scholarly journals Deciduoid Mesothelioma of Peritoneum Masquerading as Peritoneal Carcinomatosis.

2021 ◽  
Author(s):  
Jyotsna Naresh Bharti ◽  
Jeewan Ram Vishnoi
Keyword(s):  
Pleural Cavity ◽  
Subcutaneous Fat ◽  
Abdominal Distension ◽  
Axial Skeleton ◽  
Mesothelial Cells ◽  
Lower Limbs ◽  
Tunica Vaginalis ◽  
Ki 67 ◽  
Atypical Cells ◽  
Cd 68

Abstract Mesothelioma is an insidious neoplasm that develops from mesothelial cells. About 80 % of mesotheliomas originate in the pleural cavity. Other sites where it has been reported are the peritoneal cavity, tunica vaginalis, and the pericardium. A 45-year-old female presented with complaints of abdominal distention and pain for three months. Physical examination revealed signs of wasting of the appendicular and axial skeleton muscles, loss of subcutaneous fat, and hollowing of the eye sockets. There was pitting edema in the bilateral lower limbs. Per abdomen, examination revealed abdominal distension with umbilicus in the midline. On palpation, gross ascites was present, and no organomegaly, definitive mass, or lump was palpable. On percussion, the dull note was heard all over the abdomen, and fluid thrill was appreciated. The ascitic fluid examination revealed the presence of atypical cells. Omentectomy was done and sent for histopathological examination.The specimen of omentectomy was in multiple fragments and measured 17x16x3cm. Few of the fragments were nodular, soft to firm. On serial slicing, the cut section was gray-white with areas of necrosis. Microscopic examination showed sheets of malignant cells. These tumor cells were immunoreactive to EMA, Cytokeratin, Vimentin, Calretinin, WT-1, and D2-40 and immunonegative to Desmin (highlighting only the entrapped reactive mesothelial cells), Inhibin, BerEP4, TTF-1, CD 68, Napsin, ER, CEA, CDX2, PR, PAX-8, and SALL4. Ki 67 labelling index was 15%. The features were of Malignant Mesothelioma, Deciduoid variant. Deciduoid mesothelioma is a rare subtype with a poor prognosis. So, the mesothelioma should be distinguished from deciduosis.

scholarly journals Diagnosis of malignant effusion using cell block and immunohistochemistry

2019 ◽  
Vol 7 (9) ◽  
pp. 3556
Author(s):  
Bhavna Gamit ◽  
Deepshikha Dave ◽  
Neha Shahu
Keyword(s):  
Carcinoembryonic Antigen ◽  
Epithelial Membrane Antigen ◽  
Early Stage ◽  
Abdominal Distension ◽  
Mesothelial Cells ◽  
Cell Block ◽  
Malignant Effusion ◽  
Adenocarcinoma Cells ◽  
Signet Ring ◽  
Atypical Cells

The distinction between reactive mesothelial and adenocarcinoma cells specially signet ring type in serous effusions may be very difficult based only on morphological features particularly in early stage. Reactive mesothelial cells show varying degree of cytological atypia hence posing difficulty in differentiating it from adenocarcinoma cells. We report a case of 45 year old female patient presented with abdominal distension. Patient was an operated case of adenocarcinoma of stomach. Smears prepared from ascitic fluid and cell block shows large number of reactive mesothelial cells and few atypical cells. Atypical cells were immunoreactive for cytokeratin, epithelial membrane antigen and carcinoembryonic antigen. These confirmed the presence of malignant epithelial cells so we reported it as a malignant effusion.

