scholarly journals Rapid Artificial Intelligence Solutions in a Pandemic - The COVID-19-20 Lung CT Lesion Segmentation Challenge

2021 ◽  
Author(s):  
Holger Roth ◽  
Ziyue Xu ◽  
Carlos Tor Diez ◽  
Ramon Sanchez Jacob ◽  
Jonathan Zember ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Computed Tomography ◽  
State Of The Art ◽  
Automatic Detection ◽  
Patient Specific ◽  
Lesion Segmentation ◽  
Chest Computed Tomography ◽  
Public Data ◽  
Lung Ct ◽  
Detection And Quantification

Abstract Artificial intelligence (AI) methods for the automatic detection and quantification of COVID-19 lesions in chest computed tomography (CT) might play an important role in the monitoring and management of the disease. We organized an international challenge and competition for the development and comparison of AI algorithms for this task, which we supported with public data and state-of-the-art benchmark methods. Board Certified Radiologists annotated 295 public images from two sources (A and B) for algorithms training (n=199, source A), validation (n=50, source A) and testing (n=23, source A; n=23, source B). There were 1,096 registered teams of which 225 and 98 completed the validation and testing phases, respectively. The challenge showed that AI models could be rapidly designed by diverse teams with the potential to measure disease or facilitate timely and patient-specific interventions. This paper provides an overview and the major outcomes of the COVID-19 Lung CT Lesion Segmentation Challenge - 2020.

A deep Residual U-Net algorithm for automatic detection and quantification of ascites on the abdominopelvic computed tomography acquired in the emergency department (Preprint)

2021 ◽  
Author(s):  
Hoon Ko ◽  
Jimi Huh ◽  
Kyung Won Kim ◽  
Heewon Chung ◽  
Yousun Ko ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Deep Learning ◽  
Automatic Detection ◽  
High Specificity ◽  
Ct Images ◽  
Free Fluid ◽  
Detection Accuracy ◽  
Abdominopelvic Ct ◽  
Segmentation Accuracy ◽  
Detection And Quantification

BACKGROUND Detection and quantification of intraabdominal free fluid (i.e., ascites) on computed tomography (CT) are essential processes to find emergent or urgent conditions in patients. In an emergent department, automatic detection and quantification of ascites will be beneficial. OBJECTIVE We aimed to develop an artificial intelligence (AI) algorithm for the automatic detection and quantification of ascites simultaneously using a single deep learning model (DLM). METHODS 2D deep learning models (DLMs) based on a deep residual U-Net, U-Net, bi-directional U-Net, and recurrent residual U-net were developed to segment areas of ascites on an abdominopelvic CT. Based on segmentation results, the DLMs detected ascites by classifying CT images into ascites images and non-ascites images. The AI algorithms were trained using 6,337 CT images from 160 subjects (80 with ascites and 80 without ascites) and tested using 1,635 CT images from 40 subjects (20 with ascites and 20 without ascites). The performance of AI algorithms was evaluated for diagnostic accuracy of ascites detection and for segmentation accuracy of ascites areas. Of these DLMs, we proposed an AI algorithm with the best performance. RESULTS The segmentation accuracy was the highest in the deep residual U-Net with a mean intersection over union (mIoU) value of 0.87, followed by U-Net, bi-directional U-Net, and recurrent residual U-net (mIoU values 0.80, 0.77, and 0.67, respectively). The detection accuracy was the highest in the deep residual U-net (0.96), followed by U-Net, bi-directional U-net, and recurrent residual U-net (0.90, 0.88, and 0.82, respectively). The deep residual U-net also achieved high sensitivity (0.96) and high specificity (0.96). CONCLUSIONS We propose the deep residual U-net-based AI algorithm for automatic detection and quantification of ascites on abdominopelvic CT scans, which provides excellent performance.

scholarly journals Multiplexed Immunohistochemistry and Digital Pathology as the Foundation for Next-Generation Pathology in Melanoma: Methodological Comparison and Future Clinical Applications

2021 ◽  
Vol 11 ◽  
Author(s):  
Yannick Van Herck ◽  
Asier Antoranz ◽  
Madhavi Dipak Andhari ◽  
Giorgia Milli ◽  
Oliver Bechter ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Single Cell ◽  
State Of The Art ◽  
Deep Understanding ◽  
Response Rates ◽  
The State ◽  
Patient Specific ◽  
Specific Cell ◽  
Next Generation ◽  
Single Cell Profiling

