scholarly journals A Preliminary Study on Blood Lipid Profile in Patients with COVID-19

2020 ◽  
Author(s):  
Zhe Zhu ◽  
Yayun Yang ◽  
Lingyan Fan ◽  
Shuyuan Ye ◽  
Kehong Lou ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Healthy Subjects ◽  
Risk Model ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Apolipoprotein A1 ◽  
Lipoprotein Cholesterol ◽  
Blood Lipid Profile ◽  
Predictive Values ◽  
Severe Group

Abstract Background: Recently, dyslipidemia was observed in the patients with coronavirus disease 2019 (COVID-19). This study aimed to investigate the blood lipid profile in the patients with COVID-19, and explore their predictive value for COVID-19 severity.Methods: 142 consecutive patients with COVID-19 admitted to HwaMei Hospital, University of Chinese Academy of Sciences, from January 23 to April 20, 2020, and 77 age- and gender-matched healthy subjects were included in this retrospective study. The blood lipid profile in the patients with COVID-19 were investigated, and their predictive values for COVID-19 severity were analysed.Results: There were 125 and 17 cases in the non-severe and severe group, respectively. Total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and apolipoprotein A1 (ApoA1) gradually decreased across healthy controls, non-severe group, and severe group. ApoA1 was recognized as an independent risk factor for COVID-19 severity，and had the highest area under the receiver operator characteristic curve (AUC) among all the single markers (AUC: 0.896, 95% CI: 0.834-0.941). Moreover, the risk model established using ApoA1 and IL-6 enhanced the prediction efficiency (AUC: 0.977, 95% CI: 0.932-0.995). Conclusion: The blood lipid profile in the patients with COVID-19 is quite abnormal from healthy subjects, especially in the severe cases. Serum ApoA1 might serve as a good indictor to reflect the severity of COVID-19.

scholarly journals Low serum apolipoprotein A 1 is an indicator of severity in patients with coronavirus disease 2019

2020 ◽  
Author(s):  
Yayun Yang ◽  
Zhe Zhu ◽  
Lingyan Fan ◽  
Shuyuan Ye ◽  
Kehong Lou ◽  
...  
Keyword(s):  
Predictive Value ◽  
Risk Model ◽  
Laboratory Data ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Apolipoprotein A1 ◽  
Lipoprotein Cholesterol ◽  
Predictive Values ◽  
Significant Difference ◽  
Severe Group

Abstract Background: Recently, dyslipidaemia was observed in patients with coronavirus disease 2019 (COVID-19), especially in severe cases. This study aimed to explore the predictive value of blood lipid levels for COVID-19 severity.Methods: All patients with COVID-19 admitted to HwaMei Hospital, University of Chinese Academy of Sciences, from January 23 to April 20, 2020, were included in this retrospective study. General clinical characteristics and laboratory data (including blood lipid parameters) were obtained, and their predictive values for the severity were analysed.Results: In total, 142 consecutive patients with COVID-19 were included. The non-severe group included 125 cases, and 17 cases were included in the severe group. Total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and apolipoprotein A1 (ApoA1) at baseline were significantly lower in the severe group. ApoA1 and interleukin-6 (IL-6) were recognized as independent risk factors for COVID-19 severity. ApoA1 had the highest area under the receiver operator characteristic curve (AUC) among all the single markers (AUC: 0.896, 95% CI: 0.834-0.941). Moreover, the risk model established using ApoA1 and IL-6 enhanced the predictive value (AUC: 0.977, 95% CI: 0.932-0.995). On the other hand, ApoA1 levels were elevated in the severe group during treatment, and there was no significant difference between the severe and non-severe groups during the recovery stage of the disease.Conclusion: The blood lipid profile in severe COVID-19 patients is quite different from that in non-severe cases. Serum ApoA1 could severe as a good indictor to reflect the severity of COVID-19.

scholarly journals Low serum level of apolipoprotein A1 is an indicator of severity in patients with coronavirus disease 2019