Clinical-anamnestic analysis of the course and treatment of benign and borderline epithelial ovarian tumors

2016 ◽  
pp. 86-93
Author(s):  
M.Yu. Yegorov ◽  
◽  
A.A. Sukhanova ◽  
Keyword(s):  
Varicose Veins ◽  
Clinical Manifestations ◽  
Abnormal Uterine Bleeding ◽  
Abdominal Distension ◽  
Ovarian Tumors ◽  
Lower Limbs ◽  
Benign Tumors ◽  
Age Group ◽  
Venous Disorders ◽  
Serous Tumors

The objective: study the features of gynecological, physical history, diagnosis and treatment of patients with benign epithelial ovarian tumors (BeEOT) and borderline epithelial ovarian tumors (BEOT), determining the frequency of recurrence of ovarian tumors in the postoperative period. Patients and methods. According to a retrospective analysis of case histories of 112 women with epithelial ovarian tumors (EOT) underwent conservative or radical surgical treatment in a hospital, two groups were formed: I group – patients with benign epithelial ovarian tumors (BeEOT), which amounted to 85 (75.9%) women, and group II – patients with borderline epithelial ovarian tumors (BEOT), which amounted to 27 (24.1%) women. It was found that the main complaints of patients with EOT were pain (49.1%), abdominal distension (17%), and abnormal uterine bleeding (12.5%). The highest incidence of BeEOT (31.8%) observed in the age group of 41–50 years, while the peak incidence of BEOT (44.4%) corresponds to the age group of 51–60 years. Results. In BEOT endocrine pathology occurs significantly more frequently (p<0.05) than in BeEOT – 25.9% vs. 9.4%, respectively. Pathology of pancreatic-hepatobiliary system occurs significantly more frequently (p<0.05) in patients with BEOT compared with BeEOT – 81.5% versus 57.6%, respectively. Venous disorders (varicose veins of the pelvic organs, lower limbs, haemorrhoids) observed in BEOT significantly more frequently (p<0.05) than in BeEOT – 18.5% vs. 5.9%, respectively. EOT most often diagnosed in the period from 1 to 6 months after the first clinical manifestations with an average uptake of medical care 4.6±0.57 months. In assessing of peritoneal exudate cytogram the mesothelium cells are significantly more common for BeEOT (p<0.01) than BEOT – 79.4% versus 40.9%, respectively. Cervicitis is more likely significantly to occur in BeEOT (p<0.01) than in BEOT – 29.4% vs. 7.4%, respectively. The most common histological type among the benign tumors of the ovaries are endometriomas, which occurred in 48.2% of all BeEOT cases, and among the borderline tumors – serous tumors, which accounted for 59.3% of all BEOTs. Conclusion. The use of organ sparing surgery in EOT increases the risk of recurrence, especially in the case of endometrial histology or borderline variant of tumor. Key words: benign and borderline epithelial ovarian tumors, clinical-anamnestic analysis, diagnosis, treatment.

scholarly journals Primary squamous cell carcinoma of the pancreas with a large pseudocyst of the pancreas as the first manifestation: a rare case report and literature review

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xia Qiu ◽  
Yajie Meng ◽  
Meiqin Lu ◽  
Chuan Tian ◽  
Min Wang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cell Mass ◽  
Elevated Serum ◽  
Abdominal Distension ◽  
Needle Aspiration ◽  
Pancreatic Pseudocysts ◽  
Primary Squamous Cell Carcinoma ◽  
Ki 67

Abstract Background Primary squamous cell carcinoma (SCC) of the pancreas with pseudocysts, especially diagnosed by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), is extremely rare. Case presentation A 64-year-old man was admitted to our department for abdominal distension. Two months ago, he experienced abdominal pain for 1 day and was diagnosed with acute pancreatitis in another hospital. After admission, laboratory tests showed the following: amylase 400 U/L, lipase 403 U/L, and carbohydrate antigen 19–9 (CA19-9) 347 U/mL. Abdominal computed tomography (CT) revealed pancreatitis with a pseudocyst with a diameter measuring 7 cm. During linear EUS, a large pseudocyst (5.4 × 5.2 cm) was observed in the pancreatic body. EUS-FNA was performed. We obtained specimens for histopathology and placed a plastic stent through the pancreas and stomach to drain the pseudocyst. Puncture fluid examination revealed the following: CA19-9 > 12,000 U/mL carcinoembryonic antigen (CEA) 7097.42 ng/ml, amylase 27,145.3 U/L, and lipase > 6000 U/L. Cytopathology revealed an abnormal cell mass, and cancer was suspected. Furthermore, with the result of immunohistochemistry on cell mass (CK ( +), P40 ( +), p63 ( +), CK7 (−) and Ki-67 (30%)), the patient was examined as squamous cell carcinoma (SCC). However, the patient refused surgery, radiotherapy and chemotherapy. After drainage, the cyst shrank, but the patient died 3 months after diagnosis due to liver metastasis and multiple organ failure. Conclusion For patients with primary pancreatic pseudocysts with elevated serum CEA and CA19-9 levels, we should not rule out pancreatic cancer, which may also be a manifestation of primary pancreatic SCC. EUS-FNA is helpful for obtaining histopathology and cytology and thus improving diagnostic accuracy.

