% confidence interval (CI), 1.180–5.230], and the risk of hospitalization was much higher for patients with sarcopenia than for patients in the nonsarcopenic group (HR, 9.11; 95% CI, 2.295–25.182)ConclusionsSarcopenia and presarcopenia, which were defined using the ASM/wt index and handgrip strength, predicted a poorer, hospitalization-free survival in CKD patients

scholarly journals Taking Sleeping Pills and the Risk of Chronic Kidney Disease: A Nationwide Population-Based Retrospective Cohort Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Chen-Yi Liao ◽  
Chi-Hsiang Chung ◽  
Kuo-Cheng Lu ◽  
Cheng-Yi Cheng ◽  
Sung-Sen Yang ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Proportional Hazards ◽  
Population Based ◽  
Cox Proportional Hazards ◽  
Sleeping Pills ◽  
Potential Association ◽  
Increased Risk ◽  
Stage Renal Disease ◽  
End Stage

Background: Sleeping disorder has been associated with chronic kidney disease (CKD); however, the correlation between sleeping pills use and CKD has not been investigated in-depth yet. This study elucidated the potential association of sleeping pill use with the risk of CKD and CKD progression to end-stage renal disease (ESRD) requiring dialysis.Methods: This study was based on a population-based cohort that included 209,755 sleeping pill users among 989,753 individuals. After applying the exclusion criteria, 186,654 sleeping pill users and 373,308 nonusers were enrolled to monitor the occurrence of CKD. Using a cumulative daily dose, we analyzed the types of sleeping pills related to the risk of CKD and ESRD. Propensity score matching and analysis using Cox proportional hazards regression were performed with adjustments for sex, age, and comorbidities.Results: Sleeping pill use was related to increased CKD risk after adjusting for underlying comorbidities (adjusted hazard ratio [aHR] = 1.806, 95% confidence interval [CI]: 1.617–2.105, p &lt; 0.001). With the exception of hyperlipidemia, most comorbidities correlated with an increased risk of CKD. Persistent use of sleeping pills after CKD diagnosis increased the risk of concurrent ESRD (aHR = 7.542; 95% CI: 4.267–10.156; p &lt; 0.001). After the subgroup analysis for sleeping pill use, brotizolam (p = 0.046), chlordiazepoxide (p &lt; 0.001), clonazepam (p &lt; 0.001), diazepam (p &lt; 0.001), dormicum (p &lt; 0.001), estazolam (p &lt; 0.001), fludiazepam (p &lt; 0.001), flunitrazepam (p &lt; 0.001), nitrazepam (p &lt; 0.001), trazodone (p &lt; 0.001), zolpidem (p &lt; 0.001), and zopiclone (p &lt; 0.001) were found to have significant correlation with increased CKD risk.Conclusion: Sleeping pill use was related to an increased risk of CKD and ESRD. Further studies are necessary to corroborate these findings.

MO138ASSOCIATION OF NT-PROBNP WITH OBESITY IN CKD PATIENTS

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Ting-Yun Lin ◽  
Szu-Chun Hung
Keyword(s):  
Heart Failure ◽  
Clinical Outcomes ◽  
Body Mass ◽  
Proportional Hazards ◽  
Normal Weight ◽  
Cox Proportional Hazards ◽  
Asymptomatic Patients ◽  
Cox Proportional Hazards Models ◽  
Increased Risk ◽  
Ckd Stage

Abstract Background and Aims Obesity is associated with lower circulating levels of N-terminal pro-BNP (NT-proBNP) both in the general population and in patients with heart failure. In asymptomatic patients with CKD, NT-proBNP levels are generally elevated. The prevalence of obesity is markedly increasing among patients with CKD. However, whether obesity affects NT-proBNP levels and thresholds for increased risk of clinical outcomes is unclear. Method We examined the associations between NT-proBNP and obesity in 408 stage 3–5 CKD patients (268 men and 140 women; mean age 65±13 years) free of heart failure at baseline, who were categorized into 3 groups according to body mass index (BMI; kg/m2) as normal (&lt;24.0), overweight (24.0–27.9), and obese (≥28.0). Multivariate Cox proportional hazards models were used to compare the risk associations of NT-proBNP with the composite of ESKD (needing chronic dialysis or kidney transplantation) or all-cause mortality across BMI categories. Results NT-proBNP levels were significantly lower in obese patients than in normal weight and overweight subjects (P &lt;0.001). Within each CKD stage, NT-proBNP levels decreased with increasing BMI. In a multivariate analysis, NT-proBNP was inversely associated with obesity, as well as BMI and its fat and lean body mass components (all P &lt;0.001), independent of demographics, comorbidities, and severity of CKD. During a median follow-up of 2.2 years, 117 patients progressed to ESKD and 46 patients died. Overall, higher NT-proBNP levels were independently associated with ESKD or death (HR, 1.52; 95% CI, 1.22–1.89). Specifically, higher NT-proBNP levels were consistently associated with poor outcomes in all BMI categories (P for interaction = 0.096). Conclusion Obese CKD patients have significantly lower NT-proBNP levels. Nevertheless, BMI category did not modify the relationship between NT-proBNP and clinical outcomes. Increased risk may be seen at relatively lower levels of NT-proBNP in obese CKD patients.

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