2020 ◽  
Author(s):  
Yayun Yang ◽  
Zhe Zhu ◽  
Lingyan Fan ◽  
Shuyuan Ye ◽  
Kehong Lou ◽  
...  
Keyword(s):  
Risk Model ◽  
Characteristic Curve ◽  
Laboratory Data ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Apolipoprotein A1 ◽  
Lipoprotein Cholesterol ◽  
Predictive Values ◽  
Significant Difference ◽  
Severe Group

Abstract Background: Recently, dyslipidemia was observed in the patients of coronavirus disease 2019 (COVID-19), especially in the severe cases. This study aimed to explore the predictive value of blood lipid for the severity of COVID-19.Methods: All patients with COVID-19 who admitted to HwaMei Hospital, University of Chinese Academy of Sciences from January 23 to April 20, 2020 were included in this retrospective study. General clinical characteristics and laboratory data (including blood lipid parameters) were obtained, and their predictive values for the severity were analyzed.Results: 142 consecutive patients with COVID-19 were included. There were 125 cases in the non-severe group and 17 cases in the severe group. Total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (ApoA1) at baseline were significantly lower in the severe group. ApoA1 and interleukin-6 (IL-6) were recognized as independent risk factors for the severity of COVID-19. ApoA1 had the highest area under the receiver operator characteristic curve (AUROC) among all the single markers (AUROC: 0.896, 95% CI: 0.834-0.941). Moreover, the risk model established upon ApoA1 and IL-6 enhanced the predictability (AUROC: 0.977, 95% CI: 0.932-0.995). On the other hand, ApoA1 in the severe group elevated during the treatment, there was no significant difference between the severe and non-severe groups in the recovery stage of disease.Conclusion: The profile of blood lipid in the severe patients with COVID-19 is quite different from that in the non-severe cases. Serum ApoA1 could severe as a good marker to reflect the severity of COVID-19.

scholarly journals ASSOCIATION BETWEEN BLOOD LIPID PROFILE AND BLOOD GLUCOSE LEVELS IN MEN WITH CORONARY HEART DISEASE, METABOLIC SYNDROME, AND TYPE 2 DIABETES MELLITUS

2013 ◽  
Vol 12 (5) ◽  
pp. 29-33
Author(s):  
S. A. Matveeva
Keyword(s):  
Blood Glucose ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Lipoprotein Cholesterol ◽  
Blood Lipid Profile ◽  
Glucose Levels ◽  
Blood Glucose Levels

Aim.To study the associations between blood lipid profile and blood glucose levels in men with coronary heart disease (CHD), stable effort angina (SEA), metabolic syndrome (MS), and Type 2 diabetes mellitus (DM-2).Material and methods.The study included 82 men (mean age 50,5±0,9 years) with CHD, Functional Class I–III SEA, MS, and DM-2. The following lipid profile parameters were assessed: total cholesterol (TCH), triglycerides (TG), low-density lipoprotein cholesterol (LDL–CH), very low-density lipoprotein cholesterol (VLDL–CH), high-density lipoprotein cholesterol (HDL–CH), atherogenic index (AI), and triglyceride index (TGI), together with fasting blood glucose.Results.There were positive (direct) associations between higher levels (>90th percentile) of lipid profile parameters (TCH, TG, LDL–CH, VLDL– CH, HDL–CH, AI, TGI) and blood glucose, as well as between lower levels (≤10th percentile) of lipid profile parameters (TCH, TG, LDL–CH, VLDL– CH, AI, TGI) and blood glucose. At the same time, there were negative (inverse) associations between lower lipid levels (≤10th percentile of TCH, TG, LDL–CH, VLDL–CH, HDL–CH, AI, TGI) and higher glucose levels (>90th percentile), as well as between higher lipid levels (>90th percentile of TCH, TG, LDL–CH, VLDL–CH, HDL–CH, AI, TGI) and lower glucose levels (≤10th percentile).Conclusion.Dyslipidemia and hyperglycemia demonstrate synergetic proatherogenic effects in patients with CHD, SEA, MS, and DM-2, as suggested by significant heterogeneous (direct and inverse) associations between lipid profile parameters and fasting blood glucose. The results obtained provide an opportunity for the assessment of risk levels, prognosis, and need for pharmacological prevention and treatment in patients with combined cardiovascular pathology. 