scholarly journals Nested variant of urothelial carcinoma of the urinary bladder

Rare Tumors ◽  
2011 ◽  
Vol 3 (4) ◽  
pp. 132-134 ◽  
Author(s):  
Tadashi Terada
Keyword(s):  
Urothelial Carcinoma ◽  
Lamina Propria ◽  
Bladder Tumor ◽  
Clinical Course ◽  
Carcinoma Cells ◽  
Ki 67 ◽  
Atypical Cells ◽  
Nested Variant ◽  
Aggressive Clinical Course ◽  
Nephrogenic Metaplasia

The nested variant of urothelial carcinoma (NVUC) is characterized by the presence of benign-appearing urothelial carcinoma cells in the lamina propria, sparing the surface urothelial involvement. NVUC shows aggressive clinical course despite of benign-looking histology. Herein reported are two cases of NVUC. One is 80-year-old woman, and another is 78-year-old man. In both cases, atypical cells forming nests and tubules were seen in the lamina propria without surface urothelial involvement. One case resembled nephrogenic metaplasia and another proliferated Brunn's nest or inverted papilloma. Immunohistochemically, both cases showed positive p53 and high Ki67 labeling, suggesting that both cases are malignant. Immunohistochemically, one case was characterized by positive cytokeratins, EMA, p53, Ki-67 (labeling=15%), α-methylacyl CoA racemase, CA19-9, and MUC1, and another case by positive cytokeratins, EMA, p63, p53, Ki-67 (lebeling=30%), CD10, CEA, and MUC1. Cyto keratin immunoprofiles were described and other antigens’ expressions were shown. The patients are now free of tumor 6 and 15 months after the resection of the bladder tumor.

Genetic explanations 2: adaptations in body size, shape, and composition

2019 ◽  
pp. 58-74
Author(s):  
Raj S. Bhopal
Keyword(s):  
South Asians ◽  
Subcutaneous Fat ◽  
Fat Distribution ◽  
Lower Limbs ◽  
Skeletal Structure ◽  
Central Adiposity ◽  
Evolutionary Forces ◽  
Fat Deposits ◽  
Central Fat ◽  
Small Muscle

Central body fat has been shown to be metabolically harmful while peripheral fat is neutral or even beneficial. The adipose tissue (compartment) overflow and the variable disease selection hypotheses aim to explain why South Asians tend to central adiposity. The former proposes it results from a small superficial subcutaneous fat compartment especially in the lower limbs, so excess energy is deposited as fat in central compartments. The evolutionary forces for this are presumed to be climatic. The latter proposes central fat deposits in South Asians are an evolutionary adaptation to combat gastrointestinal infections. South Asians’ also have small muscle mass, and small hips, for which there are no well-defined hypotheses. The small size at birth of South Asians may be relevant to all these observations. These differences in fat distribution, muscle and skeletal structure could explain a tendency to central (apple-shaped) obesity than generalized or peripheral obesity (pear-shaped).

scholarly journals Curcumin as an Anticancer Agent in Malignant Mesothelioma: A Review