The state-of-the-art for melanoma treatment has recently witnessed an enormous revolution, evolving from a chemotherapeutic, “one-drug-for-all” approach, to a tailored molecular- and immunological-based approach with the potential to make personalized therapy a reality. Nevertheless, methods still have to improve a lot before these can reliably characterize all the tumoral features that make each patient unique. While the clinical introduction of next-generation sequencing has made it possible to match mutational profiles to specific targeted therapies, improving response rates to immunotherapy will similarly require a deep understanding of the immune microenvironment and the specific contribution of each component in a patient-specific way. Recent advancements in artificial intelligence and single-cell profiling of resected tumor samples are paving the way for this challenging task. In this review, we provide an overview of the state-of-the-art in artificial intelligence and multiplexed immunohistochemistry in pathology, and how these bear the potential to improve diagnostics and therapy matching in melanoma. A major asset of in-situ single-cell profiling methods is that these preserve the spatial distribution of the cells in the tissue, allowing researchers to not only determine the cellular composition of the tumoral microenvironment, but also study tissue sociology, making inferences about specific cell-cell interactions and visualizing distinctive cellular architectures - all features that have an impact on anti-tumoral response rates. Despite the many advantages, the introduction of these approaches requires the digitization of tissue slides and the development of standardized analysis pipelines which pose substantial challenges that need to be addressed before these can enter clinical routine.

scholarly journals Rapid screening for COVID-19 by applying artificial intelligence to chest computed tomography images: A feasibility study

2021 ◽  
Vol 5 ◽  
pp. 239920262110136
Author(s):  
Pedro Galván ◽  
José Fusillo ◽  
Felipe González ◽  
Oraldo Vukujevic ◽  
Luciano Recalde ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Computed Tomography ◽  
Pleural Effusion ◽  
Feasibility Study ◽  
Ct Images ◽  
Public Hospitals ◽  
Rt Pcr ◽  
Chest Computed Tomography ◽  
Computed Tomography Images ◽  
Respiratory Conditions

Aim: The aim of the study was to present the results and impact of the application of artificial intelligence (AI) in the rapid diagnosis of COVID-19 by telemedicine in public health in Paraguay. Methods: This is a descriptive, multi-centered, observational design feasibility study based on an AI tool for the rapid detection of COVID-19 in chest computed tomography (CT) images of patients with respiratory difficulties attending the country’s public hospitals. The patients’ digital CT images were transmitted to the AI diagnostic platform, and after a few minutes, radiologists and pneumologists specialized in COVID-19 downloaded the images for evaluation, confirmation of diagnosis, and comparison with the genetic diagnosis (reverse transcription polymerase chain reaction (RT-PCR)). It was also determined the percentage of agreement between two similar AI systems applied in parallel to study the viability of using it as an alternative method of screening patients with COVID-19 through telemedicine. Results: Between March and August 2020, 911 rapid diagnostic tests were carried out on patients with respiratory disorders to rule out COVID-19 in 14 hospitals nationwide. The average age of patients was 50.7 years, 62.6% were male and 37.4% female. Most of the diagnosed respiratory conditions corresponded to the age group of 27–59 years (252 studies), the second most frequent corresponded to the group over 60 years, and the third to the group of 19–26 years. The most frequent findings of the radiologists/pneumologists were severe pneumonia, bilateral pneumonia with pleural effusion, bilateral pulmonary emphysema, diffuse ground glass opacity, hemidiaphragmatic paresis, calcified granuloma in the lower right lobe, bilateral pleural effusion, sequelae of tuberculosis, bilateral emphysema, and fibrotic changes, among others. Overall, an average of 86% agreement and 14% diagnostic discordance was determined between the two AI systems. The sensitivity of the AI system was 93% and the specificity 80% compared with RT-PCR. Conclusion: Paraguay has an AI-based telemedicine screening system for the rapid stratified detection of COVID-19 from chest CT images of patients with respiratory conditions. This application strengthens the integrated network of health services, rationalizing the use of specialized human resources, equipment, and inputs for laboratory diagnosis.