scholarly journals A study on understanding the blood lipid profile of the hemodialysis patients in Al-Diwaniyah Province, Iraq

2019 ◽  
Vol 10 (4) ◽  
pp. 3155-3158
Author(s):  
Shaymaa Rabeea Madhkhoor ◽  
Jameel K. Alumeri
Keyword(s):  
Lipid Profile ◽  
Cholesterol Oxidase ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Hemodialysis Patients ◽  
Medical Intervention ◽  
The Body ◽  
Lipoprotein Cholesterol ◽  
Healthy Individuals ◽  
Blood Lipid Profile

One of the most frequently worldwide recorded health conditions, is a chronic renal failure (CRF), especially in elderly individuals induced due to renal damage. Kidney damage and therefore, dialysis have several detrimental effects on the body organs and their functions. According to those effects, this study was conducted to recognize the blood lipid profile of the hemodialysis patients in Al-Diwaniyah Province, Iraq. Such determination gives assurance for overall functions of the body organs in order to place proper medical management of those levels if disturbed. From Al-Diwaniyah General Teaching Hospital, Diwaniyah City, Iraq, 68 (50, 33 males and 17 females, hemodialysis CRF (H-CRF) patients and 18, 11 males and 7 females, healthy individuals) samples of blood were collected. For revealing the levels of serum blood lipids of the participants, total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were tested using a cholesterol oxidase method for TC and HDL-C, a glycerol kinase method for TG, and the Friedewald formula for LDL-C. The results unveiled significant (p˂0.01) higher TG levels in H-CRF patients than those in healthy individuals. In addition, HDL-C revealed significant (p˂0.01) lower levels in the H-CRF patients than those in healthy people. No significant (p˃0.01) data were observed from the TC and the LDL-C levels in both groups. This work demonstrates the level changes of the TGs and the HDL-C in the serum of the hemodialysis patients which need proper medical intervention for the correction of those levels.

Analysis of Lipid profile and Atherogenic index (AIP) in dyslipidemia rats given Ipomea batatas tuber extract (IBTE)

2021 ◽  
pp. 4999-5002
Author(s):  
Ni Kadek Warditiani ◽  
Ni Made Widi Astuti ◽  
Pande Made Nova Armita Sari ◽  
Dewa Ayu Swastini ◽  
I Made Agus Gelgel Wirasuta
Keyword(s):  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Lipoprotein Cholesterol ◽  
Atherogenic Index ◽  
Low Density Lipoprotein Cholesterol ◽  
Blood Lipid Profile ◽  
Ipomea Batatas ◽  
Tuber Extract

To evaluate the effect of Ipomea batatas tuber extract (IBTE) on blood lipid profile and atherogenic index in plasma (AIP) of dyslipidemia rats. First, IBTE was extracted by methanol. Fat-rich diets was given for 30 days to induce dyslipidemia in rats. Then, IBTE was given to dyslipidemia rats for 21 days. Lipid profiles in the form of total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C), high lipoprotein-cholesterol (HDL-C) and AIP in rats were measured and analyzed. The results showed that administration of IBTE 150, 300 and 600mg/kg BW was able to improve the blood lipid profile of dyslipidemia rats, where there was a decrease in levels of TC, TG and LDL-C, and an increase in HDL-C levels. In line with this, the AIP value has also decreased. The conclusion was IBTE have affect to improve the blood lipid profile of dyslipidemia rats and the AIP.

Nutritional and phytochemical composition of pecan nut [Carya illinoinensis (Wangenh.) K. Koch] and its hypocholesterolemic effect in an animal model

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Beenu Tanwar ◽  
Rajni Modgil ◽  
Ankit Goyal
Keyword(s):  
Phenolic Compounds ◽  
Lipid Profile ◽  
Density Lipoprotein ◽  
Value Added ◽  
Blood Lipid ◽  
Lipoprotein Cholesterol ◽  
Trypsin Inhibitor Activity ◽  
Hypocholesterolemic Effect ◽  
Blood Lipid Profile ◽  
Content Type