2020 ◽  
Vol 21 (5) ◽  
pp. 1839 ◽  
Author(s):  
Alfonso Baldi ◽  
Antonio De Luca ◽  
Patrizia Maiorano ◽  
Costantino D’Angelo ◽  
Antonio Giordano
Keyword(s):  
Malignant Mesothelioma ◽  
Anticancer Agent ◽  
Pleural Cavity ◽  
Great Majority ◽  
Review Article ◽  
Clinical Implications ◽  
Tunica Vaginalis ◽  
Pericardial Cavity ◽  
Anti Cancer ◽  
One Year

Malignant mesothelioma is an infrequent tumor that initiates from the mesothelial cells lining of body cavities. The great majority of mesotheliomas originate in the pleural cavity, while the remaining cases initiate in the peritoneal cavity, in the pericardial cavity or on the tunica vaginalis. Usually, mesotheliomas grow in a diffuse pattern and tend to enclose and compress the organs in the various body cavities. Mesothelioma incidence is increasing worldwide and still today, the prognosis is very poor, with a reported median survival of approximately one year from presentation. Thus, the development of alternative and more effective therapies is currently an urgent requirement. The aim of this review article was to describe recent findings about the anti-cancer activity of curcumin and some of its derivatives on mesotheliomas. The potential clinical implications of these findings are discussed.

Mesothelial Cells from Tunica Vaginalis, a Practical Source for Mesothelial Transplantation

2007 ◽  
Vol 30 (6) ◽  
pp. 495-500 ◽  
Author(s):  
T. Asano ◽  
R. Takazawa ◽  
M. Yamato ◽  
K. Kihara ◽  
T. Okano
Keyword(s):  
Cell Transplantation ◽  
Fetal Development ◽  
Mesothelial Cell ◽  
Mesothelial Cells ◽  
Clinical Use ◽  
Tunica Vaginalis ◽  
Physiological Conditions ◽  
Reliable Source ◽  
Novel Method ◽  
Near Future

Transplantation of mesothelial cells is used to repair peritoneum that is damaged by surgery, peritonitis, and peritoneal dialysis. The largest obstacle for clinical application of mesothelial cell transplantation is the lack of a reliable source of mesothelial cells. So far, they are isolated from omentum, mesentery, parietal wall and ascites. Procedures used to obtain mesothelial cells from the omentum or mesentery are invasive, however, especially in pre-operative situations. Sufficient amounts of ascites for aspiration can not be obtained under physiological conditions. We have developed a novel method of isolating mesothelial cells from the tunica vaginalis. The tunica vaginalis originates from the peritoneum and descends into the scrotum along with the testis during fetal development. This region provides a source of mesothelial cells that is convenient to approach and free from abdominal complications. Transplantation of autologous mesothelial cells that were isolated from tunica vaginalis was effective in preventing post-operative adhesions. In this review, we summarize mesothelial cell transplantation trials and describe the method of isolating mesothelial cells form the tunica vaginalis. Mesothelial cell transplantation might be widely accepted for clinical use in the near future.

scholarly journals Prostate Basal Cell Carcinoma: A Case Report

2018 ◽  
Vol 11 (1) ◽  
pp. 138-142 ◽  
Author(s):  
Sahoko Ninomiya ◽  
Takashi Kawahara ◽  
Hiromichi Iwashita ◽  
Genta Iwamoto ◽  
Daiji Takamoto ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Immunohistochemical Analysis ◽  
Pathological Examination ◽  
Ki 67 ◽  
Prostate Hyperplasia ◽  
Atypical Cells ◽  
Prostate Cancers ◽  
Benign Prostate

Prostate basal cell carcinoma (PBCC) accounts for 0.01% of all prostate cancers. A 68-year-old man complained of dysuria for 5 years on his initial visit. His PSA level was 3.87 ng/mL. Due to a diagnosis of benign prostate hyperplasia, he underwent transurethral resection of the prostate. A pathological examination revealed that basal cell-like atypical cells made alveolar with palisadal layout. Immunohistochemical analysis showed positive 34β12, P63, and Ki-67. Based on these findings, PBCC was diagnosed. Then, we performed radical prostatectomy. He was free from recurrence 22 months after the operation. We herein report an extremely rare case of PBCC.

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