Cascaded Deeply Supervised Convolutional Networks for Liver Lesion Segmentation

2021 ◽  
pp. 2152014
Author(s):  
Kaiyi Peng ◽  
Bin Fang ◽  
Mingliang Zhou
Keyword(s):  
Computed Tomography ◽  
Neural Networks ◽  
Prediction Accuracy ◽  
Deep Neural Networks ◽  
Small Volume ◽  
State Of The Art ◽  
Liver Lesion ◽  
Segmentation Method ◽  
Lesion Segmentation ◽  
Convolutional Networks

Liver lesion segmentation from abdomen computed tomography (CT) with deep neural networks remains challenging due to the small volume and the unclear boundary. To effectively tackle these problems, in this paper, we propose a cascaded deeply supervised convolutional networks (CDS-Net). The cascaded deep supervision (CDS) mechanism uses auxiliary losses to construct a cascaded segmentation method in a single network, focusing the network attention on pixels that are more difficult to classify, so that the network can segment the lesion more effectively. CDS mechanism can be easily integrated into standard CNN models and it helps to increase the model sensitivity and prediction accuracy. Based on CDS mechanism, we propose a cascaded deep supervised ResUNet, which is an end-to-end liver lesion segmentation network. We conduct experiments on LiTS and 3DIRCADb dataset. Our method has achieved competitive results compared with other state-of-the-art ones.

scholarly journals Review on Diagnosis of COVID-19 from Chest CT Images Using Artificial Intelligence

2020 ◽  
Vol 2020 ◽  
pp. 1-10 ◽  
Author(s):  
Ilker Ozsahin ◽  
Boran Sekeroglu ◽  
Musa Sani Musa ◽  
Mubarak Taiwo Mustapha ◽  
Dilber Uzun Ozsahin
Keyword(s):  
Artificial Intelligence ◽  
Computed Tomography ◽  
Neural Networks ◽  
Deep Learning ◽  
Chest Radiography ◽  
Area Under The Curve ◽  
Chest Ct ◽  
Chest Computed Tomography ◽  
Classification Tasks ◽  
Sensitivity Specificity

The COVID-19 diagnostic approach is mainly divided into two broad categories, a laboratory-based and chest radiography approach. The last few months have witnessed a rapid increase in the number of studies use artificial intelligence (AI) techniques to diagnose COVID-19 with chest computed tomography (CT). In this study, we review the diagnosis of COVID-19 by using chest CT toward AI. We searched ArXiv, MedRxiv, and Google Scholar using the terms “deep learning”, “neural networks”, “COVID-19”, and “chest CT”. At the time of writing (August 24, 2020), there have been nearly 100 studies and 30 studies among them were selected for this review. We categorized the studies based on the classification tasks: COVID-19/normal, COVID-19/non-COVID-19, COVID-19/non-COVID-19 pneumonia, and severity. The sensitivity, specificity, precision, accuracy, area under the curve, and F1 score results were reported as high as 100%, 100%, 99.62, 99.87%, 100%, and 99.5%, respectively. However, the presented results should be carefully compared due to the different degrees of difficulty of different classification tasks.

scholarly journals COVID-19 Lesion Segmentation Using Lung CT Scan Images: Comparative Study Based on Active Contour Models

2021 ◽  
Vol 11 (17) ◽  
pp. 8039
Author(s):  
Younes Akbari ◽  
Hanadi Hassen ◽  
Somaya Al-Maadeed ◽  
Susu M. Zughaier
Keyword(s):  
Image Segmentation ◽  
Ct Scan ◽  
Active Contour ◽  
State Of The Art ◽  
Age Groups ◽  
Lesion Segmentation ◽  
Active Contour Models ◽  
Contour Models ◽  
Lung Ct ◽  
Lung Ct Scan

Pneumonia is a lung infection that threatens all age groups. In this paper, we use CT scans to investigate the effectiveness of active contour models (ACMs) for segmentation of pneumonia caused by the Coronavirus disease (COVID-19) as one of the successful methods for image segmentation. A comparison has been made between the performances of the state-of-the-art methods performed based on a database of lung CT scan images. This review helps the reader to identify starting points for research in the field of active contour models on COVID-19, which is a high priority for researchers and practitioners. Finally, the experimental results indicate that active contour methods achieve promising results when there are not enough images to use deep learning-based methods as one of the powerful tools for image segmentation.

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