PurposeThe health-promoting phytochemicals such as phenolic compounds and flavonoids present in nonfatty portion of pecan nut remain overlooked. The present study aimed to evaluate the nutritional and antinutritional/phytochemical constituents of pecan nut and its effect (as a whole nut flour) on the blood lipid profile in the rat model.Design/methodology/approachThe nutritional composition as well as phytochemicals were evaluated by using standard chemical methods. A controlled randomized study was conducted to assess the hypocholesterolemic effect of nut supplementation in male Wistar albino rats.FindingsPhytochemicals/antinutrients analysis exhibited remarkable amount of phenolic compounds (47.05 ± 9.85–302.67 ± 7.72 mg GAE/100 g) and flavonoids (44.95 ± 0.23 mg/100 g) with low trypsin inhibitor activity (TIA) (1.18 ± 0.03 TIU/mg), saponins (0.49 ± 0.04 g/100 g), alkaloids (0.26 ± 0.03 mg/100 g), phytic acid (854.75 ± 15.47) and oxalates (8.15 ± 0.58 mg/100 g) content. Kernel oil showed 2.87 ± 0.75 meq O2/kg oil peroxide value (PV), well below the maximum permissible limit, demonstrating good oxidative stability of pecan oil. Pecan nut-supplemented diet exhibited a favorable alteration in the blood lipid profile by decreasing total cholesterol (TC) (from 85.42 ± 1.62–229.23 ± 3.43 to 72.24 ± 1.39–106.10 ± 1.69 mg/dl) and low-density lipoprotein cholesterol (LDL-C) (from 64.02 ± 1.96–199.07 ± 4.40 to 38.73 ± 0.79–55.48 ± 1.69 mg/dl) and increasing high density lipoprotein cholesterol (HDL-C) (from 8.70 ± 0.85–9.64 ± 1.10 to 20.25 ± 0.65–24.96 ± 0.56 mg/dl) when compared with control (CC).Research limitations/implicationsThis information would be further useful for assessing the biological quality of pecan nut as well as developing value-added food products by exploiting deoiled pecan protein concentrates.Originality/valuePecan nut is a rich source of traditional nutrients and phytochemicals and can be recommended to patients with hypercholesterolemia and related cardiovascular diseases.

scholarly journals Effect of dietary fatty acid on blood lipid profile and induced bacterial infection in rat

2015 ◽  
Vol 1 (2) ◽  
pp. 235-243
Author(s):  
Most Sumona Akter ◽  
Md Abu Yousuf ◽  
Md Yousuf Ali ◽  
Most Mahfuja Khatun ◽  
Sukumar Saha ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Lipid Profile ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Blood Cholesterol ◽  
Control Group ◽  
Blood Lipid Profile ◽  
Bacterial Colony ◽  
Group A ◽  
Group B

Ground nut is one of the commonly used decorative nutritious relish seed around the world. Ground nut have hypocholesterolamic, hypoglycemic, hypolipidemic, anti-atherosclerotic, immune-modulatory and bacterial counting effects. In Bangladesh, limited research has so far been performed on the action of ground nut in biological system and its comparative efficacy with commercialized drugs that reduce blood cholesterol. The aim of this study was carried on the effects of PUFA on blood total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL) and triglyceride (TG) and against artificial inoculation (I/N) Staphylococcus aureus infection of experimental rat by feeding of ground nut. A total of fifteen long Evans rats (Rattus norvegicus) were used for this study. The rats were randomly divided into three equal groups (n=5) and numbered as A, B and C. Group A (control), Group B (50gm ground nut/ day/group), group C (100 gm ground nut/day/group). All groups were supplied with standard broiler pellet and fresh drinking water throughout the experimental period (January to June /2012). The blood samples were collected directly from the heart at the 1st and 60th day for biochemical test (TC, LDL, HDL and TG) and test was performed as per Memorial Diagnostic Centre, Charpara, Mymensingh. Staphylococcus aureus was cultured in nutrient broth and 100 µl of their culture was inoculated into the rats through intranasal route. Among all the treated groups, the rats of group C exhibited the lowest TC value, TG and LDL and reduced blood cholesterol significantly than (control group A) followed by group B. In bacteriological examinations, it was found that the number of bacterial colony lowest in group C in comparison with the group of A and B. From the present experiment, it can be assumed that PUFA has significant effect on blood lipid profile and against bacterial infection.Asian J. Med. Biol. Res. June 2015, 1(2): 235-243

scholarly journals Plasma lipid profile of mice fed diet supplemented with broiler fat

2014 ◽  
Vol 43 (1) ◽  
pp. 21-24 ◽  
Author(s):  
GB Das ◽  
ME Hossain ◽  
MA Akbar
Keyword(s):  
Lipid Profile ◽  
Palm Oil ◽  
Low Density Lipoprotein ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
Dietary Treatment ◽  
Blood Lipid ◽  
Blood Cholesterol ◽  
Control Group ◽  
Blood Lipid Profile

This study was conducted with 180 female Swiss albino mice to examine the effects of supplementing broiler fat in the diets of mice on blood lipid profile. Twenty one days old mice were collected from ICDDRB, Mohakhali, Dhaka. They were randomly distributed in four groups having three replications each. Each replicate group had 15 mice. Results revealed that supplementation of broiler fat in mice diet significantly changed (p<0.05) triglyceride (TG) and low density lipoprotein (LDL) among groups. The control group (T0) had the highest level of cholesterol and LDL. Cholesterol, TG and LDL markedly increased (p<0.05) in all dietary treatment groups, while high density lipoprotein (HDL) significantly (p<0.01) decreased after supplementation of experimental diets. It was concluded that all the dietary treatments in general increased blood cholesterol, TG and LDL in mice fed broiler fat with different oil supplements. However, the soybean and palm oil group was comparatively better than other groups in respect of cholesterol, HDL and LDL at the blood lipid profile of mice. Therefore, it can be concluded that consumption of broiler fat with soybean and palm oil could be less harmful for mice.DOI: http://dx.doi.org/10.3329/bjas.v43i1.19380 Bang. J. Anim. Sci. 2014. 43 (1): 21-24

scholarly journals Blood Lipid Profile in Acute Coronary Syndrome and Chronic Stable Angina Patients

2015 ◽  
Vol 7 (2) ◽  
pp. 52-56 ◽  
Author(s):  
T Parvin ◽  
MH Rahman ◽  
S Ferdousi ◽  
A Shahnaz ◽  
M Mahal ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Stable Angina ◽  
Smoking Habit ◽  
Chronic Stable Angina ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Coronary Artery Diseases ◽  
Blood Lipid Profile ◽  
Coronary Syndrome ◽  
History Of

This study was designed to compare the blood lipid profile and conventional cardiovascular risk factors in patients with acute coronary syndrome (ACS) and chronic stable angina (CSA). A total of 110 patients, 55 of which were of ACS and 55 with chronic stable angina (CSA) who underwent coronary angiography in the Department of Cardiology, BSMMU, Dhaka were enrolled for the study. Lipid profile and age, sex, diabetes mellitus, hypertension, hyperlipidemia, smoking habit, family history of premature coronary artery diseases (CAD) of the patients were recorded and compared. Mean±SD age of the studied patients was 52.2±10 years. Prevalence of diabetes mellitus (p<0.05) and hypertension (p <0.05) was significantly higher in patients with CSA than that with ACS. Frequency of hyperlipidemia, smoking habit and family history of CAD was similar between groups. Patients with CSA had significantly higher triple vessel diseases (TVD) (p < 0.001) and significantly lower high-density lipoprotein cholesterol (HDLc) (p < 0.05) compared to that of patients with ACS. ACS patients had significantly higher single vessel diseases (SVD) (p <0.001) compared to that of CSA but the distribution of low-density lipoprotein cholesterol (LDLc), total cholesterol and triglycerides were variable between groups. This study showed that CSA patients had substantially higher frequency of having some CVD risk factors with alteration in certain lipid profile parameters and higher number of triple vessels disease than patients with ACS. This might aid in selecting appropriate criteria for angiographic evaluation and better management of patients with coronary artery diseases. DOI: http://dx.doi.org/10.3329/bjmb.v7i2.22413 Bangladesh J Med Biochem 2014; 7(2): 52-56

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